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Extract from the Register of European Patents

EP About this file: EP2121919

EP2121919 - MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.12.2012
Database last updated on 28.03.2026
Most recent event   Tooltip18.04.2014Lapse of the patent in a contracting state
New state(s): TR		published on 21.05.2014  [2014/21]
Applicant(s)For all designated states
Heptares Therapeutics Limited
Biopark Broadwater Road Welwyn Garden City
Hertfordshire AL7 3AX / GB
[2009/48]
Inventor(s)01 / HENDERSON, Richard
Heptares Therapeutics Limited
Biopark
Broadwater Road
Welwyn Garden City, Hertfordshire AL7 3AX / GB
02 / TATE, Christopher, Gordon
Heptares Therapeutics Limited
Biopark
Broadwater Road
Welwyn Garden City, Hertfordshire AL7 3AX / GB
03 / MAGNANI, Francesca
Heptares Therapeutics Limited
Biopark
Broadwater Road
Welwyn Garden City, Hertfordshire AL7 3AX / GB
04 / SERRANO-VEGA, Maria Josefa
Heptares Therapeutics Limited
Biopark
Broadwater Road
Welwyn Garden City, Hertfordshire AL7 3AX / GB
05 / SHIBATA, Yoko
Heptares Therapeutics Limited
Biopark
Welwyn Garden City, Hertfordshire AL7 3AX / GB
06 / WARNE, Anthony, Johannes
Heptares Therapeutics Limited
Biopark
Broadwater Road
Welwyn Garden City, Hertfordshire AL7 3AX / GB
07 / WEIR, Malcolm, Peter
Heptares Therapeutics Limited
Biopark
Broadwater Road
Welwyn Garden City, Hertfordshire AL7 3AX / GB
 [2012/04]
Former [2009/48]01 / HENDERSON, Richard
MRC Laboratory of Molecular Biology Hills Road
Cambridge CB2 2QH / GB
02 / TATE, Christopher, Gordon
MRC Laboratory of Molecular Biology Hills Road
Cambridge CB2 2QH / GB
03 / MAGNANI, Francesca
MRC Laboratory of Molecular Biology Hills Road
Cambridge CB2 2QH / GB
04 / SERRANO-VEGA, Maria Josefa
MRC Laboratory of Molecular Biology Hills Road
Cambridge CB2 2QH / GB
05 / SHIBATA, Yoko
MRC Laboratory of Molecular Biology Hills Road
Cambridge CB2 2QH / GB
06 / WARNE, Anthony, Johannes
MRC Laboratory of Molecular Biology Hills Road
Cambridge CB2 2QH / GB
07 / WEIR, Malcolm, Peter
1-3 Burtonhole Lane
London NW7 1AD / GB
Representative(s)Thomas, Philip John Duval
Potter Clarkson LLP The Belgrave Centre
Talbot Street
Nottingham NG1 5GG / GB
[N/P]
Former [2012/06]Thomas, Philip John Duval
Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham
NG1 5DD / GB
Former [2009/48]Thomas, Philip John Duval
Potter Clarkson LLP Park View House 58 The Ropewalk Nottingham
NG1 5DD / GB
Application number, filing date08718823.120.03.2008
[2009/48]
WO2008GB00986
Priority number, dateGB2007000545022.03.2007         Original published format: GB 0705450
GB2007002405208.12.2007         Original published format: GB 0724052
[2009/48]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008114020
Date:25.09.2008
Language:EN
[2008/39]
Type: A2 Application without search report 
No.:EP2121919
Date:25.11.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 25.09.2008 takes the place of the publication of the European patent application.
[2009/48]
Type: B1 Patent specification 
No.:EP2121919
Date:08.02.2012
Language:EN
[2012/06]
Search report(s)International search report - published on:EP19.03.2009
ClassificationIPC:C12N15/10, G01N33/566, C07K14/72
[2009/48]
CPC:
C12N15/1034 (EP,US); C07K14/723 (EP,CN,GB,US); C07K14/705 (GB);
C12N15/102 (GB); G01N33/50 (GB); G01N33/566 (EP,CN,US);
G01N2333/726 (EP,CN,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2012/04]
Former [2009/48]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:MUTANTE G-PROTEIN-GEKOPPELTE REZEPTOREN UND SELEKTIONSVERFAHREN DAFÜR[2009/48]
English:MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM[2009/48]
French:PROTÉINES MUTANTES ET PROCÉDÉS DE SÉLECTION DE CELLES-CI[2009/48]
Entry into regional phase11.09.2009National basic fee paid 
11.09.2009Designation fee(s) paid 
11.09.2009Examination fee paid 
Examination procedure27.03.2009Request for preliminary examination filed
International Preliminary Examining Authority: EP
11.09.2009Examination requested  [2009/48]
02.12.2009Amendment by applicant (claims and/or description)
02.02.2010Despatch of a communication from the examining division (Time limit: M04)
28.04.2010Reply to a communication from the examining division
03.03.2011Despatch of a communication from the examining division (Time limit: M04)
17.05.2011Reply to a communication from the examining division
12.07.2011Despatch of a communication from the examining division (Time limit: M02)
25.07.2011Reply to a communication from the examining division
14.11.2011Communication of intention to grant the patent
21.12.2011Fee for grant paid
21.12.2011Fee for publishing/printing paid
Divisional application(s)EP11075136.9  / EP2386635
EP12153522.3  / EP2450445
EP21171713.7  / EP3926045
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.02.2010
Opposition(s)09.11.2012No opposition filed within time limit [2013/03]
Fees paidRenewal fee
15.03.2010Renewal fee patent year 03
15.03.2011Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipCY08.02.2012
EE08.02.2012
LT08.02.2012
LV08.02.2012
MT08.02.2012
RO08.02.2012
SI08.02.2012
SK08.02.2012
TR08.02.2012
MC31.03.2012
BG08.05.2012
GR09.05.2012
IS08.06.2012
[2014/21]
Former [2013/35]CY08.02.2012
EE08.02.2012
LT08.02.2012
LV08.02.2012
MT08.02.2012
RO08.02.2012
SI08.02.2012
SK08.02.2012
MC31.03.2012
BG08.05.2012
GR09.05.2012
IS08.06.2012
Former [2013/33]CY08.02.2012
EE08.02.2012
LT08.02.2012
LV08.02.2012
RO08.02.2012
SI08.02.2012
SK08.02.2012
MC31.03.2012
BG08.05.2012
GR09.05.2012
IS08.06.2012
Former [2012/50]CY08.02.2012
EE08.02.2012
LT08.02.2012
LV08.02.2012
RO08.02.2012
SI08.02.2012
SK08.02.2012
MC31.03.2012
GR09.05.2012
IS08.06.2012
Former [2012/49]CY08.02.2012
EE08.02.2012
LT08.02.2012
LV08.02.2012
RO08.02.2012
SI08.02.2012
MC31.03.2012
GR09.05.2012
IS08.06.2012
Former [2012/48]CY08.02.2012
EE08.02.2012
LT08.02.2012
LV08.02.2012
MC31.03.2012
GR09.05.2012
IS08.06.2012
Former [2012/47]CY08.02.2012
LT08.02.2012
LV08.02.2012
MC31.03.2012
GR09.05.2012
IS08.06.2012
Former [2012/41]CY08.02.2012
LT08.02.2012
LV08.02.2012
GR09.05.2012
IS08.06.2012
Former [2012/39]LT08.02.2012
LV08.02.2012
GR09.05.2012
IS08.06.2012
Former [2012/36]LT08.02.2012
GR09.05.2012
IS08.06.2012
Former [2012/34]LT08.02.2012
IS08.06.2012
Cited inInternational search[XD]   D'ANTONA ET AL: "A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation", BRAIN RESEARCH, vol. 1108, no. 1, 7 September 2006 (2006-09-07), pages 1 - 11, XP005613784, ISSN: 0006-8993

DOI:   http://dx.doi.org/10.1016/j.brainres.2006.05.042
 [PX]   SERRANO-VEGA MARIA J ET AL: "Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 105, no. 3, 22 January 2008 (2008-01-22), pages 877 - 882, XP002487473

DOI:   http://dx.doi.org/10.1073/pnas.0711253105
 [A]   LATTION A ET AL: "Constitutively active mutants of the beta1-adrenergic receptor.", FEBS LETTERS, vol. 457, no. 3, 3 September 1999 (1999-09-03), pages 302 - 306, XP004260170, ISSN: 0014-5793

DOI:   http://dx.doi.org/10.1016/S0014-5793(99)01064-9
 [XD]   BERCHICHE YAMINA A ET AL: "Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 8, 23 February 2007 (2007-02-23), pages 5111 - 5115, XP002492833, ISSN: 0021-9258 [XD] 1,2,4-7,9-12,14,15,19,20,22,23 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.C600270200
 [PX]   LEFVRE F ET AL: "Alanine-stretch scanning mutagenesis: a simple and efficient method to probe protein structure and function.", NUCLEIC ACIDS RESEARCH, vol. 25, no. 2, 15 January 1997 (1997-01-15), pages 447 - 448, XP002492834, ISSN: 0305-1048 [PX] 1-20,22,23 * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/25.2.447
by applicant  HOPKINS, GROOM, NATURE REV. DRUG DISCOVERY, vol. 1, 2002, pages 727 - 730
   OVERINGTON ET AL., NATURE REV. DRUG DISCOVERY, vol. 5, 2006, pages 993 - 996
   FOORD ET AL., PHARMACOL. REV., vol. 57, 2005, pages 279 - 288
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.