blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2268657

EP2268657 - HISTIDINE RELATED COMPOUNDS FOR IDENTIFYING AND BLOCKING AMYLOID BETA ION CHANNELS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  14.06.2013
Database last updated on 03.10.2024
Most recent event   Tooltip17.07.2015Lapse of the patent in a contracting state
New state(s): HU, LU		published on 19.08.2015  [2015/34]
Applicant(s)For all designated states
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
6720-A Rockledge Drive, Suite 100
Bethesda, MD 20817 / US
[2012/46]
Former [2011/01]For all designated states
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
1401 Rockville Pike Suite 600
Rockville, MD 20852 / US
Inventor(s)01 / ARISPE, Nelson
14812 Village Gate Dr.
Silver Spring, MD 20906 / US
 [2011/01]
Representative(s)Dörries, Hans Ulrich
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
[N/P]
Former [2012/32]Dörries, Hans Ulrich
df-mp Fünf Höfe Theatinerstrasse 16
80333 München / DE
Former [2011/01]Dörries, Hans Ulrich
df-mp Fünf Höfe Theatinerstrasse 16
80333 München / DE
Application number, filing date09723139.318.03.2009
[2011/01]
WO2009US37502
Priority number, dateUS20080037857P19.03.2008         Original published format: US 37857 P
US20090155960P27.02.2009         Original published format: US 155960 P
[2011/01]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2009117480
Date:24.09.2009
Language:EN
[2009/39]
Type: A2 Application without search report 
No.:EP2268657
Date:05.01.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 24.09.2009 takes the place of the publication of the European patent application.
[2011/01]
Type: B1 Patent specification 
No.:EP2268657
Date:08.08.2012
Language:EN
[2012/32]
Search report(s)International search report - published on:KR07.01.2010
(Supplementary) European search report - dispatched on:EP10.03.2011
ClassificationIPC:C07K7/06, A61K38/08, A61P25/28, G01N33/68, G01N33/50
[2011/14]
CPC:
A61K38/05 (EP,US); A61K38/06 (EP,US); A61K38/07 (EP,US);
A61K38/08 (EP,US); A61P25/28 (EP); C07K14/4711 (EP,US);
C07K5/06147 (EP,US); C07K5/1024 (EP,US); G01N33/5041 (EP,US);
G01N33/5058 (EP,US); G01N33/6872 (EP,US); G01N33/6896 (EP,US);
G01N2333/4709 (EP,US); G01N2500/00 (EP,US); G01N2800/2821 (EP,US) (-)
Former IPC [2011/01]C07K7/06, A61K38/08, A61P25/28
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/01]
TitleGerman:MIT HISTIDIN VERWANDTE VERBINDUNGEN ZUR IDENTIFIZIERUNG UND BLOCKIERUNG VON AMYLOID-BETA-IONENKANÄLEN[2011/01]
English:HISTIDINE RELATED COMPOUNDS FOR IDENTIFYING AND BLOCKING AMYLOID BETA ION CHANNELS[2011/01]
French:COMPOSÉS EN RAPPORT AVEC L'HISTIDINE POUR IDENTIFIER ET BLOQUER DES CANAUX D'IONS DE BÊTA-AMYLOÏDE[2011/01]
Entry into regional phase15.10.2010National basic fee paid 
15.10.2010Search fee paid 
15.10.2010Designation fee(s) paid 
15.10.2010Examination fee paid 
Examination procedure15.10.2010Examination requested  [2011/01]
29.09.2011Amendment by applicant (claims and/or description)
09.03.2012Communication of intention to grant the patent
13.06.2012Fee for grant paid
13.06.2012Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  09.03.2012
Opposition(s)10.05.2013No opposition filed within time limit [2013/29]
Fees paidRenewal fee
29.03.2011Renewal fee patent year 03
26.03.2012Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.03.2009
AT08.08.2012
CY08.08.2012
CZ08.08.2012
DK08.08.2012
EE08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
MK08.08.2012
MT08.08.2012
PL08.08.2012
RO08.08.2012
SE08.08.2012
SI08.08.2012
SK08.08.2012
TR08.08.2012
BG08.11.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
IE18.03.2013
LU18.03.2013
MC31.03.2013
[2015/34]
Former [2015/32]AT08.08.2012
CY08.08.2012
CZ08.08.2012
DK08.08.2012
EE08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
MK08.08.2012
MT08.08.2012
PL08.08.2012
RO08.08.2012
SE08.08.2012
SI08.08.2012
SK08.08.2012
TR08.08.2012
BG08.11.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
IE18.03.2013
MC31.03.2013
Former [2014/32]AT08.08.2012
CY08.08.2012
CZ08.08.2012
DK08.08.2012
EE08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
MT08.08.2012
PL08.08.2012
RO08.08.2012
SE08.08.2012
SI08.08.2012
SK08.08.2012
BG08.11.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
IE18.03.2013
MC31.03.2013
Former [2014/07]AT08.08.2012
CY08.08.2012
CZ08.08.2012
DK08.08.2012
EE08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
PL08.08.2012
RO08.08.2012
SE08.08.2012
SI08.08.2012
SK08.08.2012
BG08.11.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
IE18.03.2013
MC31.03.2013
Former [2013/47]AT08.08.2012
CY08.08.2012
CZ08.08.2012
DK08.08.2012
EE08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
PL08.08.2012
RO08.08.2012
SE08.08.2012
SI08.08.2012
SK08.08.2012
BG08.11.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
MC31.03.2013
Former [2013/34]AT08.08.2012
CY08.08.2012
CZ08.08.2012
DK08.08.2012
EE08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
PL08.08.2012
RO08.08.2012
SE08.08.2012
SI08.08.2012
SK08.08.2012
BG08.11.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
Former [2013/23]AT08.08.2012
CY08.08.2012
CZ08.08.2012
DK08.08.2012
EE08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
PL08.08.2012
RO08.08.2012
SE08.08.2012
SI08.08.2012
SK08.08.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
Former [2013/22]AT08.08.2012
CY08.08.2012
CZ08.08.2012
DK08.08.2012
EE08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
PL08.08.2012
SE08.08.2012
SI08.08.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
Former [2013/21]AT08.08.2012
CY08.08.2012
DK08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
PL08.08.2012
SE08.08.2012
SI08.08.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
Former [2013/13]AT08.08.2012
CY08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
PL08.08.2012
SE08.08.2012
SI08.08.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
PT10.12.2012
Former [2013/12]AT08.08.2012
CY08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
PL08.08.2012
SE08.08.2012
SI08.08.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
Former [2013/11]AT08.08.2012
CY08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
LV08.08.2012
PL08.08.2012
SI08.08.2012
NO08.11.2012
GR09.11.2012
IS08.12.2012
Former [2013/10]AT08.08.2012
CY08.08.2012
FI08.08.2012
HR08.08.2012
LT08.08.2012
NO08.11.2012
IS08.12.2012
Former [2013/09]AT08.08.2012
FI08.08.2012
LT08.08.2012
NO08.11.2012
Former [2013/08]AT08.08.2012
LT08.08.2012
NO08.11.2012
Former [2013/07]AT08.08.2012
Documents cited:Search[XP]  - ARISPE N ET AL, "Efficiency of Histidine-Associating Compounds for Blocking the Alzheimer's Abeta Channel Activity and Cytotoxicity", BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, US, vol. 95, no. 10, doi:10.1529/BIOPHYSJ.108.135517, ISSN 0006-3495, (20081115), pages 4879 - 4889, (20081115), XP025928394 [XP] 1-3,5,9-14 * the whole document *

DOI:   http://dx.doi.org/10.1529/biophysj.108.135517
 [AD]  - ARISPE N, "Architecture of the Alzheimer's AbetaP ion channel pore.", JOURNAL OF MEMBRANE BIOLOGY, (20040101), vol. 197, no. 1, ISSN 0022-2631, pages 33 - 48, XP002624195 [AD] 1-3,5,9-14 * the whole document * * abstract * * page 35, column 1 * * page 37, column 2 * * figure 8 *

DOI:   http://dx.doi.org/10.1007/S00232-003-0638-7
 [A]  - ARISPE ET AL, "Abeta ion channels. Prospects for treating Alzheimer's disease with Abeta channel blockers", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, (20070801), vol. 1768, no. 8, doi:10.1016/J.BBAMEM.2007.03.014, ISSN 0005-2736, pages 1952 - 1965, XP022182215 [A] 1-3,5,9-14 * the whole document * * section 4 *

DOI:   http://dx.doi.org/10.1016/j.bbamem.2007.03.014
 [XA]  - "Oligohistidine target peptide sequence SeqID 1.", Geneseq, (20040311), Database accession no. ADH22656, URL: EBI, XP002624196 [X] 1-3,5,9,11 * compound . * [A] 12-14
 [A]  - VALLAT P ET AL, "37. Structure-lipophilicity and structure-polarity relationships of amino acids and peptides", HELVETICA CHIMICA ACTA 1995 CH, (1995), vol. 78, no. 2, ISSN 0018-019X, pages 471 - 485, XP002624197 [A] 1-3,5,9-14 * the whole document * * table 3 *

DOI:   http://dx.doi.org/10.1002/hlca.19950780218
International search[A]US6277826  (FINDEIS MARK A [US], et al);
 [A]WO2007115372  (UNIV MONASH [AU], et al);
 [X]  - KEIICH YOKOYAMA ET AL., "Peptide Inhibitors for Angiotensin I-Converting Enzyme from Thermolysin Digest of Dried Bonito.", BIOSCI. BIOTECH. BIOCHEM., (1992), vol. 56, no. 10, pages 1541 - 1545, XP002158275
 [X]  - ROSA M. TUJEBAJEVA ET AL., "Selenoprotein P Expression, Purification, and Immunochemical Characterization.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (20000303), vol. 275, no. 9, pages 6288 - 6294, XP003010719

DOI:   http://dx.doi.org/10.1074/jbc.275.9.6288
 [XP]  - STEVEN KNECHT ET AL., "Oligohis-tags: mechanisms of binding to Ni2+-NTA surfaces.", J. MOL. RECOGNIT., (2009), vol. 22, pages 270 - 279, XP008143127

DOI:   http://dx.doi.org/10.1002/jmr.941
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.