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EP2152074
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| EP2152074 - COMPOSITIONS OF (-)-E-10-OH-NT AND METHODS FOR THEIR SYNTHESIS AND USE [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 29.11.2013 Database last updated on 11.04.2026 | Most recent event Tooltip | 29.11.2013 | Application deemed to be withdrawn | published on 01.01.2014 [2014/01] | Applicant(s) | For all designated states Adolor Corporation 700 Pennsylvania Drive Exton, PA 19341 / US | [2010/07] | Inventor(s) | 01 /
LE BOURDONNEC, Bertrand 317 Ivy Lane East Fallowfield, PA 19320 / US | 02 /
DOLLE, Roland 536 Elliott Drive King Of Prussia, PA 19405 / US | [2010/07] | Representative(s) | Cockerton, Bruce Roger Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | [N/P] |
| Former [2012/24] | Cockerton, Bruce Roger Carpmaels & Ransford One Southampton Row London WC1B 5HA / GB | ||
| Former [2010/07] | Sexton, Jane Helen, et al J.A. Kemp & Co. 14 South Square Gray's Inn GB-London WC1R 5JJ / GB | Application number, filing date | 08746582.9 | 22.04.2008 | [2010/07] | WO2008US61189 | Priority number, date | US20070915103P | 30.04.2007 Original published format: US 915103 P | US20080027814P | 11.02.2008 Original published format: US 27814 P | US20080028122P | 12.02.2008 Original published format: US 28122 P | [2010/07] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2008134325 | Date: | 06.11.2008 | Language: | EN | [2008/45] | Type: | A1 Application with search report | No.: | EP2152074 | Date: | 17.02.2010 | Language: | EN | The application published by WIPO in one of the EPO official languages on 06.11.2008 takes the place of the publication of the European patent application. | [2010/07] | Search report(s) | International search report - published on: | US | 06.11.2008 | (Supplementary) European search report - dispatched on: | EP | 24.06.2011 | Classification | IPC: | A61K31/137, C07D211/32 | [2011/29] | CPC: |
A61K31/137 (EP,US);
A61K31/045 (KR);
A01N33/02 (KR);
A61K31/015 (KR);
A61K9/0019 (EP,US);
A61P1/04 (EP);
A61P15/10 (EP);
A61P25/00 (EP);
A61P25/04 (EP);
A61P25/16 (EP);
A61P25/18 (EP);
A61P25/22 (EP);
A61P25/24 (EP);
A61P25/28 (EP);
A61P25/30 (EP);
A61P29/00 (EP);
A61P5/00 (EP);
A61P9/00 (EP);
|
| Former IPC [2010/07] | A01N33/02 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2010/07] | Title | German: | ZUSAMMENSETZUNGEN VON (-)-E-10-OH-NT UND VERFAHREN ZU IHRER SYNTHESE UND VERWENDUNG | [2010/07] | English: | COMPOSITIONS OF (-)-E-10-OH-NT AND METHODS FOR THEIR SYNTHESIS AND USE | [2010/07] | French: | COMPOSITIONS DE (-)-E-10-OH-NT, PROCÉDÉS DE SYNTHÈSE ET UTILISATION | [2010/07] | Entry into regional phase | 26.11.2009 | National basic fee paid | 26.11.2009 | Search fee paid | 26.11.2009 | Designation fee(s) paid | 26.11.2009 | Examination fee paid | Examination procedure | 26.11.2009 | Examination requested [2010/07] | 10.05.2012 | Amendment by applicant (claims and/or description) | 06.03.2013 | Despatch of a communication from the examining division (Time limit: M04) | 17.07.2013 | Application deemed to be withdrawn, date of legal effect [2014/01] | 23.08.2013 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2014/01] | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 06.03.2013 | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report | 10.05.2012 | Request for further processing filed | 10.05.2012 | Full payment received (date of receipt of payment) Request granted | 10.07.2012 | Decision despatched | Fees paid | Renewal fee | 26.04.2010 | Renewal fee patent year 03 | 25.04.2011 | Renewal fee patent year 04 | 25.04.2012 | Renewal fee patent year 05 | Penalty fee | Additional fee for renewal fee | 30.04.2013 | 06 M06 Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [Y] L. BERTILSSON ET AL.: "Stereoselective efflux of (E)-10-hydroxynortriptyline enantiomers from the cerebrospinal fluid of depressed patients", PHARMACOLOGY & TOXICOLOGY, vol. 68, no. 2, 1991, pages 100 - 103, XP002640018, ISSN: 0901-9928 [Y] 1-10,17 * figure 2; tables 1, 2 * DOI: http://dx.doi.org/10.1111/j.1600-0773.1991.tb02044.x | [Y] E. NUSSER ET AL.: "Enantioselective formation and disposition of (E)- and (Z)-10-hydroxynortriptyline", DRUG METABOLISM AND DISPOSITION, vol. 16, no. 3, 1988, pages 509 - 511, XP008124284, ISSN: 0090-9556 [Y] 1-10,17 * tables 2, 3 * | [Y] E. DUMONT ET AL.: "Glucuronidation of the enantiomers of E-10-hydroxynortripyline in human and rat liver microsomes", PHARMACOLOGY & TOXICOLOGY, vol. 61, no. 5, 1987, XP002640019, ISSN: 0901-9928 [Y] 1-10,17 * tables 1-4 * | [Y] U. BREYER-PFAFF, K. NILL: "High-affinity stereoselective reduction of the enantiomers of ketotifen and of ketonic nortriptyline metabolites by aldo-keto reductases from human liver", BIOCHEMICAL PHARMACOLOGY, vol. 59, no. 3, 2000, pages 249 - 260, XP002640020, ISSN: 0006-2952 [Y] 1-10,17 * table 4 * DOI: http://dx.doi.org/10.1016/S0006-2952(99)00319-6 | [Y] DAHL-PUUSTINEN M L ET AL: "Glucuronidation of E-10-hydroxynortriptyline in human liver, kidney, and intestine. Organ-specific differences in enantioselectivity", DRUG METABOLISM AND DISPOSITION, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 17, no. 4, 1 July 1989 (1989-07-01), pages 433 - 436, XP009149045, ISSN: 0090-9556 [Y] 1-10,17 * figures 1-3; table 1 * | [Y] DAHL-PUUSTINEN M-L ET AL: "Stereoselective disposition of racemic E-10-hydroxynortriptyline in human beings", CLINICAL PHARMACOLOGY AND THERAPEUTICS, NATURE PUBLISHING GROUP, US, vol. 45, no. 6, 1 June 1989 (1989-06-01), pages 650 - 656, XP009149014, ISSN: 0009-9236 [Y] 1-10,17 * figures 1-3; tables I-III * DOI: http://dx.doi.org/10.1038/clpt.1989.86 | [Y] BREYER-PFAFF U ET AL: "Stereoselective reversible ketone formation from 10-hydroylated nortriptyline metabolites in human liver", XENOBIOTICA, TAYLOR AND FRANCIS, LONDON, GB, vol. 25, no. 12, 1 January 1995 (1995-01-01), pages 1311 - 1326, XP009149007, ISSN: 0049-8254 [Y] 1-10,17 * tables 7, 8 * DOI: http://dx.doi.org/10.3109/00498259509061920 | [Y] HEIMSTAD ET AL: "Molecular Structure and Dynamics of the Four 10-hydroxynortriptyline Isomers", NEUROPSYCHOPHARMACOLOGY, ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, US, vol. 6, no. 3, 1 January 1992 (1992-01-01), pages 137 - 144, XP009149052, ISSN: 0893-133X [Y] 1-10,17 * the whole document * | [Y] PFANDL B ET AL: "Stereoselective inhibition of nortriptyline hydroxylation in man by quinidine", XENOBIOTICA, TAYLOR AND FRANCIS, LONDON, GB, vol. 22, no. 6, 1 January 1992 (1992-01-01), pages 721 - 730, XP009149046, ISSN: 0049-8254 [Y] 1-10,17 * figures 1-3; tables 1, 2 * DOI: http://dx.doi.org/10.3109/00498259209053134 | [Y] R. M. LANE, G. B. BAKER: "Chirality and Drugs Used in Psyciatry: Nice to Know or Need to know?", CELLULAR AND MOLECULAR NEUROBIOLOGY, vol. 19, no. 3, 1999, pages 355 - 372, XP002640021 [Y] 1-10,17 * page 365 - page 366 * DOI: http://dx.doi.org/10.1023/A:1006997731966 | [A] NORDIN ET AL: "Antidepressant and Anxiolytic Profiles of E-10-Hydroxynortriptyline on Electrocorticograms of Rats", NEUROPSYCHOBIOLOGY, KARGER AG, BASEL, CH, vol. 34, no. 1, 1 January 1996 (1996-01-01), pages 44 - 48, XP009149042, ISSN: 0302-282X [A] 1-10,17 * the whole document * DOI: http://dx.doi.org/10.1159/000119290 | International search | [Y] NUSSER ET AL.: "Enantioselective formation and disposition of (E)- and (Z)-10-hydroxynortriptyline", DRUG METAB. DISPOS., 1988, XP008124284 [Y] |