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Extract from the Register of European Patents

EP About this file: EP2176294

EP2176294 - USES OF MDL-1 ANTAGONISTS [Right-click to bookmark this link]
Former [2010/16]MDL-1 USES
[2014/50]
StatusNo opposition filed within time limit
Status updated on  25.03.2016
Database last updated on 19.10.2024
Most recent event   Tooltip08.12.2017Lapse of the patent in a contracting state
New state(s): LU		published on 10.01.2018  [2018/02]
Applicant(s)For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
[2015/21]
Former [2012/33]For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway NJ 07065-0907 / US
Former [2010/16]For all designated states
Schering Corporation
2000 Galloping Hill Road
Kenilworth, New Jersey 07033 / US
Inventor(s)01 / BIGLER, Michael, E.
3624 Highland Avenue
Redwood City, California 94062 / US
02 / CUA, Daniel, J.
17418 Bear Creek Road
Boulder Creek, California 95006 / US
03 / JOYCE-SHAIKH, Barbara
2165 Booksin Avenue
San Jose, California 95125 / US
04 / PHILLIPS, Joseph, H.
1511 Walnut Drive
Palo Alto, California 94303 / US
 [2010/16]
Representative(s)Horgan, James Michael Frederic, et al
Merck Sharp & Dohme Corp.
120 Moorgate
London, EC2M 6UR / GB
[N/P]
Former [2015/21]Horgan, James Michael Frederic, et al
Merck & Co., Inc.
European Patent Department
Hertford Road
Hoddesdon
EN11 9BU / GB
Former [2011/28]Horgan, James Michael Frederic, et al
Merck & Co., Inc. European Patent Department Hertford Road Hoddesdon
EN11 9BU / GB
Former [2010/16]van den Broek, Ludovicus A.G.M.
P.O. Box 20
5340 BH Oss / NL
Application number, filing date08771835.924.06.2008
[2010/16]
WO2008US68042
Priority number, dateUS20070947314P29.06.2007         Original published format: US 947314 P
[2010/16]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009006112
Date:08.01.2009
Language:EN
[2009/02]
Type: A1 Application with search report 
No.:EP2176294
Date:21.04.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 08.01.2009 takes the place of the publication of the European patent application.
[2010/16]
Type: B1 Patent specification 
No.:EP2176294
Date:20.05.2015
Language:EN
[2015/21]
Search report(s)International search report - published on:EP08.01.2009
ClassificationIPC:C07K16/28, C07K14/705, A61K39/395, A61P19/08
[2010/16]
CPC:
C07K16/2851 (EP,US); A61K39/3955 (EP,US); A61P19/00 (EP);
A61P19/08 (EP); A61P19/10 (EP); A61P29/00 (EP);
A61P43/00 (EP); A61K2039/505 (EP,US); C07K2317/75 (EP,US);
C07K2319/30 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2015/21]
Former [2010/16]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesAL29.01.2010
BA29.01.2010
MK29.01.2010
RS29.01.2010
TitleGerman:VERWENDUNGEN VON MDL-1 ANTAGONISTEN[2014/50]
English:USES OF MDL-1 ANTAGONISTS[2014/50]
French:UTILISATION D'ANTAGONISTES DE MDL-1[2014/50]
Former [2010/16]VERWENDUNGEN VON MDL-1
Former [2010/16]MDL-1 USES
Former [2010/16]UTILISATION DE MDL-1
Entry into regional phase29.01.2010National basic fee paid 
29.01.2010Designation fee(s) paid 
29.01.2010Examination fee paid 
Examination procedure29.01.2010Amendment by applicant (claims and/or description)
29.01.2010Examination requested  [2010/16]
25.05.2010Despatch of a communication from the examining division (Time limit: M06)
12.01.2011Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
18.03.2011Reply to a communication from the examining division
27.07.2012Despatch of a communication from the examining division (Time limit: M02)
19.09.2012Reply to a communication from the examining division
21.11.2012Despatch of a communication from the examining division (Time limit: M02)
22.01.2013Reply to a communication from the examining division
02.12.2014Communication of intention to grant the patent
07.04.2015Fee for grant paid
07.04.2015Fee for publishing/printing paid
07.04.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  25.05.2010
Opposition(s)23.02.2016No opposition filed within time limit [2016/17]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
18.03.2011Request for further processing filed
18.03.2011Full payment received (date of receipt of payment)
Request granted
28.03.2011Decision despatched
Fees paidRenewal fee
31.03.2010Renewal fee patent year 03
07.06.2011Renewal fee patent year 04
31.03.2012Renewal fee patent year 05
31.03.2013Renewal fee patent year 06
31.03.2014Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU24.06.2008
AT20.05.2015
BE20.05.2015
CY20.05.2015
CZ20.05.2015
DK20.05.2015
EE20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
MC20.05.2015
MT20.05.2015
NL20.05.2015
PL20.05.2015
RO20.05.2015
SE20.05.2015
SI20.05.2015
SK20.05.2015
TR20.05.2015
IE24.06.2015
LU24.06.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
[2018/02]
Former [2017/40]HU24.06.2008
AT20.05.2015
BE20.05.2015
CY20.05.2015
CZ20.05.2015
DK20.05.2015
EE20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
MC20.05.2015
MT20.05.2015
NL20.05.2015
PL20.05.2015
RO20.05.2015
SE20.05.2015
SI20.05.2015
SK20.05.2015
TR20.05.2015
IE24.06.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2017/03]AT20.05.2015
BE20.05.2015
CZ20.05.2015
DK20.05.2015
EE20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
MC20.05.2015
MT20.05.2015
PL20.05.2015
RO20.05.2015
SI20.05.2015
SK20.05.2015
IE24.06.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2016/37]AT20.05.2015
BE20.05.2015
CZ20.05.2015
DK20.05.2015
EE20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
MC20.05.2015
PL20.05.2015
RO20.05.2015
SI20.05.2015
SK20.05.2015
IE24.06.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2016/24]AT20.05.2015
CZ20.05.2015
DK20.05.2015
EE20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
MC20.05.2015
PL20.05.2015
RO20.05.2015
SI20.05.2015
SK20.05.2015
IE24.06.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2016/20]AT20.05.2015
CZ20.05.2015
DK20.05.2015
EE20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
MC20.05.2015
PL20.05.2015
RO20.05.2015
SK20.05.2015
IE24.06.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2016/13]AT20.05.2015
CZ20.05.2015
DK20.05.2015
EE20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
MC20.05.2015
PL20.05.2015
RO20.05.2015
SK20.05.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2016/10]AT20.05.2015
CZ20.05.2015
DK20.05.2015
EE20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
PL20.05.2015
RO20.05.2015
SK20.05.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2016/09]AT20.05.2015
DK20.05.2015
EE20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2016/07]AT20.05.2015
DK20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2015/51]AT20.05.2015
FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2015/50]FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
BG20.08.2015
NO20.08.2015
GR21.08.2015
IS20.09.2015
PT21.09.2015
Former [2015/49]FI20.05.2015
HR20.05.2015
LT20.05.2015
LV20.05.2015
NO20.08.2015
GR21.08.2015
PT21.09.2015
Cited inInternational search[PX]WO2007088051  (BAYER SCHERING PHARMA AG [DE], et al) [PX] 11-18 * pages 3-5; figure 15; examples 5,7 *;
 [X]  - KOGA TAKAKO ET AL, "Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis", NATURE (LONDON), (20040415), vol. 428, no. 6984, ISSN 0028-0836, pages 758 - 763, XP009105265 [X] 11-18 * abstract * * pages 759-760; figure 2 *

DOI:   http://dx.doi.org/10.1038/nature02444
 [A]  - KAIFU TOMONORI ET AL, "Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice", JOURNAL OF CLINICAL INVESTIGATION, AMERICAN SOCIETY FOR CLINICAL INVESTIGATION, US, (20030201), vol. 111, no. 3, ISSN 0021-9738, pages 323 - 332, XP002412551 [A] 1-18 * abstract *

DOI:   http://dx.doi.org/10.1172/JCI200316923
 [A]  - HUMPHREY MARY BETH ET AL, "The signaling adapter protein DAP12 regulates multinucleation during osteoclast development", JOURNAL OF BONE AND MINERAL RESEARCH, NEW YORK, NY, US, (20040201), vol. 19, no. 2, ISSN 0884-0431, pages 224 - 234, XP002413095 [A] 1-18 * abstract * * page 227; figure 1 *

DOI:   http://dx.doi.org/10.1359/JBMR.0301234
 [A]  - HUMPHREY MARY BETH ET AL, "TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function", JOURNAL OF BONE AND MINERAL RESEARCH, (200602), vol. 21, no. 2, ISSN 0884-0431, pages 237 - 245, XP009105217 [A] 1-18 * abstract *

DOI:   http://dx.doi.org/10.1359/JBMR.051016
 [A]  - COLONNA MARCO ET AL, "The enigmatic function of TREM-2 in osteoclastogenesis", ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, SPRING ST., NY, (20070101), vol. 602, ISSN 0065-2598, pages 97 - 105, XP009105054 [A] 1-18 * the whole document *
 [A]  - TURNBULL ISAIAH R ET AL, "Activating and inhibitory functions of DAP12", NATURE REVIEWS. IMMUNOLOGY, XX, XX, (20070201), vol. 7, no. 2, ISSN 1474-1733, pages 155 - 161, XP009105068 [A] 1-18 * page 156; table 1 *

DOI:   http://dx.doi.org/10.1038/nri2014
 [A]  - BAKKER A B ET AL, "Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, (19990817), vol. 96, no. 17, ISSN 0027-8424, pages 9792 - 9796, XP009105045 [A] 1-18 * abstract *

DOI:   http://dx.doi.org/10.1073/pnas.96.17.9792
by applicantWO2007088051
    - CLARKE, NATURE, (2002), vol. 416, pages 672 - 674
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.