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Extract from the Register of European Patents

EP About this file: EP2176293

EP2176293 - CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.02.2020
Database last updated on 11.04.2026
FormerThe patent has been granted
Status updated on  01.03.2019
FormerGrant of patent is intended
Status updated on  22.10.2018
FormerExamination is in progress
Status updated on  29.09.2017
FormerRequest for examination was made
Status updated on  16.12.2016
Most recent event   Tooltip23.07.2021Lapse of the patent in a contracting state
New state(s): MT		published on 25.08.2021  [2021/34]
Applicant(s)For all designated states
Endocyte, Inc.
3000 Kent Avenue
West Lafayette, IN 47906 / US
[2019/14]
Former [2010/16]For all designated states
Endocyte, Inc.
3000 Kent Avenue
West Lafayette, IN 47906 / US
Inventor(s)01 / LEAMON, Christopher, Paul
5830 Farm Ridge Road
West Lafayette, IN 47906 / US
02 / WANG, Yu
12164 Silverado Drive
Fishers, IN 46037 / US
03 / VLAHOV, Iontcho, Radoslavov
1041 Shootingstar Court
West Lafayette, IN 47906 / US
04 / YOU, Fei
1420 West Candlewick Lane
West Lafayette, IN 47906 / US
05 / KLEINDL, Paul, Joseph
110 Monroe Crescent
Lebanon, IN 46052 / US
06 / SANTHAPURAM, Hari Krishna, R.
1704 Sandpiper Drive South
West Lafayette, IN 47906 / US
 [2010/16]
Representative(s)Grünecker Patent- und Rechtsanwälte PartG mbB
Leopoldstraße 4
80802 München / DE
[2019/14]
Former [2010/16]Elsy, David, et al
Withers & Rogers LLP Goldings House 2 Hays Lane
London SE1 2HW / GB
Application number, filing date08780966.125.06.2008
[2010/16]
WO2008US68093
Priority number, dateUS20070946092P25.06.2007         Original published format: US 946092 P
US20083618608P13.03.2008         Original published format: US 3618608 P
[2018/47]
Former [2010/16]US20070946092P25.06.2007
US2008003618613.03.2008
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009002993
Date:31.12.2008
Language:EN
[2009/01]
Type: A1 Application with search report 
No.:EP2176293
Date:21.04.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 31.12.2008 takes the place of the publication of the European patent application.
[2010/16]
Type: B1 Patent specification 
No.:EP2176293
Date:03.04.2019
Language:EN
[2019/14]
Search report(s)International search report - published on:US31.12.2008
(Supplementary) European search report - dispatched on:EP01.02.2016
ClassificationIPC:A61K47/65, A61K47/60, A61P31/00, A61P33/00, A61P35/00
[2018/44]
CPC:
C07K9/003 (EP,US); A61K47/545 (EP,US); A61K47/60 (EP,US);
A61K47/65 (EP,US); A61P31/00 (EP); A61P31/04 (EP);
A61P31/10 (EP); A61P31/12 (EP); A61P33/00 (EP);
A61P33/02 (EP); A61P33/04 (EP); A61P33/10 (EP);
A61P35/00 (EP); A61P35/02 (EP); C07H15/24 (EP,US) (-)
Former IPC [2014/51]C07K16/00, C12P21/08, G01N33/53, A61K47/48
Former IPC [2010/16]C07K16/00, C12P21/08, G01N33/53
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2019/14]
Former [2010/16]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:KONJUGATE MIT HYDROPHILEN SPACERN/LINKERN[2010/16]
English:CONJUGATES CONTAINING HYDROPHILIC SPACER LINKERS[2010/16]
French:CONJUGUÉS CONTENANT DES LIEURS ESPACEURS HYDROPHILES[2010/16]
Entry into regional phase25.01.2010National basic fee paid 
25.01.2010Search fee paid 
25.01.2010Designation fee(s) paid 
25.01.2010Examination fee paid 
Examination procedure25.01.2010Examination requested  [2010/16]
12.08.2016Amendment by applicant (claims and/or description)
02.10.2017Despatch of a communication from the examining division (Time limit: M04)
09.02.2018Reply to a communication from the examining division
23.10.2018Communication of intention to grant the patent
22.02.2019Fee for grant paid
22.02.2019Fee for publishing/printing paid
22.02.2019Receipt of the translation of the claim(s)
Divisional application(s)EP19166718.7  / EP3569251
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.10.2017
Opposition(s)06.01.2020No opposition filed within time limit [2020/11]
Fees paidRenewal fee
25.06.2010Renewal fee patent year 03
27.06.2011Renewal fee patent year 04
28.03.2012Renewal fee patent year 05
27.06.2013Renewal fee patent year 06
30.06.2014Renewal fee patent year 07
29.06.2015Renewal fee patent year 08
27.06.2016Renewal fee patent year 09
27.06.2017Renewal fee patent year 10
27.06.2018Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.06.2008
AT03.04.2019
CY03.04.2019
CZ03.04.2019
DK03.04.2019
EE03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
MT03.04.2019
NL03.04.2019
PL03.04.2019
RO03.04.2019
SE03.04.2019
SI03.04.2019
SK03.04.2019
TR03.04.2019
IE25.06.2019
LU25.06.2019
BE30.06.2019
CH30.06.2019
LI30.06.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
[2021/34]
Former [2021/33]HU25.06.2008
AT03.04.2019
CY03.04.2019
CZ03.04.2019
DK03.04.2019
EE03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
NL03.04.2019
PL03.04.2019
RO03.04.2019
SE03.04.2019
SI03.04.2019
SK03.04.2019
TR03.04.2019
IE25.06.2019
LU25.06.2019
BE30.06.2019
CH30.06.2019
LI30.06.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2021/26]AT03.04.2019
CY03.04.2019
CZ03.04.2019
DK03.04.2019
EE03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
NL03.04.2019
PL03.04.2019
RO03.04.2019
SE03.04.2019
SI03.04.2019
SK03.04.2019
TR03.04.2019
IE25.06.2019
LU25.06.2019
BE30.06.2019
CH30.06.2019
LI30.06.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2020/25]AT03.04.2019
CZ03.04.2019
DK03.04.2019
EE03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
NL03.04.2019
PL03.04.2019
RO03.04.2019
SE03.04.2019
SI03.04.2019
SK03.04.2019
TR03.04.2019
IE25.06.2019
LU25.06.2019
BE30.06.2019
CH30.06.2019
LI30.06.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2020/21]AT03.04.2019
CZ03.04.2019
DK03.04.2019
EE03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
NL03.04.2019
PL03.04.2019
RO03.04.2019
SE03.04.2019
SK03.04.2019
TR03.04.2019
IE25.06.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2020/17]AT03.04.2019
CZ03.04.2019
DK03.04.2019
EE03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
NL03.04.2019
PL03.04.2019
RO03.04.2019
SE03.04.2019
SK03.04.2019
TR03.04.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2020/11]AT03.04.2019
CZ03.04.2019
DK03.04.2019
EE03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
NL03.04.2019
PL03.04.2019
RO03.04.2019
SE03.04.2019
SK03.04.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2020/10]AT03.04.2019
CZ03.04.2019
DK03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
NL03.04.2019
PL03.04.2019
RO03.04.2019
SE03.04.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2020/09]AT03.04.2019
CZ03.04.2019
DK03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
NL03.04.2019
PL03.04.2019
SE03.04.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2020/08]AT03.04.2019
CZ03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
MC03.04.2019
NL03.04.2019
PL03.04.2019
SE03.04.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2020/04]AT03.04.2019
CZ03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
NL03.04.2019
PL03.04.2019
SE03.04.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
IS03.08.2019
PT03.08.2019
Former [2020/03]AT03.04.2019
CZ03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
NL03.04.2019
PL03.04.2019
SE03.04.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
PT03.08.2019
Former [2019/52]CZ03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
NL03.04.2019
PL03.04.2019
SE03.04.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
PT03.08.2019
Former [2019/51]CZ03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
NL03.04.2019
SE03.04.2019
BG03.07.2019
NO03.07.2019
GR04.07.2019
PT03.08.2019
Former [2019/50]CZ03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
LV03.04.2019
NL03.04.2019
SE03.04.2019
NO03.07.2019
GR04.07.2019
PT03.08.2019
Former [2019/49]CZ03.04.2019
FI03.04.2019
HR03.04.2019
LT03.04.2019
NL03.04.2019
SE03.04.2019
NO03.07.2019
PT03.08.2019
Former [2019/48]FI03.04.2019
LT03.04.2019
NL03.04.2019
SE03.04.2019
NO03.07.2019
PT03.08.2019
Former [2019/47]FI03.04.2019
LT03.04.2019
NL03.04.2019
NO03.07.2019
Former [2019/44]NL03.04.2019
Documents cited:Search[XA] US2005002942  (VLAHOV IONTCHO R et al.) [X] 1,3,4,14-19 * page 31; example 2a * * page 36; examples 6,8 *[A] 2,6,7
 [A]   LEAMON ET AL.: "COMPARATIVE PRECLINICAL ACTIVITY OF THE FOLATE-TARGETED VINCA ALKALOID CONJUGATES EC140 AND EC145", IN. J. CANCER, vol. 121, 5 June 2007 (2007-06-05), pages 1585 - 1592, XP002731968 [A] 1-4,14-19 * the whole document *

DOI:   http://dx.doi.org/10.1002/ijc.22853
International search[X] US2005002942  (VLAHOV IONTCHO R et al.)
 [Y] US2006058266  (MANOHARAN MUTHIAH et al.)
 [Y] WO2006012527  (ENDOCYTE INC et al.)
by applicantUS2005002942
   WESTERHOF, G. R.; J. H. SCHOMAGEL ET AL., MOL. PHARM., vol. 48, 1995, pages 459 - 471
   LEE ET AL.: "BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy", CLIN CANCER RES, vol. 7, 2001, pages 1429 - 1437
   ROSE: "Taxol-based combination chemotherapy and other in vivo preclinical antitumor studies", J NATL CANCER INST MONOGR, 1993, pages 47 - 53
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.