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Extract from the Register of European Patents

EP About this file: EP2229437

EP2229437 - Engineering zymogen for conditional toxicity [Right-click to bookmark this link]
Former [2010/38]ENGINEERING ZYMOGEN FOR CONDITIONAL TOXICITY
[2012/46]
StatusThe application is deemed to be withdrawn
Status updated on  09.08.2013
Database last updated on 25.09.2024
Most recent event   Tooltip09.08.2013Application deemed to be withdrawnpublished on 11.09.2013  [2013/37]
Applicant(s)For all designated states
Syngenta Participations AG
3054 Cornwallis Road
Research Triangle Park, NC 27709 / US
[2010/38]
Inventor(s)01 / JUCOVIC, Milan
3054 Cornwallis Road
Durham North Carolina 27709 / US
02 / CHEN, Jeng, S.
3054 Cornwallis Road
Durham North Carolina 27709 / US
03 / WALTERS, Frederick, S.
3054 Cornwallis Road
Durham North Carolina 27709 / US
04 / PALEKAR, Narenda, V.
3054 Cornwallis Road
Durham North Carolina 27709 / US
 [2010/38]
Representative(s)Schaberg, Ulf Günther, et al
Syngenta International AG
Intellectual Property
WRO-1004-6-22
Schwarzwaldallee 215
4058 Basel / CH
[2012/41]
Former [2010/38]Schaberg, Ulf Günther, et al
Syngenta Participations AG Seeds IP Basel Schwarzwaldallee 215
4058 Basel / CH
Application number, filing date08859771.110.12.2008
[2010/38]
WO2008US86205
Priority number, dateUS20070012864P11.12.2007         Original published format: US 12864 P
[2010/38]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009076426
Date:18.06.2009
Language:EN
[2009/25]
Type: A1 Application with search report 
No.:EP2229437
Date:22.09.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 18.06.2009 takes the place of the publication of the European patent application.
[2010/38]
Search report(s)International search report - published on:EP18.06.2009
ClassificationIPC:C12N9/10, C12N15/82, C07K19/00, A01N37/46, A01N63/02
[2012/46]
CPC:
C12N9/1077 (EP,US); A01N37/46 (EP,US); A01N63/50 (EP,US);
C12N15/8286 (EP,US); C07K2319/55 (EP,US); Y02A40/146 (EP,US)
Former IPC [2010/38]C12N9/10, C07K19/00, C12N1/19, A01H5/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2010/38]
TitleGerman:Manipulation von Zymogen für bedingte Toxizität[2012/46]
English:Engineering zymogen for conditional toxicity[2012/46]
French:Modification génétique de zymogène pour la toxicité conditionnelle[2012/46]
Former [2010/38]MANIPULATION VON ZYMOGEN FÜR BEDINGTE TOXIZITÄT
Former [2010/38]ENGINEERING ZYMOGEN FOR CONDITIONAL TOXICITY
Former [2010/38]MODIFICATION GÉNÉTIQUE DE ZYMOGÈNE POUR LA TOXICITÉ CONDITIONNELLE
Entry into regional phase07.07.2010National basic fee paid 
07.07.2010Designation fee(s) paid 
07.07.2010Examination fee paid 
Examination procedure07.07.2010Amendment by applicant (claims and/or description)
07.07.2010Examination requested  [2010/38]
17.01.2011Despatch of a communication from the examining division (Time limit: M06)
14.07.2011Reply to a communication from the examining division
14.12.2011Despatch of a communication from the examining division (Time limit: M04)
13.04.2012Reply to a communication from the examining division
09.11.2012Despatch of a communication from the examining division (Time limit: M04)
20.03.2013Application deemed to be withdrawn, date of legal effect  [2013/37]
23.04.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2013/37]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  17.01.2011
Fees paidRenewal fee
15.12.2010Renewal fee patent year 03
12.12.2011Renewal fee patent year 04
11.12.2012Renewal fee patent year 05
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[X]WO9929721  (UNIV WASHINGTON [US], et al) [X] 1,17,18,23,38-44 * abstract *;
 [X]  - VOCERO-AKBANI A M ET AL, "Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein", NATURE MEDICINE, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (19990101), vol. 5, no. 1, ISSN 1078-8956, pages 29 - 33, XP002228967 [X] 1,17,18,23,38-44 * abstract *

DOI:   http://dx.doi.org/10.1038/4710
 [DA]  - LAZURE CLAUDE, "The peptidase zymogen proregions: Nature's way of preventing undesired activation and proteolysis", CURRENT PHARMACEUTICAL DESIGN, (2002), vol. 8, no. 7, ISSN 1381-6128, pages 511 - 531, XP002516917 [DA] 1-44 * the whole document *

DOI:   http://dx.doi.org/10.2174/1381612023395691
 [A]  - BARTH HOLGER ET AL, "The uptake machinery of clostridial actin ADP-ribosylating toxins: A cell delivery system for fusion proteins and polypeptide drugs.", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, (200212), vol. 366, no. 6, ISSN 0028-1298, pages 501 - 512, XP002516918 [A] 1-44 * abstract *

DOI:   http://dx.doi.org/10.1007/S00210-002-0626-Y
 [PX]  - JUCOVIC MILAN ET AL, "From enzyme to zymogen: engineering Vip2, an ADP-ribosyltransferase from Bacillus cereus, for conditional toxicity", PROTEIN ENGINEERING DESIGN & SELECTION, (200810), vol. 21, no. 10, ISSN 1741-0126, pages 631 - 638, XP002516919 [PX] 1-44 * the whole document *

DOI:   http://dx.doi.org/10.1093/protein/gzn038
 [A]  - YONGXIA SHI ET AL, "'Cloning of vip1/vip2 genes and expression of Vip1Ca/Vip2Ac proteins in Bacillus thuringiensis", WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, KLUWER ACADEMIC PUBLISHERS, DO, (20060912), vol. 23, no. 4, ISSN 1573-0972, pages 501 - 507, XP019485239 [A] 1-44 * abstract *
Examination   - WERNICK NAOMI L B ET AL, "N-terminal Extension of the Cholera Toxin A1-chain Causes Rapid Degradation after Retrotranslocation from Endoplasmic Reticulum to Cytosol", JOURNAL OF BIOLOGICAL CHEMISTRY, (201002), vol. 285, no. 9, ISSN 0021-9258, pages 6145 - 6152
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.