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Extract from the Register of European Patents

EP About this file: EP2215229

EP2215229 - SYSTEM FOR DELIVERING NUCLEIC ACIDS FOR SUPPRESSING TARGET GENE EXPRESSION BY UTILIZING ENDOGENOUS CHYLOMICRON [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.05.2016
Database last updated on 31.08.2024
Most recent event   Tooltip13.10.2017Lapse of the patent in a contracting state
New state(s): BG, CY, HU, MT, NL, TR		published on 15.11.2017  [2017/46]
Applicant(s)For all designated states
National University Corporation Tokyo Medical and Dental University
5-45, Yushima 1-chome, Bunkyo-ku
Tokyo 113-8510 / JP
[2015/28]
Former [2010/32]For all designated states
National University Corporation Tokyo Medical and Dental University
5-45, Yushima 1-chome, Bunkyo-ku
Tokyo 113-8510 / JP
Inventor(s)01 / YOKOTA, Takanori
c/o National University Corporation Tokyo
Medical and Dental University
5-45 Yushima 1-chome
Bunkyo-ku
Tokyo 113-8510 / JP
02 / NISHINA, Kazutaka
c/o National University Corporation Tokyo
Medical and Dental University
5-45 Yushima 1-chome
Bunkyo-ku
Tokyo 113-8510 / JP
03 / MIZUSAWA, Hidehiro
c/o National University Corporation Tokyo
Medical and Dental University
5-45 Yushima 1-chome
Bunkyo-ku
Tokyo 113-8510 / JP
04 / UNNO, Toshinori
c/o National University Corporation Tokyo
Medical and Dental University
5-45 Yushima 1-chome
Bunkyo-ku
Tokyo 113-8510 / JP
 [2015/28]
Former [2010/32]01 / YOKOTA, Takanori
c/o National University Corporation Tokyo Medicaland Dental University 5-45 Yushima 1-chome Bunkyo-ku
Tokyo 113-8510 / JP
02 / NISHINA, Kazutaka
c/o National University Corporation Tokyo Medicaland Dental University 5-45 Yushima 1-chome Bunkyo-ku
Tokyo 113-8510 / JP
03 / MIZUSAWA, Hidehiro
c/o National University Corporation Tokyo Medicaland Dental University 5-45 Yushima 1-chome Bunkyo-ku
Tokyo 113-8510 / JP
04 / UNNO, Toshinori
c/o National University Corporation Tokyo Medicaland Dental University 5-45 Yushima 1-chome Bunkyo-ku
Tokyo 113-8510 / JP
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2015/28]
Former [2014/40]HOFFMANN EITLE
Patent- und Rechtsanwälte
Arabellastrasse 4
81925 München / DE
Former [2013/39]Bradbury, Simon Timothy Nicholas, et al
Appleyard Lees
15 Clare Road
Halifax
HX1 2HY / GB
Former [2010/47]French, Philip Joseph, et al
Appleyard Lees European Patent & Trade Mark Attorneys 15 Clare Road Halifax
HX1 2HY / GB
Former [2010/32]Johnson, Graham Pierssene
Appleyard Lees 15 Clare Road
Halifax HX1 2HY / GB
Application number, filing date08853348.428.11.2008
[2010/32]
WO2008JP03523
Priority number, dateUS20070990796P28.11.2007         Original published format: US 990796 P
[2010/32]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009069313
Date:04.06.2009
Language:EN
[2009/23]
Type: A1 Application with search report 
No.:EP2215229
Date:11.08.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 04.06.2009 takes the place of the publication of the European patent application.
[2010/32]
Type: B1 Patent specification 
No.:EP2215229
Date:08.07.2015
Language:EN
[2015/28]
Search report(s)International search report - published on:JP04.06.2009
(Supplementary) European search report - dispatched on:EP08.11.2011
ClassificationIPC:C12N15/09, C12N15/113
[2011/49]
CPC:
A61K48/0075 (EP,US); A61K47/42 (US); A61P43/00 (EP);
C12N15/111 (EP,US); C12N15/88 (EP,US); A61K48/00 (EP,US);
C12N2310/14 (EP,US); C12N2310/3515 (EP,US); C12N2320/32 (EP,US) (-)
Former IPC [2010/32]C12N15/09
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2015/28]
Former [2010/32]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:SYSTEM ZUR FREISETZUNG VON NUKLEINSÄUREN ZUR UNTERDRÜCKUNG DER ZIELGENEXPRESSION MIT ENDOGENEM CHYLOMIKRON[2010/32]
English:SYSTEM FOR DELIVERING NUCLEIC ACIDS FOR SUPPRESSING TARGET GENE EXPRESSION BY UTILIZING ENDOGENOUS CHYLOMICRON[2010/32]
French:SYSTÈME D'ADMINISTRATION D'ACIDES NUCLÉIQUES POUR LA SUPPRESSION DE L'EXPRESSION D'UN GÈNE CIBLE PAR L'UTILISATION D'UN CHYLOMICRON ENDOGÈNE[2015/10]
Former [2010/32]SYSTÈME D'ADMINISTRATION D'ACIDES NUCLÉIQUES POUR LA SUPPRESSION DE L'EXPRESSION D'UN GÈNE CIBLE PAR L'UTILISATION D'UNCHYLOMICRON ENDOGÈNE
Entry into regional phase24.05.2010National basic fee paid 
24.05.2010Search fee paid 
24.05.2010Designation fee(s) paid 
24.05.2010Examination fee paid 
Examination procedure03.09.2009Request for preliminary examination filed
International Preliminary Examining Authority: JP
24.05.2010Examination requested  [2010/32]
29.05.2012Amendment by applicant (claims and/or description)
03.07.2012Despatch of a communication from the examining division (Time limit: M02)
12.09.2012Reply to a communication from the examining division
26.09.2013Despatch of a communication from the examining division (Time limit: M06)
25.03.2014Reply to a communication from the examining division
14.11.2014Date of oral proceedings
02.02.2015Minutes of oral proceedings despatched
05.02.2015Communication of intention to grant the patent
20.05.2015Fee for grant paid
20.05.2015Fee for publishing/printing paid
20.05.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  03.07.2012
Opposition(s)11.04.2016No opposition filed within time limit [2016/24]
Fees paidRenewal fee
23.11.2010Renewal fee patent year 03
23.11.2011Renewal fee patent year 04
23.11.2012Renewal fee patent year 05
28.11.2013Renewal fee patent year 06
25.11.2014Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.11.2008
AT08.07.2015
BE08.07.2015
BG08.07.2015
CY08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
MT08.07.2015
NL08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
TR08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
GB28.11.2015
IE28.11.2015
LU28.11.2015
CH30.11.2015
FR30.11.2015
LI30.11.2015
[2017/39]
Former [2017/03]AT08.07.2015
BE08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
GB28.11.2015
IE28.11.2015
LU28.11.2015
CH30.11.2015
FR30.11.2015
LI30.11.2015
Former [2016/50]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
GB28.11.2015
IE28.11.2015
LU28.11.2015
CH30.11.2015
FR30.11.2015
LI30.11.2015
Former [2016/47]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
GB28.11.2015
IE28.11.2015
LU28.11.2015
CH30.11.2015
LI30.11.2015
Former [2016/45]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
IE28.11.2015
LU28.11.2015
CH30.11.2015
LI30.11.2015
Former [2016/36]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SI08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
LU28.11.2015
CH30.11.2015
LI30.11.2015
Former [2016/34]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
LU28.11.2015
CH30.11.2015
LI30.11.2015
Former [2016/31]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
LU28.11.2015
Former [2016/28]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
MC08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/23]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
RO08.07.2015
SE08.07.2015
SK08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/22]AT08.07.2015
CZ08.07.2015
DK08.07.2015
EE08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/21]AT08.07.2015
DK08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
IT08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/20]AT08.07.2015
DK08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/11]AT08.07.2015
ES08.07.2015
FI08.07.2015
HR08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/10]ES08.07.2015
FI08.07.2015
HR08.07.2015
LT08.07.2015
LV08.07.2015
PL08.07.2015
SE08.07.2015
NO08.10.2015
GR09.10.2015
IS08.11.2015
PT09.11.2015
Former [2016/09]FI08.07.2015
LT08.07.2015
LV08.07.2015
NO08.10.2015
GR09.10.2015
Former [2016/08]LT08.07.2015
NO08.10.2015
Former [2016/07]LT08.07.2015
Documents cited:Search[X]  - Y OKAMOTO, "Attempt for liver-targeted delivery of antisense oligonucleotides by cholesterol modification and oral administration", HEPATOLOGY RESEARCH, (19990201), vol. 13, no. 3, doi:10.1016/S1386-6346(98)00093-X, ISSN 1386-6346, pages 252 - 258, XP055005834 [X] 1,2,4-12,14 * page 252 * * abstract * * page 255 * * page 257 *

DOI:   http://dx.doi.org/10.1016/S1386-6346(98)00093-X
 [X]  - WOLFRUM CHRISTIAN ET AL, "Mechanisms and optimization of in vivo delivery of lipophilic siRNAs", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 25, no. 10, doi:10.1038/NBT1339, ISSN 1087-0156, (20071001), pages 1149 - 1157, (20070916), XP002493037 [X] 1,2,4-12,14 * page 1149 * * abstract * * page 1150; figure 1 * * page 1155 *

DOI:   http://dx.doi.org/10.1038/nbt1339
 [A]  - HARA T ET AL, "In vivo gene delivery to the liver using reconstituted chylomicron remnants as a novel nonviral vector", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC; US, (19971223), vol. 94, no. 26, doi:10.1073/PNAS.94.26.14547, ISSN 0027-8424, pages 14547 - 14552, XP002160608 [A] 1 * page 14547, column r *

DOI:   http://dx.doi.org/10.1073/pnas.94.26.14547
 [XP]  - NISHINA KAZUTAKA ET AL, "Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY APR 2008 LNKD- PUBMED:18362929, (200804), vol. 16, no. 4, ISSN 1525-0024, pages 734 - 740, XP002662193 [XP] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1038/MT.2008.14
International search[Y]JPH07194385  (HOECHST AG);
 [Y]JPH07303487  (HOECHST AG);
 [Y]JP2007506790  (COLEY PHARMACEUTICAL GROUP, INC.);
 [X]  - WOLFRUM C. ET AL., "Mechanisms and optimization of in vivo delivery of lipophilic siRNAs", NATURE BIOTECHNOLOGY, (200710), vol. 25, pages 1149 - 1157, XP002493037

DOI:   http://dx.doi.org/10.1038/nbt1339
Examination   - THE JOURNAL OF NUTRITION, (200702), vol. 137, no. 2, pages 345 - 350
    - NATURE REVIEWS, vol. 6, pages 443 - 453
by applicantJP2005168485
 JP2007014292
    - NATURE, (2004), vol. 432, pages 173 - 178
    - NATURE, (2006), vol. 441, pages 111 - 114
    - ACS CHEM BIOL., (2007), vol. 2, pages 237 - 241
    - NATURE, (2007), vol. 448, pages 39 - 43
    - PROC NATL ACAD SCI USA., (2007), vol. 104, pages 12982 - 12987
    - NATURE BIOTECHNOLOGY, (2007), vol. 25, pages 1149 - 1157
    - NATURE, (1990), vol. 346, no. 6287, pages 818 - 22
    - FEBS LETT, (1988), vol. 239, page 285
    - TANPAKUSHITSU-KAKUSAN-KOUSO, (1990), vol. 35, page 2191
    - NUCL ACIDS RES, (1989), vol. 17, page 7059
    - TETRAHEDRON LETTERS, (1992), vol. 33, pages 2729 - 2732
    - ACS CHEM BIOL, (2007), vol. 2, pages 237 - 241
    - PROC NATL ACAD SCI USA, (2007), vol. 104, pages 12982 - 12987
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.