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Extract from the Register of European Patents

EP About this file: EP2245571

EP2245571 - METHODS FOR DETERMINING CORRELATED RESIDUES IN A PROTEIN OR OTHER BIOPOLYMER USING MOLECULAR DYNAMICS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.02.2020
Database last updated on 18.10.2024
FormerThe patent has been granted
Status updated on  08.03.2019
FormerGrant of patent is intended
Status updated on  11.09.2018
FormerExamination is in progress
Status updated on  21.12.2016
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Zymeworks Inc.
540-1385 West 8th Avenue
Vancouver, British Columbia V6H 3V9 / CA
[N/P]
Former [2010/44]For all designated states
Zymeworks Inc.
540-1385 West 8th Avenue
Vancouver, British Colombia V6H 3V9 / CA
Inventor(s)01 / LARIO, Paula, I.
201-2080 E. Kent South
Vancouver, British Colombia V59 4X2 / CA
02 / MULLEGGER, Johannes
Suite 2 - 2135 Guelph Street
Vancouver, British Colombia V5T 3N7 / CA
03 / DIXIT, Surjit, B.
51-11651 Kingfisher Drive
Richmond
British Colombia V7E 3N5 / CA
04 / RODINGER, Tomas
Apt 305-431 Pacific Street
Vancouver, British Colombia V6Z 2P5 / CA
05 / TAN, Powell, Patrick, Cheng
11121 135A Street
Vancouver, British Colombia V3R 3A6 / CA
 [2019/15]
Former [2010/47]01 / LARIO, Paula, I.
201-2080 E. Kent South
Vancouver, British Colombia V59 4X2 / CA
02 / MULLEGGER, Johannes
Suite 2 - 2135 Guelph Street
Vancouver, British Colombia V5T 3N7 / CA
03 / DIXIT, Surjit, B.
51-11651 Kingfisher Drive Richmond
British Colombia V7E 3N5 / CA
04 / RODINGER, Tomas
Apt 305-431 Pacific Street
Vancouver, British Colombia V6Z 2P5 / CA
05 / TAN, Powell, Patrick, Cheng
11121 135A Street
Vancouver, British Colombia V3R 3A6 / CA
Former [2010/44]01 / LARIO, Paula, I.
201-2080 E. Kent South
Vancouver, British Colombia V59 4X2 / CA
02 / MULLEGGER, Johannes
Suite 2 - 2135 Guelph Street
Vancouver, British Colombia V5T 3N7 / CA
03 / DIXIT, Surjit, B.
5819 Dunbar Street
Vancouver, British Colombia V62 1W8 / CA
04 / RODINGER, Tomas
Apt 305-431 Pacific Street
Vancouver, British Colombia V6Z 2P5 / CA
05 / TAN, Powell, Patrick, Cheng
11121 135A Street
Vancouver, British Colombia V3R 3A6 / CA
Representative(s)HGF
1 City Walk
Leeds LS11 9DX / GB
[N/P]
Former [2019/15]HGF Limited
1 City Walk
Leeds LS11 9DX / GB
Former [2010/44]Harrison Goddard Foote
Belgrave Hall Belgrave Street Leeds
LS2 8DD / GB
Application number, filing date09708274.705.02.2009
[2010/44]
WO2009IB05040
Priority number, dateUS2008002643505.02.2008         Original published format: US 26435
US2008011626719.11.2008         Original published format: US 116267
[2010/44]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2009098596
Date:13.08.2009
Language:EN
[2009/33]
Type: A2 Application without search report 
No.:EP2245571
Date:03.11.2010
Language:EN
The application published by WIPO in one of the EPO official languages on 13.08.2009 takes the place of the publication of the European patent application.
[2010/44]
Type: B1 Patent specification 
No.:EP2245571
Date:10.04.2019
Language:EN
[2019/15]
Search report(s)International search report - published on:CA01.10.2009
(Supplementary) European search report - dispatched on:EP17.02.2015
ClassificationIPC:G06F19/16, G06F19/00, C12N15/11, C12N15/00, C07K14/00, C40B30/02, G01N33/68
[2015/12]
CPC:
G01N33/68 (EP,US); G16B15/00 (EP,US); G16B15/20 (EP,US);
G16B20/00 (EP,US); G16B20/30 (EP,US); G16B20/50 (EP,US);
G16B5/00 (EP,US); G16B5/20 (EP,US); G16B45/00 (EP,US) (-)
Former IPC [2010/44]G06F19/00, C12N15/11, C12N15/00, C07K14/00, C40B30/02, G01N33/68
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2019/15]
Former [2010/44]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:VERFAHREN ZUR BESTIMMUNG KORRELIERTER RESTE IN EINEM PROTEIN- ODER ANDEREN BIOPOLYMER UNTER VERWENDUNG VON MOLEKULARDYNAMIK[2010/44]
English:METHODS FOR DETERMINING CORRELATED RESIDUES IN A PROTEIN OR OTHER BIOPOLYMER USING MOLECULAR DYNAMICS[2010/44]
French:PROCÉDÉS DE DÉTERMINATION DE RÉSIDUS CORRÉLÉS DANS UNE PROTÉINE OU AUTRE BIOPOLYMÈRE METTANT EN UVRE LA DYNAMIQUE MOLÉCULAIRE[2010/44]
Entry into regional phase03.09.2010National basic fee paid 
03.09.2010Search fee paid 
03.09.2010Designation fee(s) paid 
03.09.2010Examination fee paid 
Examination procedure03.09.2010Examination requested  [2010/44]
21.10.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
21.12.2015Amendment by applicant (claims and/or description)
07.06.2016Despatch of a communication from the examining division (Time limit: M06)
19.12.2016Reply to a communication from the examining division
11.07.2018Cancellation of oral proceeding that was planned for 12.07.2018
12.07.2018Date of oral proceedings (cancelled)
12.09.2018Communication of intention to grant the patent
16.01.2019Fee for grant paid
16.01.2019Fee for publishing/printing paid
16.01.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  07.06.2016
Opposition(s)13.01.2020No opposition filed within time limit [2020/12]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
21.12.2015Request for further processing filed
21.12.2015Full payment received (date of receipt of payment)
Request granted
08.01.2016Decision despatched
Fees paidRenewal fee
15.02.2011Renewal fee patent year 03
15.02.2012Renewal fee patent year 04
12.02.2013Renewal fee patent year 05
12.02.2014Renewal fee patent year 06
26.02.2015Renewal fee patent year 07
26.02.2016Renewal fee patent year 08
27.02.2017Renewal fee patent year 09
27.02.2018Renewal fee patent year 10
27.02.2019Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU05.02.2009
AT10.04.2019
CY10.04.2019
CZ10.04.2019
DK10.04.2019
EE10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
IT10.04.2019
LT10.04.2019
LV10.04.2019
MC10.04.2019
MK10.04.2019
MT10.04.2019
NL10.04.2019
PL10.04.2019
RO10.04.2019
SE10.04.2019
SI10.04.2019
SK10.04.2019
TR10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
[2022/32]
Former [2022/27]HU05.02.2009
AT10.04.2019
CY10.04.2019
CZ10.04.2019
DK10.04.2019
EE10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
IT10.04.2019
LT10.04.2019
LV10.04.2019
MC10.04.2019
MT10.04.2019
NL10.04.2019
PL10.04.2019
RO10.04.2019
SE10.04.2019
SI10.04.2019
SK10.04.2019
TR10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
Former [2020/49]AT10.04.2019
CZ10.04.2019
DK10.04.2019
EE10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
IT10.04.2019
LT10.04.2019
LV10.04.2019
MC10.04.2019
NL10.04.2019
PL10.04.2019
RO10.04.2019
SE10.04.2019
SI10.04.2019
SK10.04.2019
TR10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
Former [2020/26]AT10.04.2019
CZ10.04.2019
DK10.04.2019
EE10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
IT10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
PL10.04.2019
RO10.04.2019
SE10.04.2019
SI10.04.2019
SK10.04.2019
TR10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
Former [2020/17]AT10.04.2019
CZ10.04.2019
DK10.04.2019
EE10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
IT10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
PL10.04.2019
RO10.04.2019
SE10.04.2019
SK10.04.2019
TR10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
Former [2020/12]AT10.04.2019
CZ10.04.2019
DK10.04.2019
EE10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
IT10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
PL10.04.2019
RO10.04.2019
SE10.04.2019
SK10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
Former [2020/11]AT10.04.2019
CZ10.04.2019
DK10.04.2019
EE10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
PL10.04.2019
RO10.04.2019
SE10.04.2019
SK10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
Former [2020/10]AT10.04.2019
CZ10.04.2019
DK10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
PL10.04.2019
RO10.04.2019
SE10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
Former [2020/09]AT10.04.2019
CZ10.04.2019
DK10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
PL10.04.2019
SE10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
Former [2020/04]AT10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
PL10.04.2019
SE10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
IS10.08.2019
PT10.09.2019
Former [2020/03]AT10.04.2019
ES10.04.2019
FI10.04.2019
HR10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
PL10.04.2019
SE10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
PT10.09.2019
Former [2019/52]ES10.04.2019
FI10.04.2019
HR10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
PL10.04.2019
SE10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
PT10.09.2019
Former [2019/51]ES10.04.2019
FI10.04.2019
HR10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
SE10.04.2019
BG10.07.2019
NO10.07.2019
GR11.07.2019
PT10.09.2019
Former [2019/50]ES10.04.2019
FI10.04.2019
HR10.04.2019
LT10.04.2019
LV10.04.2019
NL10.04.2019
SE10.04.2019
NO10.07.2019
GR11.07.2019
PT10.09.2019
Former [2019/48]ES10.04.2019
FI10.04.2019
LT10.04.2019
NL10.04.2019
SE10.04.2019
NO10.07.2019
PT10.09.2019
Former [2019/47]ES10.04.2019
FI10.04.2019
LT10.04.2019
NL10.04.2019
NO10.07.2019
Former [2019/44]NL10.04.2019
Documents cited:Search[I]US6014449  (JACOBS DONALD J [US], et al) [I] 1-21* column 5 - column 11 *;
 [I]EP1199669  (NEC RESEARCH INST INC [US]) [I] 1-21 * paragraph [0015] - paragraph [0051] *;
 [I]EP1724697  (IN SILICO SCIENCES INC [JP]) [I] 1-21 * paragraph [0009] - paragraph [0041] *;
 [I]  - JAMES E FITZGERALD ET AL, "Polypeptide Motions Are Dominated by Peptide Group Oscillations Resulting from Dihedral Angle Correlations between Nearest Neighbors", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, (20070101), vol. 46, no. 3, doi:10.1021/BI061575X, ISSN 0006-2960, pages 669 - 682, XP008140191 [I] 1-21 * abstract *

DOI:   http://dx.doi.org/10.1021/bi061575x
International search[X]US6014449  (JACOBS DONALD J [US], et al);
 [A]US2003216867  (CAMPBELL PHIL G [US], et al);
 [X]  - FITZGERALD ET AL., "Polypeptide Motions Are Dominated by Peptide Group Oscillations Resulting from Dihedral Angle Correlations between Nearest Neighbors", BIOCHEMISTRY, (2007), vol. 46, pages 669 - 682, XP008140191

DOI:   http://dx.doi.org/10.1021/bi061575x
 [A]  - KANDIRAJU ET AL., "Dihedral Angle based Dimensionality Reduction for Protein Structural Comparison", Proceedings of the International Conference on Information Technology: Coding and Computing (ITCC'05), (20050404), vol. 1, pages 14 - 19, XP008140305
 [A]  - KISHAN ET AL., "Structural Biology, Protein Conformations and Drug Designing", CURRENT PROTEIN AND PEPTIDE SCIENCE, (2007), vol. 8, pages 376 - 380, XP008140310
Examination   - VOIGT CHRISTOPHER A ET AL, "Computational method to reduce the search space for directed protein evolution", PROCEEDINGS NATIONAL ACADEMY OF SCIENCES PNAS, NATIONAL ACADEMY OF SCIENCES, US, (20010327), vol. 98, no. 7, doi:10.1073/PNAS.051614498, ISSN 0027-8424, pages 3778 - 3783, XP002193263

DOI:   http://dx.doi.org/10.1073/pnas.051614498
    - R. A. Estabrook ET AL, "Statistical coevolution analysis and molecular dynamics: Identification of amino acid pairs essential for catalysis", Proceedings National Academy of Sciences PNAS, US, (20050125), vol. 102, no. 4, doi:10.1073/pnas.0409128102, ISSN 0027-8424, pages 994 - 999, XP055446303

DOI:   http://dx.doi.org/10.1073/pnas.0409128102
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.