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EP2173379
European procedure
Extract from the Register of European Patents
EP Citations: EP2173379
| Cited in | International search | Type: | Patent literature | Publication No.: | DE10339820
[A] (HINZMANN BERND et al.) [A] 1-60 * the whole document * | Type: | Patent literature | Publication No.: | WO2004074436
[A] (INCYTE CORP et al.) [A] 1-60 * the whole document * | Type: | Patent literature | Publication No.: | WO2005040418
[A] (DEUTSCHES KREBSFORSCH et al.) [A] 1-60 * the whole document * | Type: | Non-patent literature | Publication information: | [X] ZHAO ET AL: "R-spondin1, A Novel Intestinotrophic Mitogen, Ameliorates Experimental Colitis in Mice", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 132, no. 4, 26 April 2007 (2007-04-26), pages 1331 - 1343, XP022046097, ISSN: 0016-5085 [X] 4-6,10 * page 1332 * | DOI: | http://dx.doi.org/10.1053/j.gastro.2007.02.001 | Type: | Non-patent literature | Publication information: | [X] MORITA H ET AL: "Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension", MOLECULAR AND CELLULAR BIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, US, vol. 24, no. 22, 1 January 2004 (2004-01-01), pages 9736 - 9743, XP002457162, ISSN: 0270-7306 [X] 1-3,7,8,42-48 * page 9738 * | DOI: | http://dx.doi.org/10.1128/MCB.24.22.9736-9743.2004 | Type: | Non-patent literature | Publication information: | [X] HSU S Y ET AL: "Activation of Orphan receptors by the Hormone Relaxin", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, WASHINGTON, DC, vol. 295, 25 January 2002 (2002-01-25), pages 671 - 674, XP002959429, ISSN: 0036-8075 [X] 42,43 * page 673 * | DOI: | http://dx.doi.org/10.1126/science.1065654 | Type: | Non-patent literature | Publication information: | [X] MAZERBOURG S ET AL: "Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor 4 Null Mice Exhibit Intrauterine Growth Retardation Associated with Embryonic and Perinatal Lethality", MOLECULAR ENDOCRINOLOGY, BALTIMORE, MD, US, vol. 18, no. 9, 1 January 2004 (2004-01-01), pages 2241 - 2254, XP007902746, ISSN: 0888-8809 [X] 9 * page 2253 * | DOI: | http://dx.doi.org/10.1210/me.2004-0133 | Type: | Non-patent literature | Publication information: | [A] MCCLANAHAN T ET AL: "IDENTIFICATION OF OVEREXPRESSION OF ORPHAN G PROTEIN-COUPLED RECEPTOR GPR49 IN HUMAN COLON AND OVARIAN PRIMARY TUMORS", CANCER BIOLOGY AND THERAPY, LANDES BIOSCIENCE, US, vol. 5, no. 4, 1 April 2006 (2006-04-01), pages 419 - 426, XP009071194, ISSN: 1538-4047 [A] 1-60 * the whole document * | Cited in | Examination | Type: | Non-patent literature | Publication information: | BARKER NICK ET AL: "Mining the Wnt pathway for cancer therapeutics", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, vol. 5, no. 12, 1 December 2006 (2006-12-01), pages 997 - 1014, XP002545380, ISSN: 1474-1784, DOI: 10.1038/NRD2154 | DOI: | http://dx.doi.org/10.1038/NRD2154 | Cited in | Opposition | Type: | Patent literature | Publication No.: | DE10339820
| Type: | Patent literature | Publication No.: | WO2004074436
| Type: | Patent literature | Publication No.: | WO2005040418
| Type: | Patent literature | Publication No.: | US94761104
| Type: | Patent literature | Publication No.: | WO9915660
| Type: | Patent literature | Publication No.: | WO2004005457
| Type: | Patent literature | Publication No.: | WO2005040828
| Type: | Patent literature | Publication No.: | WO2004098521
| Type: | Patent literature | Publication No.: | WO9948921
| Type: | Patent literature | Publication No.: | US2006019256
| Type: | Patent literature | Publication No.: | US94761107
| Type: | Patent literature | Publication No.: | WO9915660
| Type: | Patent literature | Publication No.: | WO2005040418
| Type: | Patent literature | Publication No.: | WO2004005457
| Type: | Patent literature | Publication No.: | WO2005040828
| Type: | Patent literature | Publication No.: | WO2004098521
| Type: | Patent literature | Publication No.: | WO9948921
| Type: | Patent literature | Publication No.: | US2006019256
| Type: | Patent literature | Publication No.: | DE10339820
| Type: | Patent literature | Publication No.: | WO2004074436
| Type: | Non-patent literature | Publication information: | ZHAO ET AL.: "R-spondin1, A Novel Intestinotrophic Mitogen, Ameliorates Experimental Colitis in Mice", GASTROENTEROLOGY, vol. 132, no. 4, 26 April 2007 (2007-04-26), pages 1331 - 1343, XP022046097 | DOI: | http://dx.doi.org/10.1053/j.gastro.2007.02.001 | Type: | Non-patent literature | Publication information: | MORITA ET AL.: "Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension", MOLECULAR AND CELLULAR BIOLOGY, vol. 24, no. 22, November 2004 (2004-11-01), pages 9736 - 9743, XP002609363 | DOI: | http://dx.doi.org/10.1128/MCB.24.22.9736-9743.2004 | Type: | Non-patent literature | Publication information: | HSU ET AL.: "Activation of Orphan Receptors by the Hormone Relaxin", SCIENCE, vol. 295, 2002, pages 671 - 674, XP055299057 | Type: | Non-patent literature | Publication information: | MAZERBOURG ET AL.: "Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor 4 Null Mice Exhibit Intrauterine Growth Retardation Associated with Embryonic and Perinatal Lethality", MOLECULAR ENDOCRINOLOGY, vol. 18, no. 9, 2004, pages 2241 - 2254, XP007902746 | DOI: | http://dx.doi.org/10.1210/me.2004-0133 | Type: | Non-patent literature | Publication information: | BARKER ET AL.: "Mining the Wnt pathway for cancer therapeutics", NATURE REVIEWS DRUG DISCOVERY, vol. 5, 2006, pages 997 - 1014, XP002545380 | DOI: | http://dx.doi.org/10.1038/NRD2154 | Type: | Non-patent literature | Publication information: | MCCLANAHAN ET AL.: "Identification of Overexpression of Orphan G Protein-Coupled Receptor GPR49 in Human Colon and Ovarian Primary Tumors", CANCER BIOLOGY AND THERAPY, vol. 5, no. 4, 2006, pages 419 - 426, XP009071194 | Type: | Non-patent literature | Publication information: | TAN ET AL.: "THE CANCER STEM CELL HYPOTHESIS: A WORK IN PROGRESS", LABORATORY INVESTIGATION, vol. 86, no. 12, 2006, pages 1203 - 1207, XP003035631 | DOI: | http://dx.doi.org/10.1038/LABINVEST.3700488 | Type: | Non-patent literature | Publication information: | DE LAU: "Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling", NATURE, vol. 476, no. 7360, 18 August 2011 (2011-08-18), pages 293 - 298, XP002679926 | DOI: | http://dx.doi.org/10.1038/NATURE10337 | Type: | Non-patent literature | Publication information: | PENG ET AL.: "Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5", CELL REPORTS, vol. 3, no. 6, 2013, pages 1885 - 1892, XP055299138 | DOI: | http://dx.doi.org/10.1016/j.celrep.2013.06.009 | Type: | Non-patent literature | Publication information: | BLAYDON ET AL.: "R-Spondins in Cutaneous Biology: Nails and Cancer", CELL CYCLE, vol. 6, no. 8, 15 April 2007 (2007-04-15), pages 895 - 897, XP055299143 | DOI: | http://dx.doi.org/10.4161/cc.6.8.4136 | Type: | Non-patent literature | Publication information: | KIM ET AL.: "R-spondin proteins - A novel link to beta-catenin activation", CELL CYCLE, vol. 5, no. 1, 2006, pages 23 - 26, XP009086215 | Type: | Non-patent literature | Publication information: | BERGMANN ET AL.: "Mutations in the Gene Encoding the Wnt-Signaling Component R-Spondin 4 (RSPO4) Cause Autosomal Recessive Anonychia", AM. J. HUM. GENET., vol. 79, December 2006 (2006-12-01), pages 1105 - 1109, XP055299145 | DOI: | http://dx.doi.org/10.1086/509789 | Type: | Non-patent literature | Publication information: | KAZANSKAYA ET AL.: "R-Spondin2 Is a Secreted Activator of Wnt/-Catenin Signaling and Is Required for Xenopus Myogenesis Secreted Frizzled-related pro", DEVELOPMENTAL CELL, vol. 7, October 2004 (2004-10-01), pages 525 - 534, XP055299150 | Type: | Non-patent literature | Publication information: | ADAMS ET AL.: "Monoclonal antibody therapy of cancer", NATURE BIOTECHNOLOGY, vol. 23, no. 9, September 2005 (2005-09-01), pages 1147 - 1157, XP002456710 | DOI: | http://dx.doi.org/10.1038/nbt1137 | Type: | Non-patent literature | Publication information: | YAMAMOTO ET AL.: "OVEREXPRESSION OF ORPHAN G-PROTEIN-COUPLED RECEPTOR, GPR49, IN HUMAN HEPATOCELLULAR CARCINOMAS WITH BETA-CATENIN MUTATIONS", HEPATOLOGY, vol. 37, no. 3, March 2003 (2003-03-01), pages 528 - 533, XP008041122 | DOI: | http://dx.doi.org/10.1053/jhep.2003.50029 | Type: | Non-patent literature | Publication information: | HSU ET AL.: "Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region", MOLECULAR ENDOCRINOLOGY, vol. 12, no. 12, December 1998 (1998-12-01), pages 1830 - 1845, XP002528150 | DOI: | http://dx.doi.org/10.1210/me.12.12.1830 | Type: | Non-patent literature | Publication information: | ROSEN STEVENS ET AL.: "Cancer Treatment and Research", EXTRACT FROM CYTOKINES AND CANCER, 2005, pages 141, XP055299175 | Type: | Non-patent literature | Publication information: | DE LAU ET AL.: "The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength", GENES & DEVELOPMENT, vol. 28, no. 4, 15 February 2014 (2014-02-15), pages 305 - 316, XP055249532 | DOI: | http://dx.doi.org/10.1101/gad.235473.113 | Type: | Non-patent literature | Publication information: | BARKER ET AL.: "Identification of stem cells in small intestine and colon by marker gene Lgr5", NATURE, vol. 449, 25 October 2007 (2007-10-25), pages 1003 - 1008, XP002457164 | DOI: | http://dx.doi.org/10.1038/nature06196 | Type: | Non-patent literature | Publication information: | KLAUSS ET AL.: "Wnt signalling and its impact on development and cancer", NATURE REVIEWS CANCER, vol. 8, no. 5, May 2008 (2008-05-01), pages 387 - 398, XP055123786 | DOI: | http://dx.doi.org/10.1038/nrc2389 | Type: | Non-patent literature | Publication information: | ZHAO ET AL.: "R-Spondin1, A Novel Intestinotrophic Mitogen, Ameliorates Experimental Colitis in Mice", GASTROENTEROLOGY, vol. 132, no. 4, April 2007 (2007-04-01), pages 1331 - 1343, XP022046097 | DOI: | http://dx.doi.org/10.1053/j.gastro.2007.02.001 | Type: | Non-patent literature | Publication information: | TAN ET AL.: "The cancer stem cell hypothesis: a work in progress", LABORATORY INVESTIGATION, vol. 86, no. 12, April 2006 (2006-04-01), pages 1203 - 1207, XP003035631 | DOI: | http://dx.doi.org/10.1038/LABINVEST.3700488 | Type: | Non-patent literature | Publication information: | DE LAU ET AL.: "Lgr5 homologues associate withWnt receptors andmediateR-spondinsignalling", NATURE, vol. 476, April 2011 (2011-04-01), pages 293 - 298, XP002679926 | DOI: | http://dx.doi.org/10.1038/NATURE10337 | Type: | Non-patent literature | Publication information: | PENG ET AL.: "Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5", CELL REPORTS, vol. 3, no. 6, 2013, pages 1885 - 1892, XP055299138 | DOI: | http://dx.doi.org/10.1016/j.celrep.2013.06.009 | Type: | Non-patent literature | Publication information: | BLAYDON ET AL.: "R-Spondins in Cutaneous Biology: Nails and Cancer", CELL CYCLE, vol. 6, no. 8, 15 April 2007 (2007-04-15), pages 895 - 897, XP055299143 | DOI: | http://dx.doi.org/10.4161/cc.6.8.4136 | Type: | Non-patent literature | Publication information: | MORITA ET AL.: "Neonatal Lethality of LGR5 Null Mice is Associated with Ankyloglossia and Gastrointestinal Distension", MOLECULAR AND CELLULAR BIOLOGY, vol. 24, no. 22, April 2004 (2004-04-01), pages 9736 - 9743, XP002609363 | DOI: | http://dx.doi.org/10.1128/MCB.24.22.9736-9743.2004 | Type: | Non-patent literature | Publication information: | KIM ET AL.: "R-Spondin Proteins: A Novel Link to -catenin Activation", CELL CYCLE, vol. 5, no. 1, 2006, pages 23 - 26, XP002486935 | Type: | Non-patent literature | Publication information: | BERGMANN ET AL.: "Mutations in the Gene Encoding the Wnt-Signaling Component R-Spondin 4 (RSP04) Cause Autosomal Recessive Anonychia", AM. J. HUM. GENET., vol. 79, December 2006 (2006-12-01), pages 1105 - 1109, XP055299145 | DOI: | http://dx.doi.org/10.1086/509789 | Type: | Non-patent literature | Publication information: | KAZANSKAYA ET AL.: "R-Spondin2 Is a Secreted Activator of Wnt/B-Catenin Signaling and Is Required for Xenopus Myogenesis", DEVELOPMENTAL CELL, vol. 7, no. 4, October 2004 (2004-10-01), pages 525 - 534, XP009046814 | DOI: | http://dx.doi.org/10.1016/j.devcel.2004.07.019 | Type: | Non-patent literature | Publication information: | ADAMS ET AL.: "Monoclonal antibody therapy of cancer", NATURE BIOTECHNOLOGY, vol. 23, no. 9, 2005, pages 1147 - 1157, XP002456710 | DOI: | http://dx.doi.org/10.1038/nbt1137 | Type: | Non-patent literature | Publication information: | YAMAMOTO ET AL.: "Overexpression of Orphan G-Protein-Coupled Receptor, Gpr49, in Human Hepatocellular Carcinomas With B-Catenin Mutations", HEPATOLOGY, vol. 37, no. 3, March 2003 (2003-03-01), pages 528 - 533, XP008041122 | DOI: | http://dx.doi.org/10.1053/jhep.2003.50029 | Type: | Non-patent literature | Publication information: | HSU ET AL.: "Characterization of Two LGR Genes Homologous to Gonadotropin and Thyrotropin Receptors with Extracellular Leucine-Rich Repeats and a G Protein-Coupled, Seven- Transmembrane Region", MOL. ENDO., vol. 12, no. 12, 1998, pages 1830 - 1845, XP002528150 | DOI: | http://dx.doi.org/10.1210/me.12.12.1830 | Type: | Non-patent literature | Publication information: | HSU ET AL.: "Activation of Orphan Receptors by the Hormone Relaxin", SCIENCE, vol. 295, 25 January 2002 (2002-01-25), pages 671 - 674, XP055299057 | Type: | Non-patent literature | Publication information: | SPRINGER ET AL.: "Cytokines and Cancer", EXTRACT FROM CYTOKINES AND CANCER, 2005, XP055302989 | Type: | Non-patent literature | Publication information: | DE LAU ET AL.: "The R-spondin/Lgrs/Rnf43 module: regulator of Wnt signal strength", GENES & DEVELOPMENT, vol. 28, no. 4, 15 February 2014 (2014-02-15), pages 305 - 316, XP055249532 | DOI: | http://dx.doi.org/10.1101/gad.235473.113 | Type: | Non-patent literature | Publication information: | BARKER ET AL.: "Identification of stem cells in small intestine and colon by marker gene Lgr5", NATURE, vol. 449, 25 October 2007 (2007-10-25), pages 1003 - 1008, XP002457164 | DOI: | http://dx.doi.org/10.1038/nature06196 | Type: | Non-patent literature | Publication information: | KLAUSS ET AL.: "Wnt signalling and its impact on development and cancer", NATURE REVIEWS CANCER, vol. 8, no. 5, May 2008 (2008-05-01), pages 387 - 398, XP055123786 | DOI: | http://dx.doi.org/10.1038/nrc2389 | Type: | Non-patent literature | Publication information: | "Anti-GPR49 / LGR5 Antibody (N-Terminus) IHC-plus? LS-A1232", THE IMMUNOHISTOCHEMISTRY ANTIBODY COMPANY, 1 June 2016 (2016-06-01), XP055303027 | Type: | Non-patent literature | Publication information: | MAZERBOURG ET AL.: "Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor 4 Null Mice Exhibit Intrauterine Growth Retardation Associated with Embryonic and Perinatal Lethality", MOLECULAR ENDOCRINOLOGY, vol. 18, no. 9, April 2004 (2004-04-01), pages 2241 - 2254, XP007902746 | DOI: | http://dx.doi.org/10.1210/me.2004-0133 | Type: | Non-patent literature | Publication information: | BARKER ET AL.: "Mining the Wnt pathway for cancer therapeutics", NATURE REVIEWS DRUG DISCOVERY, vol. 5, no. 12, December 2006 (2006-12-01), pages 997 - 1014, XP002545380 | DOI: | http://dx.doi.org/10.1038/NRD2154 | Type: | Non-patent literature | Publication information: | MCCLANAHAN ET AL.: "Identification of Overexpression of Orphan G Protein-Coupled Receptor GPR49 in Human Colon and Ovarian Primary Tumors", CANCER BIOLOGY AND THERAPY, vol. 5, no. 4, April 2006 (2006-04-01), pages 419 - 426, XP055303038 | Cited in | other | Type: | Non-patent literature | Publication information: | TAN BRENTON THOMAS ET AL: "THE CANCER STEM CELL HYPOTHESIS: A WORK IN PROGRESS", LABORATORY INVESTIGATION, vol. 86, no. 12, 2006, pages 1203 - 1207, XP003035631 | DOI: | http://dx.doi.org/10.1038/LABINVEST.3700488 | Type: | Non-patent literature | Publication information: | BARKER N. ET AL: "MINING THE WNT PATHWAY FOR CANCER THERAPEUTICS", NATURE REVIEWS. DRUG DISCOVERY, vol. 5, no. 12, December 2006 (2006-12-01), pages 997 - 1014, XP002545380 | DOI: | http://dx.doi.org/10.1038/NRD2154 |