EP2150618 - IL-12 IMMUNOTHERAPY FOR CANCER [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 17.08.2018 Database last updated on 13.07.2024 | |
Former | The patent has been granted Status updated on 08.09.2017 | ||
Former | Grant of patent is intended Status updated on 04.09.2017 | ||
Former | Examination is in progress Status updated on 09.08.2017 | ||
Former | Grant of patent is intended Status updated on 20.03.2017 | Most recent event Tooltip | 26.06.2020 | Lapse of the patent in a contracting state New state(s): CY | published on 29.07.2020 [2020/31] | Applicant(s) | For all designated states University Health Network R. Fraser Elliott Building, Room 1S-417 190 Elizabeth Street Toronto, ON M5G 2C4 / CA | [2010/06] | Inventor(s) | 01 /
MEDIN, Jeffrey, A. 251 Cocksfield Avenue North York, Ontario M3H 3T6 / CA | 02 /
PAIGE, Christopher, J. 39 McKenzie Ave. Toronto, Ontario M4W 1K1 / CA | [2010/06] | Representative(s) | Daniels, Jeffrey Nicholas, et al Page White & Farrer Limited Bedford House 21A John Street London WC1N 2BF / GB | [N/P] |
Former [2017/41] | Daniels, Jeffrey Nicholas, et al Page White & Farrer Bedford House John Street London WC1N 2BF / GB | ||
Former [2010/06] | Hill, Christopher Michael, et al Page White & Farrer Bedford House John Street London, WC1N 2BF / GB | Application number, filing date | 08748251.9 | 05.05.2008 | [2010/06] | WO2008CA00849 | Priority number, date | US20070916136P | 04.05.2007 Original published format: US 916136 P | [2010/06] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2008134879 | Date: | 13.11.2008 | Language: | EN | [2008/46] | Type: | A1 Application with search report | No.: | EP2150618 | Date: | 10.02.2010 | Language: | EN | The application published by WIPO in one of the EPO official languages on 13.11.2008 takes the place of the publication of the European patent application. | [2010/06] | Type: | B1 Patent specification | No.: | EP2150618 | Date: | 11.10.2017 | Language: | EN | [2017/41] | Search report(s) | International search report - published on: | CA | 13.11.2008 | (Supplementary) European search report - dispatched on: | EP | 06.05.2011 | Classification | IPC: | C12N15/867, A61K38/20, A61K39/00, A61K48/00, A61P35/00, A61P35/02, A61P37/04, C07K14/54, C12N15/24, C12N5/10, C12P21/02 | [2010/06] | CPC: |
A61K38/208 (EP,US);
A61K35/545 (US);
A61K39/00114 (US);
A61K39/4611 (EP);
A61K39/4613 (EP);
A61K39/46444 (EP);
A61K48/005 (EP,US);
A61P35/00 (EP);
A61P35/02 (EP);
A61P37/04 (EP);
C07K14/5434 (US);
C12N15/86 (EP,US);
C12N7/00 (US);
A61K2039/515 (US);
A61K2039/53 (US);
A61K2039/585 (US);
A61K2239/31 (EP);
A61K2239/38 (EP);
A61K2239/48 (EP);
C07K2319/00 (US);
C12N2710/16122 (US);
C12N2730/10122 (US);
C12N2740/13043 (EP,US);
C12N2740/15043 (US);
C12N2740/15071 (US);
C12N2740/16022 (US);
C12N2800/40 (US);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2017/41] |
Former [2010/06] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR | Title | German: | IL-12-IMMUNTHERAPIE GEGEN KREBS | [2010/06] | English: | IL-12 IMMUNOTHERAPY FOR CANCER | [2010/06] | French: | IMMUNOTHÉRAPIE DU CANCER AVEC L'IL-2 | [2010/06] | Entry into regional phase | 04.12.2009 | National basic fee paid | 04.12.2009 | Search fee paid | 04.12.2009 | Designation fee(s) paid | 04.12.2009 | Examination fee paid | Examination procedure | 04.12.2009 | Examination requested [2010/06] | 21.10.2010 | Observations by third parties | 01.12.2011 | Amendment by applicant (claims and/or description) | 16.03.2012 | Despatch of a communication from the examining division (Time limit: M04) | 26.07.2012 | Reply to a communication from the examining division | 12.05.2014 | Despatch of a communication from the examining division (Time limit: M06) | 24.11.2014 | Reply to a communication from the examining division | 29.05.2015 | Despatch of a communication from the examining division (Time limit: M06) | 08.12.2015 | Reply to a communication from the examining division | 05.01.2016 | Despatch of a communication from the examining division (Time limit: M04) | 05.05.2016 | Reply to a communication from the examining division | 21.03.2017 | Communication of intention to grant the patent | 31.07.2017 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 31.07.2017 | Fee for grant paid | 31.07.2017 | Fee for publishing/printing paid | 04.09.2017 | Information about intention to grant a patent | 04.09.2017 | Receipt of the translation of the claim(s) | Divisional application(s) | EP17184090.3 / EP3293266 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 16.03.2012 | Opposition(s) | 12.07.2018 | No opposition filed within time limit [2018/38] | Fees paid | Renewal fee | 30.04.2010 | Renewal fee patent year 03 | 27.05.2011 | Renewal fee patent year 04 | 29.05.2012 | Renewal fee patent year 05 | 31.05.2013 | Renewal fee patent year 06 | 30.05.2014 | Renewal fee patent year 07 | 29.05.2015 | Renewal fee patent year 08 | 31.05.2016 | Renewal fee patent year 09 | 30.05.2017 | Renewal fee patent year 10 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 05.05.2008 | AT | 11.10.2017 | CY | 11.10.2017 | CZ | 11.10.2017 | DK | 11.10.2017 | EE | 11.10.2017 | FI | 11.10.2017 | HR | 11.10.2017 | LT | 11.10.2017 | LV | 11.10.2017 | MC | 11.10.2017 | NL | 11.10.2017 | PL | 11.10.2017 | PT | 11.10.2017 | RO | 11.10.2017 | SE | 11.10.2017 | SI | 11.10.2017 | SK | 11.10.2017 | TR | 11.10.2017 | BG | 11.01.2018 | NO | 11.01.2018 | GR | 12.01.2018 | IS | 11.02.2018 | IE | 05.05.2018 | LU | 05.05.2018 | MT | 05.05.2018 | BE | 31.05.2018 | CH | 31.05.2018 | LI | 31.05.2018 | [2020/31] |
Former [2020/27] | HU | 05.05.2008 | |
AT | 11.10.2017 | ||
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
MC | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
PT | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SI | 11.10.2017 | ||
SK | 11.10.2017 | ||
TR | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
IE | 05.05.2018 | ||
LU | 05.05.2018 | ||
MT | 05.05.2018 | ||
BE | 31.05.2018 | ||
CH | 31.05.2018 | ||
LI | 31.05.2018 | ||
Former [2020/16] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
MC | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SI | 11.10.2017 | ||
SK | 11.10.2017 | ||
TR | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
IE | 05.05.2018 | ||
LU | 05.05.2018 | ||
MT | 05.05.2018 | ||
BE | 31.05.2018 | ||
CH | 31.05.2018 | ||
LI | 31.05.2018 | ||
Former [2020/08] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
MC | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SI | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
IE | 05.05.2018 | ||
LU | 05.05.2018 | ||
MT | 05.05.2018 | ||
BE | 31.05.2018 | ||
CH | 31.05.2018 | ||
LI | 31.05.2018 | ||
Former [2019/24] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
MC | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SI | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
IE | 05.05.2018 | ||
LU | 05.05.2018 | ||
BE | 31.05.2018 | ||
CH | 31.05.2018 | ||
LI | 31.05.2018 | ||
Former [2019/19] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
MC | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SI | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
IE | 05.05.2018 | ||
LU | 05.05.2018 | ||
CH | 31.05.2018 | ||
LI | 31.05.2018 | ||
Former [2019/17] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
MC | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SI | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
LU | 05.05.2018 | ||
CH | 31.05.2018 | ||
LI | 31.05.2018 | ||
Former [2019/12] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
MC | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SI | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
CH | 31.05.2018 | ||
LI | 31.05.2018 | ||
Former [2019/06] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
MC | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SI | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
Former [2018/52] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SI | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
Former [2018/42] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
RO | 11.10.2017 | ||
SE | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
Former [2018/37] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
NL | 11.10.2017 | ||
PL | 11.10.2017 | ||
SE | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
Former [2018/35] | AT | 11.10.2017 | |
CZ | 11.10.2017 | ||
DK | 11.10.2017 | ||
EE | 11.10.2017 | ||
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
NL | 11.10.2017 | ||
SE | 11.10.2017 | ||
SK | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
Former [2018/24] | AT | 11.10.2017 | |
FI | 11.10.2017 | ||
HR | 11.10.2017 | ||
LT | 11.10.2017 | ||
LV | 11.10.2017 | ||
NL | 11.10.2017 | ||
SE | 11.10.2017 | ||
BG | 11.01.2018 | ||
NO | 11.01.2018 | ||
GR | 12.01.2018 | ||
IS | 11.02.2018 | ||
Former [2018/21] | FI | 11.10.2017 | |
LT | 11.10.2017 | ||
NL | 11.10.2017 | ||
NO | 11.01.2018 | ||
Former [2018/17] | NL | 11.10.2017 | Documents cited: | Search | [I]CA2253790 (PIZZOFERRATO EVA [CA]) [I] 6 * abstract * * page 11 ff. *; | [X] - PAJTASZ-PIASECKA E ET AL, "Loss of tumorigenicity of murine colon carcinoma MC38/0 cell line after transduction with a retroviral vector carrying murine IL-12 genes.", FOLIA BIOLOGICA (PRAGUE), (2004), vol. 50, no. 1, ISSN 0015-5500, pages 7 - 14, XP002628036 [X] 10-16 * abstract * * page 8 * * page 11 - page 12 * | [I] - GAUTAM SUBHASH C ET AL, "Interleukin-12 (IL-12) gene therapy of leukemia: Immune and anti-leukemic effects of IL-12-transduced hematopoietic progenitor cells", CANCER GENE THERAPY, (200007), vol. 7, no. 7, ISSN 0929-1903, pages 1060 - 1068, XP002628037 [I] 6 * abstract * * page 1061 * DOI: http://dx.doi.org/10.1038/sj.cgt.7700201 | [I] - PIZZOFERRATO E ET AL, "Enhanced immunogenicity of B cell lymphoma genetically engineered to express both B7-1 and interleukin-12.", HUMAN GENE THERAPY 10 DEC 1997 LNKD- PUBMED:9449375, (19971210), vol. 8, no. 18, ISSN 1043-0342, pages 2217 - 2228, XP002628038 [I] 6 * abstract * * page 2220 * DOI: http://dx.doi.org/10.1089/hum.1997.8.18-2217 | [AD] - SATO TAKEYA ET AL, "Engineered human tmpk/AZT as a novel enzyme/prodrug axis for suicide gene therapy.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY MAY 2007 LNKD- PUBMED:17375075, (20070320), vol. 15, no. 5, ISSN 1525-0016, pages 962 - 970, XP002628039 [AD] 3,4 * page 962 * DOI: http://dx.doi.org/10.1038/MT.SJ.6300122 | [A] - QIAN CHENG ET AL, "Gene therapy of cancer: induction of anti-tumor immunity.", CELLULAR & MOLECULAR IMMUNOLOGY APR 2004 LNKD- PUBMED:16212896, (200404), vol. 1, no. 2, ISSN 1672-7681, pages 105 - 111, XP002628040 [A] 1-16 * page 106 * | [A] - BRECKPOT K ET AL, "Lentiviral vectors for cancer immunotherapy: transforming infectious particles into therapeutics", GENE THERAPY, (20070322), vol. 14, no. 11, ISSN 0969-7128, pages 847 - 862, XP002628041 [A] 1-16 * the whole document * DOI: http://dx.doi.org/10.1038/sj.gt.3302947 | [A] - CHANG ALEX H ET AL, "The genetic engineering of hematopoietic stem cells: the rise of lentiviral vectors, the conundrum of the ltr, and the promise of lineage-restricted vectors.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY MAR 2007 LNKD- PUBMED:17228317, (200703), vol. 15, no. 3, ISSN 1525-0024, pages 445 - 456, XP002628042 [A] 1-16 * the whole document * DOI: http://dx.doi.org/10.1038/SJ.MT.6300060 | [A] - OBANA S ET AL, "INDUCTION OF ANTI-TUMOR IMMUNITY BY MOUSE TUMOR CELLS TRANSFECTED WITH MOUSE INTERLEUKIN-12 GENE", JAPANESE JOURNAL OF MEDICAL SCIENCE AND BIOLOGY, TOKYO, JP, (19950101), vol. 48, ISSN 0021-5112, pages 221 - 236, XP008046187 [A] 1-16 * abstract * * page 232 * * figure 1 * | [A] - COLOMBO MARIO P ET AL, "Amount of interleukin 12 available at the tumor site is critical for tumor regression", CANCER RESEARCH, (1996), vol. 56, no. 11, ISSN 0008-5472, pages 2531 - 2534, XP002628043 [A] 1-16 * abstract * | [A] - MAZZOLINI GUILLERMO ET AL, "Gene therapy of cancer with interleukin-12", CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBLISHERS, NL, (20030901), vol. 9, no. 24, ISSN 1381-6128, pages 1981 - 1991, XP009145770 [A] 1-16 * the whole document * DOI: http://dx.doi.org/10.2174/1381612033454261 | [AD] - LABBE ALAIN ET AL, "Murine model of immune-mediated rejection of the acute lymphoblastic leukemia 70Z/3.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 MAY 2006 LNKD- PUBMED:16622003, (20060501), vol. 176, no. 9, ISSN 0022-1767, pages 5354 - 5361, XP002628044 [AD] 1-16 * the whole document * | [T] - LABBE ALAIN ET AL, "IL-12 immunotherapy of murine leukaemia: comparison of systemic versus gene modified cell therapy.", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE AUG 2009 LNKD- PUBMED:18624776, (200908), vol. 13, no. 8B, ISSN 1582-4934, pages 1962 - 1976, XP002628045 DOI: http://dx.doi.org/10.1111/J.1582-4934.2008.00412.X | International search | [X] - CHEN X. ET AL., "Alteration of T cell immunity by lentiviral transduction of human monocyte-derived dendritic cells", RETROVIROLOGY, (20041101), vol. 1, no. 1, pages 37 - 49, XP021010209 DOI: http://dx.doi.org/10.1186/1742-4690-1-37 | [X] - KUWATA T. ET AL., "Construction of chimeric simian and human immunodeficiency viruses that produce interleukin 12", AIDS RESEARCH AND HUMAN RETROVIRUSES, (20000301), vol. 16, no. 5, pages 465 - 470, XP008123770 | [X] - TAHARA H. ET AL., "Effective eradication of established murine tumors with Il-12 gene therapy using a polycistronic retroviral vector", JOURNAL OF IMMUNOLOGY, (1995), vol. 154, no. 12, pages 6466 - 6474, XP002049440 | [X] - MILLER G. ET AL., "Overexpression of interleukin-12 enables dendritic cells to activate NK cells and confer systemic antitumor immunity", THE FASEB JOURNAL, (200304), vol. 17, no. 6, pages 728 - 730, XP008123798 DOI: http://dx.doi.org/10.1096/FJ.02-0900FJE | [X] - MEKO J.B. ET AL., "High cytokine production and effective antitumor activity of a recombinant vaccinia virus encoding murine interleukin 12", CANCER RESEARCH, (19951101), vol. 55, pages 4765 - 4770, XP009116168 | [A] - SUZUKI T. ET AL., "Vaccination of dendritic cells loaded with interleukin-12-secreting cancer cells augments in vivo antitumor immunity: characteristics of syngeneic and allogeneic antigen-presenting cell cancer hybrid cells", CLINICAL CANCER RESEARCH, (20050101), vol. 11, no. 1, pages 58 - 66, XP008132916 | [A] - ZITVOGEL ET AL., "Construction and characterization of retroviral vectors expressing biologically active human interleukin-12", HUMAN GENE THERAPY, (199412), vol. 5, pages 1493 - 1506, XP000575529 | [A] - ROBERTSON M.J. 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