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EP About this file: EP2350127

EP2350127 - ISOLATION AND PURIFICATION OF ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY [Right-click to bookmark this link]
Status	Patent revoked Status updated on 21.10.2016 Database last updated on 05.10.2024
Most recent event Tooltip	03.06.2022	Lapse of the patent in a contracting state New state(s): TR	published on 06.07.2022 [2022/27]
Applicant(s)	For all designated states AbbVie Inc. 1 North Waukegan Road North Chicago, IL 60064 / US
	[2013/24]
Former [2011/31]	For all designated states Abbott Laboratories 100 Abbott Park Road Abbott Park, IL 60064-6008 / US
Inventor(s)	01 / HICKMAN, Robert, K. 100 Research Drive Worcester, MA 01605 / US
	02 / HUANG, Qing 100 Research Drive Worcester, MA 01605 / US
	03 / WEED, Cheryl, L. 100 Research Drive Worcester, MA 01605 / US
	04 / ENNIS, Scott, T. 100 Research Drive Worcester, MA 01605 / US
	05 / PERILLI-PALMER, Barbara 100 Research Drive Worcester, MA 01605 / US
	06 / WAN, Min 100 Research Drive Worcester, MA 01605 / US
	[2011/31]
Representative(s)	Adams, Harvey Vaughan John, et al Mathys & Squire LLP The Shard 32 London Bridge Street London SE1 9SG / GB
	[N/P]
Former [2015/05]	Modiano, Micaela Nadia, et al Modiano & Partners Thierschstrasse 11 80538 München / DE
Former [2011/31]	Modiano, Micaela Nadia, et al Modiano & Partners Thierschstrasse 11 80538 München / DE
Application number, filing date	09744006.9	20.10.2009
	[2011/31]
	WO2009US61329
Priority number, date	US20080196753P	20.10.2008 Original published format: US 196753 P
	[2011/31]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2010141039
	Date:	09.12.2010
	Language:	EN
	[2010/49]
	Type:	A1 Application with search report
	No.:	EP2350127
	Date:	03.08.2011
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 09.12.2010 takes the place of the publication of the European patent application.
	[2011/31]
	Type:	B1 Patent specification
	No.:	EP2350127
	Date:	28.01.2015
	Language:	EN
	[2015/05]
Search report(s)	International search report - published on:	EP	09.12.2010
Classification	IPC:	C07K16/00, C07K16/24	[2011/31]
	CPC:	C07K16/00 (EP,US); C07K16/241 (US); A61P1/00 (EP); A61P17/06 (EP); A61P19/02 (EP); A61P29/00 (EP); (+) A61P3/10 (EP); A61P37/02 (EP); A61P43/00 (EP); C07K1/165 (US); C07K1/18 (US); C07K1/20 (US); C07K1/22 (US); C07K1/36 (US); C07K16/244 (US); C07K2317/14 (US); C07K2317/21 (US); C07K2317/22 (US); C07K2317/24 (US); Y10S436/824 (EP,US) (-)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2011/31]
Extension states	RS	10.05.2011
Title	German:	ISOLATION UND AUFREINIGUNG VON ANTIKÖRPERN DURCH PROTEIN-A-AFFINITÄTSCHROMATOGRAPHIE	[2014/36]
	English:	ISOLATION AND PURIFICATION OF ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY	[2011/31]
	French:	ISOLEMENT ET PURIFICATION D'ANTICORPS PAR CHROMATOGRAPHIE D'AFFINITÉ DE LA PROTÉINE A	[2011/31]
	Former [2011/31]	ISOLATION UND AUFREINIGUNG VON ANTIKANTIKÖRPERN DURCH PROTEIN-A-AFFINITÄTSCHROMATOGRAPHIE
Entry into regional phase	10.05.2011	National basic fee paid
	10.05.2011	Designation fee(s) paid
	10.05.2011	Examination fee paid
Examination procedure	20.05.2010	Request for preliminary examination filed International Preliminary Examining Authority: US
	10.05.2011	Examination requested [2011/31]
	06.12.2011	Amendment by applicant (claims and/or description)
	20.09.2012	Despatch of a communication from the examining division (Time limit: M06)
	10.05.2013	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	22.07.2013	Reply to a communication from the examining division
	13.02.2014	Despatch of a communication from the examining division (Time limit: M04)
	23.06.2014	Reply to a communication from the examining division
	07.08.2014	Communication of intention to grant the patent
	05.12.2014	Fee for grant paid
	05.12.2014	Fee for publishing/printing paid
	05.12.2014	Receipt of the translation of the claim(s)
Divisional application(s)	EP15152668.8 / EP2921501
	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 20.09.2012
Opposition(s)	Opponent(s)	01 27.10.2015 ADMISSIBLE Pharmaceutical Works POLPHARMA Pelplinska Str. 19 83-200 Starogard Gdanski / PL Opponent's representative Latscha Schöllhorn Partner AG Austrasse 24 4051 Basel / CH
		[2015/49]
	12.01.2016	Invitation to proprietor to file observations on the notice of opposition
	05.07.2016	Despatch of communication that the patent will be revoked
	15.07.2016	Legal effect of revocation of patent [2016/47]
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	22.07.2013	Request for further processing filed
	22.07.2013	Full payment received (date of receipt of payment) Request granted
	05.08.2013	Decision despatched
Fees paid	Renewal fee
	10.10.2011	Renewal fee patent year 03
	05.10.2012	Renewal fee patent year 04
	07.10.2013	Renewal fee patent year 05
	07.10.2014	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	20.10.2009
	AT	28.01.2015
	BE	28.01.2015
	CY	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	MC	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	PT	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	TR	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
	IE	20.10.2015
	LU	20.10.2015
	MT	20.10.2015
	CH	31.10.2015
	LI	31.10.2015
	[2022/27]
Former [2020/22]	HU	20.10.2009
	AT	28.01.2015
	BE	28.01.2015
	CY	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	MC	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	PT	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
	IE	20.10.2015
	LU	20.10.2015
	MT	20.10.2015
	CH	31.10.2015
	LI	31.10.2015
Former [2020/21]	HU	20.10.2009
	AT	28.01.2015
	BE	28.01.2015
	CY	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	MC	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
	IE	20.10.2015
	LU	20.10.2015
	MT	20.10.2015
	CH	31.10.2015
	LI	31.10.2015
Former [2018/43]	HU	20.10.2009
	AT	28.01.2015
	BE	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	MC	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
	IE	20.10.2015
	LU	20.10.2015
	MT	20.10.2015
	CH	31.10.2015
	LI	31.10.2015
Former [2017/40]	HU	20.10.2009
	AT	28.01.2015
	BE	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	MC	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
	IE	20.10.2015
	LU	20.10.2015
	CH	31.10.2015
	LI	31.10.2015
Former [2016/45]	AT	28.01.2015
	BE	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	MC	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
	IE	20.10.2015
	LU	20.10.2015
	CH	31.10.2015
	LI	31.10.2015
Former [2016/34]	AT	28.01.2015
	BE	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	MC	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
	LU	20.10.2015
	CH	31.10.2015
	LI	31.10.2015
Former [2016/28]	AT	28.01.2015
	BE	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	MC	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
	LU	20.10.2015
Former [2016/26]	AT	28.01.2015
	BE	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
	LU	20.10.2015
Former [2016/24]	AT	28.01.2015
	BE	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
Former [2016/12]	AT	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SI	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
Former [2015/49]	AT	28.01.2015
	CZ	28.01.2015
	DK	28.01.2015
	EE	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	RO	28.01.2015
	SE	28.01.2015
	SK	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
Former [2015/39]	AT	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	LV	28.01.2015
	NL	28.01.2015
	PL	28.01.2015
	SE	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
Former [2015/38]	AT	28.01.2015
	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	PL	28.01.2015
	SE	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
	IS	28.05.2015
Former [2015/37]	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	PL	28.01.2015
	SE	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
	GR	29.04.2015
Former [2015/36]	FI	28.01.2015
	HR	28.01.2015
	LT	28.01.2015
	SE	28.01.2015
	BG	28.04.2015
	NO	28.04.2015
Former [2015/35]	LT	28.01.2015
	NO	28.04.2015
Cited in	International search	[XY]WO2008079280 (MILLIPORE CORP [US], et al) [X] 27-29 * page 15, first full §;; examples 1,2 *[Y] 1-26;
		[XY] - ISHIHARA ET AL, "Accelerated purification process development of monoclonal antibodies for shortening time to clinic", JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V, NL LNKD- DOI:10.1016/J.CHROMA.2007.10.104, (20071107), vol. 1176, no. 1-2, ISSN 0021-9673, pages 149 - 156, XP022373481 [X] 27-29 * figures 1,6,7 * [Y] 1-26 DOI: http://dx.doi.org/10.1016/j.chroma.2007.10.104
		[XY] - BRORSON KURT ET AL, "Bracketed generic inactivation of rodent retroviruses by low pH treatment for monoclonal antibodies and recombinant proteins.", BIOTECHNOLOGY AND BIOENGINEERING 5 MAY 2003, (20030505), vol. 82, no. 3, ISSN 0006-3592, pages 321 - 329, XP002576168 [X] 27-29 * see results § * [Y] 1-26 DOI: http://dx.doi.org/10.1002/bit.10574
	Examination	WO9817786
	by applicant	WO9522389
		WO9817786
		WO2008007280
		- ISHIHARA ET AL., Journal of Chromatography, ELSEVIER SCIENCE PUBLISHERS, (2007), vol. 1176
		- BRORSON ET AL., BIOTECLMOLOGY AND BIOENGINEERING, (20030505), vol. 82, no. 3
		- WARD ET AL., NATURE, (1989), vol. 341, pages 544 - 546
		- BIRD ET AL., SCIENCE, (1988), vol. 242, pages 423 - 426
		- HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 5879 - 5883
		- HOLLIGER, P. ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448
		- POLJAK, R. J. ET AL., STRUCTURE, (1994), vol. 2, pages 1121 - 1123
		- KIPRIYANOV, S. M. ET AL., HUMAN ANTIBODIES AND HYBRIDOMAS, (1995), vol. 6, pages 93 - 101
		- KIPRIYANOV, S. M. ET AL., MOL. IMMUNOL., (1994), vol. 31, pages 1047 - 1058
		- WINDHAGEN ET AL., J. EXP. MED., (1995), vol. 182, pages 1985 - 1996
		- MORITA ET AL., ARTHRITIS AND RHEUMATISM., (1998), vol. 41, pages 306 - 314
		- BUCHT ET AL., CLIN. EXP. IMMUNOL., (1996), vol. 103, pages 347 - 367
		- FAIS ET AL., J.INTERFERON RES., (1994), vol. 14, pages 235 - 238
		- PYRRONCHI ET AL., AM. J. PATH., (1997), vol. 150, pages 823 - 832
		- MONTELEONE ET AL., GASTROENTEROLOGY, (1997), vol. 112, pages 1169 - 1178
		- BERREBI ET AL., AM. J. PATH, (1998), vol. 152, pages 667 - 672
		- PYRRONCHI ET AL., ANI. J. PATH., (1997), vol. 150, pages 823 - 832

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