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EP2129771
European procedure
Extract from the Register of European Patents
EP About this file: EP2129771
| EP2129771 - METHODS FOR MODULATING EMBRYONIC STEM CELL DIFFERENTIATION [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 19.07.2019 Database last updated on 06.07.2024 | |
| Former | The patent has been granted Status updated on 10.08.2018 | ||
| Former | Grant of patent is intended Status updated on 18.04.2018 | ||
| Former | Examination is in progress Status updated on 04.11.2016 | Most recent event Tooltip | 09.07.2021 | Lapse of the patent in a contracting state New state(s): HU | published on 11.08.2021 [2021/32] | Applicant(s) | For all designated states The Government of the U.S.A. as represented by the Secretary of the Department of Health & Human Services National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 235 Rockville, MD 20852-3804 / US | [2018/36] |
| Former [2018/20] | For all designated states The Government of U.S.A. as represented by the Secretary of the Department of Health & Human Services National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 235 Rockville, MD 20852-3804 / US | ||
| Former [2009/50] | For all designated states The Government Of The U.S.A, As Represented By The Secretary, Dept. Of Health And Human Services National Institutes Of Health Office Of Technology Transfer 6011 Executive Blvd. Suite 325 Rockville, MD 20852-3804 / US | Inventor(s) | 01 /
KO, Minoru, S.H. 10516 Willow Vista Way Cockeysville, MD 21030 / US | 02 /
FALCO, Geppino 44 Pepperdine Circle Baltimore, MD 21228 / US | 03 /
LEE, Sung-lim 912 Lowe Road Baltimore, MD 21220 / US | 04 /
MONTI, Manuela 1507 W. Lombard Street Baltimore, MD 21223 / US | 05 /
STANGHELLINI, Ilaria Viale Aldo Moro 9 40127 Bologna / IT | [2018/37] |
| Former [2010/11] | 01 /
KO, Minoru, S.h. 10516 Willow Vista Way Cockeysville, MD 21030 / US | ||
| 02 /
FALCO, Geppino 44 Pepperdine Circle Baltimore, MD 21228 / US | |||
| 03 /
LEE, Sung-lim 912 Lowe Road Baltimore, MD 21220 / US | |||
| 04 /
MONTI, Manuela 1507 W. Lombard Street Baltimore, MD 21223 / US | |||
| 05 /
STANGHELLINI, Ilaria Viale Aldo Moro 9 40127 Bologna / IT | |||
| Former [2009/50] | 01 /
KO, Minoru, S.h. 10516 Willow Vista Way Cockeysville, MD 21030 / US | ||
| 02 /
FALCO, Geppino 44 Pepperdine Circle Baltimore, MD 21228 / US | |||
| 03 /
LEE, Sung-lim 912 Lowe Road Baltimore, MD 21220 / US | |||
| 04 /
MONTI, Manuela 1507 W. Lombard Street Baltimore, MD 21223 / US | |||
| 05 /
STANGHELLINI, Ilaria 3100 St. Paul Street, Apt. 314 Baltimore, MD 21218 / US | Representative(s) | Docherty, Robert Charles, et al Symbiosis IP Limited York Biotech Campus Office 14FA05 Sand Hutton York, YO41 1LZ / GB | [N/P] |
| Former [2018/37] | Docherty, Robert Charles, et al Symbiosis IP Limited NAFIC Office 14FA05 Sand Hutton York, North Yorkshire YO41 1LZ / GB | ||
| Former [2012/16] | Docherty, Robert Charles Symbiosis IP Limited Apollo House Eboracum Way Heworth Green, York YO31 7RE / GB | ||
| Former [2009/50] | Walton, Seán Malcolm, et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS / GB | Application number, filing date | 08732853.0 | 26.03.2008 | [2009/50] | WO2008US58261 | Priority number, date | US20070920215P | 26.03.2007 Original published format: US 920215 P | [2009/50] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2008118957 | Date: | 02.10.2008 | Language: | EN | [2008/40] | Type: | A2 Application without search report | No.: | EP2129771 | Date: | 09.12.2009 | Language: | EN | The application published by WIPO in one of the EPO official languages on 02.10.2008 takes the place of the publication of the European patent application. | [2009/50] | Type: | B1 Patent specification | No.: | EP2129771 | Date: | 12.09.2018 | Language: | EN | [2018/37] | Search report(s) | International search report - published on: | EP | 05.03.2009 | Classification | IPC: | C12N5/00, C12N15/00, C12N5/0735 | [2017/51] | CPC: |
C07K14/47 (EP,US);
A01K67/0275 (EP,US);
C12N15/113 (EP,US);
C12N15/85 (EP,US);
C12N5/0606 (EP,US);
C12N5/0611 (EP,US);
A01K2217/052 (EP,US);
A01K2217/15 (EP,US);
A01K2227/105 (EP,US);
A01K2267/0393 (EP,US);
C12N2310/111 (EP,US);
C12N2310/14 (EP,US);
C12N2310/53 (EP,US);
C12N2501/40 (EP,US);
C12N2510/00 (EP,US);
|
| Former IPC [2009/50] | C12N5/00, C12N15/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2018/37] |
| Former [2009/50] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR | Extension states | AL | Not yet paid | BA | Not yet paid | MK | Not yet paid | RS | Not yet paid | Title | German: | VERFAHREN ZUR MODULATION VON EMBRYONALER STAMMZELLDIFFERENZIERUNG | [2009/50] | English: | METHODS FOR MODULATING EMBRYONIC STEM CELL DIFFERENTIATION | [2009/50] | French: | PROCÉDÉS DE MODULATION DE LA DIFFÉRENTIATION DES CELLULES SOUCHES EMBRYONNAIRES | [2009/50] | Entry into regional phase | 30.09.2009 | National basic fee paid | 30.09.2009 | Designation fee(s) paid | 30.09.2009 | Examination fee paid | Examination procedure | 17.09.2009 | Amendment by applicant (claims and/or description) | 30.09.2009 | Examination requested [2009/50] | 01.02.2010 | Despatch of a communication from the examining division (Time limit: M04) | 03.06.2010 | Reply to a communication from the examining division | 15.11.2010 | Despatch of a communication from the examining division (Time limit: M04) | 21.03.2011 | Reply to a communication from the examining division | 12.08.2014 | Despatch of a communication from the examining division (Time limit: M04) | 11.12.2014 | Reply to a communication from the examining division | 05.07.2016 | Despatch of a communication from the examining division (Time limit: M04) | 02.11.2016 | Reply to a communication from the examining division | 19.04.2018 | Communication of intention to grant the patent | 25.07.2018 | Fee for grant paid | 25.07.2018 | Fee for publishing/printing paid | 25.07.2018 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 01.02.2010 | Opposition(s) | 13.06.2019 | No opposition filed within time limit [2019/34] | Fees paid | Renewal fee | 25.03.2010 | Renewal fee patent year 03 | 29.03.2011 | Renewal fee patent year 04 | 26.03.2012 | Renewal fee patent year 05 | 27.03.2013 | Renewal fee patent year 06 | 27.03.2014 | Renewal fee patent year 07 | 27.03.2015 | Renewal fee patent year 08 | 31.03.2016 | Renewal fee patent year 09 | 27.03.2017 | Renewal fee patent year 10 | 27.03.2018 | Renewal fee patent year 11 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 26.03.2008 | AT | 12.09.2018 | CY | 12.09.2018 | CZ | 12.09.2018 | DK | 12.09.2018 | EE | 12.09.2018 | ES | 12.09.2018 | FI | 12.09.2018 | HR | 12.09.2018 | IT | 12.09.2018 | LT | 12.09.2018 | LV | 12.09.2018 | MC | 12.09.2018 | NL | 12.09.2018 | PL | 12.09.2018 | RO | 12.09.2018 | SE | 12.09.2018 | SI | 12.09.2018 | SK | 12.09.2018 | TR | 12.09.2018 | BG | 12.12.2018 | NO | 12.12.2018 | GR | 13.12.2018 | IS | 12.01.2019 | PT | 12.01.2019 | IE | 26.03.2019 | LU | 26.03.2019 | MT | 26.03.2019 | BE | 31.03.2019 | CH | 31.03.2019 | LI | 31.03.2019 | [2021/32] |
| Former [2021/26] | AT | 12.09.2018 | |
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| IS | 12.01.2019 | ||
| PT | 12.01.2019 | ||
| IE | 26.03.2019 | ||
| LU | 26.03.2019 | ||
| MT | 26.03.2019 | ||
| BE | 31.03.2019 | ||
| CH | 31.03.2019 | ||
| LI | 31.03.2019 | ||
| Former [2020/29] | AT | 12.09.2018 | |
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| BG | 12.12.2018 | ||
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| GR | 13.12.2018 | ||
| IS | 12.01.2019 | ||
| PT | 12.01.2019 | ||
| IE | 26.03.2019 | ||
| LU | 26.03.2019 | ||
| MT | 26.03.2019 | ||
| BE | 31.03.2019 | ||
| CH | 31.03.2019 | ||
| LI | 31.03.2019 | ||
| Former [2020/17] | AT | 12.09.2018 | |
| CZ | 12.09.2018 | ||
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| BG | 12.12.2018 | ||
| NO | 12.12.2018 | ||
| GR | 13.12.2018 | ||
| IS | 12.01.2019 | ||
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| IE | 26.03.2019 | ||
| LU | 26.03.2019 | ||
| BE | 31.03.2019 | ||
| CH | 31.03.2019 | ||
| LI | 31.03.2019 | ||
| Former [2020/11] | AT | 12.09.2018 | |
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| SI | 12.09.2018 | ||
| SK | 12.09.2018 | ||
| BG | 12.12.2018 | ||
| NO | 12.12.2018 | ||
| GR | 13.12.2018 | ||
| IS | 12.01.2019 | ||
| PT | 12.01.2019 | ||
| IE | 26.03.2019 | ||
| LU | 26.03.2019 | ||
| BE | 31.03.2019 | ||
| CH | 31.03.2019 | ||
| LI | 31.03.2019 | ||
| Former [2020/09] | AT | 12.09.2018 | |
| CZ | 12.09.2018 | ||
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| SI | 12.09.2018 | ||
| SK | 12.09.2018 | ||
| BG | 12.12.2018 | ||
| NO | 12.12.2018 | ||
| GR | 13.12.2018 | ||
| IS | 12.01.2019 | ||
| PT | 12.01.2019 | ||
| IE | 26.03.2019 | ||
| LU | 26.03.2019 | ||
| Former [2020/01] | AT | 12.09.2018 | |
| CZ | 12.09.2018 | ||
| DK | 12.09.2018 | ||
| EE | 12.09.2018 | ||
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| BG | 12.12.2018 | ||
| NO | 12.12.2018 | ||
| GR | 13.12.2018 | ||
| IS | 12.01.2019 | ||
| PT | 12.01.2019 | ||
| LU | 26.03.2019 | ||
| Former [2019/46] | AT | 12.09.2018 | |
| CZ | 12.09.2018 | ||
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| EE | 12.09.2018 | ||
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| IS | 12.01.2019 | ||
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| Former [2019/37] | AT | 12.09.2018 | |
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| NO | 12.12.2018 | ||
| GR | 13.12.2018 | ||
| IS | 12.01.2019 | ||
| PT | 12.01.2019 | ||
| Former [2019/34] | AT | 12.09.2018 | |
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| BG | 12.12.2018 | ||
| NO | 12.12.2018 | ||
| GR | 13.12.2018 | ||
| IS | 12.01.2019 | ||
| PT | 12.01.2019 | ||
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| CZ | 12.09.2018 | ||
| EE | 12.09.2018 | ||
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| BG | 12.12.2018 | ||
| NO | 12.12.2018 | ||
| GR | 13.12.2018 | ||
| IS | 12.01.2019 | ||
| PT | 12.01.2019 | ||
| Former [2019/23] | AT | 12.09.2018 | |
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| EE | 12.09.2018 | ||
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| BG | 12.12.2018 | ||
| NO | 12.12.2018 | ||
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| IS | 12.01.2019 | ||
| Former [2019/22] | CZ | 12.09.2018 | |
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| NO | 12.12.2018 | ||
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| IS | 12.01.2019 | ||
| Former [2019/21] | ES | 12.09.2018 | |
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| NO | 12.12.2018 | ||
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| Former [2019/08] | FI | 12.09.2018 | |
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| Former [2019/07] | LT | 12.09.2018 | Cited in | International search | [X] - "Viral vector-related plasmid - pcDNA6.2/GFP-DEST.", Geneseq, (20040909), Database accession no. ADQ48564, URL: EBI, XP002492234 [X] 29-36 * the whole document * | [Y] - ZHANG WEN ET AL, "Zfp206 regulates ES cell gene expression and differentiation", NUCLEIC ACIDS RESEARCH, (200610), vol. 34, no. 17, ISSN 0305-1048, pages 4780 - 4790, XP002492233 [Y] 1-28 * page 4785, column R, paragraph 1 - page 4787, column R, paragraph 1; figure 8 * DOI: http://dx.doi.org/10.1093/nar/gkl631 | [Y] - EDELSTEIN ET AL, "The SCAN domain family of zinc finger transcription factors", GENE, ELSEVIER, AMSTERDAM, NL, (20051010), vol. 359, ISSN 0378-1119, pages 1 - 17, XP005088524 [Y] 1-28 * the whole document * DOI: http://dx.doi.org/10.1016/j.gene.2005.06.022 | [PX] - FALCO ET AL, "Zscan4: A novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells", DEVELOPMENTAL BIOLOGY, ACADEMIC PRESS, NEW YORK, NY, US, (20070702), vol. 307, no. 2, ISSN 0012-1606, pages 539 - 550, XP022137862 [PX] 1-37 * the whole document * DOI: http://dx.doi.org/10.1016/j.ydbio.2007.05.003 | [PX] - CARTER ET AL, "An in situ hybridization-based screen for heterogeneously expressed genes in mouse ES cells", GENE EXPRESSION PATTERNS, ELSEVIER, (20071104), vol. 8, no. 3, ISSN 1567-133X, pages 181 - 198, XP022420270 [PX] 44,45 * the whole document * DOI: http://dx.doi.org/10.1016/j.gep.2007.10.009 | Examination | - MICHAL ZALZMAN ET AL, "Zscan4 regulates telomere elongation and genomic stability in ES cells", NATURE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 464, no. 7290, doi:10.1038/NATURE08882, ISSN 0028-0836, (20100408), pages 858 - 863, (20100324), XP008151227 DOI: http://dx.doi.org/10.1038/nature08882 | - Tetsuya Hirata ET AL, "Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells", Scientific Reports, (20120104), vol. 2, doi:10.1038/srep00208, XP055125784 DOI: http://dx.doi.org/10.1038/srep00208 | - JIANG JING ET AL, "Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation", CELL RESEARCH, (201301), vol. 23, no. 1, Sp. Iss. SI, pages 92 - 106, XP009179503 DOI: http://dx.doi.org/10.1038/cr.2012.157 | by applicant | - BONGSO ET AL., HUM REPROD., (1989), vol. 4, pages 706 - 713 |