EP2348120 - Enzymatic reduction of 1-phenylpropanone and derivatives thereof [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 17.04.2015 Database last updated on 03.09.2024 | Most recent event Tooltip | 22.06.2018 | Lapse of the patent in a contracting state New state(s): MK | published on 25.07.2018 [2018/30] | Applicant(s) | For all designated states Universität Wien Dr.-Karl-Lueger-Ring 1 1010 Wien / AT | For all designated states Technische Universität Graz Rechbauerstraße 12 8010 Graz / AT | [2011/30] | Inventor(s) | 01 /
Brecker, Lothar Stumpergasse 57/12 1060 Wien / AT | 02 /
Vogl, Michael Maroltingergasse 76/3 1160 Wien / AT | 03 /
Kratzer, Regina Fischergasse 16 8010 Graz / AT | 04 /
Nidetzky, Bernd Carnerigasse 10/III 8010 Graz / AT | [2014/23] |
Former [2011/30] | 01 /
Brecker, Lothar Stumpergasse 57/12 1060 Wien / AT | ||
02 /
Vogl, Michael A. Baumgartnerstraße 44 C5 1208 1230 Wien / AT | |||
03 /
Kratzer, Regina Babenbergerstraße 28/III 8020 Graz / AT | |||
04 /
Nidetzky, Bernd Carnerigasse 10/III 8010 Graz / AT | Representative(s) | Maiwald GmbH Elisenhof Elisenstraße 3 80335 München / DE | [N/P] |
Former [2014/24] | Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | ||
Former [2011/30] | Maiwald Patentanwalts GmbH Elisenhof Elisenstrasse 3 80335 München / DE | Application number, filing date | 09181016.8 | 30.12.2009 | [2011/30] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP2348120 | Date: | 27.07.2011 | Language: | EN | [2011/30] | Type: | B1 Patent specification | No.: | EP2348120 | Date: | 11.06.2014 | Language: | EN | [2014/24] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 16.09.2010 | Classification | IPC: | C12P7/22, C12P41/00, C12N9/04 | [2014/03] | CPC: |
C12P41/002 (EP);
C12N9/0006 (EP);
C12P7/22 (EP);
C12Y101/01307 (EP)
|
Former IPC [2011/30] | C12P7/04, C12P7/22, C12P41/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2011/30] | Title | German: | Enzymatische Reduktion von 1-Phenylpropanon und Derivate davon | [2011/30] | English: | Enzymatic reduction of 1-phenylpropanone and derivatives thereof | [2011/30] | French: | Réduction enzymatique de 1-phénylpropanone et dérivés associés | [2011/30] | Examination procedure | 19.01.2012 | Amendment by applicant (claims and/or description) | 19.01.2012 | Examination requested [2012/09] | 17.02.2012 | Despatch of a communication from the examining division (Time limit: M06) | 17.08.2012 | Reply to a communication from the examining division | 20.12.2013 | Communication of intention to grant the patent | 29.04.2014 | Fee for grant paid | 29.04.2014 | Fee for publishing/printing paid | 29.04.2014 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 17.02.2012 | Opposition(s) | 12.03.2015 | No opposition filed within time limit [2015/21] | Fees paid | Renewal fee | 19.12.2011 | Renewal fee patent year 03 | 17.12.2012 | Renewal fee patent year 04 | 17.12.2013 | Renewal fee patent year 05 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 30.12.2009 | AT | 11.06.2014 | BE | 11.06.2014 | BG | 11.06.2014 | CY | 11.06.2014 | CZ | 11.06.2014 | DK | 11.06.2014 | EE | 11.06.2014 | ES | 11.06.2014 | FI | 11.06.2014 | HR | 11.06.2014 | IT | 11.06.2014 | LT | 11.06.2014 | LV | 11.06.2014 | MC | 11.06.2014 | MK | 11.06.2014 | MT | 11.06.2014 | NL | 11.06.2014 | PL | 11.06.2014 | RO | 11.06.2014 | SE | 11.06.2014 | SI | 11.06.2014 | SK | 11.06.2014 | SM | 11.06.2014 | TR | 11.06.2014 | NO | 11.09.2014 | GR | 12.09.2014 | IS | 11.10.2014 | PT | 13.10.2014 | GB | 30.12.2014 | IE | 30.12.2014 | LU | 30.12.2014 | CH | 31.12.2014 | FR | 31.12.2014 | LI | 31.12.2014 | [2018/30] |
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Former [2014/48] | LT | 11.06.2014 | Documents cited: | Search | [X]JPH04234989 ; | [X]JPH04234990 ; | [Y]WO02057475 (COUNCIL SCIENT IND RES [IN], et al) [Y] 8 * abstract * * page 3, line 29 - line 31; figure 2 * | [X] - CHOI YUN HEE ET AL, "Asymmetric synthesis of (S)-3-chloro-1-phenyl-1-propanol using Saccharomyces cerevisiae reductase with high enantioselectivity", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, (201006), vol. 87, no. 1, pages 185 - 193, XP002598229 [X] 1,5-8,12 * abstract * * page 185, column 2 - page 190, column 1 * DOI: http://dx.doi.org/10.1007/s00253-010-2442-5 | [X] - HAMMOND ET AL, "Biocatalytic synthesis towards both antipodes of 3-hydroxy-3-phenylpropanitrile a precursor to fluoxetine, atomoxetine and nisoxetine", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.TETLET.2006.12.057, (20070117), vol. 48, no. 7, ISSN 0040-4039, pages 1217 - 1219, XP005834125 [X] 1,6-9,12,13 * the whole document * DOI: http://dx.doi.org/10.1016/j.tetlet.2006.12.057 | [X] - DATABASE WPI, 0, Derwent World Patents Index, vol. 1992, no. 40, Database accession no. 1992-327633, XP002598230 & JPH04234989 A 19920824 (DAICEL CHEM IND LTD) [X] 1,2,5,6,12 * abstract * | [X] - DATABASE WPI, 0, Derwent World Patents Index, vol. 1992, no. 40, Database accession no. 1992-327634, XP002598231 & JPH04234990 A 19920824 (DAICEL CHEM IND LTD) [X] 1,2,5,12 * abstract * | [X] - WU X ET AL, "Enantioselective synthesis of ethyl (S)-2-hydroxy-4-phenylbutyrate by recombinant diketoreductase", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB, vol. 20, no. 21, ISSN 0957-4166, (20091104), pages 2504 - 2509, (20091201), XP026791010 [X] 1,5,12 * abstract * | [X] - ANKATI, H. ET AL, "Asymetric synthesis of both antipodes of beta-hydroxy nitriles and beta-hydroxy carboxylic acids via enzymatic reduction or sequential reduction/hdrolysis", JOURNAL OF ORGANIC CHEMISTRY, (20090122), vol. 74, pages 1658 - 1662, XP002598232 [X] 1-4,6,9,12,13 * page 1660 - page 1661 * DOI: http://dx.doi.org/10.1021/jo802495f | [X] - LAVANDERA, I. ET AL., "Stereoselective bioreduction of bulky-bulky ketones by a novel ADH from Ralstonia sp.", JOURNAL OF ORGANIC CHEMISTRY, (20080703), vol. 73, pages 6003 - 6005, XP002598233 [X] 1,6,12 * table 1 * DOI: http://dx.doi.org/10.1021/jo800849d | [X] - SALVI N A ET AL, "Asymmetric reduction of halo-substituted arylalkanones with Rhizopus arrhizus", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB LNKD- DOI:10.1016/J.TETASY.2008.07.035, vol. 19, no. 16, ISSN 0957-4166, (20080822), pages 1992 - 1997, (20080829), XP025347802 [X] 1-6,12 * the whole document * DOI: http://dx.doi.org/10.1016/j.tetasy.2008.07.035 | [X] - LAVANDERA I ET AL, "Asymmetric anti-Prelog reduction of ketones catalysed by Paracoccus pantotrophus and Comamonas sp. cells via hydrogen transfer", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB LNKD- DOI:10.1016/J.TETASY.2008.08.005, vol. 19, no. 16, ISSN 0957-4166, (20080822), pages 1954 - 1958, (20080827), XP025347795 [X] 1,6,12 * page 1956, column 2, paragraph 2; figure 3 * DOI: http://dx.doi.org/10.1016/j.tetasy.2008.08.005 | [X] - HAGE A ET AL, "Asymmetric reduction of ketones via whole cell bioconversions and transfeR HYDRogenation: complementary approaches", TETRAHEDRON ASYMMETRY, PERGAMON PRESS LTD, OXFORD, GB LNKD- DOI:10.1016/S0957-4166(01)00172-0, (20010508), vol. 12, no. 7, ISSN 0957-4166, pages 1025 - 1034, XP004241685 [X] 1-6,12 * page 1025 - page 1028 * DOI: http://dx.doi.org/10.1016/S0957-4166(01)00172-0 | [X] - BROUSSY, S. ET AL., "Enatioselective, ketoreductase-based entry into pharmaceutical building blocks: ethanol as tunable nicotinamide reductant", ORGANIC LETTERS, (20081217), vol. 11, no. 2, pages 305 - 308, XP002598234 [X] 1,5,6,9,12,13 * page 305 - page 306; table 1 * DOI: http://dx.doi.org/10.1021/ol802464g | [Y] - KRATZER REGINA ET AL, "Whole-cell bioreduction of aromatic Î+--keto esters using Candida tenuis xylose reductase and Candida boidinii formate dehydrogenase co-expressed in Escherichia coli", MICROBIAL CELL FACTORIES, BIOMED CENTRAL, LONDON, NL LNKD- DOI:10.1186/1475-2859-7-37, (20081210), vol. 7, no. 1, ISSN 1475-2859, page 37, XP021049876 [Y] 9-15 * the whole document * DOI: http://dx.doi.org/10.1186/1475-2859-7-37 | [Y] - PETSCHACHER BARBARA ET AL, "The coenzyme specificity of Candida tenuis xylose reductase (AKR2B5) explored by site-directed mutagenesis and X-ray crystallography", BIOCHEMICAL JOURNAL, (200501), vol. 385, no. Part 1, ISSN 0264-6021, pages 75 - 83, XP002598235 [Y] 9-15 * abstract * * page 82, column 2, paragraph l * | [Y] - KUMAR A ET AL, "A NEW CHEMOENZYMATIC ENANTIOSELECTIVE SYNTHESIS OF R-(-)-TOMOXETINE, (R)- AND (S)-FLUOXETINE", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/S0040-4039(00)85993-6, (19910101), vol. 32, no. 16, ISSN 0040-4039, pages 1901 - 1904, XP002269009 [Y] 8 * the whole document * DOI: http://dx.doi.org/10.1016/S0040-4039(00)85993-6 | Examination | - JACK LIANG ET AL, "Development of a Biocatalytic Process as an Alternative to the (-)-DIP-Cl-Mediated Asymmetric Reduction of a Key Intermediate of Montelukast", ORGANIC PROCESS RESEARCH & DEVELOPMENT, (20100115), vol. 14, no. 1, doi:10.1021/op900272d, ISSN 1083-6160, pages 193 - 198, XP055018991 DOI: http://dx.doi.org/10.1021/op900272d | - REGINA KRATZER ET AL, "Identification of Candida tenuis xylose reductase as highly selective biocatalyst for the synthesis of aromatic ?-hydroxy esters and improvement of its efficiency by protein engineering", CHEMICAL COMMUNICATIONS, (20070101), no. 10, doi:10.1039/b616475g, ISSN 1359-7345, page 1047, XP055019037 DOI: http://dx.doi.org/10.1039/B616475G | - REGINA KRATZER ET AL, "Probing the substrate binding site of Candida tenuis xylose reductase (AKR2B5) with site-directed mutagenesis", BIOCHEMICAL JOURNAL, (20060101), vol. 393, no. 1, doi:10.1042/BJ20050831, ISSN 0264-6021, page 51, XP055018940 DOI: http://dx.doi.org/10.1042/BJ20050831 | by applicant | US4314081 | WO2008026227 | WO2006009884 | US7473804 | - BOHREN ET AL., J. BIOD. CHEM., (1989), vol. 264, pages 9547 - 9551 | - JEZ ET AL., BIOCHEM. J., (1997), vol. 326, pages 625 - 636 | - KRATZER ET AL., BIOCHEM. J., (2006), vol. 393, pages 51 - 58 | - PIVAL ET AL., FEBS LETTERS, (2008), vol. 582, pages 4095 - 4099 | - NIDETZKY ET AL., BIOCHEMISTRY, (2001), vol. 40, pages 10371 - 10381 | - KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI USA, (1993), vol. 90, pages 5873 - 5877 | - ALTSCHUL ET AL., MOL. BIOI., vol. 215, (1990), pages 403 - 410, URL: http://www.ncbi.nlm.nih.gov/blast/Blast.cge | - J. CHROMAT., (2000), vol. 737, pages 195 - 202 | - BIOCHEM. J., (2005), vol. 385, pages 75 - 83 | - NUCLEIC ACIDS RES., (1989), vol. 17, pages 6545 - 6551 | - BIOL. CHEM., (1999), vol. 380, pages 1395 - 1403 | - Organikum, JOHANN AMBROSIUS BARTH VERLAG, (1996), vol. 20, page 362 | - J. MED. CHEM., (2008), vol. 51, pages 3841 - 3855 | - ANGEW. CHEM. INT. ED., (2005), vol. 44, pages 1687 - 1689 | - BIOORG. MED. CHEM., (2006), vol. 14, pages 7501 - 7511 | - ORG. BIOMOL. CHEM., (2005), vol. 3, pages 2513 - 2518 | - J. CHEM. SOC, PERKIN TRANS., (2000), vol. 1, pages 1767 - 1769 |