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Extract from the Register of European Patents

EP About this file: EP2046396

EP2046396 - METHODS AND AGENTS FOR PREPARING 18F-RADIOLABELED FLUORINATING AGENTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  23.05.2014
Database last updated on 31.08.2024
Most recent event   Tooltip15.07.2016Lapse of the patent in a contracting state
New state(s): TR		published on 17.08.2016  [2016/33]
Applicant(s)For all designated states
The Board of Regents of the University of Nebraska
3835 Holdrege Street
Lincoln, NE 68503 / US
[2009/16]
Inventor(s)01 / DIMAGNO, Stephen, G.
2300 Van Dorn Street
Lincoln, NE 68502 / US
02 / SUN, Haoran
2224 U Street, Apt. No.102
Lincoln, NE 68503 / US
 [2009/16]
Representative(s)Hackney, Nigel John, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
[N/P]
Former [2013/29]Hackney, Nigel John, et al
Mewburn Ellis LLP
33 Gutter Lane
London
EC2V 8AS / GB
Former [2009/16]Hackney, Nigel John, et al
Mewburn Ellis LLP 33 Gutter Lane London
EC2V 8AS / GB
Application number, filing date07872250.116.07.2007
[2009/16]
WO2007US73623
Priority number, dateUS20060831460P18.07.2006         Original published format: US 831460 P
[2009/16]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008082695
Date:10.07.2008
Language:EN
[2008/28]
Type: A2 Application without search report 
No.:EP2046396
Date:15.04.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 10.07.2008 takes the place of the publication of the European patent application.
[2009/16]
Type: B1 Patent specification 
No.:EP2046396
Date:17.07.2013
Language:EN
[2013/29]
Search report(s)International search report - published on:US23.10.2008
(Supplementary) European search report - dispatched on:EP23.07.2009
ClassificationIPC:A61K51/04, C07B59/00
[2009/34]
CPC:
A61K51/04 (EP,US)
Former IPC [2009/16]A61K51/04
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/16]
TitleGerman:VERFAHREN UND MITTEL ZUR HERSTELLUNG 18F-STRAHLENMARKIERTER FLUORINIERENDER MITTEL[2009/16]
English:METHODS AND AGENTS FOR PREPARING 18F-RADIOLABELED FLUORINATING AGENTS[2009/16]
French:PROCÉDÉS ET AGENTS PERMETTANT DE PRÉPARER DES AGENTS FLUORANTS RADIOMARQUÉS 18F[2009/16]
Entry into regional phase09.02.2009National basic fee paid 
09.02.2009Search fee paid 
09.02.2009Designation fee(s) paid 
09.02.2009Examination fee paid 
Examination procedure09.02.2009Examination requested  [2009/16]
20.11.2009Despatch of a communication from the examining division (Time limit: M08)
14.07.2010Reply to a communication from the examining division
25.01.2011Despatch of a communication from the examining division (Time limit: M08)
27.09.2011Reply to a communication from the examining division
24.01.2013Communication of intention to grant the patent
28.05.2013Fee for grant paid
28.05.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  20.11.2009
Opposition(s)22.04.2014No opposition filed within time limit [2014/26]
Fees paidRenewal fee
28.07.2009Renewal fee patent year 03
26.07.2010Renewal fee patent year 04
25.07.2011Renewal fee patent year 05
25.07.2012Renewal fee patent year 06
06.05.2013Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU16.07.2007
BG17.07.2013
CY17.07.2013
CZ17.07.2013
EE17.07.2013
FI17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MT17.07.2013
PL17.07.2013
RO17.07.2013
SI17.07.2013
SK17.07.2013
TR17.07.2013
GR18.10.2013
IS17.11.2013
[2016/33]
Former [2016/32]HU16.07.2007
BG17.07.2013
CY17.07.2013
CZ17.07.2013
EE17.07.2013
FI17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MT17.07.2013
PL17.07.2013
RO17.07.2013
SI17.07.2013
SK17.07.2013
GR18.10.2013
IS17.11.2013
Former [2016/28]BG17.07.2013
CY17.07.2013
CZ17.07.2013
EE17.07.2013
FI17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MT17.07.2013
PL17.07.2013
RO17.07.2013
SI17.07.2013
SK17.07.2013
GR18.10.2013
IS17.11.2013
Former [2016/25]BG17.07.2013
CY17.07.2013
CZ17.07.2013
EE17.07.2013
FI17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
PL17.07.2013
RO17.07.2013
SI17.07.2013
SK17.07.2013
GR18.10.2013
IS17.11.2013
Former [2016/21]CY17.07.2013
CZ17.07.2013
EE17.07.2013
FI17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
PL17.07.2013
RO17.07.2013
SI17.07.2013
SK17.07.2013
GR18.10.2013
IS17.11.2013
Former [2014/23]CY17.07.2013
CZ17.07.2013
EE17.07.2013
FI17.07.2013
LT17.07.2013
LV17.07.2013
PL17.07.2013
RO17.07.2013
SI17.07.2013
SK17.07.2013
GR18.10.2013
IS17.11.2013
Former [2014/22]CY17.07.2013
FI17.07.2013
LT17.07.2013
LV17.07.2013
PL17.07.2013
RO17.07.2013
SI17.07.2013
GR18.10.2013
IS17.11.2013
Former [2014/18]CY17.07.2013
FI17.07.2013
LT17.07.2013
LV17.07.2013
PL17.07.2013
SI17.07.2013
GR18.10.2013
IS17.11.2013
Former [2014/12]FI17.07.2013
LT17.07.2013
LV17.07.2013
PL17.07.2013
SI17.07.2013
CY31.07.2013
GR18.10.2013
IS17.11.2013
Former [2014/11]FI17.07.2013
LT17.07.2013
PL17.07.2013
CY31.07.2013
IS17.11.2013
Former [2014/10]LT17.07.2013
CY31.07.2013
IS17.11.2013
Former [2014/08]LT17.07.2013
Documents cited:Search[X]US2006089514  (DIMAGNO STEPHEN G [US], et al) [X] 14,17-23 * the whole document *;
 [X]  - KARL O.CHRISTE ET AL., "Syntheses, properties and structures of anhydrous tetramethylammonium fluoride and its 1:1 adduct with trans-3-amino-2-butenenitrile", J. AM. CHEM. SOC., (1990), vol. 112, pages 7619 - 7625, XP002535739 [X] 14,17-23 * Synthesis of N(CH3)4F left hand column page 7621 *

DOI:   http://dx.doi.org/10.1021/JA00177A025
 [A]  - JAE MIN JEONG ET AL, "Synthesis of No-Carrier-Added [18F]Fluoroacetate", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, (19970101), vol. 39, no. 5, ISSN 0362-4803, pages 395 - 399, XP002432125 [A] 1-23 * page 397, preparation of [18F]TBAF *

DOI:   http://dx.doi.org/10.1002/(SICI)1099-1344(199705)39:5<395::AID-JLCR985>3.0.CO;2-4
 [A]  - ROBERT F. CUNICO ET AL., "geminal-Dehalosilylation of alpha-halo-beta,beta-dimethylvinyltrimethylsilanes: generation of isopropylidene carbene", J. ORGANOMET. CHEM., (1978), vol. 162, pages 1 - 16, XP002535740 [A] 1-23 * p10,11 synthesis of tetramethylammonium fluoride and elemental analysis *

DOI:   http://dx.doi.org/10.1016/S0022-328X(00)89075-0
 [A]  - RAMESH K. SHARMA ET AL., "Instability of anhydrous tetra-n-alkylammonium fluorides", J. ORG. CHEM., (1983), vol. 48, pages 2112 - 2114, XP002535741 [A] 1-23 * the whole document *

DOI:   http://dx.doi.org/10.1021/jo00160a041
International search[A]  - FORD W.T., "Synthesis of Trineopentylamine", JOURNAL OF ORGANIC CHEMISTRY, vol. 38, no. 20, pages 3614 - 3615, XP008102438

DOI:   http://dx.doi.org/10.1021/jo00960a038
ExaminationUS4978769
 EP0534317
 US6103659
    - PLESCHKE A. ET AL., "Halex reactions of aromatic compounds catalysed by 2-azaallenium, carbophsophazenium, aminophosphonium and diphosphazenium salts: a carbophosphazenium, a comparative study", J. FLUOR. CHEM., (2004), vol. 125, no. 6, pages 1031 - 1038
    - SHEPPARD T., "Metal catalysed halogen exchange reactions of aryl halides", ORG. BIOMOL. CHEM., (2009), vol. 7, pages 1043 - 1052
    - AMII H ET AL., "C-F Bond Activation in Organic Synthesis", CHEM. REV., (2009), vol. 109, pages 2119 - 2183
    - DIMANGO S. ET AL., "Anhydrous Tetrabutylammonium Fluoride", J. AM. CHEM. SOC., (2005), vol. 127, pages 2050 - 2051
by applicant   - JAE MIN JEONG ET AL., "Synthesis of No-Carrier-Added [18F]Fluoroacetate", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, (19970101), vol. 39, no. 5, doi:doi:10.1002/(SICI)1099-1344(199705)39:5<395::AID-JLCR985>3.0.CO;2-4, pages 395 - 300, XP002432125

DOI:   http://dx.doi.org/10.1002/(SICI)1099-1344(199705)39:5<395::AID-JLCR985>3.0.CO;2-4
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.