EP2349210 - PROCESSES AND COMPOSITIONS FOR LIPOSOMAL AND EFFICIENT DELIVERY OF GENE SILENCING THERAPEUTICS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 22.01.2016 Database last updated on 09.09.2024 | Most recent event Tooltip | 22.06.2018 | Lapse of the patent in a contracting state New state(s): MK | published on 25.07.2018 [2018/30] | Applicant(s) | For all designated states Marina Biotech, Inc. 3830 Monte Villa Parkway Bothell WA 98021-7266 / US | [2011/31] | Inventor(s) | 01 /
POLISKY, Barry, A. 449 Mountain View Road Boulder CO 80302 / US | 02 /
ADAMI, Roger, C. 18719 36th Dr.SE Bothell WA 98012 / US | 03 /
TEMPLIN, Michael, V. 19112 30th Drive SE Bothell WA 98012 / US | 04 /
HARVIE, Pierrot 17725 Hall Road 105 Bothell WA 98011 / US | 05 /
JOHNS, Rachel, E. 2503 Ne 150th Street Shoreline WA 98155 / US | 06 /
GIYANANI, Jaya, S. 16275 NE 85th Street 308 Redmond WA 98052 / US | 07 /
HOUSTON, Michael, E. 15 Horseshoe Drive Acton MA 01720 / US | [2011/31] | Representative(s) | Roques, Sarah Elizabeth J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB | [2015/12] |
Former [2011/31] | Roques, Sarah Elizabeth J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ / GB | Application number, filing date | 09744527.4 | 16.10.2009 | [2011/31] | WO2009US60930 | Priority number, date | US20080106062P | 16.10.2008 Original published format: US 106062 P | US20090167379P | 07.04.2009 Original published format: US 167379 P | [2011/31] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2010045512 | Date: | 22.04.2010 | Language: | EN | [2010/16] | Type: | A2 Application without search report | No.: | EP2349210 | Date: | 03.08.2011 | Language: | EN | The application published by WIPO in one of the EPO official languages on 22.04.2010 takes the place of the publication of the European patent application. | [2011/31] | Type: | B1 Patent specification | No.: | EP2349210 | Date: | 18.03.2015 | Language: | EN | [2015/12] | Search report(s) | International search report - published on: | EP | 27.01.2011 | Classification | IPC: | A61K9/127, A61K48/00, C12N15/11, C12N15/88 | [2011/31] | CPC: |
A61K9/1271 (EP,US);
A61K9/127 (KR,US);
A61K48/00 (KR);
A61K9/1277 (US);
A61P1/16 (EP);
A61P13/10 (EP);
A61P19/00 (EP);
A61P19/02 (EP);
A61P19/08 (EP);
A61P25/00 (EP);
A61P29/00 (EP);
A61P3/00 (EP);
A61P3/06 (EP);
A61P31/12 (EP);
A61P35/00 (EP);
A61P43/00 (EP);
A61P9/00 (EP);
C12N15/11 (KR);
C12N15/111 (EP,US);
C12N15/113 (US);
C12N15/88 (EP,KR,US);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2011/31] | Extension states | AL | Not yet paid | BA | Not yet paid | RS | Not yet paid | Title | German: | VERFAHREN UND ZUSAMMENSETZUNGEN ZUR LIPOSOMALEN UND EFFIZIENTEN ZUFÜHRUNG VON GENE-SILENCING-THERAPEUTIKA | [2011/31] | English: | PROCESSES AND COMPOSITIONS FOR LIPOSOMAL AND EFFICIENT DELIVERY OF GENE SILENCING THERAPEUTICS | [2011/31] | French: | PROCÉDÉS ET COMPOSITIONS POUR UNE ADMINISTRATION LIPOSOMALE ET EFFICACE DE PRODUITS THÉRAPEUTIQUES DE SILENÇAGE DE GÈNE | [2011/31] | Entry into regional phase | 12.05.2011 | National basic fee paid | 12.05.2011 | Designation fee(s) paid | 12.05.2011 | Examination fee paid | Examination procedure | 12.05.2011 | Examination requested [2011/31] | 20.12.2011 | Amendment by applicant (claims and/or description) | 22.03.2012 | Despatch of a communication from the examining division (Time limit: M06) | 18.09.2012 | Reply to a communication from the examining division | 29.11.2013 | Despatch of a communication from the examining division (Time limit: M06) | 30.05.2014 | Reply to a communication from the examining division | 09.10.2014 | Communication of intention to grant the patent | 09.02.2015 | Fee for grant paid | 09.02.2015 | Fee for publishing/printing paid | 09.02.2015 | Receipt of the translation of the claim(s) | Divisional application(s) | EP15153333.8 / EP2902013 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 22.03.2012 | Opposition(s) | 21.12.2015 | No opposition filed within time limit [2016/08] | Fees paid | Renewal fee | 11.10.2011 | Renewal fee patent year 03 | 11.10.2012 | Renewal fee patent year 04 | 25.03.2014 | Renewal fee patent year 05 | 14.10.2014 | Renewal fee patent year 06 | Penalty fee | Additional fee for renewal fee | 31.10.2013 | 05   M06   Fee paid on   25.03.2014 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 16.10.2009 | AT | 18.03.2015 | BE | 18.03.2015 | BG | 18.03.2015 | CY | 18.03.2015 | CZ | 18.03.2015 | DK | 18.03.2015 | EE | 18.03.2015 | ES | 18.03.2015 | FI | 18.03.2015 | HR | 18.03.2015 | IT | 18.03.2015 | LT | 18.03.2015 | LV | 18.03.2015 | MC | 18.03.2015 | MK | 18.03.2015 | MT | 18.03.2015 | NL | 18.03.2015 | PL | 18.03.2015 | RO | 18.03.2015 | SE | 18.03.2015 | SI | 18.03.2015 | SK | 18.03.2015 | SM | 18.03.2015 | TR | 18.03.2015 | NO | 18.06.2015 | GR | 19.06.2015 | IS | 18.07.2015 | PT | 20.07.2015 | IE | 16.10.2015 | LU | 16.10.2015 | CH | 31.10.2015 | LI | 31.10.2015 | [2018/30] |
Former [2017/38] | HU | 16.10.2009 | |
AT | 18.03.2015 | ||
BE | 18.03.2015 | ||
BG | 18.03.2015 | ||
CY | 18.03.2015 | ||
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
MC | 18.03.2015 | ||
MT | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
SM | 18.03.2015 | ||
TR | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
IE | 16.10.2015 | ||
LU | 16.10.2015 | ||
CH | 31.10.2015 | ||
LI | 31.10.2015 | ||
Former [2016/45] | AT | 18.03.2015 | |
BE | 18.03.2015 | ||
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
MC | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
IE | 16.10.2015 | ||
LU | 16.10.2015 | ||
CH | 31.10.2015 | ||
LI | 31.10.2015 | ||
Former [2016/37] | AT | 18.03.2015 | |
BE | 18.03.2015 | ||
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
MC | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
LU | 16.10.2015 | ||
CH | 31.10.2015 | ||
LI | 31.10.2015 | ||
Former [2016/34] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
MC | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
LU | 16.10.2015 | ||
CH | 31.10.2015 | ||
LI | 31.10.2015 | ||
Former [2016/28] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
MC | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
LU | 16.10.2015 | ||
Former [2016/26] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
LU | 16.10.2015 | ||
Former [2016/12] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SI | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
Former [2016/07] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
DK | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
Former [2016/03] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
IT | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
Former [2015/51] | AT | 18.03.2015 | |
CZ | 18.03.2015 | ||
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
Former [2015/50] | CZ | 18.03.2015 | |
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
NL | 18.03.2015 | ||
PL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
IS | 18.07.2015 | ||
PT | 20.07.2015 | ||
Former [2015/49] | CZ | 18.03.2015 | |
EE | 18.03.2015 | ||
ES | 18.03.2015 | ||
FI | 18.03.2015 | ||
HR | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
NL | 18.03.2015 | ||
RO | 18.03.2015 | ||
SE | 18.03.2015 | ||
SK | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
PT | 20.07.2015 | ||
Former [2015/41] | FI | 18.03.2015 | |
HR | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
NL | 18.03.2015 | ||
SE | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
Former [2015/39] | FI | 18.03.2015 | |
HR | 18.03.2015 | ||
LT | 18.03.2015 | ||
LV | 18.03.2015 | ||
SE | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
Former [2015/37] | FI | 18.03.2015 | |
HR | 18.03.2015 | ||
LT | 18.03.2015 | ||
SE | 18.03.2015 | ||
NO | 18.06.2015 | ||
GR | 19.06.2015 | ||
Former [2015/36] | FI | 18.03.2015 | |
HR | 18.03.2015 | ||
LT | 18.03.2015 | ||
SE | 18.03.2015 | ||
NO | 18.06.2015 | ||
Former [2015/35] | LT | 18.03.2015 | |
NO | 18.06.2015 | Cited in | International search | [AP]WO2008137758 (NASTECH PHARM CO [US], et al) [AP] 1-34 * the whole document * * page 90, line 14 *; | [AP]WO2009046220 (MDRNA INC [US], et al) [AP] 1-34; | [Y] - GABIZON AA ET AL., "Pros and cons of the liposome platform in cancer drug targeting", JOURNAL OF LIPOSOME RESEARCH, (2006), vol. 16, no. 3, ISSN 0898-2104, pages 175 - 183, XP002591241 [Y] 1-34 * the whole document * DOI: http://dx.doi.org/10.1080/08982100600848769 | [Y] - MAINARDES R M ET AL, "Liposomes and micro/nanoparticles as colloidal carriers for nasal drug delivery", CURRENT DRUG DELIVERY, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, (20060101), vol. 3, no. 3, doi:10.2174/156720106777731019, ISSN 1567-2018, pages 275 - 285, XP009095996 [Y] 1-34 * the whole document * DOI: http://dx.doi.org/10.2174/156720106777731019 | [Y] - SHARMA A ET AL, "LIPOSOMES IN DRUG DELIVERY: PROGRESS AND LIMITATIONS", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, (19970101), vol. 154, no. 2, doi:10.1016/S0378-5173(97)00135-X, ISSN 0378-5173, pages 123 - 140, XP008047948 [Y] 1-34 * the whole document * DOI: http://dx.doi.org/10.1016/S0378-5173(97)00135-X | [Y] - MINGHUI FAN ET AL, "Preparation of salidroside nano-liposomes by ethanol injection method and in vitro release study", EUROPEAN FOOD RESEARCH AND TECHNOLOGY, ZEITSCHRIFT FÜR LEBENSMITTELUNTERSUCHUNG UND -FORSCHUNG A, SPRINGER, BERLIN, DE, (20070725), vol. 227, no. 1, ISSN 1438-2385, pages 167 - 174, XP019621668 [Y] 1-34 * the whole document * * page 168, column 2, paragraph 2 * | [Y] - MAITANI Y ET AL, "MODIFIED ETHANOL INJECTION METHOD FOR LIPOSOMES CONTAINING beta-SITOSTEROL beta-D-GLUCOSIDE.", JOURNAL OF LIPOSOME RESEARCH, (2001), vol. 11, no. 1, ISSN 1532-2394, pages 115 - 125, XP002591242 [Y] 1-34 * the whole document * * page 117; figures 2,3; table 1 * | [Y] - PONS M ET AL, "Liposomes obtained by the ethanol injection method", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 95, no. 1-3, doi:10.1016/0378-5173(93)90389-W, ISSN 0378-5173, (19930630), pages 51 - 56, (19930630), XP023831858 [Y] 1-34 * the whole document * * page 52 * DOI: http://dx.doi.org/10.1016/0378-5173(93)90389-W | [Y] - SKALKO NATASA ET AL, "Liposomes with nifedipine and nifedipine-cyclodextrin complex: Calorimetrical and plasma stability comparison", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, (1996), vol. 4, no. 6, ISSN 0928-0987, pages 359 - 366, XP002591243 [Y] 1-34 * the whole document * * paragraph [02.3] * | [A] - FREDERIKSEN LENE ET AL, "Preparation of liposomes encapsulating water-soluble compounds using supercritical carbon dioxide", JOURNAL OF PHARMACEUTICAL SCIENCES, (1997), vol. 86, no. 8, ISSN 0022-3549, pages 921 - 928, XP002591244 [A] 1-34 | [A] - MAITANI ET AL, "Cationic liposome (DC-Chol/DOPE=1:2) and a modified ethanol injection method to prepare liposomes, increased gene expression", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, (20070817), vol. 342, no. 1-2, doi:10.1016/J.IJPHARM.2007.04.035, ISSN 0378-5173, pages 33 - 39, XP022206304 [A] 1-34 DOI: http://dx.doi.org/10.1016/j.ijpharm.2007.04.035 | Examination | - NGUYEN T ET AL, "RNAi therapeutics: An update on delivery", CURRENT OPINION IN MOLECULAR THERAPEUTICS 200804 GB, (200804), vol. 10, no. 2, ISSN 1464-8431, pages 158 - 167 |