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Extract from the Register of European Patents

EP About this file: EP2170353

EP2170353 - PHOSPHATE-MODIFIED OLIGONUCLEOTIDE ANALOGS WITH IMMUNOSTIMULATORY ACTIVITY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  08.04.2016
Database last updated on 31.08.2024
Most recent event   Tooltip08.04.2016No opposition filed within time limitpublished on 11.05.2016  [2016/19]
Applicant(s)For all designated states
AdiuTide Pharmaceuticals GmbH
Alt Fechenheim 34
60386 Frankfurt am Main / DE
[2011/36]
Former [2010/32]For all designated states
Uhlmann, Eugen
Zum Talblick 31
61479 Glashütten / DE
Former [2010/14]For all designated states
Coley Pharmaceutical GmbH
Merowingerplatz 1a
40225 Düsseldorf / DE
Inventor(s)01 / JURK, Marion
Klosterstr. 4
41540 Dormagen / DE
02 / UHLMANN, Eugen
Zum Talblick 31
61479 Glashuetten / DE
 [2010/14]
Representative(s)Kalhammer, Georg, et al
Lederer & Keller
Patentanwälte Partnerschaft mbB
Unsöldstrasse 2
80538 München / DE
[2015/23]
Former [2010/25]Kalhammer, Georg, et al
Lederer & Keller Patentanwälte Prinzregentenstrasse 16
80538 München / DE
Former [2010/14]Porter, Jonathan Philip
Pfizer Limited European Patent Department IPC 748 Ramsgate Road
Sandwich, Kent CT13 9NJ / GB
Application number, filing date08750947.715.05.2008
[2010/14]
WO2008IB01206
Priority number, dateUS20070930764P18.05.2007         Original published format: US 930764 P
[2010/14]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2008142513
Date:27.11.2008
Language:EN
[2008/48]
Type: A2 Application without search report 
No.:EP2170353
Date:07.04.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 27.11.2008 takes the place of the publication of the European patent application.
[2010/14]
Type: B1 Patent specification 
No.:EP2170353
Date:03.06.2015
Language:EN
[2015/23]
Search report(s)International search report - published on:EP27.08.2009
ClassificationIPC:A61P37/08, A61K47/48, A61K31/7125, A61K45/06, A61P35/00, A61P31/00, A61P11/06, A61P37/00
[2014/27]
CPC:
C12N15/117 (EP,US); A61K31/7125 (EP,US); A61K45/06 (EP,US);
A61P11/00 (EP); A61P11/06 (EP); A61P31/00 (EP);
A61P35/00 (EP); A61P37/00 (EP); A61P37/02 (EP);
A61P37/04 (EP); A61P37/08 (EP); C12N2310/17 (EP,US);
C12N2310/311 (EP,US); C12N2310/3125 (EP,US); C12N2310/315 (EP,US);
Y02A50/30 (EP,US) (-)
C-Set:
A61K31/7125, A61K2300/00 (EP,US)
Former IPC [2010/14]A61K31/7125, A61K45/06, A61P35/00, A61P31/00, A61P11/06, A61P37/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2015/23]
Former [2010/14]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:PHOSPHAT-MODIFIZIERTE OLIGONUCLEOTID-ANALOGA MIT IMMUNOSTIMULATORISCHER WIRKUNG[2010/14]
English:PHOSPHATE-MODIFIED OLIGONUCLEOTIDE ANALOGS WITH IMMUNOSTIMULATORY ACTIVITY[2010/14]
French:ANALOGUES D'OLIGONUCLÉOTIDES MODIFIÉS PAR PHOSPHATE, PRÉSENTANT UNE ACTIVITÉ IMMUNOSTIMULANTE AMÉLIORÉE[2010/14]
Entry into regional phase18.12.2009National basic fee paid 
01.03.2010Designation fee(s) paid 
01.03.2010Examination fee paid 
Examination procedure09.12.2009Amendment by applicant (claims and/or description)
01.03.2010Examination requested  [2010/14]
07.06.2010Despatch of a communication from the examining division (Time limit: M06)
15.11.2010Reply to a communication from the examining division
01.07.2013Despatch of a communication from the examining division (Time limit: M04)
11.11.2013Reply to a communication from the examining division
20.03.2014Despatch of a communication from the examining division (Time limit: M02)
16.05.2014Reply to a communication from the examining division
13.06.2014Communication of intention to grant the patent
01.12.2014Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
02.02.2015Fee for grant paid
02.02.2015Fee for publishing/printing paid
02.02.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  07.06.2010
Opposition(s)04.03.2016No opposition filed within time limit [2016/19]
Request for further processing for:The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
02.02.2015Request for further processing filed
02.02.2015Full payment received (date of receipt of payment)
Request granted
13.02.2015Decision despatched
Fees paidRenewal fee
27.05.2010Renewal fee patent year 03
26.05.2011Renewal fee patent year 04
29.03.2012Renewal fee patent year 05
28.05.2013Renewal fee patent year 06
27.05.2014Renewal fee patent year 07
21.04.2015Renewal fee patent year 08
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Cited inInternational search[X]US6693187  (DELLINGER DOUGLAS J [US]) [X] 1 * column 9, lines 15-40; compound FORMULA X * * claim 3 *;
 [Y]WO2006116458  (COLEY PHARM GMBH [DE], et al) [Y] 1-15 * page 4, lines 10-25 * * claim 1 *;
 [A]WO2004005476  (COLEY PHARM GROUP INC [US]) [A] 1-15 * page 38, lines 18-31 *;
 [A]US2004198688  (KRIEG ARTHUR M [US], et al) [A] 1-15 * paragraphs [0063] , [0064] *;
 [A]US6207646  (KRIEG ARTHUR M [US], et al) [A] 1-15 * example 10 *
 [X]  - DELLINGER DOUGLAS J ET AL, "Oligodeoxyribonucleotide analogs functionalized with phosphonoacetate and thiophosphonoacetate diesters.", CURRENT PROTOCOLS IN NUCLEIC ACID CHEMISTRY / EDITED BY SERGE L. BEAUCAGE ... [ET AL.] OCT 2004, (200410), vol. Chapter 4, ISSN 1934-9289, page Unit 4.24, XP008107901 [X] 1-3 * table 4.24.5 *
 [XY]  - SHEEHAN DAVID ET AL, "Biochemical properties of phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides.", NUCLEIC ACIDS RESEARCH 15 JUL 2003, (20030715), vol. 31, no. 14, ISSN 1362-4962, pages 4109 - 4118, XP002534849 [X] 1-3 * abstract * * page 4112; table 1 * * page 4115, column 1, paragraph LAST - column 2, paragraph 1 * * page 4117, column 2, paragraph LAST * [Y] 1-15

DOI:   http://dx.doi.org/10.1093/NAR/GKG439
 [A]  - RUDOLPH M JONATHAN ET AL, "PHOSPHONOACETATE DERIVATIVES OF OLIGODEOXYRIBONUCLEOTIDES", NUCLEOSIDES & NUCLEOTIDES, MARCEL DEKKER, INC, US, (19960101), vol. 15, no. 11-12, ISSN 0732-8311, pages 1725 - 1739, XP009074695 [A] 1-15
 [A]  - MUTWIRI G K ET AL, "Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, (20040531), vol. 97, no. 1, ISSN 0168-3659, pages 1 - 17, XP004508971 [A] 1-15

DOI:   http://dx.doi.org/10.1016/j.jconrel.2004.02.022
Examination   - UHLMANN EUGEN, Immune stimulatory oligonucleotides, THERAPEUTIC OLIGONUCLEOTIDES ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, CAMBRIDGE CB4 4WF, CAMBS, UK SERIES : RSC BIOMOLECULAR SCIENCES (ISSN 1757-7152(PRINT)), PAGE(S) 142-162, (2008), ISSN null
    - RUTZ MARK ET AL, "Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner", EUROPEAN JOURNAL OF IMMUNOLOGY, (200409), vol. 34, no. 9, ISSN 0014-2980, pages 2541 - 2550
    - AGRAWAL SUDHIR ET AL, "Medicinal chemistry and therapeutic potential of CpG DNA", TRENDS IN MOLECULAR MEDICINE, (200203), vol. 8, no. 3, ISSN 1471-4914, pages 114 - 121
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.