blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2340251

EP2340251 - PYRROLO[4,3,2-DE]QUINOLIN-8-AMINE COMPOUNDS AND METHODS OF THEIR PREPARATION AND USE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.05.2015
Database last updated on 02.11.2024
Most recent event   Tooltip22.06.2018Lapse of the patent in a contracting state
New state(s): MK		published on 25.07.2018  [2018/30]
Applicant(s)For all designated states
Wyeth LLC
235 East 42nd Street
New York, NY 10017-5755 / US
[2014/10]
Former [2011/27]For all designated states
Wyeth LLC
Five Giralda Farms
Madison, NJ 07940 / US
Inventor(s)01 / HE, Min
36 Tuxedo Lane
Congers NY 10920 / US
02 / JANSO, Jeffrey, Edwin
55 North Mountain Avenue
Apt B8
Montclair NJ 07042 / US
03 / YU, Ker
26 Buckingham Circle
Pine Brook NJ 07058 / US
04 / MCDONALD, Leonard, Alexander
323 Briar Patch
Mountainside NJ 07092 / US
05 / BARBIERI, Laurel, Rita
333 Greenbush Road
Blauvelt NY 10913 / US
06 / GOPALSAMY, Ariamala
21 Whispering Pines Drive
Mahway NJ 07430 / US
 [2014/29]
Former [2011/27]01 / HE, Min
36 Tuxedo Lane
Congers NY 10920 / US
02 / JANSO, Jeffrey, Edwin
55 North Mountain Avenue Apt B8
Montclair NJ 07042 / US
03 / YU, Ker
26 Buckingham Circle
Pine Brook NJ 07058 / US
04 / MCDONALD, Leonard, Alexander
323 Briar Patch
Mountainside NJ 07092 / US
05 / BARBIERI, Laurel, Rita
333 Greenbush Road
Blauvelt NY 10913 / US
06 / GOPALSAMY, Ariamala
21 Whispering Pines Drive
Mahway NJ 07430 / US
Representative(s)Pfizer
European Patent Department
23-25 avenue du Docteur Lannelongue
75668 Paris Cedex 14 / FR
[2012/33]
Former [2012/14]Ruddock, Keith Stephen, et al
Pfizer
European Patent Department
23-25 avenue du Docteur Lannelongue
75668 Paris Cedex 14 / FR
Former [2011/27]Lane, Graham Mark Hamilton
Pfizer Limited European Patent Department Ramsgate Road
Sandwich CT13 9NJ / GB
Application number, filing date09791426.112.08.2009
[2011/27]
WO2009US53543
Priority number, dateUS20080088192P12.08.2008         Original published format: US 88192 P
US20080122449P15.12.2008         Original published format: US 122449 P
[2011/27]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010019659
Date:18.02.2010
Language:EN
[2010/07]
Type: A1 Application with search report 
No.:EP2340251
Date:06.07.2011
Language:EN
The application published by WIPO in one of the EPO official languages on 18.02.2010 takes the place of the publication of the European patent application.
[2011/27]
Type: B1 Patent specification 
No.:EP2340251
Date:16.07.2014
Language:EN
[2014/29]
Search report(s)International search report - published on:EP18.02.2010
ClassificationIPC:C07D471/06, C12R1/04, A61K31/437, A61P35/00, C12P17/18
[2014/02]
CPC:
C07D471/06 (EP,US); A61P35/00 (EP); C12N1/205 (EP,US);
C12P17/182 (EP,US); C12R2001/04 (EP,US)
Former IPC [2011/27]C07D471/06, C12R1/04, A61K31/437, A61P35/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2011/27]
TitleGerman:PYRROLO[4,3,2-DE]CHINOLIN-8-AMINVERBINDUNGEN UND VERFAHREN ZU IHRER HERSTELLUNG UND ANWENDUNG[2011/27]
English:PYRROLO[4,3,2-DE]QUINOLIN-8-AMINE COMPOUNDS AND METHODS OF THEIR PREPARATION AND USE[2011/27]
French:COMPOSÉS PYRROLO[4,3,2-DE]QUINOLÉIN-8-AMINES ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION[2011/27]
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase14.03.2011National basic fee paid 
14.03.2011Designation fee(s) paid 
14.03.2011Examination fee paid 
Examination procedure10.03.2011Amendment by applicant (claims and/or description)
14.03.2011Examination requested  [2011/27]
09.03.2012Despatch of a communication from the examining division (Time limit: M04)
10.07.2012Reply to a communication from the examining division
18.01.2013Despatch of a communication from the examining division (Time limit: M04)
21.05.2013Reply to a communication from the examining division
05.03.2014Communication of intention to grant the patent
05.06.2014Fee for grant paid
05.06.2014Fee for publishing/printing paid
05.06.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  09.03.2012
Opposition(s)17.04.2015No opposition filed within time limit [2015/26]
Fees paidRenewal fee
31.08.2011Renewal fee patent year 03
31.08.2012Renewal fee patent year 04
02.09.2013Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU12.08.2009
AT16.07.2014
BE16.07.2014
CY16.07.2014
CZ16.07.2014
DK16.07.2014
EE16.07.2014
FI16.07.2014
HR16.07.2014
LT16.07.2014
LV16.07.2014
MC16.07.2014
MK16.07.2014
MT16.07.2014
NL16.07.2014
PL16.07.2014
RO16.07.2014
SE16.07.2014
SI16.07.2014
SK16.07.2014
SM16.07.2014
TR16.07.2014
LU12.08.2014
CH31.08.2014
LI31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
[2018/30]
Former [2016/33]HU12.08.2009
AT16.07.2014
BE16.07.2014
CY16.07.2014
CZ16.07.2014
DK16.07.2014
EE16.07.2014
FI16.07.2014
HR16.07.2014
LT16.07.2014
LV16.07.2014
MC16.07.2014
MT16.07.2014
NL16.07.2014
PL16.07.2014
RO16.07.2014
SE16.07.2014
SI16.07.2014
SK16.07.2014
SM16.07.2014
TR16.07.2014
LU12.08.2014
CH31.08.2014
LI31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2016/32]HU12.08.2009
AT16.07.2014
BE16.07.2014
CY16.07.2014
CZ16.07.2014
DK16.07.2014
EE16.07.2014
FI16.07.2014
HR16.07.2014
LT16.07.2014
LV16.07.2014
MC16.07.2014
MT16.07.2014
NL16.07.2014
PL16.07.2014
RO16.07.2014
SE16.07.2014
SI16.07.2014
SK16.07.2014
SM16.07.2014
CH31.08.2014
LI31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2016/28]AT16.07.2014
CY16.07.2014
CZ16.07.2014
DK16.07.2014
EE16.07.2014
FI16.07.2014
LT16.07.2014
LV16.07.2014
MC16.07.2014
MT16.07.2014
NL16.07.2014
PL16.07.2014
RO16.07.2014
SE16.07.2014
SI16.07.2014
SK16.07.2014
SM16.07.2014
BE31.08.2014
CH31.08.2014
LI31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2016/22]AT16.07.2014
CY16.07.2014
CZ16.07.2014
DK16.07.2014
EE16.07.2014
FI16.07.2014
LT16.07.2014
LV16.07.2014
MC16.07.2014
NL16.07.2014
PL16.07.2014
RO16.07.2014
SE16.07.2014
SI16.07.2014
SK16.07.2014
SM16.07.2014
BE31.08.2014
CH31.08.2014
LI31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2015/50]AT16.07.2014
CY16.07.2014
CZ16.07.2014
DK16.07.2014
EE16.07.2014
FI16.07.2014
LT16.07.2014
LV16.07.2014
MC16.07.2014
NL16.07.2014
PL16.07.2014
RO16.07.2014
SE16.07.2014
SI16.07.2014
SK16.07.2014
BE31.08.2014
CH31.08.2014
LI31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2015/23]AT16.07.2014
CY16.07.2014
CZ16.07.2014
DK16.07.2014
EE16.07.2014
FI16.07.2014
LT16.07.2014
LV16.07.2014
MC16.07.2014
NL16.07.2014
PL16.07.2014
RO16.07.2014
SE16.07.2014
SK16.07.2014
BE31.08.2014
CH31.08.2014
LI31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2015/22]AT16.07.2014
CY16.07.2014
DK16.07.2014
FI16.07.2014
LT16.07.2014
LV16.07.2014
MC16.07.2014
NL16.07.2014
PL16.07.2014
RO16.07.2014
SE16.07.2014
BE31.08.2014
CH31.08.2014
LI31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2015/20]AT16.07.2014
CY16.07.2014
FI16.07.2014
LT16.07.2014
LV16.07.2014
MC16.07.2014
NL16.07.2014
PL16.07.2014
SE16.07.2014
BE31.08.2014
CH31.08.2014
LI31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2015/19]AT16.07.2014
CY16.07.2014
FI16.07.2014
LT16.07.2014
LV16.07.2014
NL16.07.2014
PL16.07.2014
SE16.07.2014
BE31.08.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2015/12]AT16.07.2014
CY16.07.2014
FI16.07.2014
LT16.07.2014
LV16.07.2014
NL16.07.2014
PL16.07.2014
SE16.07.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
IS16.11.2014
PT17.11.2014
Former [2015/11]CY16.07.2014
FI16.07.2014
LT16.07.2014
PL16.07.2014
SE16.07.2014
BG16.10.2014
NO16.10.2014
GR17.10.2014
PT17.11.2014
Former [2015/10]FI16.07.2014
LT16.07.2014
SE16.07.2014
BG16.10.2014
NO16.10.2014
Former [2015/09]FI16.07.2014
LT16.07.2014
SE16.07.2014
Former [2015/08]LT16.07.2014
Cited inInternational search[DX]US5843955  (TAMAOKI TATSUYA [JP], et al) [DX] 17-20 * column 1, line 51 - line 55; claim 1 * * example 1 * * column 3, line 67 - column 4, line 6 * * column 6, line 59 - line 61 *;
 [DX]US6815449  (AKAMA TSUTOMU [US], et al) [DX] 1-10,12-16 * claims 1,9 * * compounds 1-114 * * column 1, lines 11-13 *;
 [A]  - NAGATA, HIROYUKI; OCHIAI, KEIKO; AOTANI, YUMIKO; ANDO, KATSUHIKO; YOSHIDA, MAYUMI; ET AL., "Lymphostin (LK6-A), a Novel Immunosuppressant from Streptomyces sp. KY11783: Taxonomy of the Producing Organism, Fermentation, Isolation and Biological Activities", JOURNAL OF ANTIBIOTICS, (1997), vol. 50, no. 7, pages 537 - 542, XP009125261 [A] 11,17-21 * the whole document *
 [A]  - AOTANI, YUMIKO; NAGATA, HIROYUKI; YOSHIDA, MAYUMI, "Lymphostin (LK6-A), a Novel Immunosuppressant from Streptomyces sp. KY11783: Structural Elucidation", JOURNAL OF ANTIBIOTICS, (1997), vol. 50, no. 7, pages 543 - 545, XP009125260 [A] 11,17-21 * the whole document *
 [A]  - NAGATA, HIROYUKI; YANO, HIROSHI; SASAKI, KIMIHITO; SATO, SOICHIRO; NAKANISHI, SATOSHI; TAKAHASHI, ISAMI; TAMAOKI, TATSUYA, "Inhibition of Lymphocyte Kinase Lck and Phosphatidylinositol 3-kinase by a Novel Immunosuppressant, Lymphostin", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, (2002), vol. 66, no. 3, pages 501 - 507, XP002553866 [A] 11,17-21 * the whole document *

DOI:   http://dx.doi.org/10.1271/bbb.66.501
 [A]  - TATSUTA K ET AL, "The first total synthesis of lymphostin", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, (20040322), vol. 45, no. 13, ISSN 0040-4039, pages 2847 - 2850, XP004494431 [A] 1-21 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.tetlet.2004.01.140
Examination   - Akimasa Miyanaga ET AL, "Discovery and Assembly-Line Biosynthesis of the Lymphostin Pyrroloquinoline Alkaloid Family of mTOR Inhibitors in Salinispora Bacteria", Journal of the American Chemical Society, (20110831), vol. 133, no. 34, doi:10.1021/ja205655w, ISSN 0002-7863, pages 13311 - 13313, XP055048787

DOI:   http://dx.doi.org/10.1021/ja205655w
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.