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EP About this file: EP2215124

EP2215124 - ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9) [Right-click to bookmark this link]
Status	Patent maintained as amended Status updated on 16.06.2023 Database last updated on 03.04.2025
Most recent event Tooltip	24.11.2023	Correction of patent specification	published on 27.12.2023 [2023/52]
Applicant(s)	For all designated states Amgen Inc. One Amgen Center Drive Thousand Oaks, CA 91320-1799 / US
	[2023/29]
Former [2010/32]	For all designated states Amgen Inc. One Amgen Center Drive Thousand Oaks, CA 91320-1799 / US
Inventor(s)	01 / JACKSON, Simon, Mark 2071 Birch Avenue San Carlos, CA 94070 / US
	02 / WALKER, Nigel Pelham, Clinton 20 Howland Hill Lane Burlingame, CA 94010-6033 / US
	03 / PIPER, Derek, Evan 675 Giannini Drive Santa Clara, CA 95051 / US
	04 / SHAN, Bei 349 Quay Lane Redwood City, CA 94065 / US
	05 / SHEN, Wenyan 60 Pugh Road Wayne, PA 19087 / US
	06 / CHAN, Joyce Chi, Yee 314 College Avenue San Francisco, CA 94112 / US
	07 / KING, Chadwick, Terence 1325 Moody Avenue North Vancouver British Columbia V7L 3T5 / CA
	08 / KETCHEM, Randal, Robert 6332 152nd St. Se Snohomish, WA 98296 / US
	09 / MEHLIN, Christopher 2806 Northwest 61st Street Seattle, WA 98107 / US
	10 / CARABEO, Teresa, Arazas 1 Christopher Street, Apt. 8A New York, NY 10014 / US
	11 / CAO, Qiong 582 King Drive, Apt. 6 Dalt City, CA 94015 / US
	[2016/08]
Former [2010/32]	01 / JACKSON, Simon, Mark 2071 Birch Avenue San Carlos, CA 94070 / US
	02 / WALKER, Nigel Pelham, Clinton 20 Howland Hill Lane Burlingame, CA 94010-6033 / US
	03 / PIPER, Derek, Evan 675 Giannini Drive Santa Clara, CA 95051 / US
	04 / SHAN, Bei 349 Quay Lane Redwood City, CA 94065 / US
	05 / SHEN, Wenyan 60 Pugh Road Wayne, PA 19087 / US
	06 / CHAN, Joyce Chi, Yee 314 College Avenue San Francisco, CA 94112 / US
	07 / KING, Chadwick, Terence 1325 Moody Avenue North Vancouver British Columbia V7L 3T5 / CA
	08 / KETCHEM, Randal, Robert 6332 152nd St. Se Snohomish, WA 98296 / US
	09 / MEHLIN, Christopher 2806 Northwest 61st Street Seattle, WA 98107 / US
	10 / CARABEO, Teresa, Arazas 1 Christopher Street, Apt. 8A New York, NY 10014 / US
	11 / CAO, Qiong 582 King Drive, Apt. 6 Dalt City, CA 94015 / US
Representative(s)	Dörries, Hans Ulrich df-mp Patentanwälte Rechtsanwälte PartG mbB Theatinerstraße 16 80333 München / DE
	[N/P]
Former [2016/08]	Dörries, Hans Ulrich df-mp Dörries Frank-Molnia & Pohlman Patentanwälte Rechtsanwälte PartG mbB Theatinerstrasse 16 80333 München / DE
Former [2010/32]	Dörries, Hans Ulrich df-mp Fünf Höfe Theatinerstrasse 16 80333 München / DE
Former [2010/32]	Dörries, Hans Ulrich Df-mp Fünf Höfe Theatinerstraße 16 80333 München / DE
Application number, filing date	08798550.3	22.08.2008
	[2010/32]
	WO2008US74097
Priority number, date	US20080010630P	09.01.2008 Original published format: US 10630 P
	US20080086133P	04.08.2008 Original published format: US 86133 P
	US20070957668P	23.08.2007 Original published format: US 957668 P
	US20070008965P	21.12.2007 Original published format: US 8965 P
	[2010/32]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2009026558
	Date:	26.02.2009
	Language:	EN
	[2009/09]
	Type:	A1 Application with search report
	No.:	EP2215124
	Date:	11.08.2010
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 26.02.2009 takes the place of the publication of the European patent application.
	[2010/32]
	Type:	B1 Patent specification
	No.:	EP2215124
	Date:	24.02.2016
	Language:	EN
	[2016/08]
	Type:	B2 New European patent specification
	No.:	EP2215124
	Date:	19.07.2023
	Language:	EN
	[2023/29]
	Type:	B9 Corrected patent specification
	No.:	EP2215124
	Date:	27.12.2023
	[2023/52]
Search report(s)	International search report - published on:	EP	26.02.2009
Classification	IPC:	A61P3/00, A61P7/00, A61P9/00, A61P25/28, A61P43/00, C07K16/40, A61P3/06, A61K39/395, A61K45/06, A61K31/22, A61K31/366, A61K31/40, A61K31/405, A61K31/44, A61K31/47, A61K31/505, A61K31/66, A61K39/00, C12N15/115, A61P9/10	[2022/51]
	CPC:	C07K16/40 (EP,EA,IL,KR,US); A61K39/395 (EP,EA,IL,US); A61K31/22 (EP,EA,IL,US); A61K31/366 (EP,EA,IL,US); A61K31/40 (EP,EA,IL,US); A61K31/405 (EP,EA,IL,US); (+) A61K31/44 (EP,EA,IL,US); A61K31/47 (EP,EA,IL,US); A61K31/505 (EP,EA,IL,US); A61K31/66 (EP,EA,IL,US); A61K39/3955 (EP,EA,IL,US); A61K45/06 (EP,EA,IL,US); A61P25/28 (EP,IL); A61P3/00 (EP,IL); A61P3/06 (EP,IL,KR); A61P43/00 (EP,IL); A61P7/00 (EP,IL); A61P9/00 (EP,IL); A61P9/10 (EP,IL); C12N15/1137 (EA,IL,US); A61K2039/505 (EP,EA,IL,KR,US); A61K2300/00 (IL); C07K2299/00 (EP,EA,IL,US); C07K2317/14 (EA,IL,US); C07K2317/24 (KR); C07K2317/34 (EP,EA,IL,US); C07K2317/76 (EP,EA,IL,US); C07K2317/92 (EP,EA,IL,KR,US) (-)
	C-Set:	A61K31/22, A61K2300/00 (US,EP); A61K31/366, A61K2300/00 (US,EP); A61K31/405, A61K2300/00 (US,EP); A61K31/40, A61K2300/00 (US,EP); (+) A61K31/44, A61K2300/00 (EP,US); A61K31/47, A61K2300/00 (EP,US); A61K31/505, A61K2300/00 (EP,US); A61K31/66, A61K2300/00 (EP,US); A61K39/3955, A61K2300/00 (US,EP); A61K39/395, A61K2300/00 (EP,US) (-)
	Former IPC [2016/02]	C07K16/40, A61P3/06, A61K39/395, A61K45/06, A61K31/22, A61K31/366, A61K31/40, A61K31/405, A61K31/44, A61K31/47, A61K31/505, A61K31/66, A61K39/00, C12N15/113
	Former IPC [2013/47]	C07K16/40, A61P3/06, A61K39/395, A61K45/06, A61K31/22, A61K31/366, A61K31/40, A61K31/405, A61K31/44, A61K31/47, A61K31/505, A61K31/66
	Former IPC [2010/32]	C07K16/40, A61P3/06, A61K39/395
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2016/08]
Former [2010/32]	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR
Extension states	AL	18.03.2010
	BA	18.03.2010
	MK	18.03.2010
	RS	18.03.2010
Title	German:	ANTIGENBINDENDE PROTEINE GEGEN PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYP 9 (PCSK9)	[2010/32]
	English:	ANTIGEN BINDING PROTEINS TO PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 (PCSK9)	[2010/32]
	French:	PROTÉINES DE LIAISON À UN ANTIGÈNE POUR LA PROPROTÉINE CONVERTASE SUBTILISINE KEXINE DE TYPE 9 (PCSK9)	[2016/02]
	Former [2010/32]	PROTÉINES DE LIAISON À UN ANTIGÈNE POUR PROPROTÉINE CONVERTASE SUBTILISINE KEXINE DE TYPE 9 (PCSK9)
Entry into regional phase	18.03.2010	National basic fee paid
	18.03.2010	Designation fee(s) paid
	18.03.2010	Examination fee paid
Examination procedure	18.03.2010	Examination requested [2010/32]
	13.04.2010	Amendment by applicant (claims and/or description)
	05.01.2011	Despatch of a communication from the examining division (Time limit: M06)
	15.07.2011	Reply to a communication from the examining division
	15.06.2012	Despatch of a communication from the examining division (Time limit: M06)
	21.12.2012	Reply to a communication from the examining division
	22.12.2012	Observations by third parties
	02.01.2013	Observations by third parties
	03.01.2013	Observations by third parties
	21.06.2013	Despatch of a communication from the examining division (Time limit: M04)
	28.06.2013	Reply to a communication from the examining division
	05.02.2014	Despatch of a communication from the examining division (Time limit: M04)
	05.06.2014	Reply to a communication from the examining division
	27.06.2014	Observations by third parties
	24.07.2014	Despatch of a communication from the examining division (Time limit: M04)
	28.11.2014	Reply to a communication from the examining division
	14.01.2015	Despatch of a communication from the examining division (Time limit: M04)
	24.02.2015	Reply to a communication from the examining division
	28.09.2015	Observations by third parties
	01.10.2015	Observations by third parties
	09.10.2015	Cancellation of oral proceeding that was planned for 27.11.2015
	19.10.2015	Observations by third parties
	01.11.2015	Observations by third parties
	27.11.2015	Date of oral proceedings
	27.11.2015	Date of oral proceedings (cancelled)
	09.12.2015	Fee for grant paid
	09.12.2015	Fee for publishing/printing paid
	10.12.2015	Minutes of oral proceedings despatched
	15.12.2015	Communication of intention to grant the patent
	16.12.2015	Receipt of the translation of the claim(s)
	09.03.2020	Observations by third parties
	18.03.2020	Observations by third parties
	01.04.2020	Observations by third parties
	30.09.2020	Observations by third parties
	21.10.2020	Observations by third parties
	22.10.2020	Observations by third parties
	23.10.2020	Observations by third parties
Divisional application(s)	EP13151343.4 / EP2615113
	EP13151352.5 / EP2641917
	EP13151375.6 / EP2615114
	EP13151377.2 Application deemed to be withdrawn : 16.02.2013
	EP13151381.4 / EP2641918
	EP15202482.4 Application refused : 12.06.2016
	EP16157015.5 Application refused : 08.10.2016
	EP16164634.4 Application refused : 10.09.2016
	EP16178361.8 Application refused : 16.02.2017
	EP16189650.1 Application refused : 05.02.2017
	EP16204336.8 / EP3202791
	EP19207796.4 / EP3666797
	EP23173456.7 / EP4248976
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 05.01.2011
Opposition(s)	Opponent(s)	01 24.02.2016 01.12.2016 ADMISSIBLE Sanofi 54 Rue La Boétie 75008 Paris / FR Opponent's representative Zwicker, Jörk ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
		02 22.11.2016 04.06.2018 WITHDRAWN Strawman Limited Orchard Lea Horns Lane Combe, Witney Oxfordshire OX29 8NH / GB Opponent's representative Mewburn Ellis LLP, et al, et al Aurora Building Counterslip Bristol BS1 6BX / GB
		03 24.11.2016 02.12.2016 ADMISSIBLE Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285 / US Opponent's representative Ingham, Stephen Howard Eli Lilly and Company Limited 8 Arlington Square West Downshire Way Bracknell, Berkshire RG12 1PU / GB
		04 24.11.2016 02.12.2016 ADMISSIBLE Sanofi-Aventis Deutschland GmbH/Sanofi-Aventis Groupe S.A./Sanofi Winthrop Industries S.A. Brüningstr. 50/54 rue de la Boétie/ 20 Avenue Raymond Aron 65926 Frankfurt am Main/75008 Paris/92160 Antony / DE Opponent's representative Zwicker, Jörk, et al, et al ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
		05 24.11.2016 02.12.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
		[2021/37]
	Former [2019/04]
	Opponent(s)	01 24.02.2016 01.12.2016 ADMISSIBLE Sanofi 54 Rue La Boétie 75008 Paris / FR Opponent's representative Zwicker, Jörk ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
		02 22.11.2016 04.06.2018 WITHDRAWN Strawman Limited Orchard Lea Horns Lane Combe, Witney Oxfordshire OX29 8NH / GB Opponent's representative Mewburn Ellis LLP, et al, et al City Tower 40 Basinghall Street London EC2V 5DE / GB
		03 24.11.2016 02.12.2016 ADMISSIBLE Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285 / US Opponent's representative Ingham, Stephen Howard Eli Lilly and Company Ltd European Patent Operations Lilly Research Centre Erl Wood Manor, Sunninghill Road Windlesham, Surrey, GU20 6PH / GB
		04 24.11.2016 02.12.2016 ADMISSIBLE Sanofi-Aventis Deutschland GmbH/Sanofi-Aventis Groupe S.A./Sanofi Winthrop Industries S.A. Brüningstr. 50/54 rue de la Boétie/ 20 Avenue Raymond Aron 65926 Frankfurt am Main/75008 Paris/92160 Antony / DE Opponent's representative Zwicker, Jörk, et al, et al ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
		05 24.11.2016 02.12.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative Goodfellow, Hugh Robin Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	Former [2018/28]
	Opponent(s)	01 24.02.2016 01.12.2016 ADMISSIBLE Sanofi 54 Rue La Boétie 75008 Paris / FR Opponent's representative Zwicker, Jörk ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
		02 22.11.2016 04.06.2018 WITHDRAWN Strawman Limited Orchard Lea Horns Lane Combe, Witney Oxfordshire OX29 8NH / GB Opponent's representative Walton, Seán Malcolm, et al, et al Mewburn Ellis LLP City Tower 40 Basinghall Street London EC2V 5DE / GB
		03 24.11.2016 02.12.2016 ADMISSIBLE Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285 / US Opponent's representative Ingham, Stephen Howard Eli Lilly and Company Ltd European Patent Operations Lilly Research Centre Erl Wood Manor, Sunninghill Road Windlesham, Surrey, GU20 6PH / GB
		04 24.11.2016 02.12.2016 ADMISSIBLE Sanofi-Aventis Deutschland GmbH/Sanofi-Aventis Groupe S.A./Sanofi Winthrop Industries S.A. Brüningstr. 50/54 rue de la Boétie/ 20 Avenue Raymond Aron 65926 Frankfurt am Main/75008 Paris/92160 Antony / DE Opponent's representative Zwicker, Jörk, et al, et al ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
		05 24.11.2016 02.12.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative Goodfellow, Hugh Robin Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	Former [2017/01]
	Opponent(s)	01 24.02.2016 01.12.2016 ADMISSIBLE Sanofi 54 Rue La Boétie 75008 Paris / FR Opponent's representative Zwicker, Jörk ZSP Patentanwälte PartG mbB Radlkoferstrasse 2 81373 München / DE
		02 22.11.2016 Strawman Limited Orchard Lea Horns Lane Combe, Witney Oxfordshire OX29 8NH / GB Opponent's representative Walton, Seán Malcolm, et al, et al Mewburn Ellis LLP City Tower 40 Basinghall Street London EC2V 5DE / GB
		03 24.11.2016 ADMISSIBLE Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285 / US Opponent's representative Ingham, Stephen H. Eli Lilly and Company Ltd European Patent Operations Lilly Research Centre Erl Wood Manor, Sunninghill Road Windlesham, Surrey, GU20 6PH / GB
		04 24.11.2016 ADMISSIBLE Sanofi-Aventis Deutschland GmbH/Sanofi-Aventis Groupe S.A./Sanofi Winthrop Industries S.A. Brüningstr. 50/54 rue de la Boétie/ 20 Avenue Raymond Aron 65926 Frankfurt am Main/75008 Paris/92160 Antony / DE Opponent's representative Zwicker, Jörk, et al, et al ZSP Patentanwälte PartG mbB Radlkoferstrasse 2 81373 München / DE
		05 24.11.2016 ADMISSIBLE Regeneron Pharmaceuticals, Inc. 777 Old Saw Mill River Road Tarrytown NY 10591 / US Opponent's representative Goodfellow, Hugh Robin Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB
	Former [2016/52]
	Opponent(s)	01 24.02.2016 ADMISSIBLE Sanofi 54 Rue La Boétie 75008 Paris / FR Opponent's representative Zwicker, Jörk ZSP Patentanwälte PartG mbB Radlkoferstrasse 2 81373 München / DE
		02 22.11.2016 Strawman Limited Orchard Lea Horns Lane Combe, Witney Oxfordshire OX29 8NH / GB Opponent's representative Walton, Seán Malcolm, et al, et al Mewburn Ellis LLP City Tower 40 Basinghall Street London EC2V 5DE / GB
		03 24.11.2016 Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285 / US Opponent's representative Ingham, Stephen H. Eli Lilly and Company Ltd European Patent Operations Lilly Research Centre Erl Wood Manor, Sunninghill Road Windlesham, Surrey, GU20 6PH / GB
	Former [2016/13]
	Opponent(s)	01 24.02.2016 Sanofi 54 Rue La Boétie 75008 Paris / FR Opponent's representative Zwicker, Jörk ZSP Patentanwälte PartG mbB Radlkoferstrasse 2 81373 München / DE
	10.01.2017	Invitation to proprietor to file observations on the notice of opposition
	02.05.2017	Reply of patent proprietor to notice(s) of opposition
	28.11.2018	Date of oral proceedings
	08.03.2019	Despatch of minutes of oral proceedings
	10.02.2021	Despatch of a communication from the opposition division (Time limit: M04)
	16.06.2021	Reply to a communication from the opposition division
	07.04.2022	Cancellation of oral proceeding that was planned for 10.06.2022
	14.04.2022	Despatch of a communication from the opposition division (Time limit: M04)
	10.06.2022	Date of oral proceedings
	24.11.2022	Despatch of interlocutory decision in opposition
	04.12.2022	Legal effect of interlocutory decision in opposition
	14.03.2023	Despatch of communication that the patent will be maintained as amended
	12.06.2023	Fee for printing new specification paid
Appeal following opposition	08.05.2019	Appeal received No. T0845/19
	18.07.2019	Statement of grounds filed
	29.10.2020	Result of appeal procedure: maintenance in amended form
	23.12.2020	Despatch of the decision of the Board of Appeal
	30.11.2018	Appeal received No. T0845/19
	18.07.2019	Statement of grounds filed
	29.10.2020	Result of appeal procedure: maintenance in amended form
	23.12.2020	Despatch of the decision of the Board of Appeal
	30.11.2018	Appeal received No. T0845/19
	08.07.2019	Statement of grounds filed
	29.10.2020	Result of appeal procedure: maintenance in amended form
	23.12.2020	Despatch of the decision of the Board of Appeal
	28.10.2020	Date of oral proceedings
	24.11.2020	Minutes of the oral proceedings despatched
Fees paid	Renewal fee
	17.08.2010	Renewal fee patent year 03
	11.08.2011	Renewal fee patent year 04
	10.08.2012	Renewal fee patent year 05
	19.08.2013	Renewal fee patent year 06
	13.08.2014	Renewal fee patent year 07
	10.08.2015	Renewal fee patent year 08
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited in	International search	[PX]WO2008057458 (MERCK & CO INC [US], et al);
		[PX]WO2008057457 (MERCK & CO INC [US], et al);
		[PX]WO2008057459 (MERCK & CO INC [US], et al);
		[PX]WO2008063382 (MERCK & CO INC [US], et al);
		[E]WO2008125623 (NOVARTIS AG [CH], et al);
		[E]WO2008133647 (MERCK & CO INC [US], et al);
	Examination	EP2615114
	other	EP2615114
		EP2215124
		WO2008125623
		EP2615114
	Opposition	WO2006081171
		WO2008057457
		WO2008125623
		WO2009026558
		WO2009100297
		WO2008057458
		WO2008057459
		WO2008063382
		WO2008105797
		WO2008133647
		WO2009055783
		EP2615114
		EP2215124

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.

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