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Extract from the Register of European Patents

EP About this file: EP2116255

EP2116255 - INTRATHECAL ADMINISTRATION OF HGF AFTER SPINAL CORD INJURY [Right-click to bookmark this link]
Former [2009/46]THERAPEUTIC AGENT FOR SPINAL CORD INJURY
[2012/43]
StatusNo opposition filed within time limit
Status updated on  14.02.2014
Database last updated on 05.10.2024
Most recent event   Tooltip15.07.2016Lapse of the patent in a contracting state
New state(s): TR		published on 17.08.2016  [2016/33]
Applicant(s)For all designated states
Keio University
15-45 Mita 2-chome Minato-ku
Tokyo 108-8345 / JP
For all designated states
Osaka University
1-1, Yamadaoka Suita-shi
Osaka 565-0871 / JP
For all designated states
Kringle Pharma Inc.
2F Saito Biotechnology Incubator 7-7-15
Saitoasagi
Ibaraki-shi
Osaka 567-0085 / JP
[2013/17]
Former [2009/46]For all designated states
Keio University
15-45 Mita 2-chome Minato-ku
Tokyo 108-8345 / JP
For all designated states
Osaka University
1-1, Yamadaoka Suita-shi
Osaka 565-0871 / JP
For all designated states
Kringle Pharma Inc.
Senri Asahi Hankyu Bldg. 5-3, Shinsenrihigashimachi 1-chome Toyonaka-shi
Osaka 560-0082 / JP
Inventor(s)01 / OKANO, Hideyuki
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
02 / TOYAMA, Yoshiaki
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
03 / NAKAMURA, Masaya
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
04 / IWANAMI, Akio
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
05 / KITAMURA, Kazuya
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
06 / NAKAMURA, Toshikazu
Okazakihoshoji-cho 1-4
Sakyo-ku, Kyoto-shi
Kyoto 606-8333 / JP
07 / FUNAKOSHI, Hiroshi
Grande 18-302, Kamui 3jo 11-2-4
Asahikawa-shi
Hokkaido 070-8013 / JP
08 / HANADA, Keigo
c/o Kringle Pharma Inc.
2F Saito Biotechnology Incubator 7-7-15
Saitoasagi, Iabaraki-shi
Osaka 567-0085 / JP
 [2013/17]
Former [2013/15]01 / OKANO, Hideyuki
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
02 / TOYAMA, Yoshiaki
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
03 / NAKAMURA, Masaya
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
04 / IWANAMI, Akio
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
05 / KITAMURA, Kazuya
c/o School of Medicine
Keio University
35 Shinanomachi
Shinjuku-ku
Tokyo 160-8582 / JP
06 / NAKAMURA, Toshikazu
c/o Osaka University
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
07 / FUNAKOSHI, Hiroshi
c/o Osaka University
1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
08 / HANADA, Keigo
c/o Kringle Pharma Inc.
Senri Asahi Hankyu Bldg., 5-3
Shinsenrihigashimachi 1-chome
Toyonaka-shi Osaka 560-0082 / JP
Former [2009/46]01 / OKANO, Hideyuki
c/o School of Medicine Keio University 35 Shinanomachi Shinjuku-ku
Tokyo 160-8582 / JP
02 / TOYAMA, Yoshiaki
c/o School of Medicine Keio University 35 Shinanomachi Shinjuku-ku
Tokyo 160-8582 / JP
03 / NAKAMURA, Masaya
c/o School of Medicine Keio University 35 Shinanomachi Shinjuku-ku
Tokyo 160-8582 / JP
04 / IWANAMI, Akio
c/o School of Medicine Keio University 35 Shinanomachi Shinjuku-ku
Tokyo 160-8582 / JP
05 / KITAMURA, Kazuya
c/o School of Medicine Keio University 35 Shinanomachi Shinjuku-ku
Tokyo 160-8582 / JP
06 / NAKAMURA, Toshikazu
c/o Osaka University 1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
07 / FUNAKOSHI, Hiroshi
c/o Osaka University 1-1 Yamadaoka
Suita-shi Osaka 565-0871 / JP
08 / HANADA, Keigo
c/o Kringle Pharma Inc. Senri Asahi Hankyu Bldg., 5-3 Shinsenrihigashimachi 1-chome
Toyonaka-shi Osaka 560-0082 / JP
Representative(s)Kalhammer, Georg, et al
Lederer & Keller
Patentanwälte Partnerschaft mbB
Unsöldstrasse 2
80538 München / DE
[N/P]
Former [2013/15]Kalhammer, Georg, et al
Lederer & Keller Patentanwälte Unsöldstrasse 2
80538 München / DE
Former [2009/46]Kalhammer, Georg, et al
Lederer & Keller Patentanwälte Prinzregentenstrasse 16
80538 München / DE
Application number, filing date08721006.828.02.2008
[2009/46]
WO2008JP53557
Priority number, dateWO2007JP5380428.02.2007         Original published format: PCT/JP2007/053804
[2009/46]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008105507
Date:04.09.2008
Language:JA
[2008/36]
Type: A1 Application with search report 
No.:EP2116255
Date:11.11.2009
Language:EN
[2009/46]
Type: B1 Patent specification 
No.:EP2116255
Date:10.04.2013
Language:EN
[2013/15]
Search report(s)International search report - published on:JP04.09.2008
(Supplementary) European search report - dispatched on:EP04.04.2011
ClassificationIPC:A61K38/18, A61K9/08, A61P25/28, A61P25/00, A61K9/00, A61K9/14, A61K9/20, A61K9/50
[2012/43]
CPC:
A61K38/1833 (EP,US); A61K9/0004 (EP,US); A61K9/0024 (EP,US);
A61K9/0085 (EP,US); A61K9/146 (EP,US); A61K9/2063 (EP,US);
A61K9/5026 (EP,US); A61K9/5031 (EP,US); A61P25/00 (EP);
A61P25/28 (EP) (-)
Former IPC [2011/17]A61K38/22, A61K9/08, A61P25/28, A61P25/00
Former IPC [2009/46]A61K38/22, A61K9/08, A61P25/28
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/46]
TitleGerman:INTRATHEKALE VERABREICHUNG VON HGF NACH EINER RÜCKENMARKSVERLETZUNGEN[2012/43]
English:INTRATHECAL ADMINISTRATION OF HGF AFTER SPINAL CORD INJURY[2012/43]
French:ADMINISTRATION INTRATHÉCALE D'HGF APRÈS UNE LÉSION DE LA MOELLE ÉPINIÈRE[2012/43]
Former [2009/46]MITTEL ZUR BEHANDLUNG VON RÜCKENMARKSVERLETZUNGEN
Former [2009/46]THERAPEUTIC AGENT FOR SPINAL CORD INJURY
Former [2009/46]AGENT THÉRAPEUTIQUE POUR LÉSION DE LA MOELLE ÉPINIÈRE
Entry into regional phase16.07.2009Translation filed 
16.07.2009National basic fee paid 
16.07.2009Search fee paid 
16.07.2009Designation fee(s) paid 
16.07.2009Examination fee paid 
Examination procedure16.07.2009Examination requested  [2009/46]
31.10.2011Amendment by applicant (claims and/or description)
07.02.2012Invitation to provide information on prior art
21.02.2012Reply to the invitation to provide information on prior art
23.04.2012Despatch of a communication from the examining division (Time limit: M02)
02.07.2012Reply to a communication from the examining division
02.11.2012Communication of intention to grant the patent
28.02.2013Fee for grant paid
28.02.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.04.2012
Opposition(s)13.01.2014No opposition filed within time limit [2014/12]
Fees paidRenewal fee
29.01.2010Renewal fee patent year 03
28.01.2011Renewal fee patent year 04
28.02.2012Renewal fee patent year 05
26.02.2013Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.02.2008
AT10.04.2013
CY10.04.2013
CZ10.04.2013
EE10.04.2013
HR10.04.2013
LT10.04.2013
LV10.04.2013
MC10.04.2013
MT10.04.2013
PL10.04.2013
RO10.04.2013
SI10.04.2013
SK10.04.2013
TR10.04.2013
BG10.07.2013
GR11.07.2013
[2016/33]
Former [2016/32]HU28.02.2008
AT10.04.2013
CY10.04.2013
CZ10.04.2013
EE10.04.2013
HR10.04.2013
LT10.04.2013
LV10.04.2013
MC10.04.2013
MT10.04.2013
PL10.04.2013
RO10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
Former [2016/12]AT10.04.2013
CY10.04.2013
CZ10.04.2013
EE10.04.2013
HR10.04.2013
LT10.04.2013
LV10.04.2013
MC10.04.2013
MT10.04.2013
PL10.04.2013
RO10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
Former [2014/44]AT10.04.2013
CY10.04.2013
CZ10.04.2013
EE10.04.2013
HR10.04.2013
LT10.04.2013
LV10.04.2013
MC10.04.2013
PL10.04.2013
RO10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
Former [2014/11]AT10.04.2013
CY10.04.2013
CZ10.04.2013
EE10.04.2013
HR10.04.2013
LT10.04.2013
LV10.04.2013
PL10.04.2013
RO10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
Former [2014/10]AT10.04.2013
CY10.04.2013
CZ10.04.2013
EE10.04.2013
HR10.04.2013
LT10.04.2013
LV10.04.2013
PL10.04.2013
SI10.04.2013
SK10.04.2013
BG10.07.2013
GR11.07.2013
Former [2014/09]AT10.04.2013
CY10.04.2013
EE10.04.2013
HR10.04.2013
LT10.04.2013
LV10.04.2013
PL10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
Former [2013/52]AT10.04.2013
CY10.04.2013
HR10.04.2013
LT10.04.2013
LV10.04.2013
PL10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
Former [2013/51]AT10.04.2013
HR10.04.2013
LT10.04.2013
LV10.04.2013
PL10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
Former [2013/50]AT10.04.2013
LT10.04.2013
LV10.04.2013
PL10.04.2013
SI10.04.2013
BG10.07.2013
GR11.07.2013
Former [2013/48]AT10.04.2013
LT10.04.2013
SI10.04.2013
Former [2013/47]LT10.04.2013
SI10.04.2013
Former [2013/37]SI10.04.2013
Documents cited:Search[Y]  - KATO N. ET AL., "Nonviral HVJ liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve.", NEUROSCIENCE RESEARCH, (2005), vol. 52, pages 299 - 310, XP002629213 [Y] 1-16 * see abstract, page 300 right col., Fig.7 *

DOI:   http://dx.doi.org/10.1016/j.neures.2005.04.004
 [Y]  - SHI E. ET AL, "Nonviral gene transfer of hepatocyte growth factor attenuates neurologic injury after spinal cord ischemia in rabbits.", J. THORACIC AND CARDIOVASC. SURGERY, (200610), vol. 132, no. 4, pages 941 - 947, XP002629214 [Y] 1-16 * abstract *

DOI:   http://dx.doi.org/10.1016/j.jtcvs.2006.06.018
International search[X]WO2006077675  (KRINGLE PHARMA INC [JP], et al);
 [X]WO03045439  (ANGES MG INC [JP], et al);
 [XP]WO2007032396  (UNIV KEIO [JP], et al)
 [X]  - KITAMURA H., "Sekizui Sonsho ni Taisuru Hepatocyte Growth Factor no Yukosei no Kento", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, (2006), vol. 80, no. 8, page S884, XP003023237
 [X]  - KITAMURA K., "Sekizui Sonsho ni Taisuru Hepatocyte Growth Factor no Yokusei no Kento", JOURNAL OF THE JAPAN SPINE RESEARCH SOCIETY, (2006), vol. 17, no. 1, page 557, XP003023238
 [X]  - IWANAMI A., "Sekizui Sonsho ni Taisuru Hepatocyte Growth Factor (HGF) no Yukosei no Kento", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, (2005), vol. 79, no. 8, page S764, XP003010152
by applicantWO03045439
 WO2005100577
 JPH05111382
 JPS6128521
    - BIOCHEM. BIOPHYS. RES. COMMUN., (1984), vol. 122, pages 1450 - 1459
    - NATURE, (1989), vol. 342, pages 440 - 443
    - NAT. NEUROSCI., (1999), vol. 2, pages 213 - 217
    - CLIN. CHIM ACTA., (2003), vol. 327, pages 1 - 23
    - THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, (20050825), vol. 79, no. 8, page S764
    - BIOCHEM. BIOPHYS. RES. COMMUN., (1989), vol. 163, page 967
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.