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Extract from the Register of European Patents

EP About this file: EP2288388

EP2288388 - ACHIEVEMENT OF HIGH THERAPEUTIC INDEX THROUGH MOLECULAR IMAGING GUIDED TARGETED DRUG TREATMENT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.07.2017
Database last updated on 03.01.2025
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): IS		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
Siemens Medical Solutions USA, Inc.
51, Valley Stream Parkway
Malvern, PA 19355-1406 / US
[2011/09]
Inventor(s)01 / KOLB, Hartmuth, C.
6413 Pacific Avenue
Playa Del Rey CA 90293 / US
02 / WALSH, Joseph, C.
831 Galloway St.
Pacific Palisades CA 90272 / US
03 / CHEN, Kai
3641 Westwood Blvd. Apt. 6
Los Angeles CA 90034 / US
04 / KASI, Dhanalakshmi
3340 Overland Ave. Apt. 4
Los Angeles CA 90034 / US
05 / GANGADHARMATH, Umesh, B.
3714 Bagley Ave. Apt. 6
Los Angeles CA 90034 / US
06 / SCOTT, Peter, J.h.
4077 Glencoe Avenue Apt. 317
Marina-del-rey CA 90292 / US
07 / CHEN, Gang
3717 Cardiff Ave. Apt. 111
Los Angeles, CA 90034 / US
08 / MOCHARLA, Vani, P.
3201 Overland Ave. Apt. 6125
Los Angeles CA 90034 / US
 [2011/14]
Former [2011/09]01 / KOLB, Hartmuth, C.
6413 Pacific Avenue
Playa Del Rey CA 90293 / US
02 / WALSH, Joseph, C.
831 Galloway St.
Pacific Palisades CA 90272 / US
03 / CHEN, Kai
3641 Westwood Blvd. Apt. 6
Los Angeles CA 90034 / US
04 / KASI, Dhanalakshmi
3340 Overland Ave. Apt. 4
Los Angeles CA 90034 / US
05 / GANGADHARMATH, Umesh, B.
3714 Bagley Ave. Apt. 6
Los Angeles CA 90034 / US
06 / SCOTT, Peter, J.h.
4077 Glencoe Avenue Apt. 317
Marina-del-rey CA 90292 / US
07 / CHEN, Gang
10770 Lawler Street Apt. 2
Log Angeles CA 90034 / US
08 / MOCHARLA, Vani, P.
3201 Overland Ave. Apt. 6125
Los Angeles CA 90034 / US
Representative(s)Maier, Daniel Oliver, et al
Siemens AG
Postfach 22 16 34
80506 München / DE
[N/P]
Former [2014/35]Maier, Daniel Oliver, et al
Siemens AG
Postfach 22 16 34
80506 München / DE
Former [2011/09]French, Clive Harry
Siemens AG P.O. Box 22 16 34
80506 München / DE
Application number, filing date09758718.201.06.2009
[2011/09]
WO2009US03309
Priority number, dateUS2008005777430.05.2008         Original published format: US 57774
[2011/09]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2009148554
Date:10.12.2009
Language:EN
[2009/50]
Type: A1 Application with search report 
No.:EP2288388
Date:02.03.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 10.12.2009 takes the place of the publication of the European patent application.
[2011/09]
Type: B1 Patent specification 
No.:EP2288388
Date:31.08.2016
Language:EN
[2016/35]
Search report(s)International search report - published on:EP10.12.2009
ClassificationIPC:A61K51/08, A61P35/00
[2011/09]
CPC:
A61K51/088 (EP,US); A61K51/082 (EP,US); A61P35/00 (EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2016/35]
Former [2011/09]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:ERREICHUNG EINES HOHEN THERAPIEINDEX MITTELS, DURCH MOLEKULARER BILDGEBUNG GESTEUERTER, GEZIELTER MEDIKAMENTENBEHANDLUNG[2016/16]
English:ACHIEVEMENT OF HIGH THERAPEUTIC INDEX THROUGH MOLECULAR IMAGING GUIDED TARGETED DRUG TREATMENT[2011/09]
French:OBTENTION D'UN INDICE THÉRAPEUTIQUE ÉLEVÉ PAR TRAITEMENT MÉDICAMENTAUX CIBLÉ GUIDÉ PAR L'IMAGERIE MOLÉCULAIRE[2011/09]
Former [2011/09]ERREICHUNG EINES HOHEN THERAPIEINDEX MITTELS DURCH MOLEKÜLABBILDUNG GESTEUERTER GEZIELTER MEDIKAMENTENBEHANDLUNG
Entry into regional phase27.10.2010National basic fee paid 
27.10.2010Designation fee(s) paid 
27.10.2010Examination fee paid 
Examination procedure18.03.2010Request for preliminary examination filed
International Preliminary Examining Authority: EP
27.10.2010Examination requested  [2011/09]
23.02.2011Amendment by applicant (claims and/or description)
10.10.2013Despatch of a communication from the examining division (Time limit: M06)
13.03.2014Reply to a communication from the examining division
19.02.2015Despatch of a communication from the examining division (Time limit: M04)
02.03.2015Reply to a communication from the examining division
30.03.2016Communication of intention to grant the patent
15.06.2016Receipt of the translation of the claim(s)
20.07.2016Fee for grant paid
20.07.2016Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  10.10.2013
Opposition(s)01.06.2017No opposition filed within time limit [2017/32]
Fees paidRenewal fee
20.06.2011Renewal fee patent year 03
18.06.2012Renewal fee patent year 04
20.06.2013Renewal fee patent year 05
20.06.2014Renewal fee patent year 06
18.06.2015Renewal fee patent year 07
21.06.2016Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU01.06.2009
AT31.08.2016
BE31.08.2016
CY31.08.2016
CZ31.08.2016
DK31.08.2016
EE31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
IT31.08.2016
LT31.08.2016
LV31.08.2016
MC31.08.2016
MK31.08.2016
PL31.08.2016
RO31.08.2016
SE31.08.2016
SI31.08.2016
SK31.08.2016
TR31.08.2016
BG30.11.2016
NO30.11.2016
GR01.12.2016
IS31.12.2016
PT02.01.2017
[2020/33]
Former [2020/15]HU01.06.2009
AT31.08.2016
BE31.08.2016
CY31.08.2016
CZ31.08.2016
DK31.08.2016
EE31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
IT31.08.2016
LT31.08.2016
LV31.08.2016
MC31.08.2016
MK31.08.2016
PL31.08.2016
RO31.08.2016
SE31.08.2016
SI31.08.2016
SK31.08.2016
TR31.08.2016
BG30.11.2016
NO30.11.2016
GR01.12.2016
PT02.01.2017
Former [2019/51]HU01.06.2009
AT31.08.2016
BE31.08.2016
CY31.08.2016
CZ31.08.2016
DK31.08.2016
EE31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
IT31.08.2016
LT31.08.2016
LV31.08.2016
MC31.08.2016
MK31.08.2016
PL31.08.2016
RO31.08.2016
SE31.08.2016
SI31.08.2016
SK31.08.2016
BG30.11.2016
NO30.11.2016
GR01.12.2016
PT02.01.2017
Former [2019/46]HU01.06.2009
AT31.08.2016
BE31.08.2016
CY31.08.2016
CZ31.08.2016
DK31.08.2016
EE31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
IT31.08.2016
LT31.08.2016
LV31.08.2016
MC31.08.2016
PL31.08.2016
RO31.08.2016
SE31.08.2016
SI31.08.2016
SK31.08.2016
BG30.11.2016
NO30.11.2016
GR01.12.2016
PT02.01.2017
Former [2019/31]HU01.06.2009
AT31.08.2016
BE31.08.2016
CZ31.08.2016
DK31.08.2016
EE31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
IT31.08.2016
LT31.08.2016
LV31.08.2016
MC31.08.2016
PL31.08.2016
RO31.08.2016
SE31.08.2016
SI31.08.2016
SK31.08.2016
BG30.11.2016
NO30.11.2016
GR01.12.2016
PT02.01.2017
Former [2018/11]AT31.08.2016
BE31.08.2016
CZ31.08.2016
DK31.08.2016
EE31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
IT31.08.2016
LT31.08.2016
LV31.08.2016
MC31.08.2016
PL31.08.2016
RO31.08.2016
SE31.08.2016
SI31.08.2016
SK31.08.2016
BG30.11.2016
NO30.11.2016
GR01.12.2016
PT02.01.2017
Former [2017/37]AT31.08.2016
BE31.08.2016
CZ31.08.2016
DK31.08.2016
EE31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
IT31.08.2016
LT31.08.2016
LV31.08.2016
PL31.08.2016
RO31.08.2016
SE31.08.2016
SI31.08.2016
SK31.08.2016
BG30.11.2016
NO30.11.2016
GR01.12.2016
PT02.01.2017
Former [2017/32]AT31.08.2016
BE31.08.2016
CZ31.08.2016
DK31.08.2016
EE31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
IT31.08.2016
LT31.08.2016
LV31.08.2016
PL31.08.2016
RO31.08.2016
SE31.08.2016
SK31.08.2016
BG30.11.2016
NO30.11.2016
GR01.12.2016
PT02.01.2017
Former [2017/13]AT31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
LT31.08.2016
LV31.08.2016
SE31.08.2016
NO30.11.2016
GR01.12.2016
Former [2017/11]AT31.08.2016
ES31.08.2016
FI31.08.2016
HR31.08.2016
LT31.08.2016
SE31.08.2016
NO30.11.2016
GR01.12.2016
Former [2017/10]FI31.08.2016
HR31.08.2016
LT31.08.2016
SE31.08.2016
NO30.11.2016
Former [2017/09]FI31.08.2016
LT31.08.2016
NO30.11.2016
Former [2017/07]LT31.08.2016
Cited inInternational search[X]WO2008033557  (SIEMENS MEDICAL SOLUTIONS [US], et al) [X] 1-17,19-22 * compounds 3,10,11,21,27,37,38 *;
 [X]WO2006135233  (UNIV UTRECHT HOLDING BV [NL], et al) [X] 7,8,11,12,19-22 * figures 2,3,6 *;
 [X]WO2007018431  (SYNTARGA BV [NL], et al) [X] 7-17,19-22 * figures 1,2,10 *
 [X]  - SCHMIDT, U.; MUNDINGER, K.; RIEDL, B.; HAAS, G.; LAU, R., "Synthesis of Enantiomerically Pure and Compatibly Protected (2S,3R)- and (2S,3S)-Diaminobutyric Acids", SYNTHESIS, (1992), no. 12, pages 1201 - 1202, XP002541157 [X] 1-3,5 * compound 2 *

DOI:   http://dx.doi.org/10.1055/s-1992-26332
 [X]  - KUIJPERS B H M ET AL, "Expedient synthesis of triazole-linked glycosyl amino acids and peptides", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, (20040902), vol. 6, no. 18, ISSN 1523-7060, pages 3123 - 3126, XP002403019 [X] 1-3,5 * compounds 22-27 *

DOI:   http://dx.doi.org/10.1021/ol048841o
 [X]  - OPPOLZER W, LIENARD P, "Non-destructive Cleavage of N-Acylsultams Under Neutral Conditions: Preparation of Enantiomerically Pure Fmoc-Protected alpha-Amino Acids", HELVETICA CHIMICA ACTA, (1992), vol. 75, pages 2572 - 2582, XP002541158 [X] 1-3,5 * compound 13F *

DOI:   http://dx.doi.org/10.1002/hlca.19920750812
 [X]  - FRANKE R ET AL, "Peptide ligation through click chemistry for the generation of assembled and scaffolded peptides", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 46, no. 26, ISSN 0040-4039, (20050627), pages 4479 - 4482, (20050627), XP025386107 [X] 7,8,11,12,19 * Scheme 2 *

DOI:   http://dx.doi.org/10.1016/j.tetlet.2005.04.107
by applicantUS5358704
 US5262532
 US5219553
 US5188816
 US5155215
 US5087440
 US4885363
    - CAMARERO; MUIR, J. AM. CHEM. SOC., (1999), vol. 121, pages 5597 - 5598
    - HRUBY, V.J. ET AL., "Conformational restrictions of biologically active peptides via amino acid side chain groups", LIFE SCI, (198207), vol. 31, no. 3, pages 189 - 199
    - KOIVUNEN, E. ET AL., "Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins", BIOTECHNOLOGY, (199503), vol. 13, no. 3, pages 265 - 270
    - ZHANG, L. ET AL., "Synthesis and Application of Unprotected Cyclic Peptides as Building Blocks for Peptide Dendrimers", J. AM. CHEM. SOC., (199703), vol. 119, no. 10, pages 2363 - 2370
    - SCOTT, C. ET AL., "Structural requirements for the biosynthesis of backbone cyclic peptide libraries", CHEMISTRY AND BIOLOGY, (2001), vol. 8, pages 801 - 815
    - MEYER ET AL., INVEST. RADIOL., (1990), vol. 25, page S53
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.