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Extract from the Register of European Patents

EP About this file: EP2134719

EP2134719 - CYCLOPAMINE LACTAM ANALOGS AND METHODS OF USE THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  23.05.2014
Database last updated on 02.11.2024
Most recent event   Tooltip15.07.2016Lapse of the patent in a contracting state
New state(s): TR		published on 17.08.2016  [2016/33]
Applicant(s)For all designated states
Infinity Discovery, Inc.
780 Memorial Drive
Cambridge, MA 02139 / US
[2009/52]
Inventor(s)01 / GROGAN, Michael, J.
27 Dunster Lane
Winchester, MA 01890 / US
02 / TREMBLAY, Martin
47 Heywood Avenue
Melrose, MA 02176 / US
03 / LESCARBEAU, Andre
33 Mecham Road
Somerville, MA 02144 / US
04 / CASTRO, Alfredo, C.
43 Wildwood Street
Winchester, MA 01890 / US
 [2009/52]
Representative(s)Hatzmann, Martin
V.O.
Johan de Wittlaan 7
2517 JR Den Haag / NL
[2013/29]
Former [2009/52]Hatzmann, Martin
Vereenigde Johan de Wittlaan 7
2517 JR Den Haag / NL
Application number, filing date08731680.807.03.2008
[2009/52]
WO2008US56229
Priority number, dateUS20070893591P07.03.2007         Original published format: US 893591 P
[2009/52]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008109829
Date:12.09.2008
Language:EN
[2008/37]
Type: A1 Application with search report 
No.:EP2134719
Date:23.12.2009
Language:EN
The application published by WIPO in one of the EPO official languages on 12.09.2008 takes the place of the publication of the European patent application.
[2009/52]
Type: B1 Patent specification 
No.:EP2134719
Date:17.07.2013
Language:EN
[2013/29]
Search report(s)International search report - published on:KR12.09.2008
(Supplementary) European search report - dispatched on:EP19.07.2011
ClassificationIPC:C07D491/048, C07D215/06, A61P35/00
[2009/52]
CPC:
C07D491/20 (EP,US); C07D491/048 (KR); A61K31/58 (KR);
A61P17/06 (EP); A61P35/00 (EP); A61P35/02 (EP);
A61P43/00 (EP); C07D215/06 (EP,KR,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2009/52]
Extension statesAL11.09.2009
BA11.09.2009
MK11.09.2009
RS11.09.2009
TitleGerman:CYCLOPAMIN-LACTAM-ANALOGA UND VERFAHREN ZU IHRER VERWENDUNG[2009/52]
English:CYCLOPAMINE LACTAM ANALOGS AND METHODS OF USE THEREOF[2009/52]
French:ANALOGUES DE CYCLOPAMINE LACTAME ET PROCÉDÉS D'UTILISATION DE CEUX-CI[2009/52]
Entry into regional phase11.09.2009National basic fee paid 
11.09.2009Search fee paid 
11.09.2009Designation fee(s) paid 
11.09.2009Examination fee paid 
Examination procedure11.09.2009Examination requested  [2009/52]
09.02.2012Amendment by applicant (claims and/or description)
02.03.2012Despatch of a communication from the examining division (Time limit: M06)
22.10.2012Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
18.12.2012Reply to a communication from the examining division
29.01.2013Communication of intention to grant the patent
31.05.2013Fee for grant paid
31.05.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.03.2012
Opposition(s)22.04.2014No opposition filed within time limit [2014/26]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
18.12.2012Request for further processing filed
18.12.2012Full payment received (date of receipt of payment)
Request granted
10.01.2013Decision despatched
Fees paidRenewal fee
25.03.2010Renewal fee patent year 03
29.03.2011Renewal fee patent year 04
26.03.2012Renewal fee patent year 05
27.03.2013Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.03.2008
AT17.07.2013
BE17.07.2013
BG17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MT17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
TR17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
LU07.03.2014
CH31.03.2014
LI31.03.2014
[2016/33]
Former [2016/32]HU07.03.2008
AT17.07.2013
BE17.07.2013
BG17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MT17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
LU07.03.2014
CH31.03.2014
LI31.03.2014
Former [2016/27]AT17.07.2013
BE17.07.2013
BG17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MC17.07.2013
MT17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
LU07.03.2014
CH31.03.2014
LI31.03.2014
Former [2016/25]AT17.07.2013
BE17.07.2013
BG17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MT17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
LU07.03.2014
CH31.03.2014
LI31.03.2014
Former [2016/12]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
MT17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
LU07.03.2014
CH31.03.2014
LI31.03.2014
Former [2015/08]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
LU07.03.2014
CH31.03.2014
LI31.03.2014
Former [2014/48]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
LU07.03.2014
Former [2014/24]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
IT17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/23]AT17.07.2013
BE17.07.2013
CY17.07.2013
CZ17.07.2013
DK17.07.2013
EE17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
SK17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/22]AT17.07.2013
BE17.07.2013
CY17.07.2013
DK17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
RO17.07.2013
SE17.07.2013
SI17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/21]AT17.07.2013
BE17.07.2013
CY17.07.2013
DK17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
SE17.07.2013
SI17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/18]AT17.07.2013
BE17.07.2013
CY17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
SE17.07.2013
SI17.07.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/14]AT17.07.2013
BE17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
NL17.07.2013
PL17.07.2013
SE17.07.2013
SI17.07.2013
CY14.08.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/12]AT17.07.2013
BE17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
LV17.07.2013
PL17.07.2013
SE17.07.2013
SI17.07.2013
CY14.08.2013
NO17.10.2013
GR18.10.2013
ES28.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/11]AT17.07.2013
BE17.07.2013
FI17.07.2013
HR17.07.2013
LT17.07.2013
PL17.07.2013
SE17.07.2013
CY14.08.2013
NO17.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/10]AT17.07.2013
BE17.07.2013
HR17.07.2013
LT17.07.2013
SE17.07.2013
CY14.08.2013
NO17.10.2013
IS17.11.2013
PT18.11.2013
Former [2014/09]AT17.07.2013
BE17.07.2013
HR17.07.2013
LT17.07.2013
SE17.07.2013
NO17.10.2013
PT18.11.2013
Former [2014/08]LT17.07.2013
NO17.10.2013
PT18.11.2013
Former [2014/07]NO17.10.2013
Documents cited:Search   [ ] - No further relevant documents disclosed
International search[A]WO02078704  (TAS SINAN [TR], et al);
 [A]WO03088964  (TAS SINAN [TR], et al);
 [A]WO2006026430  (INFINITY PHARMACEUTICALS INC [US], et al);
 [A]  - QUALTHROUGH D. ET AL., "Hedgehog Signaling in Colorectal Tumour Cells: Induction of Apoptosis with Cyclopamine Treatment", INTERNATIONAL JOURNAL OF CANCER, (2004), vol. 110, no. 6, pages 831 - 837, XP008113922

DOI:   http://dx.doi.org/10.1002/ijc.20227
 [A]  - CHEN J.K. ET AL., "Inhibition of Hedgehog signaling by direct binding of cyclopamineto Smoothened", GENES & DEVELOPMENT, (2002), vol. 16, no. 21, pages 2743 - 2748, XP002998650

DOI:   http://dx.doi.org/10.1101/gad.1025302
by applicantWO03088964
 WO2006026430
    - CHEN J.K. ET AL., "Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened", GENES & DEVELOPMENT, (2002), vol. 16, doi:doi:10.1101/gad.1025302, pages 2743 - 2748, XP002998650

DOI:   http://dx.doi.org/10.1101/gad.1025302
    - QUALTHROUGH D. ET AL., "Hedgehog Signalling in Colorectal Tumor Cells: Induction of Apoptosis with Cyclopamine Treatment", INTERNATIONAL JOURNAL OF CANCER, (2004), vol. 110, doi:doi:10.1002/ijc.20227, pages 831 - 837, XP008113922

DOI:   http://dx.doi.org/10.1002/ijc.20227
    - NAKAMURA ET AL., BBRC, (1997), vol. 237, page 465
    - VAN DER HORST ET AL., BONE, (2003), vol. 33, page 899
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