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EP About this file: EP2099931

EP2099931 - USE OF LECITHIN:RETINOL ACYL TRANSFERASE GENE PROMOTER METHYLATION IN EVALUATING THE CANCER STATE OF A SUBJECT [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 15.06.2012 Database last updated on 13.11.2024
Most recent event Tooltip	15.06.2012	Application deemed to be withdrawn	published on 18.07.2012 [2012/29]
Applicant(s)	For all designated states CORNELL RESEARCH FOUNDATION, INC. Cornell Center for Technology Enterprise & Commercialization 395 Pine Tree Road, Suite 310 Ithaca, NY 14850 / US
	For all designated states Sloan Kettering Cancer Center 460 East 63rd Street New York, NY 10065-7901 / US
	For all designated states UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY 335 George Street, P.O. Box 3200 New Brunswick, NJ 08901 / US
	[2009/38]
Inventor(s)	01 / BARANY, Francis 450 East 63rd Street, Apt. 12C New York, NY 10021 / US
	02 / CHENG, Yu-Wei 10319 68 Road Apartment 3J Forest Hills, NY 11375 / US
	03 / PATY, Philip 345 East 68th Street, Apt. 1D New York, NY 10065 / US
	04 / NOTTERMAN, Daniel 7 Symmes Court Cranbury, NJ 08512 / US
	[2010/07]
Former [2009/38]	01 / BARANY, Francis 450 East 63rd Street, Apt. 12C New York, NY 10021 / US
	02 / CHENG, Yu-Wei 564 Main Street, Apt. 6E Roosevelt Island, NY 10044 / US
	03 / PATY, Philip 345 East 68th Street, Apt. 1C New York, NY 10021 / US
	04 / NOTTERMAN, Daniel 7 Symmes Court Cranbury, NJ 08512 / US
Representative(s)	Miles, John Stephen Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB
	[N/P]
Former [2009/38]	Miles, John Stephen Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham NG1 5DD / GB
Application number, filing date	07869512.9	19.12.2007
	[2009/38]
	WO2007US88116
Priority number, date	US20060870765P	19.12.2006 Original published format: US 870765 P
	[2009/38]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2008077095
	Date:	26.06.2008
	Language:	EN
	[2008/26]
	Type:	A2 Application without search report
	No.:	EP2099931
	Date:	16.09.2009
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 26.06.2008 takes the place of the publication of the European patent application.
	[2009/38]
Search report(s)	International search report - published on:	US	04.12.2008
	(Supplementary) European search report - dispatched on:	EP	27.10.2010
Classification	IPC:	C12Q1/68, C07H21/02, C07H21/04	[2009/38]
	CPC:	C12Q1/6886 (EP,US); C12Q2600/106 (EP,US); C12Q2600/118 (EP,US); C12Q2600/154 (EP,US); C12Q2600/16 (EP,US)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR [2009/38]
Title	German:	VERWENDUNG VON LECITHIN:RETINOL-ACYLTRANSFERASE-GENPROMOTERMETHYLIERUNG BEI DER BEURTEILUNG DES KREBSSTATUS EINER PERSON	[2009/38]
	English:	USE OF LECITHIN:RETINOL ACYL TRANSFERASE GENE PROMOTER METHYLATION IN EVALUATING THE CANCER STATE OF A SUBJECT	[2009/38]
	French:	EVALUATION DE L'ÉTAT CANCÉREUX PAR MÉTHYLATION DU GÈNE PROMOTEUR DE LA LÉCITHINE-RÉTINOL ACYLTRANSFÉRASE	[2009/40]
	Former [2009/38]	EVALUATION DE L'ETAT CANCEREUX PAR METHYLATION DU GENE PROMOTEUR DE LA LECITHINE-RETINOL ACYLTRANSFERASE
Entry into regional phase	17.07.2009	National basic fee paid
	17.07.2009	Search fee paid
	17.07.2009	Designation fee(s) paid
	17.07.2009	Examination fee paid
Examination procedure	17.07.2009	Examination requested [2009/38]
	23.05.2011	Amendment by applicant (claims and/or description)
	13.07.2011	Despatch of a communication from the examining division (Time limit: M06)
	24.01.2012	Application deemed to be withdrawn, date of legal effect [2012/29]
	27.02.2012	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2012/29]
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 13.07.2011
Fees paid	Renewal fee
	28.12.2009	Renewal fee patent year 03
	27.12.2010	Renewal fee patent year 04
	27.12.2011	Renewal fee patent year 05
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[E]WO2008087040 (EPIGENOMICS AG [DE]; LIEBENBERG VOLKER [DE]; DISTLER JUERGEN [DE]; LEW) [E] 1-26 * pages 57-60; example 1 * * claims 1,2,4-6 * * tables 2, 4b *;
		[AD]US2005227265 (BARANY FRANCIS [US] ET AL) [AD] 1-30 * paragraphs [0001] - [0019] * * figures 34-47 *;
		[A]WO2006084051 (WAYNE JOHN CANCER INST [US]; HOON DAVE S B [US]; UMETANI NAOYUKI [US]) [A] 1-30 * page 28, lines 5-15 * * page 33, lines 5-26 * * claims 1,8 *;
		[XI] - DEW STEPHANIE E ET AL, "Effects of pharmacological retinoids on several vitamin A-metabolizing enzymes", CANCER RESEARCH, (1993), vol. 53, no. 13, ISSN 0008-5472, pages 2965 - 2969, XP002603751 [X] 27,28,30 * abstract * * page 2965, column left, paragraph 2nd and 3rd full * [I] 29
		[X] - KELLOFF ET AL, "Chemopreventive Drug Development: Perspectives and Progress", CANCER EPIDEMIOLOGY, BIOMARKERS AND PREVENTION, PHILADELPHIA, PA, US, (19940101), vol. 3, no. 1, ISSN 1055-9965, pages 85 - 98, XP002113719 [X] 27-30 * abstract * * table 1 *
		[XI] - CHANSRI N ET AL, "Inhibition of liver metastasis by all-trans retinoic acid incorporated into O/W emulsions in mice", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL LNKD- DOI:10.1016/J.IJPHARM.2006.05.008, vol. 321, no. 1-2, ISSN 0378-5173, (20060914), pages 42 - 49, (20060914), XP025113262 [X] 27,28,30 * abstract * [I] 29 DOI: http://dx.doi.org/10.1016/j.ijpharm.2006.05.008
		[I] - BOORJIAN STEPHEN ET AL, "Reduced lecithin: retinol acyltransferase expression correlates with increased pathologic tumor stage in bladder cancer.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 15 MAY 2004 LNKD- PUBMED:15161698, (20040515), vol. 10, no. 10, ISSN 1078-0432, pages 3429 - 3437, XP002603752 [I] 1-26 * abstract * * page 3430, column right, paragraph 1st full *
		[I] - ZHAN HUI CHUN ET AL, "Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 15 OCT 2003 LNKD- PUBMED:14581364, (20031015), vol. 9, no. 13, ISSN 1078-0432, pages 4897 - 4905, XP002603753 [I] 1-26 * abstract * * page 4901, column right, paragraph 1st full * * page 4902, column left, paragraph 1st full * * page 4902, paragraph bridging - page 4903 *
		[A] - NAGASAKA TAKESHI ET AL, "Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20031101), vol. 9, no. 14, ISSN 1078-0432, pages 5306 - 5312, XP002578044 [A] 1-30 * abstract *
	International search	[A]US6200756

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