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Extract from the Register of European Patents

EP About this file: EP2348120

EP2348120 - Enzymatic reduction of 1-phenylpropanone and derivatives thereof [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.04.2015
Database last updated on 03.09.2024
Most recent event   Tooltip22.06.2018Lapse of the patent in a contracting state
New state(s): MK		published on 25.07.2018  [2018/30]
Applicant(s)For all designated states
Universität Wien
Dr.-Karl-Lueger-Ring 1
1010 Wien / AT
For all designated states
Technische Universität Graz
Rechbauerstraße 12
8010 Graz / AT
[2011/30]
Inventor(s)01 / Brecker, Lothar
Stumpergasse 57/12
1060 Wien / AT
02 / Vogl, Michael
Maroltingergasse 76/3
1160 Wien / AT
03 / Kratzer, Regina
Fischergasse 16
8010 Graz / AT
04 / Nidetzky, Bernd
Carnerigasse 10/III
8010 Graz / AT
 [2014/23]
Former [2011/30]01 / Brecker, Lothar
Stumpergasse 57/12
1060 Wien / AT
02 / Vogl, Michael
A. Baumgartnerstraße 44 C5 1208
1230 Wien / AT
03 / Kratzer, Regina
Babenbergerstraße 28/III
8020 Graz / AT
04 / Nidetzky, Bernd
Carnerigasse 10/III
8010 Graz / AT
Representative(s)Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
[N/P]
Former [2014/24]Maiwald Patentanwalts GmbH
Elisenhof
Elisenstrasse 3
80335 München / DE
Former [2011/30]Maiwald Patentanwalts GmbH
Elisenhof Elisenstrasse 3
80335 München / DE
Application number, filing date09181016.830.12.2009
[2011/30]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2348120
Date:27.07.2011
Language:EN
[2011/30]
Type: B1 Patent specification 
No.:EP2348120
Date:11.06.2014
Language:EN
[2014/24]
Search report(s)(Supplementary) European search report - dispatched on:EP16.09.2010
ClassificationIPC:C12P7/22, C12P41/00, C12N9/04
[2014/03]
CPC:
C12P41/002 (EP); C12N9/0006 (EP); C12P7/22 (EP);
C12Y101/01307 (EP)
Former IPC [2011/30]C12P7/04, C12P7/22, C12P41/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2011/30]
TitleGerman:Enzymatische Reduktion von 1-Phenylpropanon und Derivate davon[2011/30]
English:Enzymatic reduction of 1-phenylpropanone and derivatives thereof[2011/30]
French:Réduction enzymatique de 1-phénylpropanone et dérivés associés[2011/30]
Examination procedure19.01.2012Amendment by applicant (claims and/or description)
19.01.2012Examination requested  [2012/09]
17.02.2012Despatch of a communication from the examining division (Time limit: M06)
17.08.2012Reply to a communication from the examining division
20.12.2013Communication of intention to grant the patent
29.04.2014Fee for grant paid
29.04.2014Fee for publishing/printing paid
29.04.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  17.02.2012
Opposition(s)12.03.2015No opposition filed within time limit [2015/21]
Fees paidRenewal fee
19.12.2011Renewal fee patent year 03
17.12.2012Renewal fee patent year 04
17.12.2013Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.12.2009
AT11.06.2014
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Documents cited:Search[X]JPH04234989  ;
 [X]JPH04234990  ;
 [Y]WO02057475  (COUNCIL SCIENT IND RES [IN], et al) [Y] 8 * abstract * * page 3, line 29 - line 31; figure 2 *
 [X]  - CHOI YUN HEE ET AL, "Asymmetric synthesis of (S)-3-chloro-1-phenyl-1-propanol using Saccharomyces cerevisiae reductase with high enantioselectivity", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, (201006), vol. 87, no. 1, pages 185 - 193, XP002598229 [X] 1,5-8,12 * abstract * * page 185, column 2 - page 190, column 1 *

DOI:   http://dx.doi.org/10.1007/s00253-010-2442-5
 [X]  - HAMMOND ET AL, "Biocatalytic synthesis towards both antipodes of 3-hydroxy-3-phenylpropanitrile a precursor to fluoxetine, atomoxetine and nisoxetine", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.TETLET.2006.12.057, (20070117), vol. 48, no. 7, ISSN 0040-4039, pages 1217 - 1219, XP005834125 [X] 1,6-9,12,13 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.tetlet.2006.12.057
 [X]  - DATABASE WPI, 0, Derwent World Patents Index, vol. 1992, no. 40, Database accession no. 1992-327633, XP002598230 & JPH04234989 A 19920824 (DAICEL CHEM IND LTD) [X] 1,2,5,6,12 * abstract *
 [X]  - DATABASE WPI, 0, Derwent World Patents Index, vol. 1992, no. 40, Database accession no. 1992-327634, XP002598231 & JPH04234990 A 19920824 (DAICEL CHEM IND LTD) [X] 1,2,5,12 * abstract *
 [X]  - WU X ET AL, "Enantioselective synthesis of ethyl (S)-2-hydroxy-4-phenylbutyrate by recombinant diketoreductase", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 20, no. 21, ISSN 0957-4166, (20091104), pages 2504 - 2509, (20091201), XP026791010 [X] 1,5,12 * abstract *
 [X]  - ANKATI, H. ET AL, "Asymetric synthesis of both antipodes of beta-hydroxy nitriles and beta-hydroxy carboxylic acids via enzymatic reduction or sequential reduction/hdrolysis", JOURNAL OF ORGANIC CHEMISTRY, (20090122), vol. 74, pages 1658 - 1662, XP002598232 [X] 1-4,6,9,12,13 * page 1660 - page 1661 *

DOI:   http://dx.doi.org/10.1021/jo802495f
 [X]  - LAVANDERA, I. ET AL., "Stereoselective bioreduction of bulky-bulky ketones by a novel ADH from Ralstonia sp.", JOURNAL OF ORGANIC CHEMISTRY, (20080703), vol. 73, pages 6003 - 6005, XP002598233 [X] 1,6,12 * table 1 *

DOI:   http://dx.doi.org/10.1021/jo800849d
 [X]  - SALVI N A ET AL, "Asymmetric reduction of halo-substituted arylalkanones with Rhizopus arrhizus", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB LNKD- DOI:10.1016/J.TETASY.2008.07.035, vol. 19, no. 16, ISSN 0957-4166, (20080822), pages 1992 - 1997, (20080829), XP025347802 [X] 1-6,12 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.tetasy.2008.07.035
 [X]  - LAVANDERA I ET AL, "Asymmetric anti-Prelog reduction of ketones catalysed by Paracoccus pantotrophus and Comamonas sp. cells via hydrogen transfer", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB LNKD- DOI:10.1016/J.TETASY.2008.08.005, vol. 19, no. 16, ISSN 0957-4166, (20080822), pages 1954 - 1958, (20080827), XP025347795 [X] 1,6,12 * page 1956, column 2, paragraph 2; figure 3 *

DOI:   http://dx.doi.org/10.1016/j.tetasy.2008.08.005
 [X]  - HAGE A ET AL, "Asymmetric reduction of ketones via whole cell bioconversions and transfeR HYDRogenation: complementary approaches", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB LNKD- DOI:10.1016/S0957-4166(01)00172-0, (20010508), vol. 12, no. 7, ISSN 0957-4166, pages 1025 - 1034, XP004241685 [X] 1-6,12 * page 1025 - page 1028 *

DOI:   http://dx.doi.org/10.1016/S0957-4166(01)00172-0
 [X]  - BROUSSY, S. ET AL., "Enatioselective, ketoreductase-based entry into pharmaceutical building blocks: ethanol as tunable nicotinamide reductant", ORGANIC LETTERS, (20081217), vol. 11, no. 2, pages 305 - 308, XP002598234 [X] 1,5,6,9,12,13 * page 305 - page 306; table 1 *

DOI:   http://dx.doi.org/10.1021/ol802464g
 [Y]  - KRATZER REGINA ET AL, "Whole-cell bioreduction of aromatic Î+--keto esters using Candida tenuis xylose reductase and Candida boidinii formate dehydrogenase co-expressed in Escherichia coli", MICROBIAL CELL FACTORIES, BIOMED CENTRAL, LONDON, NL LNKD- DOI:10.1186/1475-2859-7-37, (20081210), vol. 7, no. 1, ISSN 1475-2859, page 37, XP021049876 [Y] 9-15 * the whole document *

DOI:   http://dx.doi.org/10.1186/1475-2859-7-37
 [Y]  - PETSCHACHER BARBARA ET AL, "The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography", BIOCHEMICAL JOURNAL, (200501), vol. 385, no. Part 1, ISSN 0264-6021, pages 75 - 83, XP002598235 [Y] 9-15 * abstract * * page 82, column 2, paragraph l *
 [Y]  - KUMAR A ET AL, "A NEW CHEMOENZYMATIC ENANTIOSELECTIVE SYNTHESIS OF R-(-)-TOMOXETINE, (R)- AND (S)-FLUOXETINE", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/S0040-4039(00)85993-6, (19910101), vol. 32, no. 16, ISSN 0040-4039, pages 1901 - 1904, XP002269009 [Y] 8 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)85993-6
Examination   - JACK LIANG ET AL, "Development of a Biocatalytic Process as an Alternative to the (-)-DIP-Cl-Mediated Asymmetric Reduction of a Key Intermediate of Montelukast", ORGANIC PROCESS RESEARCH & DEVELOPMENT, (20100115), vol. 14, no. 1, doi:10.1021/op900272d, ISSN 1083-6160, pages 193 - 198, XP055018991

DOI:   http://dx.doi.org/10.1021/op900272d
    - REGINA KRATZER ET AL, "Identification of Candida tenuis xylose reductase as highly selective biocatalyst for the synthesis of aromatic ?-hydroxy esters and improvement of its efficiency by protein engineering", CHEMICAL COMMUNICATIONS, (20070101), no. 10, doi:10.1039/b616475g, ISSN 1359-7345, page 1047, XP055019037

DOI:   http://dx.doi.org/10.1039/B616475G
    - REGINA KRATZER ET AL, "Probing the substrate binding site of Candida tenuis xylose reductase (AKR2B5) with site-directed mutagenesis", BIOCHEMICAL JOURNAL, (20060101), vol. 393, no. 1, doi:10.1042/BJ20050831, ISSN 0264-6021, page 51, XP055018940

DOI:   http://dx.doi.org/10.1042/BJ20050831
by applicantUS4314081
 WO2008026227
 WO2006009884
 US7473804
    - BOHREN ET AL., J. BIOD. CHEM., (1989), vol. 264, pages 9547 - 9551
    - JEZ ET AL., BIOCHEM. J., (1997), vol. 326, pages 625 - 636
    - KRATZER ET AL., BIOCHEM. J., (2006), vol. 393, pages 51 - 58
    - PIVAL ET AL., FEBS LETTERS, (2008), vol. 582, pages 4095 - 4099
    - NIDETZKY ET AL., BIOCHEMISTRY, (2001), vol. 40, pages 10371 - 10381
    - KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI USA, (1993), vol. 90, pages 5873 - 5877
    - ALTSCHUL ET AL., MOL. BIOI., vol. 215, (1990), pages 403 - 410, URL: http://www.ncbi.nlm.nih.gov/blast/Blast.cge
    - J. CHROMAT., (2000), vol. 737, pages 195 - 202
    - BIOCHEM. J., (2005), vol. 385, pages 75 - 83
    - NUCLEIC ACIDS RES., (1989), vol. 17, pages 6545 - 6551
    - BIOL. CHEM., (1999), vol. 380, pages 1395 - 1403
    - Organikum, JOHANN AMBROSIUS BARTH VERLAG, (1996), vol. 20, page 362
    - J. MED. CHEM., (2008), vol. 51, pages 3841 - 3855
    - ANGEW. CHEM. INT. ED., (2005), vol. 44, pages 1687 - 1689
    - BIOORG. MED. CHEM., (2006), vol. 14, pages 7501 - 7511
    - ORG. BIOMOL. CHEM., (2005), vol. 3, pages 2513 - 2518
    - J. CHEM. SOC, PERKIN TRANS., (2000), vol. 1, pages 1767 - 1769
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