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Extract from the Register of European Patents

EP About this file: EP2303275

EP2303275 - SMOOTHENED RECEPTOR MODULATORS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  12.04.2013
Database last updated on 22.08.2024
Most recent event   Tooltip12.04.2013Application deemed to be withdrawnpublished on 15.05.2013  [2013/20]
Applicant(s)For all designated states
Duke University
P.O. Box 90083
Durham, NC 27708-0083 / US
[2011/14]
Inventor(s)01 / CHEN, Wei
Duke University P.O. Box 90083
Durham, NC 27708-0083 / US
02 / BARAK, Lawrence
Duke University P.O. Box 90083
Durham, NC 27708-0083 / US
03 / LYERLY, H., Kim
Duke University P.O. Box 90083
Durham, NC 27708-0083 / US
04 / WANG, Jiangbo
Duke University P.O. Box 90083
Durham, NC 27708-0083 / US
 [2011/14]
Representative(s)Atkinson, Peter Birch, et al
Marks & Clerk LLP
1 New York Street
Manchester M1 4HD / GB
[N/P]
Former [2011/38]Atkinson, Peter Birch, et al
Marks & Clerk LLP
1 New York Street
Manchester, M1 4HD / GB
Former [2011/14]Atkinson, Peter Birch, et al
Marks & Clerk LLP Sussex House 83-85 Mosley Street Manchester
M2 3LG / GB
Application number, filing date09767052.516.06.2009
[2011/14]
WO2009US03604
Priority number, dateUS20080129302P17.06.2008         Original published format: US 129302 P
[2011/14]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2009154739
Date:23.12.2009
Language:EN
[2009/52]
Type: A2 Application without search report 
No.:EP2303275
Date:06.04.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 23.12.2009 takes the place of the publication of the European patent application.
[2011/14]
Search report(s)International search report - published on:KR01.07.2010
(Supplementary) European search report - dispatched on:EP10.04.2012
ClassificationIPC:A61K31/506, A61K31/5375, A61K31/426, A61P35/00
[2011/14]
CPC:
A61K31/426 (EP,US); A61K31/4439 (EP,US); A61K31/454 (EP,US);
A61K31/455 (EP,US); A61K31/506 (EP,US); A61K31/5377 (EP,US);
A61K31/538 (EP,US); A61K31/55 (EP,US); A61K31/5513 (EP,US);
A61P35/00 (EP); C07D239/48 (EP,US); C07D265/36 (EP,US);
C07D277/32 (EP,US); C07D401/04 (EP,US); C07D401/12 (EP,US);
C07D401/14 (EP,US); C07D403/04 (EP,US); C07D403/12 (EP,US);
C07D403/14 (EP,US); C07D405/14 (EP,US); C07D409/14 (EP,US);
C07D413/14 (EP,US); C07D417/12 (EP,US); C07D417/14 (EP,US);
C07D471/04 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/14]
TitleGerman:GEGLÄTTETE REZEPTORMODULATOREN[2011/14]
English:SMOOTHENED RECEPTOR MODULATORS[2011/14]
French:MODULATEURS DU RÉCEPTEUR SMOOTHENED[2011/14]
Entry into regional phase17.01.2011National basic fee paid 
17.01.2011Search fee paid 
17.01.2011Designation fee(s) paid 
17.01.2011Examination fee paid 
Examination procedure17.01.2011Examination requested  [2011/14]
18.03.2011Amendment by applicant (claims and/or description)
13.11.2012Application deemed to be withdrawn, date of legal effect  [2013/20]
19.12.2012Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2013/20]
Fees paidRenewal fee
23.05.2011Renewal fee patent year 03
Penalty fee
Additional fee for renewal fee
30.06.201204   M06   Not yet paid
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[A]WO2006028958  (GENENTECH INC [US], et al) [A] 1,2,8,9,11 * paragraph [0152]; claims 1,33,34 *;
 [A]WO2006026430  (INFINITY PHARMACEUTICALS INC [US], et al) [A] 1,2,8,9,11 * claims 40-42, 47 *;
 [A]WO0126644  (CURIS INC [US]) [A] 1,2,8,9,11 * page 73, line 12 - page 74, line 32 * * figure 32 *;
 [A]US2003139457  (BAXTER ANTHONY DAVID [GB], et al) [A] 1,2,8,9,11 * figure 32 * * paragraphs [0192] - [0194] - [ 218] *;
 [A]US2004067985  (HAVIV FORTUNA [US], et al) [A] 1,2,8,9,11 * example 169 * * paragraph [0088]; claim 1 * * claims 28, 31-32 * * paragraph [0112] *;
 [A]WO03076395  (JANSSEN PHARMACEUTICA NV [BE], et al) [A] 1,2,8,9,11 * pages 40-41 * * page 20, line 31 - page 22, line 9; claim 10 *;
 [A]WO2007076294  (CHEN WEI [US], et al) [A] 1,2,8,9,11 * claims 1-21 * * paragraphs [0005] - [0006] *;
 [A]  - RUBIN LEE L ET AL, "Targeting the Hedgehog pathway in cancer", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, (20061201), vol. 5, no. 12, doi:10.1038/NRD2086, ISSN 1474-1776, pages 1026 - 1033, XP002520119 [A] 1,2,8,9,11 * table 1 * * page 1028; compounds Cur-61414 *

DOI:   http://dx.doi.org/10.1038/NRD2086
 [AP]  - MILLER-MOSLIN K ET AL, "1-Amino-4-benzylphthalazines as Orally Available Smoothened Antagonists with Antitumor Activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 52, doi:10.1021/JM900309J, ISSN 0022-2623, (20090101), pages 3954 - 3968, (20090526), XP002549293 [AP] 1,2,8,9,11 * figures 1-2; table 3 *

DOI:   http://dx.doi.org/10.1021/jm900309j
International search[A]US2005054656  (CHIANG PHOEBE [US], et al);
 [A]US2007167459  (HABASHITA HIROMU [JP], et al);
 [A]WO2005097765  (EXELIXIS INC [US], et al);
 [A]US2005130970  (MILLER MARK T [US], et al)
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.