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Extract from the Register of European Patents

EP About this file: EP2153832

EP2153832 - HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS [Right-click to bookmark this link]
Former [2010/07]Heterocyclic aspartyl protease inhibitors
[2015/40]
StatusNo opposition filed within time limit
Status updated on  13.01.2017
Database last updated on 02.11.2024
Most recent event   Tooltip13.07.2018Lapse of the patent in a contracting state
New state(s): TR		published on 15.08.2018  [2018/33]
Applicant(s)For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
For all designated states
Pharmacopeia, LLC
10275 Science Center Drive
San Diego, CA 92121 / US
[2016/10]
Former [2012/33]For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway NJ 07065-0907 / US
For all designated states
Pharmacopeia, LLC
10275 Science Center Drive
San Diego, CA 92121 / US
Former [2010/07]For all designated states
Schering Corporation
2000 Galloping Hill Road
Kenilworth, NJ 07033-0530 / US
For all designated states
Pharmacopeia, LLC
10275 Science Center Drive
San Diego CA 92121 / US
Inventor(s)01 / Zhu, Zhaoning
6 Cypress Court
Plainsboro, NJ 08536 / US
02 / Mckittrick, Brian
14 Millbrook Road
New Vernon, NJ 07976 / US
03 / Sun, Zhong-Yue
12 Straton Court
Parlin, NJ 08859 / US
04 / Ye, Yuanzan, C.
103 Othen Street
Edison, NJ 08817 / US
05 / Strickland, Corey
825 Newmans Lane
Martinsville, NJ 08836 / US
06 / Smith, Elizabeth M.
166 Grove Street
Verona, NJ 07044 / US
07 / Stamford, Andrew
27 Overlook Road
Chatham Township, NJ 07928 / US
08 / Greenlee, William, J
115 Herrick Avenue
Teaneck, NJ 07666 / US
09 / Wu, Yusheng
235 East 40th Street Apt. 20C
New York, NY 10016 / US
10 / Iserloh, Ulrich
1110 Park Avenue Apt. 2L
Hoboken, NJ 07030 / US
11 / Mazzola, Robert
6 Greenwich Church Road
Stewartsville, NJ 08886 / US
12 / Caldwell, John
86 Upper Lakeview Avenue
Ringwood, NJ 07456 / US
13 / Cumming, Jared
417 Center Street
Garwood, NJ 07027 / US
14 / Wang, Lingyan
41 Cortland Drive
East Brunswick, NJ 08816 / US
15 / Guo, Tao
1606 Dahlia Circle
Dayton, NJ 08810 / US
16 / Le, Thuy, X. H.
16 Black Gum Drive
Monmouth Junction, NJ 08852 / US
17 / Saionz, Kurt, W
508 Linden Place
Cranford, NJ 07016 / US
18 / Babu, Suresh, D.
1407 Aspen Drive
Plainsboro, NJ 08536 / US
19 / Voigt, Johannes H.
10 Willow Street
Cranford, NJ 07016 / US
20 / Hunter, Rachael C.
1000 Hedgerow Circle
Wayne, PA 19087 / US
 [2016/10]
Former [2010/07]01 / Zhu Zhaoning
6 Cypress Court
Plainsboro, NJ 08536 / US
02 / Mckittrick, Brian
14 Millbrook Road
New Vernon, NJ 07976 / US
03 / Sun, Zhong-Yue
12 Straton Court
Parlin, NJ 08859 / US
04 / Ye, Yuanzan, C.
103 Othen Street
Edison, NJ 08817 / US
05 / Strickland, Corey
825 Newmans Lane
Martinsville, NJ 08836 / US
06 / Smith, Elizabeth M.
166 Grove Street
Verona, NJ 07044 / US
07 / Stamford, Andrew
27 Overlook Road
Chatham Township, NJ 07928 / US
08 / Greenlee, William, J
115 Herrick Avenue
Teaneck, NJ 07666 / US
09 / Wu, Yusheng
235 East 40th Street Apt. 20C
New York, NY 10016 / US
10 / Iserloh, Ulrich
1110 Park Avenue Apt. 2L
Hoboken, NJ 07030 / US
11 / Mazzola, Robert
6 Greenwich Church Road
Stewartsville, NJ 08886 / US
12 / Caldwell, John
86 Upper Lakeview Avenue
Ringwood, NJ 07456 / US
13 / Cumming, Jared
417 Center Street
Garwood, NJ 07027 / US
14 / Wang, Lingyan
41 Cortland Drive
East Brunswick, NJ 08816 / US
15 / Guo, Tao
1606 Dahlia Circle
Dayton, NJ 08810 / US
16 / Le, Thuy, X. H.
16 Black Gum Drive
Monmouth Junction, NJ 08852 / US
17 / Saionz, Kurt, W
508 Linden Place
Cranford, NJ 07016 / US
18 / Babu, Suresh, D.
1407 Aspen Drive
Plainsboro, NJ 08536 / US
19 / Voigt, Johannes H.
10 Willow Street
Cranfordn, NJ 07016 / US
20 / Hunter, Rachael C.
1000 Hedgerow Circle
Wayne, PA 19087 / US
Representative(s)Buchan, Gavin MacNicol, et al
Merck Sharp & Dohme Limited
European Patent Department
Hertford Road
Hoddesdon
Hertfordshire EN11 9BU / GB
[2016/10]
Former [2012/11]Simpson, Tobias Rutger, et al
Mathys & Squire LLP 120 Holborn
London EC1N 2SQ / GB
Former [2010/07]Bowman, Paul Alan, et al
Mathys & Squire LLP 120 Holborn
GB-London EC1N 2SQ / GB
Application number, filing date09174520.813.12.2004
[2010/07]
Priority number, dateUS20030529535P15.12.2003         Original published format: US 529535 P
[2010/07]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2153832
Date:17.02.2010
Language:EN
[2010/07]
Type: A3 Search report 
No.:EP2153832
Date:22.06.2011
[2011/25]
Type: B1 Patent specification 
No.:EP2153832
Date:09.03.2016
Language:EN
[2016/10]
Search report(s)(Supplementary) European search report - dispatched on:EP20.05.2011
ClassificationIPC:A61K31/4168, A61K31/4178, C07D233/88, C07D239/22, C07D271/06, C07D401/04, C07D401/10, C07D401/12, C07D401/14, C07D403/06, C07D403/10, C07D403/14, C07D405/06, C07D405/14, C07D407/14, C07D409/06, C07D413/12, C07D413/14, C07D417/12, A61P25/00, A61P31/00
[2010/07]
CPC:
C07D233/88 (EP,KR); A61P13/12 (EP); A61P25/00 (EP);
A61P25/28 (EP); A61P31/00 (EP); A61P31/10 (EP);
A61P31/18 (EP); A61P33/00 (EP); A61P33/02 (EP);
A61P33/06 (EP); A61P35/00 (EP); A61P43/00 (EP);
A61P9/00 (EP); A61P9/12 (EP); C07D235/02 (EP);
C07D239/22 (EP); C07D271/07 (EP); C07D401/04 (EP);
C07D401/06 (EP); C07D401/10 (EP,KR); C07D401/12 (EP,KR);
C07D401/14 (EP); C07D403/04 (EP); C07D403/06 (EP,KR);
C07D403/10 (EP); C07D403/12 (EP); C07D405/04 (EP);
C07D405/06 (EP); C07D405/10 (EP); C07D405/12 (EP);
C07D405/14 (EP); C07D409/06 (EP); C07D409/10 (EP);
C07D409/14 (EP); C07D413/06 (EP); C07D413/12 (EP);
C07D413/14 (EP); C07D417/12 (EP) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/10]
Former [2010/07]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
Extension statesAL29.10.2009
BA29.10.2009
HR29.10.2009
LV29.10.2009
MK29.10.2009
YU29.10.2009
TitleGerman:HETEROZYKLISCHE ASPARTYL-PROTEASEHEMMER[2015/40]
English:HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS[2015/40]
French:INHIBITEURS DE PROTÉASE ASPARTYLE HÉTÉROCYCLIQUE[2015/40]
Former [2010/07]Heterozyklische Aspartyl-Proteasehemmer
Former [2010/07]Heterocyclic aspartyl protease inhibitors
Former [2010/07]Inhibiteurs de protease aspartyle heterocyclique
Examination procedure29.10.2009Examination requested  [2010/07]
19.12.2011Amendment by applicant (claims and/or description)
08.03.2012Despatch of a communication from the examining division (Time limit: M06)
25.10.2012Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
04.01.2013Reply to a communication from the examining division
26.09.2014Despatch of a communication from the examining division (Time limit: M06)
01.04.2015Reply to a communication from the examining division
29.05.2015Despatch of a communication from the examining division (Time limit: M04)
31.07.2015Reply to a communication from the examining division
04.09.2015Communication of intention to grant the patent
22.12.2015Fee for grant paid
22.12.2015Fee for publishing/printing paid
22.12.2015Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP04813947.1  / EP1699455
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20040813947) is  12.07.2007
Opposition(s)12.12.2016No opposition filed within time limit [2017/07]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
04.01.2013Request for further processing filed
04.01.2013Full payment received (date of receipt of payment)
Request granted
24.01.2013Decision despatched
Fees paidRenewal fee
29.10.2009Renewal fee patent year 03
29.10.2009Renewal fee patent year 04
29.10.2009Renewal fee patent year 05
29.10.2009Renewal fee patent year 06
22.11.2010Renewal fee patent year 07
07.12.2011Renewal fee patent year 08
07.12.2012Renewal fee patent year 09
06.12.2013Renewal fee patent year 10
05.12.2014Renewal fee patent year 11
07.12.2015Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU13.12.2004
AT09.03.2016
BE09.03.2016
CY09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
MC09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SI09.03.2016
SK09.03.2016
TR09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
[2018/29]
Former [2018/28]HU13.12.2004
AT09.03.2016
BE09.03.2016
CY09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
MC09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SI09.03.2016
SK09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2017/47]AT09.03.2016
BE09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
MC09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SI09.03.2016
SK09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2017/37]AT09.03.2016
BE09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SI09.03.2016
SK09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2017/20]AT09.03.2016
BE09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
BG09.06.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2017/07]AT09.03.2016
BE09.03.2016
CZ09.03.2016
DK09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2017/03]AT09.03.2016
BE09.03.2016
CZ09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
IT09.03.2016
LT09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2016/51]AT09.03.2016
CZ09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
LT09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
GR10.06.2016
IS09.07.2016
PT11.07.2016
Former [2016/50]AT09.03.2016
CZ09.03.2016
EE09.03.2016
ES09.03.2016
FI09.03.2016
LT09.03.2016
NL09.03.2016
PL09.03.2016
RO09.03.2016
SE09.03.2016
SK09.03.2016
GR10.06.2016
IS09.07.2016
Former [2016/49]EE09.03.2016
ES09.03.2016
FI09.03.2016
LT09.03.2016
NL09.03.2016
PL09.03.2016
SE09.03.2016
GR10.06.2016
IS09.07.2016
Former [2016/48]ES09.03.2016
FI09.03.2016
LT09.03.2016
NL09.03.2016
PL09.03.2016
SE09.03.2016
GR10.06.2016
IS09.07.2016
Former [2016/40]ES09.03.2016
FI09.03.2016
LT09.03.2016
NL09.03.2016
PL09.03.2016
SE09.03.2016
GR10.06.2016
Former [2016/39]ES09.03.2016
FI09.03.2016
LT09.03.2016
PL09.03.2016
SE09.03.2016
GR10.06.2016
Former [2016/36]ES09.03.2016
FI09.03.2016
LT09.03.2016
PL09.03.2016
GR10.06.2016
Former [2016/35]ES09.03.2016
FI09.03.2016
GR10.06.2016
Documents cited:Search[A]WO9004917  (ABBOTT LAB [US]) [A] 1-20* claim 1 *
by applicantWO02074719
    - OPARIL, S ET AL., N ENGL J MED, (1974), vol. 291, pages 381 - 401
    - MOORE ET AL., Purification of HTLV-I Protease and Synthesis of Inhibitors for the treatment of HTLV-I Infection 55, AMERICAN CHEMICAL SOCIETY, (20031116), page 1073
    - NA BYOUNG-KUK ET AL., "Aspartic proteases of Plasmodium vivax are highly conserved in wild isolates", KOREAN JOURNAL OF PRASITOLOGY, (200406), vol. 42, no. 2, pages 61 - 6
    - T. HIGUCHI; V. STELLA, "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, (1987), vol. 14
    - S. BERGE ET AL., JOURNAL OF PHARMACEUTICAL SCIENCES, (1977), vol. 66, no. L, pages 1 - 19
    - P. GOULD, INTERNATIONAL J. OF PHARMACEUTICS, (1986), vol. 33, pages 201 - 217
    - The Orange Book, FOOD & DRUG ADMINISTRATION
    - Handbook of Pharmaceutical Salts: Properties, Selection, and Use, INT'L. UNION OF PURE AND APPLIED CHEMISTRY, (2002), pages 330 - 331
    - UGI, I., ANGEW. CHEM., (1962), vol. 74, pages 9 - 22
    - HULL, R. ET AL., J. CHEM. SOC., (1963), pages 6028 - 6033
    - HUSSEIN, A. Q. ET AL., CHEM. BER., (1979), vol. 112, pages 1948 - 1955
    - MIYASHITA, A.; MATSUDA, H.; HIAGASKINO, T., CHEM. PHARM. BULL., (1992), vol. 40, no. 10, pages 2627 - 2631
    - VARGA, I. ET AL., TETRAHEDRON, (2003), vol. 59, pages 655 - 662
    - FURNISS, B. S. ET AL., Vogel's Textbook of Practical Organic Chemistry., (1989), pages 1034 - 1035
    - J-Q YU; E.J. COREY, ORGANIC LETTERS, (2002), vol. 4, pages 2727 - 2730
    - TERAO, Y ET AL., CHEMICAL AND PHARMACEUTICAL BULLETIN, (1985), vol. 33, no. 7, pages 2762 - 2766
    - COLDHAM, I ET AL., JOUMAL OF ORGANIC CHEMISTRY, (2002), vol. 67, no. 17, pages 6185 - 6187
    - WINKLER J. D. ET AL., TETRAHEDRON, (1998), vol. 54, pages 7045 - 7056
    - PAGE ET AL., TETRAHEDRON, (1992), vol. 35, pages 7265 - 7274
    - Y.YASUDA ET AL., J. BIOCHEM., (1999), vol. 125, page 1137
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.