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Extract from the Register of European Patents

EP About this file: EP2157191

EP2157191 - Use of PITX2 nucleic acids for the improved treatment of breast cell proliferative disorders [Right-click to bookmark this link]
Former [2010/08]Method and nucleic acids for the improved treatment of breast cell proliferative disorders
[2013/23]
StatusNo opposition filed within time limit
Status updated on  31.10.2014
Database last updated on 02.11.2024
Most recent event   Tooltip08.07.2016Lapse of the patent in a contracting state
New state(s): HU, TR		published on 10.08.2016  [2016/32]
Applicant(s)For all designated states
Epigenomics AG
Kleine Präsidentenstraße 1
10178 Berlin / DE
[N/P]
Former [2010/08]For all designated states
Epigenomics AG
Intellectual Property Kleine Präsidentenstrasse 1
10178 Berlin / DE
Inventor(s)01 / Foekens, John
Filosofentuin 35
2908 XA Rotterdam / NL
02 / Harbeck, Nadia
Palnkamer Strasse 18
83624 Otterfing / DE
03 / König, Thomas
Skalitzer Strasse 18
10999 Berlin / DE
04 / Maier, Sabine
606 Barclay Boulevard
Princeton New Jersey 08540 / US
05 / Martens, John
Schiekade 121 h
3033 BK Rotterdam / NL
06 / Model, Fabian
Debenzer Strasse 73
12683 Berlin / DE
07 / Nimmrich, Inko
Rudolf-Schwarz-Strasse 15
10407 Berlin / DE
08 / Rujan, Tamas
Wintererstrasse 47a
79104 Freiburg / DE
09 / Schmitt, Armin
Hortensienstrasse 29
12203 Berlin / DE
10 / Schmitt, Manfred
Hohenaschenauerstrasse 10
81669 München / DE
11 / Look, Maxime, P.
Stade de Colombes 55
1098 VS Amsterdam / NL
12 / Marx, Almuth
Freilandstrasse 12a
90482 Nürnberg / DE
13 / Höfler, Heinz
Ismaningerstrasse 64
81675 München / DE
 [2010/08]
Representative(s)Zwicker, Jörk, et al
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[N/P]
Former [2013/52]Zwicker, Jörk, et al
ZSP Patentanwälte
Partnerschaftsgesellschaft
Radlkoferstrasse 2
81373 München / DE
Former [2012/25]Zwicker, Jörk, et al
Dr. Volker Vossius
Patent- und Rechtsanwaltskanzlei
Geibelstrasse 6
81679 München / DE
Former [2010/08]Krauss, Jan
Forrester & Boehmert Pettenkoferstrasse 20-22
80366 München / DE
Application number, filing date09009372.501.10.2003
[2010/08]
Priority number, dateDE200214577901.10.2002         Original published format: DE 10245779
DE200310009607.01.2003         Original published format: DE 10300096
DE200311795517.04.2003         Original published format: DE 10317955
[2010/08]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2157191
Date:24.02.2010
Language:EN
[2010/08]
Type: A3 Search report 
No.:EP2157191
Date:09.06.2010
[2010/23]
Type: B1 Patent specification 
No.:EP2157191
Date:25.12.2013
Language:EN
[2013/52]
Search report(s)(Supplementary) European search report - dispatched on:EP12.05.2010
ClassificationIPC:C12Q1/68
[2010/08]
CPC:
C12Q1/6886 (EP,US); A61P35/00 (EP); C12Q2600/106 (EP,US);
C12Q2600/154 (EP,US); C12Q2600/158 (EP,US); C12Q2600/16 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   RO,   SE,   SI,   SK,   TR [2010/08]
TitleGerman:Verwendung von PITX2 Nukleinsäuren für die verbesserte Behandlung von proliferativen Erkrankungen von Mammazellen[2013/23]
English:Use of PITX2 nucleic acids for the improved treatment of breast cell proliferative disorders[2013/23]
French:Utilisation d'acides nucléiques de PITX2 pour le traitement amélioré des troubles cellulaires prolifératifs du sein[2013/23]
Former [2010/08]Verfahren und Nukleinsäuren die verbesserte Behandlung von proliferativen Erkrankungen von Mammazellen
Former [2010/08]Method and nucleic acids for the improved treatment of breast cell proliferative disorders
Former [2010/08]Procédé et acides nucléiques pour le traitement amélioré des troubles cellulaires proliférables du sein
Examination procedure20.07.2009Examination requested  [2010/08]
09.12.2010Amendment by applicant (claims and/or description)
17.03.2011Despatch of a communication from the examining division (Time limit: M06)
20.09.2011Reply to a communication from the examining division
09.07.2012Despatch of a communication from the examining division (Time limit: M04)
12.11.2012Reply to a communication from the examining division
12.07.2013Communication of intention to grant the patent
12.11.2013Fee for grant paid
12.11.2013Fee for publishing/printing paid
Parent application(s)   TooltipEP03808704.5  / EP1554407
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20030808704) is  20.07.2006
Opposition(s)26.09.2014No opposition filed within time limit [2014/49]
Fees paidRenewal fee
20.07.2009Renewal fee patent year 03
20.07.2009Renewal fee patent year 04
20.07.2009Renewal fee patent year 05
20.07.2009Renewal fee patent year 06
14.10.2009Renewal fee patent year 07
28.10.2010Renewal fee patent year 08
29.08.2011Renewal fee patent year 09
26.10.2012Renewal fee patent year 10
29.10.2013Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.10.2003
AT25.12.2013
BE25.12.2013
BG25.12.2013
CY25.12.2013
CZ25.12.2013
DK25.12.2013
EE25.12.2013
FI25.12.2013
MC25.12.2013
NL25.12.2013
RO25.12.2013
SE25.12.2013
SI25.12.2013
SK25.12.2013
TR25.12.2013
GR26.03.2014
PT28.04.2014
[2016/32]
Former [2016/28]AT25.12.2013
BE25.12.2013
BG25.12.2013
CY25.12.2013
CZ25.12.2013
DK25.12.2013
EE25.12.2013
FI25.12.2013
MC25.12.2013
NL25.12.2013
RO25.12.2013
SE25.12.2013
SI25.12.2013
SK25.12.2013
GR26.03.2014
PT28.04.2014
Former [2016/25]AT25.12.2013
BE25.12.2013
BG25.12.2013
CY25.12.2013
CZ25.12.2013
DK25.12.2013
EE25.12.2013
FI25.12.2013
MC25.12.2013
NL25.12.2013
RO25.12.2013
SE25.12.2013
SI25.12.2013
SK25.12.2013
PT28.04.2014
Former [2015/27]AT25.12.2013
BE25.12.2013
CY25.12.2013
CZ25.12.2013
DK25.12.2013
EE25.12.2013
FI25.12.2013
MC25.12.2013
NL25.12.2013
RO25.12.2013
SE25.12.2013
SI25.12.2013
SK25.12.2013
PT28.04.2014
Former [2015/24]AT25.12.2013
BE25.12.2013
CY25.12.2013
CZ25.12.2013
DK25.12.2013
EE25.12.2013
FI25.12.2013
NL25.12.2013
RO25.12.2013
SE25.12.2013
SI25.12.2013
SK25.12.2013
PT28.04.2014
Former [2014/48]AT25.12.2013
BE25.12.2013
CY25.12.2013
CZ25.12.2013
DK25.12.2013
EE25.12.2013
FI25.12.2013
NL25.12.2013
RO25.12.2013
SE25.12.2013
SK25.12.2013
PT28.04.2014
Former [2014/39]AT25.12.2013
BE25.12.2013
CY25.12.2013
CZ25.12.2013
EE25.12.2013
FI25.12.2013
NL25.12.2013
RO25.12.2013
SE25.12.2013
SK25.12.2013
PT28.04.2014
Former [2014/37]AT25.12.2013
BE25.12.2013
CY25.12.2013
CZ25.12.2013
EE25.12.2013
FI25.12.2013
RO25.12.2013
SE25.12.2013
SK25.12.2013
PT28.04.2014
Former [2014/36]BE25.12.2013
EE25.12.2013
FI25.12.2013
SE25.12.2013
Former [2014/34]BE25.12.2013
FI25.12.2013
SE25.12.2013
Former [2014/22]FI25.12.2013
SE25.12.2013
Documents cited:Search[XY]WO0119845  (UNIV JOHNS HOPKINS MED [US]) [X] 1-4,6,7 * page 37; claims 25-28; table 4; sequences 23, 24 * * page 7; tables 1, 4, 5 * [Y] 8;
 [XY]WO0192565  (EPIGENOMICS AG [DE], et al) [X] 1-7 * the whole document * * page 15; claims 3-4, 6, 9; sequences 127, 128 * * page 19 - page 20 * [Y] 8;
 [A]EP1167975  (UNIV PARIS DESCARTES [FR]) [A] 1-9 * the whole document *;
 [A]WO02059347  (UNIV JOHNS HOPKINS MED [US]) [A] 1-9 * the whole document *;
 [XP]WO02077272  (EPIGENOMICS AG [DE], et al) [XP] 1-4,7 * the whole document * * claims 29, 42, 51; sequences 188, 333 *;
 [X]  - "2819627.3prime NIH_MGC_7 Homo sapiens cDNA clone 2819627 3', mRNA sequence.", EMBL, (20000107), Database accession no. AW247159, URL: EBI, XP002579903 [X] 1,2 * abstract *
 [X]  - "S8E7 AGS-1 Pneumocystis carinii f. sp. carinii cDNA 3', mRNA sequence.", EMBL, (20000201), Database accession no. AW332443, URL: EBI, XP002579904 [X] 1,2 * abstract *
 [X]  - "S32D4 AGS-1 Pneumocystis carinii f. sp. carinii cDNA 3', mRNA sequence.", EMBL, (20000201), Database accession no. AW334249, URL: EBI, XP002579905 [X] 1,2 * abstract *
 [X]  - "Homo sapiens mRNA; EST DKFZp566N082_r1 (from clone DKFZp566N082)", EMBL, (19990312), Database accession no. AL038397, URL: EBI, XP002579906 [X] 1,2 * abstract *
 [X]  - "2821119.3prime NIH_MGC_7 Homo sapiens cDNA clone 2821119 3', mRNA sequence.", EMBL, (20000107), Database accession no. AW248747, URL: EBI, XP002579907 [X] 1,2 * abstract *
 [X]  - "Homo sapiens mRNA; EST DKFZp566J0546_r1 (from clone DKFZp566J0546)", EMBL, (19990312), Database accession no. AL038686, URL: EBI, XP002579908 [X] 1,2 * abstract *
 [X]  - "Homo sapiens mRNA; EST DKFZp566I1846_r1 (from clone DKFZp566I1846)", EMBL, (19990312), Database accession no. AL038650, URL: EBI, XP002579909 [X] 1,2 * abstract *
 [X]  - "yz25d06.s1 Soares_multiple_sclerosis_2NbHMSP Homo sapiens cDNA clone IMAGE:284075 3' similar to gb:M55047 SYNAPTOTAGMIN I (HUMAN);, mRNA sequence.", EMBL, (19960218), Database accession no. N53413, URL: EBI, XP002579910 [X] 1,2 * abstract *
 [A]  - TOYOTA M ET AL, "Methylation profiling in acute myeloid leukemia", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US LNKD- DOI:10.1182/BLOOD.V97.9.2823, (20010501), vol. 97, no. 9, ISSN 0006-4971, pages 2823 - 2829, XP002226261 [A] 1-9 * the whole document *

DOI:   http://dx.doi.org/10.1182/blood.V97.9.2823
 [A]  - HUANG TIM HUI-MING ET AL, "Methylation profiling of CpG islands in human breast cancer cells", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY LNKD- DOI:10.1093/HMG/8.3.459, (19990301), vol. 8, no. 3, ISSN 0964-6906, pages 459 - 470, XP002175857 [A] 1-9 * the whole document *

DOI:   http://dx.doi.org/10.1093/hmg/8.3.459
 [A]  - YAN P S ET AL, "Dissecting complex epigenetic alterations in breast cancer using CpG Island microarrays", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER REREARCH, US, (20011201), vol. 61, no. 23, ISSN 0008-5472, pages 8375 - 8380, XP002243660 [A] 1-9 * the whole document *
 [L]  - MARTENS J W M ET AL, "Epigenetic signature predicts failure of endocrine therapy in patients with recurrent breast cancer", BREAST CANCER RESEARCH AND TREATMENT, SPRINGER, NEW YORK, NY, (20030101), vol. 82, no. Supplement 1, ISSN 0167-6806, page S72, XP008030522
by applicantWO9500669
 WO9515373
 WO9745560
 WO9746705
 US5744305
 US5786146
 US5837832
 WO9928498
 US6265171
 US6331393
 US6596488
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.