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Extract from the Register of European Patents

EP About this file: EP2118298

EP2118298 - NUCLEIC ACID-BASED TESTS FOR RHD TYPING [Right-click to bookmark this link]
Former [2009/47]NUCLEIC ACID-BASED TESTS FOR RHD TYPING, GENDER DETERMINATION AND NUCLEIC ACID QUANTIFICATION
[2011/41]
StatusNo opposition filed within time limit
Status updated on  15.11.2013
Database last updated on 14.11.2024
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU, LU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
SEQUENOM, INC.
3595 John Hopkins Court
San Diego, California 92121 / US
[2009/47]
Inventor(s)01 / OETH, Paul, Andrew
4140-162 Via Candidiz
San Diego, CA 92130 / US
02 / EHRICH, Mathias
1947 Diamond Street
San Diego, CA 92109 / US
03 / LEE, Min, Seob
9725 Oviedo St.
San Diego, CA 92129 / US
 [2009/47]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[N/P]
Former [2013/02]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Former [2009/47]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Application number, filing date08729318.907.02.2008
[2009/47]
WO2008US53342
Priority number, dateUS20070888942P08.02.2007         Original published format: US 888942 P
[2009/47]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008098142
Date:14.08.2008
Language:EN
[2008/33]
Type: A2 Application without search report 
No.:EP2118298
Date:18.11.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 14.08.2008 takes the place of the publication of the European patent application.
[2009/47]
Type: B1 Patent specification 
No.:EP2118298
Date:09.01.2013
Language:EN
[2013/02]
Search report(s)International search report - published on:US27.11.2008
(Supplementary) European search report - dispatched on:EP11.01.2011
ClassificationIPC:C12P19/34, C12Q1/68
[2012/16]
CPC:
C12Q1/6881 (EP,US); C12Q2600/156 (EP,US); C12Q2600/16 (EP,US)
Former IPC [2009/47]C12P19/34
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/47]
TitleGerman:TESTS AUF NUKLEINSÄUREBASIS FÜR RHD-TYPISIERUNG[2011/41]
English:NUCLEIC ACID-BASED TESTS FOR RHD TYPING[2011/41]
French:TESTS A BASE D'ACIDE NUCLÉIQUE DESTINÉS AU TYPAGE RHD[2011/41]
Former [2009/47]TEST AUF NUKLEINSÄUREBASIS FÜR RHD-TYPISIERUNG, GESCHLECHTSBESTIMMUNG UND NUKLEINSÄURE-QUANTIFIZIERUNG
Former [2009/47]NUCLEIC ACID-BASED TESTS FOR RHD TYPING, GENDER DETERMINATION AND NUCLEIC ACID QUANTIFICATION
Former [2009/47]TESTS A BASE D'ACIDE NUCLÉIQUE DESTINÉS AU TYPAGE RHD, À LA DÉTERMINATION DU SEXE ET LA QUANTIFICATION D'ACIDE NUCLÉIQUE
Entry into regional phase07.09.2009National basic fee paid 
07.09.2009Search fee paid 
07.09.2009Designation fee(s) paid 
07.09.2009Examination fee paid 
Examination procedure07.09.2009Examination requested  [2009/47]
04.08.2011Amendment by applicant (claims and/or description)
12.10.2011Despatch of a communication from the examining division (Time limit: M04)
22.02.2012Reply to a communication from the examining division
04.04.2012Despatch of a communication from the examining division (Time limit: M02)
24.05.2012Reply to a communication from the examining division
24.07.2012Communication of intention to grant the patent
29.11.2012Fee for grant paid
29.11.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  12.10.2011
Opposition(s)10.10.2013No opposition filed within time limit [2013/51]
Fees paidRenewal fee
16.02.2010Renewal fee patent year 03
15.02.2011Renewal fee patent year 04
15.02.2012Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.02.2008
AT09.01.2013
BE09.01.2013
CY09.01.2013
CZ09.01.2013
DK09.01.2013
EE09.01.2013
FI09.01.2013
HR09.01.2013
IT09.01.2013
LT09.01.2013
LV09.01.2013
MT09.01.2013
PL09.01.2013
RO09.01.2013
SI09.01.2013
SK09.01.2013
TR09.01.2013
LU07.02.2013
MC28.02.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
[2015/34]
Former [2015/32]AT09.01.2013
BE09.01.2013
CY09.01.2013
CZ09.01.2013
DK09.01.2013
EE09.01.2013
FI09.01.2013
HR09.01.2013
IT09.01.2013
LT09.01.2013
LV09.01.2013
MT09.01.2013
PL09.01.2013
RO09.01.2013
SI09.01.2013
SK09.01.2013
TR09.01.2013
MC28.02.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
Former [2014/32]AT09.01.2013
BE09.01.2013
CY09.01.2013
CZ09.01.2013
DK09.01.2013
EE09.01.2013
FI09.01.2013
HR09.01.2013
IT09.01.2013
LT09.01.2013
LV09.01.2013
MT09.01.2013
PL09.01.2013
RO09.01.2013
SI09.01.2013
SK09.01.2013
MC28.02.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
Former [2014/03]AT09.01.2013
BE09.01.2013
CY09.01.2013
CZ09.01.2013
DK09.01.2013
EE09.01.2013
FI09.01.2013
HR09.01.2013
IT09.01.2013
LT09.01.2013
LV09.01.2013
PL09.01.2013
RO09.01.2013
SI09.01.2013
SK09.01.2013
MC28.02.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
Former [2013/52]AT09.01.2013
BE09.01.2013
CY09.01.2013
CZ09.01.2013
DK09.01.2013
EE09.01.2013
FI09.01.2013
HR09.01.2013
LT09.01.2013
LV09.01.2013
PL09.01.2013
RO09.01.2013
SI09.01.2013
SK09.01.2013
MC28.02.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
Former [2013/49]AT09.01.2013
BE09.01.2013
CZ09.01.2013
DK09.01.2013
EE09.01.2013
FI09.01.2013
HR09.01.2013
LT09.01.2013
LV09.01.2013
PL09.01.2013
RO09.01.2013
SI09.01.2013
SK09.01.2013
MC28.02.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
Former [2013/48]AT09.01.2013
BE09.01.2013
DK09.01.2013
EE09.01.2013
FI09.01.2013
HR09.01.2013
LT09.01.2013
LV09.01.2013
PL09.01.2013
SI09.01.2013
MC28.02.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
Former [2013/42]AT09.01.2013
BE09.01.2013
FI09.01.2013
HR09.01.2013
LT09.01.2013
LV09.01.2013
PL09.01.2013
SI09.01.2013
MC28.02.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
Former [2013/41]AT09.01.2013
BE09.01.2013
FI09.01.2013
HR09.01.2013
LT09.01.2013
LV09.01.2013
PL09.01.2013
SI09.01.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
Former [2013/40]AT09.01.2013
BE09.01.2013
FI09.01.2013
LT09.01.2013
LV09.01.2013
PL09.01.2013
SI09.01.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
PT09.05.2013
Former [2013/38]AT09.01.2013
BE09.01.2013
FI09.01.2013
LT09.01.2013
LV09.01.2013
PL09.01.2013
SI09.01.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
Former [2013/37]AT09.01.2013
BE09.01.2013
FI09.01.2013
LT09.01.2013
PL09.01.2013
SI09.01.2013
BG09.04.2013
NO09.04.2013
GR10.04.2013
ES20.04.2013
IS09.05.2013
Former [2013/36]AT09.01.2013
BE09.01.2013
LT09.01.2013
PL09.01.2013
SI09.01.2013
BG09.04.2013
NO09.04.2013
ES20.04.2013
IS09.05.2013
Former [2013/35]BE09.01.2013
LT09.01.2013
SI09.01.2013
BG09.04.2013
NO09.04.2013
IS09.05.2013
Former [2013/34]LT09.01.2013
SI09.01.2013
BG09.04.2013
NO09.04.2013
IS09.05.2013
Former [2013/33]LT09.01.2013
SI09.01.2013
NO09.04.2013
Former [2013/26]SI09.01.2013
Documents cited:Search[Y]  - FINNING K M ET AL, "Prediction of fetal D status from maternal plasma: Introduction of a new noninvasive fetal RHD genotyping service", TRANSFUSION (BETHESDA), (200208), vol. 42, no. 8, ISSN 0041-1132, pages 1079 - 1085, XP002614098 [Y] 1-4 * abstract * * page 1080, column 2, paragraph 2 - page 1081, column 1, paragraph 2; tables 1-2 * * page 1082, column 2, paragraph 3 *

DOI:   http://dx.doi.org/10.1046/j.1537-2995.2002.00165.x
 [Y]  - DING CHUNMING ET AL, "MS analysis of single-nucleotide differences in circulating nucleic acids: Application to noninvasive prenatal diagnosis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20040720), vol. 101, no. 29, ISSN 0027-8424, pages 10762 - 10767, XP002614099 [Y] 1-4 * abstract * * page 10766, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1073/pnas.0403962101
 [IP]  - LI YING ET AL, "Noninvasive genotyping fetal Kell blood group (KEL1) using cell-free fetal DNA in maternal plasma by MALDI-TOF mass spectrometry.", PRENATAL DIAGNOSIS MAR 2008 LNKD- PUBMED:18241084, (20080204), vol. 28, no. 3, ISSN 0197-3851, pages 203 - 208, XP002614100 [IP] 1-4 * abstract * * page 203, column 1, paragraph 1 * * page 207, column 1, line 4 *

DOI:   http://dx.doi.org/10.1002/pd.1936
 [A]  - FAAS B H W ET AL, "Rh E/e genotyping by allele-specific primer amplification", BLOOD, (1995), vol. 85, no. 3, ISSN 0006-4971, pages 829 - 832, XP002614101 [A] 1-4 * abstract *
 [A]  - XIAO YAN ZHONG ET AL, "RISK FREE SIMULTANEOUS PRENATAL IDENTIFICATION OF FETAL RHESUS D STATUS AND SEX BY MULTIPLEX REAL-TIME PCR USING CELL FREE FETAL DNA IN MATERNAL PLASMA", SWISS MEDICAL WEEKLY, EMH SWISS MEDICAL PUBLISHERS, BASEL, CH, (20010210), vol. 131, no. 5/06, ISSN 1424-7860, pages 70 - 74, XP008007703 [A] 1-4 * the whole document *
 [A]  - SINGLETON B K ET AL, "THE PRESENCE OF RHD PSEUDOGENE CONTAINING A 37 BASE PAIR DUPLICATION AND A NONSENSE MUTATION IN AFRICANS WITH THE RH D-NEGATIVE BLOOD GROUP PHENOTYPE", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, (20000101), vol. 95, no. 1, ISSN 0006-4971, pages 12 - 18, XP001011309 [A] 1-4 * the whole document *
 [A]  - VAN DER SCHOOT C E ET AL, "Non-invasive antenatal RHD typing", TRANSFUSION CLINIQUE ET BIOLOGIQUE, ARNETTE-BLACKWELL, PARIS, FR, vol. 13, no. 1-2, doi:10.1016/J.TRACLI.2006.02.021, ISSN 1246-7820, (20060301), pages 53 - 57, (20060301), XP025173431 [A] 1-4 * page 55, column 2, paragraph 2 *

DOI:   http://dx.doi.org/10.1016/j.tracli.2006.02.021
 [A]  - VAN DER SCHOOT C E ET AL, "Prenatal typing of Rh and Kell blood group system antigens: the edge of a watershed.", TRANSFUSION MEDICINE REVIEWS JAN 2003 LNKD- PUBMED:12522770, (200301), vol. 17, no. 1, ISSN 0887-7963, pages 31 - 44, XP005453310 [A] 1-4 * the whole document *
International search[Y]WO2006032897  (UNIV BRISTOL [GB], et al);
 [Y]  - DENOMME G.A. ET AL., "High-througput multiplex single-nucleotide polymorphism analysis for red cell and platelet antigen genotypes", TRANSFUSION, (200505), vol. 45, pages 660 - 666, XP002469115

DOI:   http://dx.doi.org/10.1111/j.1537-2995.2005.04365.x
 [Y]  - BEIBOER ET AL., "Rapid genotyping of blood group antigens by multiplex polymerase chain reaction and DNA microarray hybridization", TRANSFUSION, (200505), vol. 45, pages 667 - 679, XP002372539

DOI:   http://dx.doi.org/10.1111/j.1537-2995.2005.04319.x
 [Y]  - VAN KIM ET AL., "Molecular Cloning and primary structure of the human blood group RhD polypeptide", PROC. NATL. ACAD. SCI., (1992), vol. 89, pages 10925 - 10929, XP001166976

DOI:   http://dx.doi.org/10.1073/pnas.89.22.10925
 [Y]  - BUCK G.A. ET AL., "Design Strategies and Performance of Custom DNA Sequencing Primers", BIOTECHNIQUES, (199909), vol. 27, no. 3, pages 528 - 536, XP008043062
 [A]  - LO Y.M.D., "Recent developments in fetal nucleic acids in maternal plasma: implications to nonivasive prenatal fetal blood group genotyping", TRANSFUSION ET BIOLOGIQUE, (2006), vol. 13, no. 1/2, pages 50 - 52, XP005391598

DOI:   http://dx.doi.org/10.1016/j.tracli.2006.02.010
by applicantUS4656127
 US4683195
 US4683202
 US4851331
 US4965188
 US5492806
 US5525464
 US5547835
 US5589330
 US5605798
 US5656493
 US5679524
 US5691141
 US5695940
 US5834189
 US5849542
 US5849483
 US5869242
 US5876934
 US5908755
 US5912118
 US5928906
 US5976802
 US5981186
 US5998143
 US6004744
 US6013431
 US6017702
 US6018041
 US6043031
 US6046005
 US6045996
 US6087095
 WO0052625
 US6136541
 US6140054
 US6142681
 US6156501
 US6194144
 US6197506
 WO0120039
 US6210891
 WO0125485
 WO0127327
 WO0127329
 US6223127
 WO0129259
 US6225625
 US6229911
 US6239273
 US6258538
    - FINNING K M ET AL., TRANSFUSION (BETHESDA, (200208), vol. 42, no. 8, pages 1079 - 1085
    - CHEN; KWOK, NUCLEIC ACIDS RESEARCH, (1997), vol. 25, pages 347 - 353
    - CHEN ET AL., PROC. NATL. ACAD. SCI. USA, (1997), vol. 94/20, pages 10756 - 10761
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.