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Extract from the Register of European Patents

EP About this file: EP2152853

EP2152853 - IN VITRO MODEL OF LATENT MYCOBACTERIAL INFECTION [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  20.01.2017
Database last updated on 20.09.2024
Most recent event   Tooltip20.01.2017Application deemed to be withdrawnpublished on 22.02.2017  [2017/08]
Applicant(s)For all designated states
University Of Central Florida Research Foundation, Inc.
12201 Research Parkway, Suite 501
Orlando FL 32826-3246 / US
[2010/07]
Inventor(s)01 / KOLATTUKUDY, Papachan, E.
University Of Central Florida Research Foundation Inc. 12201 Research Pkwy., Ste. 501
Orlando, FL 32826-3246 / US
02 / SIRAKOVA, Tatiana
University Of Central Florida Research Foundation Inc. 12201 Research Pkwy., Ste. 501
Orlando, FL 32826-3246 / US
03 / DANIEL, Jaiyanth
University Of Central Florida Research Foundation Inc. 12201 Research Pkwy., Ste. 501
Orlando, FL 32826-3246 / US
04 / DEB, Chirajyoti
University Of Central Florida Research Foundation Inc. 12201 Research Pkwy., Ste. 501
Orlando, FL 32826-3246 / US
 [2010/07]
Representative(s)Goodfellow, Hugh Robin
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2010/07]Bullett, Rachel Margaret, et al
Carpmaels & Ransford 43-45 Bloomsbury Square
London WC1A 2RA / GB
Application number, filing date08746514.222.04.2008
[2010/07]
WO2008US61110
Priority number, dateUS20070914838P30.04.2007         Original published format: US 914838 P
[2010/07]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2008134298
Date:06.11.2008
Language:EN
[2008/45]
Type: A1 Application with search report 
No.:EP2152853
Date:17.02.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 06.11.2008 takes the place of the publication of the European patent application.
[2010/07]
Search report(s)International search report - published on:US06.11.2008
(Supplementary) European search report - dispatched on:EP17.05.2010
ClassificationIPC:C12N1/12, C12N1/20
[2010/07]
CPC:
C12N1/36 (EP,US); C12N1/20 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/07]
TitleGerman:IN-VITRO-MODELL EINER LATENTEN MYKOBAKTERIENINFEKTION[2010/07]
English:IN VITRO MODEL OF LATENT MYCOBACTERIAL INFECTION[2010/07]
French:MODÈLE IN VITRO D'INFECTION MYCOBACTÉRIENNE LATENTE[2010/07]
Entry into regional phase27.11.2009National basic fee paid 
27.11.2009Search fee paid 
27.11.2009Designation fee(s) paid 
27.11.2009Examination fee paid 
Examination procedure23.02.2009Request for preliminary examination filed
International Preliminary Examining Authority: US
27.11.2009Examination requested  [2010/07]
07.12.2010Amendment by applicant (claims and/or description)
28.07.2014Despatch of a communication from the examining division (Time limit: M06)
14.05.2015Reply to a communication from the examining division
10.05.2016Despatch of a communication from the examining division (Time limit: M04)
21.09.2016Application deemed to be withdrawn, date of legal effect  [2017/08]
19.10.2016Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2017/08]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.07.2014
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
14.05.2015Request for further processing filed
14.05.2015Full payment received (date of receipt of payment)
Request granted
09.06.2015Decision despatched
Fees paidRenewal fee
04.05.2010Renewal fee patent year 03
12.04.2011Renewal fee patent year 04
27.04.2012Renewal fee patent year 05
25.04.2013Renewal fee patent year 06
14.04.2014Renewal fee patent year 07
28.04.2015Renewal fee patent year 08
25.04.2016Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
30.04.201003   M06   Fee paid on   28.05.2010
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]  - ZAHRT THOMAS C, "Molecular mechanisms regulating persistent Mycobacterium tuberculosis infection.", MICROBES AND INFECTION, (200302), vol. 5, no. 2, ISSN 1286-4579, pages 159 - 167, XP002580440 [X] 1-3,8-10 * paragraph [0004]; figure 3 * * paragraph [04.3] *

DOI:   http://dx.doi.org/10.1016/S1286-4579(02)00083-7
 [X]  - CAPPELLETTY ET AL, "Evaluation of an intracellular pharmacokinetic in vitro infection model as a tool to assess tuberculosis therapy", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, ELSEVIER SCIENCE, AMSTERDAM, NL LNKD- DOI:10.1016/J.IJANTIMICAG.2006.10.001, (20070112), vol. 29, no. 2, ISSN 0924-8579, pages 212 - 216, XP005827912 [X] 4-7 * abstract * * page 213, column 1, paragraph 3; figures 2(b),3 * * page 215, column 2, line 11 - line 18 *

DOI:   http://dx.doi.org/10.1016/j.ijantimicag.2006.10.001
 [A]  - DANIEL JAIYANTH ET AL, "Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture", JOURNAL OF BACTERIOLOGY, (200408), vol. 186, no. 15, ISSN 0021-9193, pages 5017 - 5030, XP002580441 [A] 1-10 * page 5028, column 2, lines 12-20 * * page 5028, column 2, paragraph l *

DOI:   http://dx.doi.org/10.1128/JB.186.15.5017-5030.2004
 [A]  - WAYNE L G ET AL, "Nonreplicating persistence of mycobacterium tuberculosis.", ANNUAL REVIEW OF MICROBIOLOGY 2001 LNKD- PUBMED:11544352, (2001), vol. 55, ISSN 0066-4227, pages 139 - 163, XP002580442 [A] 1-10 * page 144 - page 145 *
 [T]  - DEB CHIRAJYOTI ET AL, "A Novel In Vitro Multiple-Stress Dormancy Model for Mycobacterium tuberculosis Generates a Lipid-Loaded, Drug-Tolerant, Dormant Pathogen", PLOS ONE, (200906), vol. 4, no. 6, ISSN 1932-6203, XP002580443 [T] * the whole document *

DOI:   http://dx.doi.org/10.1371/journal.pone.0006077
 [A]  - MARIAM DENEKE H ET AL, "Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (200404), vol. 48, no. 4, ISSN 0066-4804, pages 1289 - 1294, XP002580444 [A] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1128/AAC.48.4.1289-1294.2004
 [A]  - THEUS S A ET AL, "Activated THP-1 cells: An attractive model for the assessment of intracellular growth rates of Mycobacterium tuberculosis isolates.", INFECTION AND IMMUNITY, (200402), vol. 72, no. 2, ISSN 0019-9567, pages 1169 - 1173, XP002580445 [A] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1128/IAI.72.2.1169-1173.2004
International search[X]US7105170  (QUINN FREDERICK D [US], et al);
 [X]  - BETTS J.C. ET AL., "Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistance by gene and protein expression profiling", MOL. MICROBIOL., (200202), vol. 43, no. 3, pages 717 - 731, XP002223692

DOI:   http://dx.doi.org/10.1046/j.1365-2958.2002.02779.x
 [Y]  - SIRAKOVA T.D. ET AL, "Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress", MICROBIOLOGY, (200609), vol. 152, no. 9, pages 2717 - 2725, XP008123057

DOI:   http://dx.doi.org/10.1099/MIC.0.28993-0
 [Y]  - AUWERX J., "The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation", EXPERIENTIA, (19910115), vol. 47, no. 1, pages 22 - 31, XP000218599

DOI:   http://dx.doi.org/10.1007/BF02041244
 [Y]  - CHAUHAN, "Effect of Carbon Dioxide on the primary isolation of Mycobacteria", INDIAN JOUR. TUBERCULOSIS, (1991), vol. 38, pages 81 - 85, XP008123502
 [Y]  - MUTTUCUMARU ET AL., "Gene expression profile of Mycobacterium tuberculosis in anon-replicating state", TUBERCULOSIS, (200405), vol. 84, pages 239 - 246, XP008123058

DOI:   http://dx.doi.org/10.1016/J.TUBE.2003.12.006
Examination   - C. J. RIENDEAU ET AL, "THP-1 Cell Apoptosis in Response to Mycobacterial Infection", INFECTION AND IMMUNITY, (20030101), vol. 71, no. 1, doi:10.1128/IAI.71.1.254-259.2003, ISSN 0019-9567, pages 254 - 259, XP055130564

DOI:   http://dx.doi.org/10.1128/IAI.71.1.254-259.2003
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.