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Extract from the Register of European Patents

EP About this file: EP2293846

EP2293846 - Depsipeptides and their therapeutic use [Right-click to bookmark this link]
Former [2011/11]DEPSIPEPTIDES AND THEIR THERAPEUTIC USE
[2012/49]
StatusNo opposition filed within time limit
Status updated on  16.05.2014
Database last updated on 21.03.2026
Most recent event   Tooltip22.06.2018Lapse of the patent in a contracting state
New state(s): MK		published on 25.07.2018  [2018/30]
Applicant(s)For all designated states
Karus Therapeutics Limited
93 Innovation Drive
Milton Park
Abingdon, Oxfordshire OX14 4RZ / GB
[2013/43]
Former [2011/11]For all designated states
Karus Therapeutics Limited
Southampton Science Park 2 Venture Road Chilworth Southampton
Hampshire SO16 7NP / GB
Inventor(s)01 / SHUTTLEWORTH, Stephen, Joseph
Karus Therapeutics Limited
Southampton Science Park
2 Venture Road
Chilworth
Southampton Hampshire SO16 7NP / GB
02 / SILVA, Franck, Alexandre
Karus Therapeutics Limited
Southampton Science Park
2 Venture Road
Chilworth
Southampton Hampshire SO16 7NP / GB
03 / TOMASSI, Cyrille, Davy
Karus Therapeutics Limited
Southampton Science Park
2 Venture Road
Chilworth
Southampton Hampshire SO16 7NP / GB
04 / CECIL, Alexander, Richard, Liam
Karus Therapeutics Limited
Southampton Science Park
2 Venture Road
Chilworth
Southampton Hampshire SO16 7NP / GB
05 / HILL, Thomas, James
Karus Therapeutics Limited
Southampton Science Park
2 Venture Road
Chilworth
Southampton Hampshire SO16 7NP / GB
 [2012/50]
Former [2011/11]01 / SHUTTLEWORTH, Stephen, Joseph
Karus Therapeutics Limited Southampton Science Park 2 Venture Road Chilworth
Southampton Hampshire SO16 7NP / GB
02 / SILVA, Franck, Alexandre
Karus Therapeutics Limited Southampton Science Park 2 Venture Road Chilworth
Southampton Hampshire SO16 7NP / GB
03 / TOMASSI, Cyrille, Davy
Karus Therapeutics Limited Southampton Science Park 2 Venture Road Chilworth
Southampton Hampshire SO16 7NP / GB
04 / CECIL, Alexander, Richard, Liam
Karus Therapeutics Limited Southampton Science Park 2 Venture Road Chilworth
Southampton Hampshire SO16 7NP / GB
05 / HILL, Thomas, James
Karus Therapeutics Limited Southampton Science Park 2 Venture Road Chilworth
Southampton Hampshire SO16 7NP / GB
Representative(s)Law, Fiona, et al
Gill Jennings & Every LLP The Broadgate Tower
20 Primrose Street
London EC2A 2ES / GB
[N/P]
Former [2014/14]Stevens, Fiona, et al
Gill Jennings & Every LLP The Broadgate Tower
20 Primrose Street
London EC2A 2ES / GB
Former [2011/11]Perry, Robert Edward, et al
Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London
EC2A 2ES / GB
Application number, filing date09750136.522.05.2009
[2011/11]
WO2009GB50554
Priority number, dateGB2008000932422.05.2008         Original published format: GB 0809324
GB2008000932822.05.2008         Original published format: GB 0809328
[2012/01]
Former [2011/11]GB2008000932422.05.2008
GB2008000932822.05.2008
US20090174092P30.04.2009
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009141658
Date:26.11.2009
Language:EN
[2009/48]
Type: A1 Application with search report 
No.:EP2293846
Date:16.03.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 26.11.2009 takes the place of the publication of the European patent application.
[2011/11]
Type: B1 Patent specification 
No.:EP2293846
Date:10.07.2013
Language:EN
[2013/28]
Search report(s)International search report - published on:EP26.11.2009
ClassificationIPC:A61P35/00, C07K5/02, C07K5/10
[2012/49]
CPC:
C07K5/02 (EP,US); A61K38/15 (GB); A61P1/02 (EP);
A61P13/08 (EP); A61P15/00 (EP); A61P15/02 (EP);
A61P17/00 (EP); A61P17/02 (EP); A61P17/06 (EP);
A61P17/10 (EP); A61P17/14 (EP); A61P19/10 (EP);
A61P25/00 (EP); A61P29/00 (EP); A61P3/00 (EP);
A61P3/10 (EP); A61P31/00 (EP); A61P31/04 (EP);
A61P35/00 (EP); A61P35/02 (EP); A61P37/00 (EP);
A61P37/06 (EP); A61P43/00 (EP); A61P7/00 (EP);
A61P7/06 (EP); A61P9/00 (EP); A61P9/04 (EP);
C07K11/02 (GB); C07K5/1008 (EP,US); C07K5/101 (EP,US);
C07K5/1016 (EP,US); C07K5/1021 (EP,US); C07K5/1024 (EP,US);
Y02P20/55 (EP,US) (-)
Former IPC [2011/11]A61P35/00, C07K5/02
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/11]
TitleGerman:Depsipeptide und therapeutische Verwendung davon[2012/49]
English:Depsipeptides and their therapeutic use[2012/49]
French:Depsipeptides et leur utilisation thérapeutique[2012/49]
Former [2011/11]DEPSIPEPTIDE UND IHRE THERAPEUTISCHE VERWENDUNG
Former [2011/11]DEPSIPEPTIDES AND THEIR THERAPEUTIC USE
Former [2011/11]DEPSIPEPTIDES ET LEUR UTILISATION THÉRAPEUTIQUE
Entry into regional phase21.12.2010National basic fee paid 
21.12.2010Designation fee(s) paid 
21.12.2010Examination fee paid 
Examination procedure10.11.2010Amendment by applicant (claims and/or description)
21.12.2010Examination requested  [2011/11]
25.06.2011Loss of particular rights, legal effect: Priority
10.08.2011Despatch of communication of loss of particular rights: Priority 0003
24.04.2012Despatch of a communication from the examining division (Time limit: M04)
23.08.2012Reply to a communication from the examining division
21.01.2013Communication of intention to grant the patent
13.05.2013Fee for grant paid
13.05.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.04.2012
Opposition(s)11.04.2014No opposition filed within time limit [2014/25]
Fees paidRenewal fee
11.05.2011Renewal fee patent year 03
29.03.2012Renewal fee patent year 04
10.05.2013Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.05.2009
AT10.07.2013
BG10.07.2013
CY10.07.2013
CZ10.07.2013
EE10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
LV10.07.2013
MC10.07.2013
MK10.07.2013
MT10.07.2013
PL10.07.2013
RO10.07.2013
SI10.07.2013
SK10.07.2013
TR10.07.2013
NO10.10.2013
GR11.10.2013
IS10.11.2013
PT11.11.2013
[2018/30]
Former [2016/33]HU22.05.2009
AT10.07.2013
BG10.07.2013
CY10.07.2013
CZ10.07.2013
EE10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
LV10.07.2013
MC10.07.2013
MT10.07.2013
PL10.07.2013
RO10.07.2013
SI10.07.2013
SK10.07.2013
TR10.07.2013
NO10.10.2013
GR11.10.2013
IS10.11.2013
PT11.11.2013
Former [2016/32]HU22.05.2009
AT10.07.2013
BG10.07.2013
CY10.07.2013
CZ10.07.2013
EE10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
LV10.07.2013
MC10.07.2013
MT10.07.2013
PL10.07.2013
RO10.07.2013
SI10.07.2013
SK10.07.2013
NO10.10.2013
GR11.10.2013
IS10.11.2013
PT11.11.2013
Former [2016/28]AT10.07.2013
BG10.07.2013
CY10.07.2013
CZ10.07.2013
EE10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
LV10.07.2013
MC10.07.2013
MT10.07.2013
PL10.07.2013
RO10.07.2013
SI10.07.2013
SK10.07.2013
NO10.10.2013
GR11.10.2013
IS10.11.2013
PT11.11.2013
Former [2016/16]AT10.07.2013
CY10.07.2013
CZ10.07.2013
EE10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
LV10.07.2013
MC10.07.2013
MT10.07.2013
PL10.07.2013
RO10.07.2013
SI10.07.2013
SK10.07.2013
NO10.10.2013
GR11.10.2013
IS10.11.2013
PT11.11.2013
Former [2015/09]AT10.07.2013
CY10.07.2013
CZ10.07.2013
EE10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
LV10.07.2013
MC10.07.2013
PL10.07.2013
RO10.07.2013
SI10.07.2013
SK10.07.2013
NO10.10.2013
GR11.10.2013
IS10.11.2013
PT11.11.2013
Former [2014/23]AT10.07.2013
CY10.07.2013
CZ10.07.2013
EE10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
LV10.07.2013
PL10.07.2013
RO10.07.2013
SI10.07.2013
SK10.07.2013
NO10.10.2013
GR11.10.2013
IS10.11.2013
PT11.11.2013
Former [2014/22]AT10.07.2013
CY10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
LV10.07.2013
PL10.07.2013
RO10.07.2013
SI10.07.2013
NO10.10.2013
GR11.10.2013
IS10.11.2013
PT11.11.2013
Former [2014/12]AT10.07.2013
CY10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
LV10.07.2013
PL10.07.2013
SI10.07.2013
NO10.10.2013
GR11.10.2013
IS10.11.2013
PT11.11.2013
Former [2014/11]AT10.07.2013
CY10.07.2013
FI10.07.2013
HR10.07.2013
LT10.07.2013
PL10.07.2013
SI10.07.2013
NO10.10.2013
IS10.11.2013
PT11.11.2013
Former [2014/10]AT10.07.2013
CY10.07.2013
HR10.07.2013
LT10.07.2013
SI10.07.2013
NO10.10.2013
IS10.11.2013
PT11.11.2013
Former [2014/09]AT10.07.2013
HR10.07.2013
LT10.07.2013
SI10.07.2013
NO10.10.2013
PT11.11.2013
Former [2014/08]LT10.07.2013
SI10.07.2013
NO10.10.2013
PT11.11.2013
Former [2014/07]SI10.07.2013
NO10.10.2013
Former [2013/49]SI10.07.2013
Cited inInternational search[X]   YUREK-GEORGE ALEXANDER ET AL: "The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, US, vol. 50, no. 23, 15 November 2007 (2007-11-15), pages 5720 - 5726, XP002470763, ISSN: 0022-2623 [X] 1,3-5,9-12,14-20 * compounds 8A, 8B *

DOI:   http://dx.doi.org/10.1021/jm0703800
 [X]   DOI T ET AL: "A total synthesis of spiruchostatin A", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 47, no. 7, 13 February 2006 (2006-02-13), pages 1177 - 1180, XP025003430, ISSN: 0040-4039, [retrieved on 20060213] [X] 1,3,4,7,9-12,14-20 * page 1177, paragraph 1; compounds 1A, 1B *

DOI:   http://dx.doi.org/10.1016/j.tetlet.2005.12.031
 [X]   YUREK-GEORGE ALEXANDER ET AL: "Total synthesis of spiruchostatin A, a potent histone deacetylase inhibitor", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC., US, vol. 126, no. 4, 4 February 2004 (2004-02-04), pages 1030 - 1031, XP002470762, ISSN: 0002-7863 [X] 1,3,4,7,9-12,14-20 * page 1031, paragraph bridging column 1 and column 2;;; compounds 5, 6 *

DOI:   http://dx.doi.org/10.1021/ja039258q
 [X]   MASUOKA Y ET AL: "Spiruchostatins A and B, novel gene expression-enhancing substances produced by Pseudomonas sp", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 42, no. 1, 1 January 2001 (2001-01-01), pages 41 - 44, XP004227786, ISSN: 0040-4039 [X] 1,3,4,7,9-12,14-20 * page 41, paragraph 1; compounds 1, 2 *

DOI:   http://dx.doi.org/10.1016/S0040-4039(00)01874-8
 [A]   KOCH K N ET AL: "Synthesis of conformationally restricted cyclic pentadepsipeptides via direct amide cyclization", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 57, no. 12, 17 March 2001 (2001-03-17), pages 2311 - 2326, XP004231511, ISSN: 0040-4020 [A] 2 * compound 14C *

DOI:   http://dx.doi.org/10.1016/S0040-4020(01)00091-6
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