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EP About this file: EP2229459

EP2229459 - Methods and compositions for prevention or treatment of RSV infection [Right-click to bookmark this link]
Former [2010/38]	METHODS AND COMPOSITIONS FOR PREVENTION OR TREATMENT OF RSV INFECTION
	[2014/14]
Status	No opposition filed within time limit Status updated on 03.07.2015 Database last updated on 10.07.2024
Most recent event Tooltip	15.07.2016	Lapse of the patent in a contracting state New state(s): MT	published on 17.08.2016 [2016/33]
Applicant(s)	For all designated states Alnylam Pharmaceuticals, Inc. 300 Third Street, 3rd Floor Cambridge, MA 02142 / US
	[2010/38]
Inventor(s)	01 / VAISHNAW, Akshay c/o Alnylam Pharmaceuticals 300 Third Street Third Floor Cambridge, MA 02142 / US
	02 / NOCHUR, Saraswathy c/o Alnylam Pharmaceuticals 300 Third Street Third Floor Cambridge, MA 02142 / US
	03 / ELBASHIR, Sayda c/o Alnylam Pharmaceuticals 300 Third Street Third Floor Cambridge, MA 02142 / US
	04 / MANOHARAN, Muthiah c/o Alnylam Pharmaceuticals 300 Third Street Third Floor Cambridge, MA 02142 / US
	05 / MEYERS, Rachel c/o Alnylam Pharmaceuticals, Inc. 300 Third Street, thir Floor Cambridge, MA 02142 / US
	[2014/35]
Former [2010/38]	01 / VAISHNAW, Akshay c/o Alnylam Pharmaceuticals 300 Third Street Third Floor Cambridge, MA 02142 / US
	02 / NOCHUR, Saraswathy c/o Alnylam Pharmaceuticals 300 Third Street Third Floor Cambridge, MA 02142 / US
	03 / ELBASHIR, Sayda c/o Alnylam Pharmaceuticals 300 Third Street Third Floor Cambridge, MA 02142 / US
	04 / MANOHARAN, Muthiah c/o Alnylam Pharmaceuticals 300 Third Street Third Floor Cambridge, MA 02142 / US
	05 / MEYERS, Rachel c/o Alnylam Pharmaceuticals, Inc. 300 Third Street, thir Floor Cambridge, MA 02142 / US
Representative(s)	Vossius & Partner Patentanwälte Rechtsanwälte mbB Siebertstrasse 3 81675 München / DE
	[N/P]
Former [2014/35]	Vossius & Partner Siebertstrasse 4 81675 München / DE
Former [2010/38]	Vossius & Partner Siebertstrasse 4 81675 München / DE
Application number, filing date	08859358.7	15.12.2008
	[2010/38]
	WO2008US86889
Priority number, date	US20070013428P	13.12.2007 Original published format: US 13428 P
	US20070014887P	19.12.2007 Original published format: US 14887 P
	US20080021309P	15.01.2008 Original published format: US 21309 P
	US20080034084P	05.03.2008 Original published format: US 34084 P
	US20080049076P	30.04.2008 Original published format: US 49076 P
	[2010/38]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2009076679
	Date:	18.06.2009
	Language:	EN
	[2009/25]
	Type:	A1 Application with search report
	No.:	EP2229459
	Date:	22.09.2010
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 18.06.2009 takes the place of the publication of the European patent application.
	[2010/38]
	Type:	B1 Patent specification
	No.:	EP2229459
	Date:	27.08.2014
	Language:	EN
	[2014/35]
Search report(s)	International search report - published on:	US	18.06.2009
	(Supplementary) European search report - dispatched on:	EP	13.12.2010
Classification	IPC:	C12N15/113, A61K31/7088, A61P31/14	[2014/14]
	CPC:	A61K31/708 (EP,US); A61K31/713 (EP,US); A61M11/00 (US); A61P11/00 (EP); A61P11/02 (EP); A61P11/04 (EP); (+) A61P11/14 (EP); A61P21/00 (EP); A61P25/04 (EP); A61P27/16 (EP); A61P29/00 (EP); A61P31/04 (EP); A61P31/10 (EP); A61P31/12 (EP); A61P31/14 (EP); A61P37/00 (EP); A61P37/06 (EP); A61P7/00 (EP); C12N15/1131 (EP,US); C12N2310/14 (EP,US) (-)
	Former IPC [2011/01]	C12N15/11
	Former IPC [2010/38]	C12Q1/70
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2010/38]
Title	German:	Verfahren und Zusammensetzungen zur Vorbeugung oder Behandlung einer RSV-Infektion	[2014/14]
	English:	Methods and compositions for prevention or treatment of RSV infection	[2014/14]
	French:	Procédés et compositions de prévention ou de traitement d'infection à virus respiratoire syncytial (RSV)	[2014/14]
	Former [2010/38]	VERFAHREN UND ZUSAMMENSETZUNGEN ZUR VORBEUGUNG ODER BEHANDLUNG EINER RSV-INFEKTION
	Former [2010/38]	METHODS AND COMPOSITIONS FOR PREVENTION OR TREATMENT OF RSV INFECTION
	Former [2010/38]	PROCÉDÉS ET COMPOSITIONS DE PRÉVENTION OU DE TRAITEMENT D'INFECTION À VIRUS RESPIRATOIRE SYNCYTIAL (RSV)
Entry into regional phase	05.07.2010	National basic fee paid
	05.07.2010	Search fee paid
	05.07.2010	Designation fee(s) paid
	05.07.2010	Examination fee paid
Examination procedure	05.07.2010	Examination requested [2010/38]
	04.07.2011	Amendment by applicant (claims and/or description)
	12.08.2011	Despatch of a communication from the examining division (Time limit: M04)
	30.01.2012	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	10.04.2012	Reply to a communication from the examining division
	19.07.2012	Despatch of a communication from the examining division (Time limit: M04)
	29.11.2012	Reply to a communication from the examining division
	19.02.2013	Despatch of a communication from the examining division (Time limit: M04)
	28.06.2013	Reply to a communication from the examining division
	04.03.2014	Communication of intention to grant the patent
	14.07.2014	Fee for grant paid
	14.07.2014	Fee for publishing/printing paid
	14.07.2014	Receipt of the translation of the claim(s)
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 12.08.2011
Opposition(s)	28.05.2015	No opposition filed within time limit [2015/32]
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	10.04.2012	Request for further processing filed
	10.04.2012	Full payment received (date of receipt of payment) Request granted
	26.04.2012	Decision despatched
Fees paid	Renewal fee
	27.12.2010	Renewal fee patent year 03
	27.12.2011	Renewal fee patent year 04
	26.12.2012	Renewal fee patent year 05
	27.12.2013	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	15.12.2008
	AT	27.08.2014
	BE	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	MC	27.08.2014
	MT	27.08.2014
	NL	27.08.2014
	PL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SI	27.08.2014
	SK	27.08.2014
	TR	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IE	15.12.2014
	LU	15.12.2014
	IS	27.12.2014
	PT	29.12.2014
	CH	31.12.2014
	LI	31.12.2014
	[2016/33]
Former [2016/32]	HU	15.12.2008
	AT	27.08.2014
	BE	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	MC	27.08.2014
	NL	27.08.2014
	PL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SI	27.08.2014
	SK	27.08.2014
	TR	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IE	15.12.2014
	LU	15.12.2014
	IS	27.12.2014
	PT	29.12.2014
	CH	31.12.2014
	LI	31.12.2014
Former [2016/27]	AT	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	MC	27.08.2014
	NL	27.08.2014
	PL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SI	27.08.2014
	SK	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IE	15.12.2014
	LU	15.12.2014
	IS	27.12.2014
	PT	29.12.2014
	BE	31.12.2014
	CH	31.12.2014
	LI	31.12.2014
Former [2015/50]	AT	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	NL	27.08.2014
	PL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SI	27.08.2014
	SK	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IE	15.12.2014
	LU	15.12.2014
	IS	27.12.2014
	PT	29.12.2014
	BE	31.12.2014
	CH	31.12.2014
	LI	31.12.2014
Former [2015/47]	AT	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	NL	27.08.2014
	PL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SK	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IE	15.12.2014
	LU	15.12.2014
	IS	27.12.2014
	PT	29.12.2014
	BE	31.12.2014
	CH	31.12.2014
	LI	31.12.2014
Former [2015/46]	AT	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	NL	27.08.2014
	PL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SK	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IE	15.12.2014
	LU	15.12.2014
	IS	27.12.2014
	PT	29.12.2014
	BE	31.12.2014
Former [2015/35]	AT	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	NL	27.08.2014
	PL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SK	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	LU	15.12.2014
	IS	27.12.2014
	PT	29.12.2014
	BE	31.12.2014
Former [2015/30]	AT	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	NL	27.08.2014
	PL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SK	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IS	27.12.2014
	PT	29.12.2014
	BE	31.12.2014
Former [2015/24]	AT	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	NL	27.08.2014
	PL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SK	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IS	27.12.2014
	PT	29.12.2014
Former [2015/23]	AT	27.08.2014
	CY	27.08.2014
	CZ	27.08.2014
	DK	27.08.2014
	EE	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	NL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	SK	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IS	27.12.2014
	PT	29.12.2014
Former [2015/22]	AT	27.08.2014
	CY	27.08.2014
	DK	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	IT	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	NL	27.08.2014
	RO	27.08.2014
	SE	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IS	27.12.2014
	PT	29.12.2014
Former [2015/16]	AT	27.08.2014
	CY	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	NL	27.08.2014
	SE	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IS	27.12.2014
	PT	29.12.2014
Former [2015/12]	AT	27.08.2014
	CY	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	HR	27.08.2014
	LT	27.08.2014
	LV	27.08.2014
	SE	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	IS	27.12.2014
	PT	29.12.2014
Former [2015/11]	CY	27.08.2014
	ES	27.08.2014
	FI	27.08.2014
	LT	27.08.2014
	SE	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
	GR	28.11.2014
	PT	29.12.2014
Former [2015/10]	ES	27.08.2014
	FI	27.08.2014
	LT	27.08.2014
	SE	27.08.2014
	BG	27.11.2014
	NO	27.11.2014
Former [2015/09]	FI	27.08.2014
	LT	27.08.2014
	SE	27.08.2014
Former [2015/08]	LT	27.08.2014
Documents cited:	Search	[I]WO2006074346 (ALNYLAM PHARMACEUTICALS INC [US], et al) [I] 1-17 * page 4; table 1c *;
		[Y]WO2005097817 (ALNYLAM PHARMACEUTICALS [US], et al) [Y] 1-17 * page 101 *;
		[A]WO2006062596 (UNIV SOUTH ALABAMA [US], et al) [A] 1-17 * the whole document *;
		[Y] - GLANVILLE ET AL, "Intravenous Ribavirin Is a Safe and Cost-effective Treatment for Respiratory Syncytial Virus Infection After Lung Transplantation", JOURNAL OF HEART AND LUNG TRANSPLANTATION, MOSBY-YEAR BOOK, INC., ST LOUIS, MO, US, (20051201), vol. 24, no. 12, doi:DOI:10.1016/J.HEALUN.2005.06.027, ISSN 1053-2498, pages 2114 - 2119, XP005215204 [Y] 1-17 * the whole document * DOI: http://dx.doi.org/10.1016/j.healun.2005.06.027
		[YP] - DEVINCENZO ET AL, "Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, (20071226), vol. 77, no. 3, doi:DOI:10.1016/J.ANTIVIRAL.2007.11.009, ISSN 0166-3542, pages 225 - 231, XP022454778 [YP] 1-17 * the whole document * DOI: http://dx.doi.org/10.1016/j.antiviral.2007.11.009
		[A] - BITKO VIRA ET AL, "Inhibition of respiratory viruses by nasally administered siRNA", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20050101), vol. 11, no. 1, doi:DOI:10.1038/NM1164, ISSN 1078-8956, pages 50 - 55, XP002410945 [A] 1-17 * the whole document * DOI: http://dx.doi.org/10.1038/nm1164
		[A] - ZHANG WEIDONG ET AL, "Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20050101), vol. 11, no. 1, doi:DOI:10.1038/NM1174, ISSN 1078-8956, pages 56 - 62, XP002410946 [A] 1-17 * the whole document * DOI: http://dx.doi.org/10.1038/nm1174
		[A] - KARRAS ET AL, "Inhaled antisense oligonucleotide therapies: Inspiration and progress", DRUG DISCOVERY TODAY: THERAPEUTIC STRATEGIES, ELSEVIER, (20061123), vol. 3, no. 3, doi:DOI:10.1016/J.DDSTR.2006.08.002, ISSN 1740-6773, pages 335 - 341, XP005777440 [A] 1-17 * page 339 * DOI: http://dx.doi.org/10.1016/j.ddstr.2006.08.002
		[A] - BARIK SAILEN, "Inhaled short interfering RNA as a promising approach to the therapy of viral respiratory infections", DRUGS OF THE FUTURE, (200506), vol. 30, no. 6, ISSN 0377-8282, pages 567 - 572, XP002611353 [A] 1-17 * the whole document * DOI: http://dx.doi.org/10.1358/dof.2005.030.06.915726
		[A] - KONG XIAOYUAN ET AL, "Respiratory syncytial virus infection in Fischer 344 rats is attenuated by short interfering RNA against the RSV-NS1 gene", GENETIC VACCINES AND THERAPY, BIOMED CENTRAL, LONDON, GB, (20070201), vol. 5, no. 1, doi:DOI:10.1186/1479-0556-5-4, ISSN 1479-0556, page 4, XP021024869 [A] 1-17 * the whole document * DOI: http://dx.doi.org/10.1186/1479-0556-5-4
	Examination	- HORNUNG V ET AL, "Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20050220), vol. 11, no. 3, doi:10.1038/NM1191, ISSN 1078-8956, pages 263 - 270, XP002371477 DOI: http://dx.doi.org/10.1038/nm1191
	by applicant	US4501729
		- OPENSHAW, P.J.M, RESPIR. RES, (2002), vol. 3, no. SUPL.1, pages S15 - S20
		- EASTON, A.J ET AL, CLIN. MICROBIOL. REV., (2004), vol. 17, pages 390 - 412
		- MAGGON, K ET AL, REV. MED. VIROL., (2004), vol. 14, pages 149 - 168
		- FIRE ET AL, NATURE, (1998), vol. 391, pages 806 - 811
		WO2005US11490
		WO2004US01193
		WO2004US11822
		WO2004US11829
		WO2004US07070
		US20040916185

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