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Extract from the Register of European Patents

EP About this file: EP2139325

EP2139325 - Bithionol as anti-angiogenic agent [Right-click to bookmark this link]
Former [2010/01]ANTI-ANGIOGENIC AGENTS AND METHODS OF USE
[2014/37]
StatusNo opposition filed within time limit
Status updated on  20.11.2015
Database last updated on 25.09.2024
Most recent event   Tooltip13.10.2017Lapse of the patent in a contracting state
New state(s): CY, HU, PT, TR		published on 15.11.2017  [2017/46]
Applicant(s)For all designated states
Southern Research Institute
Office of Commercialization And Intellectual Property 2000 9th Avenue South P.O. Box 55305
Birmingham, Alabama 35205 / US
[2010/01]
Inventor(s)01 / QU, Zhican
705 Lake Crescent Circle
Birmingham, AL 35226 / US
02 / ROY, Anshu, Mittal
c/o Southern Research Institute
Office of Commercialization and IP
2000 9th Avenue South
P.O. Box 55305
Birmingham, Alabama 3520 / US
03 / ANANTHAN, Subramaniam
1816 Forest Haven Lane
Birmingham, AL 35216 / US
 [2015/03]
Former [2010/10]01 / QU, Zhican
705 Lake Crescent Circle
Birmingham, AL 35226 / US
02 / ROY, Anshu, Mittal
c/o Southern Research Institute Office of Commercialization and IP 2000 9th Avenue South P.O. Box 55305
Birmingham, Alabama 3520 / US
03 / ANANTHAN, Subramaniam
1816 Forest Haven Lane
Birmingham, AL 35216 / US
Former [2010/01]01 / QU, Zhican
705 Lake Crescent Circle
Birmingham, AL 35226 / US
02 / ROY, Anshu, Mittal
1407 17th Way South
Birmingham, AL 35205 / US
03 / ANANTHAN, Subramaniam
1816 Forest Haven Lane
Birmingham, AL 35216 / US
Representative(s)Zanoli, Enrico, et al
Zanoli & Giavarini S.p.A.
Via Melchiorre Gioia, 64
20125 Milano / IT
[N/P]
Former [2015/03]Zanoli, Enrico, et al
Zanoli & Giavarini S.r.l.
Via Melchiorre Gioia, 64
20125 Milano / IT
Former [2010/01]Zanoli, Enrico, et al
Zanoli & Giavarini S.r.l. Via Melchiorre Gioia, 64
20125 Milano / IT
Application number, filing date08827229.914.04.2008
[2010/01]
WO2008US60186
Priority number, dateUS20070911645P13.04.2007         Original published format: US 911645 P
[2010/01]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2009023299
Date:19.02.2009
Language:EN
[2009/08]
Type: A2 Application without search report 
No.:EP2139325
Date:06.01.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 19.02.2009 takes the place of the publication of the European patent application.
[2010/01]
Type: B1 Patent specification 
No.:EP2139325
Date:14.01.2015
Language:EN
[2015/03]
Search report(s)International search report - published on:US22.05.2009
(Supplementary) European search report - dispatched on:EP18.08.2011
ClassificationIPC:A01N43/54, C07D239/42, C07D471/04, A61K31/095, A61K31/10, A61K31/09, A61P43/00, A61P35/00
[2011/37]
CPC:
A61K31/445 (EP,US); A61K31/542 (KR); A61K31/095 (EP,US);
A61K31/343 (EP,KR,US); A61K31/4465 (KR); A61K31/519 (EP,US);
A61K31/5415 (EP,US); A61K31/55 (EP,US); A61P1/00 (EP);
A61P1/04 (EP); A61P15/00 (EP); A61P15/08 (EP);
A61P17/00 (EP); A61P17/06 (EP); A61P19/02 (EP);
A61P19/04 (EP); A61P27/02 (EP); A61P27/06 (EP);
A61P29/00 (EP); A61P3/00 (EP); A61P3/04 (EP);
A61P3/06 (EP); A61P3/10 (EP); A61P35/00 (EP);
A61P35/04 (EP); A61P43/00 (EP); A61P9/00 (EP);
A61P9/10 (EP); A61P9/14 (EP) (-)
Former IPC [2010/01]A01N43/54, C07D239/42, C07D471/04
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/01]
Extension statesALNot yet paid
BANot yet paid
MKNot yet paid
RSNot yet paid
TitleGerman:Bithionol als Anti-Angiogenese-Mittel[2014/37]
English:Bithionol as anti-angiogenic agent[2014/37]
French:Bithionol comme agent anti-angiogénique[2014/37]
Former [2010/01]ANTI-ANGIOGENESE-MITTEL UND ANWENDUNGSVERFAHREN DAFÜR
Former [2010/01]ANTI-ANGIOGENIC AGENTS AND METHODS OF USE
Former [2010/01]AGENTS ANTI-ANGIOGÉNIQUES ET PROCÉDÉS D'UTILISATION
Entry into regional phase13.10.2009National basic fee paid 
13.10.2009Search fee paid 
13.10.2009Designation fee(s) paid 
13.10.2009Examination fee paid 
Examination procedure13.10.2009Examination requested  [2010/01]
16.03.2012Amendment by applicant (claims and/or description)
13.11.2012Despatch of a communication from the examining division (Time limit: M04)
12.03.2013Reply to a communication from the examining division
30.10.2013Despatch of a communication from the examining division (Time limit: M04)
29.01.2014Reply to a communication from the examining division
15.08.2014Communication of intention to grant the patent
04.12.2014Fee for grant paid
04.12.2014Fee for publishing/printing paid
04.12.2014Receipt of the translation of the claim(s)
Divisional application(s)EP09178514.7  / EP2161023
EP11188940.8  / EP2420230
EP11188941.6  / EP2420236
EP11188943.2  / EP2420238
EP11188944.0  / EP2420239
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  13.11.2012
Opposition(s)15.10.2015No opposition filed within time limit [2015/52]
Fees paidRenewal fee
25.03.2010Renewal fee patent year 03
25.04.2011Renewal fee patent year 04
25.04.2012Renewal fee patent year 05
29.04.2013Renewal fee patent year 06
28.04.2014Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU14.04.2008
AT14.01.2015
BE14.01.2015
CY14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
MT14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SI14.01.2015
SK14.01.2015
TR14.01.2015
BG14.04.2015
GB14.04.2015
IE14.04.2015
IT14.04.2015
LU14.04.2015
NO14.04.2015
ES15.04.2015
GR15.04.2015
CH30.04.2015
FR30.04.2015
LI30.04.2015
IS14.05.2015
PT14.05.2015
[2017/39]
Former [2017/03]AT14.01.2015
BE14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
MT14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SI14.01.2015
SK14.01.2015
BG14.04.2015
GB14.04.2015
IE14.04.2015
IT14.04.2015
LU14.04.2015
NO14.04.2015
ES15.04.2015
GR15.04.2015
CH30.04.2015
FR30.04.2015
LI30.04.2015
IS14.05.2015
Former [2016/35]AT14.01.2015
BE14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SI14.01.2015
SK14.01.2015
BG14.04.2015
GB14.04.2015
IE14.04.2015
IT14.04.2015
LU14.04.2015
NO14.04.2015
ES15.04.2015
GR15.04.2015
CH30.04.2015
FR30.04.2015
LI30.04.2015
IS14.05.2015
Former [2016/24]AT14.01.2015
BE14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SI14.01.2015
SK14.01.2015
BG14.04.2015
GB14.04.2015
IE14.04.2015
IT14.04.2015
LU14.04.2015
NO14.04.2015
GR15.04.2015
CH30.04.2015
FR30.04.2015
LI30.04.2015
IS14.05.2015
Former [2016/20]AT14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SI14.01.2015
SK14.01.2015
BG14.04.2015
GB14.04.2015
IE14.04.2015
IT14.04.2015
LU14.04.2015
NO14.04.2015
GR15.04.2015
CH30.04.2015
FR30.04.2015
LI30.04.2015
IS14.05.2015
Former [2016/12]AT14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SI14.01.2015
SK14.01.2015
BG14.04.2015
GB14.04.2015
IT14.04.2015
LU14.04.2015
NO14.04.2015
GR15.04.2015
CH30.04.2015
FR30.04.2015
LI30.04.2015
IS14.05.2015
Former [2016/08]AT14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SK14.01.2015
BG14.04.2015
GB14.04.2015
IT14.04.2015
LU14.04.2015
NO14.04.2015
GR15.04.2015
CH30.04.2015
LI30.04.2015
IS14.05.2015
Former [2016/07]AT14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SK14.01.2015
BG14.04.2015
GB14.04.2015
LU14.04.2015
NO14.04.2015
GR15.04.2015
CH30.04.2015
LI30.04.2015
IS14.05.2015
Former [2016/06]AT14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SK14.01.2015
BG14.04.2015
LU14.04.2015
NO14.04.2015
GR15.04.2015
CH30.04.2015
LI30.04.2015
IS14.05.2015
Former [2016/01]AT14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
MC14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SK14.01.2015
BG14.04.2015
LU14.04.2015
NO14.04.2015
GR15.04.2015
IS14.05.2015
Former [2015/52]AT14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SK14.01.2015
BG14.04.2015
LU14.04.2015
NO14.04.2015
GR15.04.2015
IS14.05.2015
Former [2015/49]AT14.01.2015
CZ14.01.2015
DK14.01.2015
EE14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
NL14.01.2015
PL14.01.2015
RO14.01.2015
SE14.01.2015
SK14.01.2015
BG14.04.2015
NO14.04.2015
GR15.04.2015
IS14.05.2015
Former [2015/39]AT14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
LV14.01.2015
NL14.01.2015
PL14.01.2015
SE14.01.2015
BG14.04.2015
NO14.04.2015
GR15.04.2015
IS14.05.2015
Former [2015/38]AT14.01.2015
FI14.01.2015
HR14.01.2015
LT14.01.2015
PL14.01.2015
SE14.01.2015
BG14.04.2015
NO14.04.2015
GR15.04.2015
IS14.05.2015
Former [2015/37]FI14.01.2015
HR14.01.2015
LT14.01.2015
PL14.01.2015
SE14.01.2015
BG14.04.2015
NO14.04.2015
GR15.04.2015
Former [2015/36]FI14.01.2015
HR14.01.2015
LT14.01.2015
SE14.01.2015
BG14.04.2015
NO14.04.2015
Former [2015/35]LT14.01.2015
NO14.04.2015
Documents cited:Search[XP]US2007225238  (CHARLIER HENRY A JR [US]) [XP] 1-3 * abstract * * page 2, paragraphs 14,28; claim - * * figures 3A,3B *;
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 [X]US2005250709  (KHODADOUST MEHRAN [US]) [X] 1-3 * abstract * * page 4, paragraph 40 * * page 4, paragraph 47 * * page 5, paragraphs 54,55; claims 6-8 *;
 [X]WO2007005670  (UNIV NEW YORK STATE RES FOUND [US], et al) [X] 1,2 * abstract * * page 3, paragraph 7 * * page 4, paragraph 10 * * page 5, paragraph 13; claims 1,3,6 *;
 CN1562930  [ ] (CHINESE MEDICINE & NATURAL MED [CN]);
 [A]WO02060375  (INSIGHT STRATEGY AND MARKETING [IL], et al) [A] 1-3 * claims 1,2,21-27 *;
 [X]  - XU Y-M ET AL, "Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, (20050201), vol. 13, no. 3, doi:10.1016/J.BMC.2004.10.061, ISSN 0968-0896, pages 657 - 659, XP004710829 [X] 1,2 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.bmc.2004.10.061
 [X]  - YAO, XINSHENG ET AL, "Extraction of derivatives of polyhalogenated diphenyl ethers from Phyllospongia and their medical applications", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20051012), Database accession no. 2005:1089487, URL: STN, XP002656515 [X] 1,2 * abstract *
    [ ] - REGISTRY, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (19951121), Database accession no. 170473-64-0, XP002656516 [ ] * abstract *
    [ ] - REGISTRY, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (19841116), Database accession no. 80246-27-1, XP002656517 [ ] * abstract *
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DOI:   http://dx.doi.org/10.1007/s00280-001-0399-x
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DOI:   http://dx.doi.org/10.1093/carcin/bgh278
 [A]  - Berea Williams et al., "Inhibitors of human carbonyl reductase", Journal of the Idaho Academy of Science, (200506), URL: http://findarticles.com/p/articles/mi_hb182/is_1_41/ai_n29221077/, (20110809), XP002656519 [A] 1-3 * the whole document *
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Examination   - CORBETT ET AL., Discovery of Solid Tumor Active Agents Using a Soft-Agar-Colony-Formation Disk-Diffusion-Assay, vol. CHAPT. 3, pages 35 - 87
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.