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EP2106261
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EP About this file: EP2106261
| EP2106261 - ANTAGONISTS OF PCSK9 [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 06.07.2012 Database last updated on 24.08.2024 | Most recent event Tooltip | 06.07.2012 | Application deemed to be withdrawn | published on 08.08.2012 [2012/32] | 06.07.2012 | Change - extension states | published on 08.08.2012 [2012/32] | Applicant(s) | For all designated states Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065 / US | [2010/10] |
| Former [2009/41] | For all designated states Merck & Co., Inc. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US | Inventor(s) | 01 /
SITLANI, Ayesha 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US | 02 /
SPARROW, Carl, P. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US | 03 /
PANDIT, Shilpa 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US | 04 /
CONDRA, Jon, H. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US | 05 /
WOOD, Dana, D. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US | 06 /
FISHER, Timothy, S. 126 East Lincoln Avenue Rahway, NJ 07065-0907 / US | [2009/41] | Representative(s) | Hussain, Deeba, et al Merck Sharp & Dohme Corp. 120 Moorgate London, EC2M 6UR / GB | [N/P] |
| Former [2009/50] | Hussain, Deeba, et al Merck & Co., Inc. Hertford Road Hoddesdon Hertfordshire EN11 9BU / GB | ||
| Former [2009/41] | Hussain, Deeba, et al Merck & Co., Inc. European Patent Dept. Hertford Road Hoddesdon Hertfordshire EN11 9BU / GB | Application number, filing date | 07874101.4 | 02.11.2007 | [2009/41] | WO2007US23169 | Priority number, date | US20060857292P | 07.11.2006 Original published format: US 857292 P | [2009/41] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2008133647 | Date: | 06.11.2008 | Language: | EN | [2008/45] | Type: | A2 Application without search report | No.: | EP2106261 | Date: | 07.10.2009 | Language: | EN | The application published by WIPO in one of the EPO official languages on 06.11.2008 takes the place of the publication of the European patent application. | [2009/41] | Search report(s) | International search report - published on: | US | 26.02.2009 | (Supplementary) European search report - dispatched on: | EP | 28.04.2010 | Classification | IPC: | A61K39/00, A61K39/395, C07K16/40 | [2010/21] | CPC: |
C07K16/40 (EP,US);
A61P3/00 (EP);
A61P35/00 (EP);
A61P7/00 (EP);
A61P9/00 (EP);
C07K2317/55 (EP,US);
|
| Former IPC [2009/41] | A61K39/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, PL, PT, RO, SE, SI, SK, TR [2009/41] | Title | German: | PCSK9-ANTAGONISTEN | [2009/41] | English: | ANTAGONISTS OF PCSK9 | [2009/41] | French: | ANTAGONISTES DE PCSK9 | [2009/41] | Entry into regional phase | 08.06.2009 | National basic fee paid | 08.06.2009 | Search fee paid | 26.08.2009 | Designation fee(s) paid | 26.08.2009 | Examination fee paid | Examination procedure | 26.08.2009 | Examination requested [2009/41] | 04.04.2011 | Amendment by applicant (claims and/or description) | 02.08.2011 | Despatch of a communication from the examining division (Time limit: M06) | 14.02.2012 | Application deemed to be withdrawn, date of legal effect [2012/32] | 20.03.2012 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2012/32] | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 02.08.2011 | Request for further processing for: | The application is deemed to be withdrawn due to failure to indicate the wish to proceed further with the application | 04.04.2011 | Request for further processing filed | 04.04.2011 | Full payment received (date of receipt of payment) Request granted | 26.05.2011 | Decision despatched | The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report | 04.04.2011 | Request for further processing filed | 04.04.2011 | Full payment received (date of receipt of payment) Request granted | 26.05.2011 | Decision despatched | Fees paid | Renewal fee | 06.11.2009 | Renewal fee patent year 03 | 22.10.2010 | Renewal fee patent year 04 | 07.11.2011 | Renewal fee patent year 05 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [I] - LAGACE THOMAS A ET AL, "Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US LNKD- DOI:10.1172/JCI29383, (20061101), vol. 116, no. 11, ISSN 0021-9738, pages 2995 - 3005, XP002493243 [I] 1-23 * page 3002, column r, paragraph 3 - page 3004, column l, paragraph 1 * DOI: http://dx.doi.org/10.1172/JCI29383 | [I] - RASHID S ET AL, "Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA. (PNAS), NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US LNKD- DOI:10.1073/PNAS.0501652102, (20050412), vol. 102, no. 15, ISSN 0027-8424, pages 5374 - 5379, XP002478031 [I] 1-23 * page 5375, column l; figures 1-7; tables 1-2 * DOI: http://dx.doi.org/10.1073/pnas.0501652102 | [I] - BENJANNET SUZANNE ET AL, "The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US LNKD- DOI:10.1074/JBC.M606495200, vol. 281, no. 41, ISSN 0021-9258, (20061013), pages 30561PRG - 30572, (20060815), XP002506016 [I] 1-23 * the whole document * DOI: http://dx.doi.org/10.1074/jbc.m606495200 | [I] - GROZDANOV PETAR N ET AL, "Expression and localization of PCSK9 in rat hepatic cells", BIOCHEMISTRY AND CELL BIOLOGY. BIOCHIMIE ET BIOLOGIE CELLULAIRE, NRC RESEARCH PRESS, CA LNKD- DOI:10.1139/O05-155, (20060201), vol. 84, no. 1, ISSN 0829-8211, pages 80 - 92, XP008095646 [I] 1-23 * page 81, column r, paragraph 1; figures 1-7 * DOI: http://dx.doi.org/10.1139/O05-155 | [T] - NI YAN G ET AL, "A PCSK9 C-terminal Domain Binding Fab Inhibits PCSK9 Internalization and Restores LDL-uptake", CIRCULATION, & 82ND SCIENTIFIC SESSION OF THE AMERICAN-HEART-ASSOCIATION; ORLANDO, FL, USA; NOVEMBER 14 -18, 2009, (200911), vol. 120, no. 18, Suppl. 2, ISSN 0009-7322, page S477, XP008121212 [T] 1-23 * the whole document * | International search | [A]US2004248177 (ABI FADEL MARIANNE [LB], et al); | [A]US2005147612 (YAYON AVNER [IL], et al); | [A] - BARRELL ET AL., GENOME NET:PIR, Database accession no. T18240, XP008138560 | [A] - AURY ET AL., GENOME NET:UNI PROT, Database accession no. A0E922, XP008138562 |