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Extract from the Register of European Patents

EP About this file: EP2205251

EP2205251 - A METHOD TO AMPLIFY CARDIAC STEM CELLS IN VITRO AND IN VIVO [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.11.2017
Database last updated on 18.10.2024
FormerThe patent has been granted
Status updated on  09.12.2016
FormerGrant of patent is intended
Status updated on  02.12.2016
Most recent event   Tooltip06.03.2020Lapse of the patent in a contracting state
New state(s): TR		published on 08.04.2020  [2020/15]
Applicant(s)For all designated states
Vestion Inc.
41219 Fisher Drive
Miami, Florida 33109 / US
[2017/24]
Former [2010/28]For all designated states
University of Miami
1475 NW 12th Avenue, Suite 2012
Miami, FL 33136 / US
Inventor(s)01 / HARE, Joshua, M.
6010 Aqua Path
Miami Beach, FL 33141 / US
02 / CHATZISTERGOS, Konstantinos
915 NW 1st Avenue
Miami, FL 33136 / US
03 / HELDMAN, Alan W.
11406 Four Fillies Road
Miami, FL 33156 / US
 [2017/24]
Former [2010/28]01 / HARE, Joshua, M.
6010 Aqua Path
Miami Beach FL 33141 / US
02 / CHATZISTERGOS, Konstantinos
915 NW 1st Avenue
Miami FL 33136 / US
Representative(s)Brearley, Helen Rebecca
Elkington and Fife LLP
Prospect House
8 Pembroke Road
Sevenoaks
Kent TN13 1XR / GB
[N/P]
Former [2017/02]Brearley, Helen Rebecca
Elkington and Fife LLP Prospect House 8 Pembroke Road Sevenoaks
Kent TN13 1XR / GB
Former [2010/28]Brearley, Helen Rebecca
Elkington and Fife LLP Prospect House 8 Pembroke Road Sevenoaks
Kent TN13 1XR / GB
Application number, filing date08835478.201.10.2008
[2010/28]
WO2008US78379
Priority number, dateUS20070976663P01.10.2007         Original published format: US 976663 P
[2010/28]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009046058
Date:09.04.2009
Language:EN
[2009/15]
Type: A1 Application with search report 
No.:EP2205251
Date:14.07.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 09.04.2009 takes the place of the publication of the European patent application.
[2010/28]
Type: B1 Patent specification 
No.:EP2205251
Date:11.01.2017
Language:EN
[2017/02]
Search report(s)International search report - published on:US09.04.2009
(Supplementary) European search report - dispatched on:EP24.02.2012
ClassificationIPC:A61K35/28, A61K35/34, A61P9/10
[2016/31]
CPC:
A61K35/28 (EP); A61K35/34 (EP); A61P9/10 (EP);
C12N5/0663 (EP); A61K2035/124 (EP)
C-Set:
A61K35/34, A61K35/28 (EP)
Former IPC [2010/28]A61K35/12
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2017/02]
Former [2010/28]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:VERFAHREN ZUR AMPLIFIKATION VON HERZSTAMMZELLEN IN VITRO UND IN VIVO[2010/28]
English:A METHOD TO AMPLIFY CARDIAC STEM CELLS IN VITRO AND IN VIVO[2010/28]
French:PROCÉDÉ POUR AMPLIFIER DES CELLULES CARDIAQUES SOUCHES IN VITRO ET IN VIVO[2010/28]
Entry into regional phase28.04.2010National basic fee paid 
28.04.2010Search fee paid 
28.04.2010Designation fee(s) paid 
28.04.2010Examination fee paid 
Examination procedure28.04.2010Amendment by applicant (claims and/or description)
28.04.2010Examination requested  [2010/28]
27.05.2014Despatch of a communication from the examining division (Time limit: M06)
05.12.2014Reply to a communication from the examining division
20.07.2016Communication of intention to grant the patent
30.11.2016Fee for grant paid
30.11.2016Fee for publishing/printing paid
30.11.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  27.05.2014
Opposition(s)12.10.2017No opposition filed within time limit [2017/51]
Fees paidRenewal fee
12.10.2010Renewal fee patent year 03
11.10.2011Renewal fee patent year 04
11.10.2012Renewal fee patent year 05
28.10.2013Renewal fee patent year 06
27.10.2014Renewal fee patent year 07
27.10.2015Renewal fee patent year 08
27.10.2016Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.10.2008
AT11.01.2017
CY11.01.2017
CZ11.01.2017
DK11.01.2017
EE11.01.2017
FI11.01.2017
HR11.01.2017
IT11.01.2017
LT11.01.2017
LV11.01.2017
MC11.01.2017
PL11.01.2017
RO11.01.2017
SI11.01.2017
SK11.01.2017
TR11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
LU01.10.2017
MT01.10.2017
[2020/15]
Former [2019/46]HU01.10.2008
AT11.01.2017
CY11.01.2017
CZ11.01.2017
DK11.01.2017
EE11.01.2017
FI11.01.2017
HR11.01.2017
IT11.01.2017
LT11.01.2017
LV11.01.2017
MC11.01.2017
PL11.01.2017
RO11.01.2017
SI11.01.2017
SK11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
LU01.10.2017
MT01.10.2017
Former [2019/31]HU01.10.2008
AT11.01.2017
CZ11.01.2017
DK11.01.2017
EE11.01.2017
FI11.01.2017
HR11.01.2017
IT11.01.2017
LT11.01.2017
LV11.01.2017
MC11.01.2017
PL11.01.2017
RO11.01.2017
SI11.01.2017
SK11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
LU01.10.2017
MT01.10.2017
Former [2018/43]AT11.01.2017
CZ11.01.2017
DK11.01.2017
EE11.01.2017
FI11.01.2017
HR11.01.2017
IT11.01.2017
LT11.01.2017
LV11.01.2017
MC11.01.2017
PL11.01.2017
RO11.01.2017
SI11.01.2017
SK11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
LU01.10.2017
MT01.10.2017
Former [2018/36]AT11.01.2017
CZ11.01.2017
DK11.01.2017
EE11.01.2017
FI11.01.2017
HR11.01.2017
IT11.01.2017
LT11.01.2017
LV11.01.2017
MC11.01.2017
PL11.01.2017
RO11.01.2017
SI11.01.2017
SK11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
LU01.10.2017
Former [2018/29]AT11.01.2017
CZ11.01.2017
DK11.01.2017
EE11.01.2017
FI11.01.2017
HR11.01.2017
IT11.01.2017
LT11.01.2017
LV11.01.2017
MC11.01.2017
PL11.01.2017
RO11.01.2017
SI11.01.2017
SK11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
Former [2018/14]AT11.01.2017
CZ11.01.2017
DK11.01.2017
EE11.01.2017
FI11.01.2017
HR11.01.2017
IT11.01.2017
LT11.01.2017
LV11.01.2017
PL11.01.2017
RO11.01.2017
SI11.01.2017
SK11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
Former [2017/50]AT11.01.2017
CZ11.01.2017
DK11.01.2017
EE11.01.2017
FI11.01.2017
HR11.01.2017
IT11.01.2017
LT11.01.2017
LV11.01.2017
PL11.01.2017
RO11.01.2017
SK11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
Former [2017/49]AT11.01.2017
CZ11.01.2017
EE11.01.2017
FI11.01.2017
HR11.01.2017
IT11.01.2017
LT11.01.2017
LV11.01.2017
PL11.01.2017
RO11.01.2017
SK11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
Former [2017/48]AT11.01.2017
CZ11.01.2017
FI11.01.2017
HR11.01.2017
LT11.01.2017
LV11.01.2017
PL11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
Former [2017/41]AT11.01.2017
FI11.01.2017
HR11.01.2017
LT11.01.2017
LV11.01.2017
PL11.01.2017
BG11.04.2017
NO11.04.2017
GR12.04.2017
IS11.05.2017
PT11.05.2017
Documents cited:Search[X]WO0006701  (GENZYME CORP [US]) [X] 1-8,22 * page 8, line 15 - page 9, line 12; example 2; claim 1 *;
 [X]  - HOU ET AL, "Transplantation of mesenchymal stem cells from human bone marrow improves damaged heart function in rats", INTERNATIONAL JOURNAL OF CARDIOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20070125), vol. 115, no. 2, doi:10.1016/J.IJCARD.2006.03.028, ISSN 0167-5273, pages 220 - 228, XP005858417 [X] 1-8,22 * pages 224-225 *

DOI:   http://dx.doi.org/10.1016/j.ijcard.2006.03.028
 [X]  - WENHUI JIANG ET AL, "Homing and differentiation of mesenchymal stem cells delivered intravenously to ischemic myocardium in vivo: a time-series study", PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY, SPRINGER, BERLIN, DE, (20060817), vol. 453, no. 1, doi:10.1007/S00424-006-0117-Y, ISSN 1432-2013, pages 43 - 52, XP019443285 [X] 1-8,22 * pages 47-49 *

DOI:   http://dx.doi.org/10.1007/s00424-006-0117-y
 [X]  - DAI W ET AL, "Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: Short- and long-term effects", CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, US, (20050712), vol. 112, no. 2, doi:10.1161/CIRCULATIONAHA.104.527937, ISSN 0009-7322, pages 214 - 223, XP002482182 [X] 1-8,22 * page 217 *

DOI:   http://dx.doi.org/10.1161/CIRCULATIONAHA.104.527937
 [X]  - HUANG ET AL, "Transplantation of angiogenin-overexpressing mesenchymal stem cells synergistically augments cardiac function in a porcine model of chronic ischemia", JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, MOSBY-YEAR BOOK, INC., ST. LOUIS, MO, US, (20061129), vol. 132, no. 6, doi:10.1016/J.JTCVS.2006.08.021, ISSN 0022-5223, pages 1329 - 1338, XP005752949 [X] 1-8,22 * page 1332 - page 1333 *

DOI:   http://dx.doi.org/10.1016/j.jtcvs.2006.08.021
 [X]  - WANG ET AL, "The roles of mesenchymal stem cells (MSCs) therapy in ischemic heart diseases", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (20070609), vol. 359, no. 2, doi:10.1016/J.BBRC.2007.05.112, ISSN 0006-291X, pages 189 - 193, XP022107148 [X] 1-8,22 * page 190 - page 191 *

DOI:   http://dx.doi.org/10.1016/j.bbrc.2007.05.112
 [Y]  - LI ET AL, "Bone marrow mesenchymal stem cells differentiate into functional cardiac phenotypes by cardiac microenvironment", JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS, GB, (20070124), vol. 42, no. 2, doi:10.1016/J.YJMCC.2006.07.002, ISSN 0022-2828, pages 295 - 303, XP005853927 [Y] 1-8,22 * page 300 *

DOI:   http://dx.doi.org/10.1016/j.yjmcc.2006.07.002
 [Y]  - TOMA C ET AL, "Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart", CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, US, (20020108), vol. 105, no. 1, doi:10.1161/HC0102.101442, ISSN 0009-7322, pages 93 - 98, XP002984364 [Y] 1-8,22 * page 96; figure 5 *

DOI:   http://dx.doi.org/10.1161/hc0102.101442
International search[Y]US2003054973  (ANVERSA PIERO [US]);
 [X]US2006008450  (VERFAILLIE CATHERINE M [US], et al);
 [Y]US2007053839  (ZHANG JIANYI [US])
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.