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Extract from the Register of European Patents

EP About this file: EP2189537

EP2189537 - DETECTION AND TREATMENT OF SCHIZOPHRENIA [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.08.2015
Database last updated on 08.04.2026
Most recent event   Tooltip14.08.2015No opposition filed within time limitpublished on 16.09.2015  [2015/38]
Applicant(s)For all designated states
Renascience Co., Ltd.
1793-549 Kanamori
Machida-shi, Tokyo 194-0012 / JP
For all designated states
Tokyo Metropolitan Institute of Medical Science
1-6, Kamikitazawa 2-chome
Setagaya-ku
Tokyo 156-8506 / JP
[2014/26]
Former [2014/02]For all designated states
Renascience Co., Ltd.
1793-549 Kanamori
Machida-shi, Tokyo 194-0012 / JP
For all designated states
Tokyo Metropolitan Institute of Medical Science
1-6, Kamikitazawa 2-chome
Setagaya-ku
Tokyo 156-8506 / JP
For all designated states
Medical and Biological Laboratories Co., Ltd.
Sumitomo-shoji Marunouchi Building 5F 5-10, Marunouchi 3-chome Naka-ku, Nagoya-shi
Aichi 460-0002 / JP
Former [2013/47]For all designated states
TOKAI UNIVERSITY EDUCATIONAL SYSTEM
28-4 Tomigaya 2-chome Shibuya-ku
Tokyo 151-0063 / JP
For all designated states
Tokyo Metropolitan Institute of Medical Science
1-6, Kamikitazawa 2-chome
Setagaya-ku
Tokyo 156-8506 / JP
For all designated states
Renascience CO., LTD.
1793-549 Kanamori
Machida-shi, Tokyo 194-0012 / JP
For all designated states
Medical and Biological Laboratories Co., Ltd.
Sumitomo-shoji Marunouchi Building 5F 5-10, Marunouchi 3-chome Naka-ku, Nagoya-shi
Aichi 460-0002 / JP
Former [2011/48]For all designated states
TOKAI UNIVERSITY EDUCATIONAL SYSTEM
28-4 Tomigaya 2-chome Shibuya-ku
Tokyo 151-0063 / JP
For all designated states
Tokyo Metropolitan Institute of Medical Science
1-6, Kamikitazawa 2-chome
Setagaya-ku
Tokyo / JP
For all designated states
Renascience CO., LTD.
1793-549 Kanamori
Machida-shi, Tokyo 194-0012 / JP
For all designated states
Medical and Biological Laboratories Co., Ltd.
Sumitomo-shoji Marunouchi Building 5F 5-10, Marunouchi 3-chome Naka-ku, Nagoya-shi
Aichi 460-0002 / JP
Former [2010/21]For all designated states
TOKAI UNIVERSITY EDUCATIONAL SYSTEM
28-4 Tomigaya 2-chome Shibuya-ku
Tokyo 151-0063 / JP
For all designated states
Tokyo Metropolitan Organization for Medical Research
8-1, Nishi-Shinjuku 2-chome Shinjuku-ku
Tokyo 163-8001 / JP
For all designated states
Renascience CO., LTD.
1793-549 Kanamori
Machida-shi, Tokyo 194-0012 / JP
For all designated states
Medical and Biological Laboratories Co., Ltd.
Sumitomo-shoji Marunouchi Building 5F 5-10, Marunouchi 3-chome Naka-ku, Nagoya-shi
Aichi 460-0002 / JP
Inventor(s)01 / ITOKAWA, Masanari
30-6, Yanagi-machi
Sakato-shi
Saitama 350-0216 / JP
02 / MIYATA, Toshio
20-1-1-43, Sanjyo-machi
Aoba-ku, Sendai
Miyagi 981-0935 / JP
03 / ARAI, Makoto
7-1-8-505, Asahi-machi
Kashiwa-shi
Chiba 277-0852 / JP
 [2014/41]
Former [2013/47]01 / ITOKAWA, Masanori
30-6, Yanagi-machi
Sakato-shi
Saitama 350-0216 / JP
02 / MIYATA, Toshio
20-1-1-43, Sanjyo-machi
Aoba-ku, Sendai
Miyagi 981-0935 / JP
03 / ARAI, Makoto
7-1-8-505, Asahi-machi
Kashiwa-shi
Chiba 277-0852 / JP
Former [2011/02]01 / ITOKAWA, Masanari
30-6, Yanagi-machi Sakato-shi
Saitama 350-0216 / JP
02 / MIYATA, Toshio
20-1-1-43, Sanjyo-machi Aoba-ku, Sendai
Miyagi 981-0935 / JP
03 / ARAI, Makoto
7-1-8-505, Asahi-machi Kashiwa-shi
Chiba 277-0852 / JP
Former [2010/21]01 / ITOKAWA, Masanari
c/o TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH 8-1 Nishishinjuku 2-chome Shinjuku-ku
Tokyo 163-8001 / JP
02 / MIYATA, Toshio
c/o TOKAI UNIVERSITY 143 Shimokasuya
Isehara-shi Kanagawa 259-1193 / JP
03 / ARAI, Makoto
c/o TOKYO METROPOLITAN ORGANIZATION FOR MEDICAL RESEARCH 8-1 Nishishinjuku 2-chome Shinjuku-ku
Tokyo 163-8001 / JP
Representative(s)Müller-Boré & Partner Patentanwälte PartG mbB
Friedenheimer Brücke 21
80639 München / DE
[N/P]
Former [2014/41]Müller-Boré & Partner Patentanwälte PartG mbB
Friedenheimer Brücke 21
80639 München / DE
Former [2010/21]Müller-Boré & Partner Patentanwälte
Grafinger Strasse 2
81671 München / DE
Application number, filing date08792016.131.07.2008
[2010/21]
WO2008JP63803
Priority number, dateJP2007021404720.08.2007         Original published format: JP 2007214047
[2010/21]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009025159
Date:26.02.2009
Language:JA
[2009/09]
Type: A1 Application with search report 
No.:EP2189537
Date:26.05.2010
Language:EN
[2010/21]
Type: B1 Patent specification 
No.:EP2189537
Date:08.10.2014
Language:EN
[2014/41]
Search report(s)International search report - published on:JP26.02.2009
(Supplementary) European search report - dispatched on:EP14.07.2010
ClassificationIPC:C12Q1/68, A61K31/415, A61K31/4152, A61K31/437, A61K31/4415, A61K31/4439, A61K45/00, A61P25/18, C12N15/09, G01N30/88, G01N33/15, G01N33/50
[2010/21]
CPC:
A61K31/415 (EP,US); C12Q1/527 (US); A61K31/4152 (EP,US);
A61K31/437 (EP,US); A61K31/4415 (EP,US); A61K31/4439 (EP,US);
A61P25/00 (EP); A61P25/18 (EP); A61P43/00 (EP);
C12Q1/686 (US); C12Q1/6883 (EP,US); G01N33/6893 (EP,US);
C12Q2600/106 (EP,US); C12Q2600/112 (US); C12Q2600/136 (EP,US);
C12Q2600/156 (EP,US); C12Q2600/158 (EP,US); G01N2333/988 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/21]
TitleGerman:NACHWEIS UND BEHANDLUNG VON SCHIZOPHRENIE[2010/21]
English:DETECTION AND TREATMENT OF SCHIZOPHRENIA[2010/21]
French:DÉTECTION ET TRAITEMENT DE LA SCHIZOPHRÉNIE[2010/21]
Entry into regional phase22.03.2010Translation filed 
22.03.2010National basic fee paid 
22.03.2010Search fee paid 
22.03.2010Designation fee(s) paid 
22.03.2010Examination fee paid 
Examination procedure22.03.2010Examination requested  [2010/21]
02.02.2011Amendment by applicant (claims and/or description)
15.07.2011Despatch of a communication from the examining division (Time limit: M06)
13.01.2012Reply to a communication from the examining division
22.03.2012Despatch of a communication from the examining division (Time limit: M06)
26.09.2012Reply to a communication from the examining division
22.10.2013Communication of intention to grant the patent
21.01.2014Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
17.07.2014Communication of intention to grant the patent
18.08.2014Receipt of the translation of the claim(s)
21.08.2014Fee for grant paid
21.08.2014Fee for publishing/printing paid
Divisional application(s)EP13003496.0  / EP2662453
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.07.2011
Opposition(s)09.07.2015No opposition filed within time limit [2015/38]
Fees paidRenewal fee
29.07.2010Renewal fee patent year 03
28.07.2011Renewal fee patent year 04
30.07.2012Renewal fee patent year 05
31.07.2013Renewal fee patent year 06
30.07.2014Renewal fee patent year 07
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Documents cited:Search[X] WO2006132205  (INBIOTEX INC et al.) [X] 1-3,11-13 * See entire document *
 [X] EP1897549  (INBIOTEX INC et al.) * See paragraph 0001, 0009, claims: radical scavengers to treat diseases mediated by free oxygen damage. See paragraph 4 radical scavengers to prevent glycation end products (AGE) from proteins. See paragraphs 0005 and 0024: treatment of schizophrenia *
 [Y] JPS52102431  (KYOWA HAKKO KOGYO KK) [Y] 1-3,11-13 * See pyridoxine for the treatment of schizophrenia *
 [Y] US2005249823  (MURPHY TANYA K et al.) [Y] 1-3,11-13 * See paragraphs 23, 39, claims: vitamin B6 and its use for the treatment of schizophrenia *
 [Y] EP1693369  (UNIV TOKAI EDUCATIONAL SYSTEM et al.) [Y] 1,2,11,13 * Preferred compounds of formula (1) and (2) as protein modifier production inhibitors (to prevent reactions between proteins and reactive carbonyl groups) *
 [X]   OZYURT ET AL: "A preliminary study of the levels of testis oxidative stress parameters after MK-801-induced experimental psychosis model: Protective effects of CAPE", TOXICOLOGY, LIMERICK, IR, vol. 230, no. 1, 12 January 2007 (2007-01-12), pages 83 - 89, XP005828714, ISSN: 0300-483X [X] 1-3,11-13 * See abstract, pg 86, 2nd column, par. 3, 4, page 88, 2nd col last par; pg 88, 2nd col. last paragraph: schizophrenia is associated with oxidative stress and high proteins carbonyl levels, which are diminished with administration of "CAPE" *
 [Y]   PRABAKARAN S ET AL: "Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress", MOLECULAR PSYCHIATRY, BASINGSTOKE, GB LNKD- DOI:10.1038/SJ.MP.4001532, vol. 9, no. 7, 1 July 2004 (2004-07-01), pages 684 - 697, XP002490229, ISSN: 1359-4184, [retrieved on 20040420] [Y] 1-3,11-13 * See abstract and page 690 ff: schizophrenia is associated with oxidative stress *

DOI:   http://dx.doi.org/10.1038/sj.mp.4001532
 [Y]   "Peripheral oxyradical scavenging enzymes in Schizophrenia - Ravinder Reddy, M.D. (by invitation), Sukdeb Mukherjee, M.D., Sahebarao Mahadik, Ph.D. (by invitation), J. Murthy, Ph.D. (by invitation), David B. Schnur, M.D. (by invitation) New York State Psychiatric Institute, New York, NY 10032", 1 May 1990, BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY, US LNKD- DOI:10.1016/0006-3223(90)90221-M, PAGE(S) 106, ISSN: 0006-3223, XP024250226 [Y] 1-3,11-13 * See abstract: schizophrenia is associated with deregulation of oxyradical metabolism *

DOI:   http://dx.doi.org/10.1016/0006-3223(90)90221-M
 [Y]   VOZIYAN P A ET AL: "Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage.", CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS AUG 2005 LNKD- PUBMED:15905958, vol. 62, no. 15, August 2005 (2005-08-01), pages 1671 - 1681, XP019200797, ISSN: 1420-682X [Y] 1-3,11-13 * See abstract, page 1674" scavenging of toxic carbonyl compounds" and page 1678, "Treatment of conditions in which oxidative reactions and carbonyl compounds confer toxicity" *

DOI:   http://dx.doi.org/10.1007/s00018-005-5082-7
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 [Y]   GALE C.P. ET AL.: "Common polymorphisms in the glyoxalase-1 gene and their association with pro-thrombotic factors", DIAB.VASC.DIS.RES., vol. 1, no. 1, 2004, pages 34 - 39, XP008132143 [Y]

DOI:   http://dx.doi.org/10.3132/DVDR.2004.004
 [Y]   MIYATA T. ET AL.: "Glyoxalase I deficiency is associated with an unusual level of advanced glycation end products in a hemodialysis patient", KIDNEY INT., vol. 60, no. 6, 2001, pages 2351 - 2359, XP002355559 [Y]

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 [Y]   POLITI P. ET AL.: "Association analysis of the functional Ala111Glu polymorphism of the glyoxalase I gene in panic disorder", NEUROSCI.LETT., vol. 396, no. 2, 2006, pages 163 - 166, XP025023590 [Y]

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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.