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Extract from the Register of European Patents

EP About this file: EP2216047

EP2216047 - REGULATOR FOR SIGNALING OF TOLL-LIKE RECEPTOR, WHICH COMPRISES CATHEPSIN INHIBITOR AS ACTIVE INGREDIENT [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  30.11.2012
Database last updated on 25.09.2024
Most recent event   Tooltip30.11.2012Application deemed to be withdrawnpublished on 02.01.2013  [2013/01]
Applicant(s)For all designated states
Velcura Therapeutics, Inc.
570 High St.
Northville, MI 48167 / US
[2012/11]
Former [2012/01]For all designated states
Nippon Chemiphar Co., Ltd.
2-3, Iwamoto-cho 2-chome Chiyoda-ku
Tokyo 1010032 / JP
Former [2010/32]For all designated states
National University Corporation Tokyo Medical and Dental University
1-5-45 Yushima Bunkyo-ku
Tokyo 113-8510 / JP
For all designated states
Nippon Chemiphar Co., Ltd.
2-3, Iwamoto-cho 2-chome Chiyoda-ku
Tokyo 1010032 / JP
Inventor(s)01 / TAKAYANAGI, Hiroshi
36-8 Kamiyama-cho Shibuya-ku
Tokyo 150-0047 / JP
02 / ASAGIRI, Masataka
9500 Gilman Dr. MC 0375 NSB3318
La Jolla, California 9209-30375 / US
03 / HIRAI, Toshitake
15-4 Nakanodaikashima-cho
Noda-shi Chiba 278-0036 / JP
 [2010/32]
Representative(s)Hiebl, Inge Elisabeth
Kraus & Weisert
Patentanwälte PartGmbB
Thomas-Wimmer-Ring 15
80539 München / DE
[N/P]
Former [2010/32]Hiebl, Inge Elisabeth
Kraus & Weisert Patent- und Rechtsanwälte Thomas-Wimmer-Ring 15
80539 München / DE
Application number, filing date08841616.923.10.2008
[2010/32]
WO2008JP69235
Priority number, dateJP2007027693724.10.2007         Original published format: JP 2007276937
[2010/32]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009054454
Date:30.04.2009
Language:JA
[2009/18]
Type: A1 Application with search report 
No.:EP2216047
Date:11.08.2010
Language:EN
[2010/32]
Search report(s)International search report - published on:JP30.04.2009
(Supplementary) European search report - dispatched on:EP30.11.2011
ClassificationIPC:A61K45/00, A61K31/336, A61P1/04, A61P11/06, A61P13/12, A61P17/06, A61P19/00, A61P25/00, A61P35/00, A61P37/00, A61P37/02, A61P37/06, A61P37/08, A61P43/00, C07D303/48, A61K31/427, A61K31/495, A61K31/55
[2011/52]
CPC:
C07D303/48 (EP,US); A61K31/00 (EP,US); A61K31/336 (EP,US);
A61K31/427 (EP,US); A61K31/495 (EP,US); A61K31/55 (EP,US);
A61P1/04 (EP); A61P11/06 (EP); A61P13/12 (EP);
A61P17/06 (EP); A61P19/00 (EP); A61P25/00 (EP);
A61P29/00 (EP); A61P35/00 (EP); A61P37/00 (EP);
A61P37/02 (EP); A61P37/06 (EP); A61P37/08 (EP);
A61P43/00 (EP) (-)
Former IPC [2010/32]A61K45/00, A61K31/336, A61P1/04, A61P11/06, A61P13/12, A61P17/06, A61P19/00, A61P25/00, A61P35/00, A61P37/00, A61P37/02, A61P37/06, A61P37/08, A61P43/00, C07D303/48
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/32]
Extension statesAL25.05.2010
BA25.05.2010
MK25.05.2010
RS25.05.2010
TitleGerman:REGULATOR ZUR SIGNALISIERUNG DES TOLL-LIKE-REZEPTORS MIT EINEM CATHEPSIN-INHIBITOR ALS WIRKSTOFF[2010/32]
English:REGULATOR FOR SIGNALING OF TOLL-LIKE RECEPTOR, WHICH COMPRISES CATHEPSIN INHIBITOR AS ACTIVE INGREDIENT[2010/32]
French:RÉGULATEUR POUR LA SIGNALISATION DU RÉCEPTEUR TOLL-LIKE, COMPORTANT UN INHIBITEUR DE LA CATHEPSINE COMME PRINCIPE ACTIF[2010/32]
Entry into regional phase25.05.2010Translation filed 
25.05.2010National basic fee paid 
25.05.2010Search fee paid 
25.05.2010Designation fee(s) paid 
25.05.2010Examination fee paid 
Examination procedure25.05.2010Examination requested  [2010/32]
30.06.2012Application deemed to be withdrawn, date of legal effect  [2013/01]
09.08.2012Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2013/01]
Fees paidRenewal fee
26.10.2010Renewal fee patent year 03
25.10.2011Renewal fee patent year 04
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X]WO0158886  (NOVARTIS AG [CH], et al) [X] 1-8,10-12 * claims 4, 7 * * page 6, paragraph 3 - page 7, paragraph 1 *;
 [X]WO2005014006  (NOVARTIS AG [CH], et al) [X] 1-8,10-12 * claims 1, 4, 6, 7 *;
 [X]EP1022276  (NIPPON CHEMIPHAR CO [JP]) [X] 1 * claims 1-12 *;
 [X]JPH06336428  (TAKEDA CHEMICAL INDUSTRIES LTD, et al) [X] 1 * claims 1-7 *;
 [X]WO0055124  (AXYS PHARM INC [US], et al) [X] 1 * claim 1 * * page 21, lines 8-26 *;
 [X]US2001008901  (GABRIEL TOBIAS [DE], et al) [X] 1 * paragraph [0042]; claim 1 *;
 [X]WO02100849  (BOEHRINGER INGELHEIM PHARMA [US]) [X] 1 * claims 1, 22, 24 *;
 [X]WO9740066  (MASSACHUSETTS INST TECHNOLOGY [US], et al) [X] 1 * claims 1, 2, 3 *;
 [X]WO2004017911  (SMITHKLINE BEECHAM CORP [US], et al) [X] 1 * claims 1-6 *;
 [X]WO0189451  (SMITHKLINE BEECHAM CORP [US], et al) [X] 1 * the whole document *;
 [X]WO2006109045  (UNIV BELFAST [GB], et al) [X] 1 * the whole document *;
 [X]  - OLGA VASILJEVA ET AL, "Emerging Roles of Cysteine Cathepsins in Disease and their Potential as Drug Targets", CURRENT PHARMACEUTICAL DESIGN, (20070201), vol. 13, no. 4, doi:10.2174/138161207780162962, ISSN 1381-6128, pages 387 - 403, XP055012551 [X] 1-12 * page 396, column 2, paragraph 4 - page 397, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.2174/138161207780162962
 [X]  - TSUKUBA T ET AL, "Cathepsin E-deficient mice show increased susceptibility to bacterialinfection associated with the decreased expression of multiple cellsurface Toll-like receptors", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY / OUP, TOKYO; JP, (20060101), vol. 140, no. 1, doi:10.1093/JH/MVJ132, ISSN 0021-924X, pages 57 - 66, XP008135678 [X] 1 * abstract *

DOI:   http://dx.doi.org/10.1093/JH/MVJ132
 [XP]  - MASATAKA ASAGIRI ET AL, "Cathepsin K-Dependent Toll- Like Receptor 9 Signaling Revealed inExperimental Arthritis", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, WASHINGTON, DC; US, (20080201), vol. 319, no. 5863, doi:10.1126/SCIENCE.1150110, ISSN 0036-8075, pages 624 - 627, XP008135679 [XP] 1 * abstract *

DOI:   http://dx.doi.org/10.1126/science.1150110
International search[X]JPH06336428  (TAKEDA CHEMICAL INDUSTRIES LTD, et al);
 [X]WO9911640  (NIPPON CHEMIPHAR CO [JP], et al);
 [X]JP2000509376  ;
 [X]JP2002539190  ;
 [X]JP2003519125  ;
 [X]JP2004526662  ;
 [X]JP2005501017  ;
 [X]JP2006505526  ;
 [X]JP2006519768  ;
 [X]WO2006109045  (UNIV BELFAST [GB], et al);
by applicantWO9630354
 WO9721694
 WO9847887
 WO9911640
 JPH11263783
 JP2000186046
 WO0149288
 WO0158886
 WO0170232
 WO03053331
 WO03075836
 WO03091202
 JP2004517918
 WO2004108661
 WO2005000800
 WO2005066180
 JP2006514004
 JP2006520781
 WO2007025774
 JP2007511593
 JP2007524615
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.