EP2340841 - OSTEOGENESIS PROMOTER COMPRISING [4-(METHYLTHIO)PHENYLTHIO]METHANEBISPHOSPHONIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 15.09.2017 Database last updated on 05.12.2024 | Most recent event Tooltip | 06.03.2020 | Lapse of the patent in a contracting state New state(s): TR | published on 08.04.2020 [2020/15] | Applicant(s) | For all designated states Tohoku University 2-1-1, Katahira Aoba-ku Sendai-shi Miyagi 980-8577 / JP | For all designated states Showa University 1-5-8 Hatanodai Shinagawa-ku Tokyo, 1428555 / JP | [2011/27] | Inventor(s) | 01 /
SHINODA, Hisashi c/o TOHOKU UNIVERSITY 2-1-1 Katahira Aoba-ku Sendai-shi Miyagi 980-8577 / JP | 02 /
IGARASHI, Kaoru c/o TOHOKU UNIVERSITY 2-1-1 Katahira Aoba-ku Sendai-shi Miyagi 980-8577 / JP | 03 /
MURAKAMI, shinobu c/o TOHOKU UNIVERSITY 2-1-1 Katahira Aoba-ku Sendai-shi Miyagi 980-8577 / JP | 04 /
SUZUKI, Keiko c/o SHOWA UNIVERSITY 1-5-8 Hatanodai Shinagawa-ku Tokyo 142-8555 / JP | [2016/45] |
Former [2011/27] | 01 /
SHINODA, Hisashi c/o TOHOKU UNIVERSITY 2-1-1 Katahira Aoba-ku Sendai-shi Miyagi 980-8577 / JP | ||
02 /
IGARASHI, Kaoru c/o TOHOKU UNIVERSITY 2-1-1 Katahira Aoba-ku Sendai-shi Miyagi 980-8577 / JP | |||
03 /
MURAKAMI, shinobu c/o TOHOKU UNIVERSITY 2-1-1 Katahira Aoba-ku Sendai-shi Miyagi 980-8577 / JP | |||
04 /
SUZUKI, Keiko c/o SHOWA UNIVERSITY 1-5-8 Hatanodai Shinagawa-ku Tokyo 142-8555 / JP | Representative(s) | J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB | [N/P] |
Former [2016/45] | Woods, Geoffrey Corlett J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB | ||
Former [2011/27] | Woods, Geoffrey Corlett J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5JJ / GB | Application number, filing date | 09811231.1 | 05.08.2009 | [2011/27] | WO2009JP03758 | Priority number, date | JP20080225484 | 03.09.2008 Original published format: JP 2008225484 | [2011/27] | Filing language | JA | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2010026701 | Date: | 11.03.2010 | Language: | JA | [2010/10] | Type: | A1 Application with search report | No.: | EP2340841 | Date: | 06.07.2011 | Language: | EN | [2011/27] | Type: | B1 Patent specification | No.: | EP2340841 | Date: | 09.11.2016 | Language: | EN | [2016/45] | Search report(s) | International search report - published on: | JP | 11.03.2010 | (Supplementary) European search report - dispatched on: | EP | 29.02.2012 | Classification | IPC: | A61K31/663, A61K9/08, A61K47/02, A61P1/02, A61P19/08, A61P43/00 | [2011/27] | CPC: |
A61K31/663 (EP,US);
A61P1/02 (EP);
A61P15/00 (EP);
A61P19/08 (EP);
A61P43/00 (EP)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR [2016/45] |
Former [2011/27] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR | Extension states | AL | Not yet paid | BA | Not yet paid | RS | Not yet paid | Title | German: | OSTEOGENESEPROMOTER MIT [4-(METHYLTHIO)PHENYLTHIO]METHANBISPHOSPHONSÄURE ODER PHARMAZEUTISCH AKZEPTABLEM SALZ DARAUS ALS WIRKSTOFF | [2011/27] | English: | OSTEOGENESIS PROMOTER COMPRISING [4-(METHYLTHIO)PHENYLTHIO]METHANEBISPHOSPHONIC ACID OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AS ACTIVE INGREDIENT | [2011/27] | French: | PROMOTEUR D'OSTÉOGENÈSE COMPRENANT L'ACIDE [4-(MÉTHYLTHIO)PHÉNYLTHIO]MÉTHANEBISPHOSPHONIQUE OU SEL PHARMACEUTIQUEMENT ACCEPTABLE DE CELUI-CI EN TANT QU'INGRÉDIENT ACTIF | [2011/27] | Entry into regional phase | 31.03.2011 | Translation filed | 31.03.2011 | National basic fee paid | 31.03.2011 | Search fee paid | 31.03.2011 | Designation fee(s) paid | 31.03.2011 | Examination fee paid | Examination procedure | 31.03.2011 | Examination requested [2011/27] | 28.09.2012 | Amendment by applicant (claims and/or description) | 12.12.2013 | Despatch of a communication from the examining division (Time limit: M04) | 20.03.2014 | Reply to a communication from the examining division | 01.06.2016 | Communication of intention to grant the patent | 27.09.2016 | Fee for grant paid | 27.09.2016 | Fee for publishing/printing paid | 27.09.2016 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 12.12.2013 | Opposition(s) | 10.08.2017 | No opposition filed within time limit [2017/42] | Fees paid | Renewal fee | 11.08.2011 | Renewal fee patent year 03 | 10.08.2012 | Renewal fee patent year 04 | 19.08.2013 | Renewal fee patent year 05 | 13.08.2014 | Renewal fee patent year 06 | 10.08.2015 | Renewal fee patent year 07 | 11.08.2016 | Renewal fee patent year 08 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 05.08.2009 | AT | 09.11.2016 | BE | 09.11.2016 | CY | 09.11.2016 | CZ | 09.11.2016 | DK | 09.11.2016 | EE | 09.11.2016 | ES | 09.11.2016 | FI | 09.11.2016 | HR | 09.11.2016 | IT | 09.11.2016 | LT | 09.11.2016 | LV | 09.11.2016 | MC | 09.11.2016 | MK | 09.11.2016 | NL | 09.11.2016 | PL | 09.11.2016 | RO | 09.11.2016 | SE | 09.11.2016 | SI | 09.11.2016 | SK | 09.11.2016 | SM | 09.11.2016 | TR | 09.11.2016 | BG | 09.02.2017 | NO | 09.02.2017 | GR | 10.02.2017 | IS | 09.03.2017 | PT | 09.03.2017 | IE | 05.08.2017 | LU | 05.08.2017 | MT | 05.08.2017 | [2020/15] |
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Former [2017/12] | LV | 09.11.2016 | Documents cited: | Search | [XI]US5527940 (KAWABE NORIO [JP], et al) [X] 1-3,6,7 * column 9; examples 2, 3; compounds 12, 13 * * column 27 - column 28; examples 34, 35 * [I] 4,5,8-13; | [I]EP1057488 (TORAY INDUSTRIES [JP]) [I] 1-13 * claims 6, 8 * | International search | [A]WO0038693 (TORAY INDUSTRIES [JP], et al); | [A]WO0108690 (TORAY INDUSTRIES [JP], et al); | [A]WO0117562 (YAMANOUCHI PHARMA CO LTD [JP], et al); | [A]WO9419359 (TORAY INDUSTRIES [JP]); | [A]WO9305052 (TORAY INDUSTRIES [JP]) | [A] - IWASE M ET AL., "A novel bisphosphonate inhibits inflammatory bone resorption in a rat osteolysis model with continuous infusion of polyethylene particles", JOURNAL OF ORTHOPAEDIC RESEARCH, (2002), vol. 20, pages 499 - 505, XP008147712 DOI: http://dx.doi.org/10.1016/S0736-0266(01)00155-3 | [A] - KANGJUNG KIM, "Osteolysis no Yakubutsugakuteki Yobo to Chiryo", JOURNAL OF JAPANESE SOCIETY FOR BIOMATERIALS, (2005), vol. 23, no. 6, pages 390 - 395, XP008148008 | Examination | - SHIBUTANI T ET AL, "Local application of bisphosphonate stimulates alveolar bone formation following tooth extraction", JOURNAL OF BONE AND MINERAL RESEARCH, & TWENTY-SECOND ANNUAL MEETING OF THE AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH; TORONTO, ONTARIO, CANADA; SEPTEMBER 22-26, 2000, (200009), vol. 15, no. Suppl. 1, ISSN 0884-0431, page S339, XP055091863 DOI: http://dx.doi.org/10.1002/jbmr.5650150102 | - BOBYN J D ET AL, "Zoledronic acid causes enhancement of bone growth into porous implants.", THE JOURNAL OF BONE AND JOINT SURGERY. BRITISH VOLUME MAR 2005, (200503), vol. 87, no. 3, ISSN 0301-620X, pages 416 - 420, XP009174868 DOI: http://dx.doi.org/10.1302/0301-620X.87B3.14665 | - KAJIWARA H ET AL, "The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 26, no. 6, ISSN 0142-9612, (20050201), pages 581 - 587, (20050201), XP027767834 | - TANZER MICHAEL ET AL, "The Otto Aufranc Award: bone augmentation around and within porous implants by local bisphosphonate elution.", CLINICAL ORTHOPAEDICS AND RELATED RESEARCH DEC 2005, (200512), vol. 441, ISSN 0009-921X, pages 30 - 39, XP009174866 DOI: http://dx.doi.org/10.1097/01.blo.0000194728.62996.2d | by applicant | JP8026048B | JP3626500B | JP2546067B | WO0105403 | JP3566984B | - TAKAOKA Y, NAGAI H, MORI H, TANAHASHI M, "The effect of MPMBP on experimental arthritis in mice", BIOL PHARMACO BULL, (1997), vol. 20, pages 1147 - 50 | - TANAHASHI M, FUNABA Y, ITOH M, KAWABE N, NAKADATE-MATSUSHIMA T, "Inhibitory effect of MPMBP on rat adjuvant arthritis", PHARMACOLOGY, (1998), vol. 56, pages 242 - 251 | - TANAHASHI M, KOIKE J, KAWABE N, NAKADATE-MATSUSHIMA T, "Inhibitory effect of TRL-530 on inflammatory cytokines in bone marrow of rats with adjuvant arthritis", PHARMACOLOGY, (1998), vol. 56, pages 237 - 241 | - IWASE M, KIM KJ, KOBAYASHI Y, ITOH M, ITOH T, "A novel bisphosphonate inhibits inflammatory bone resorption in a rat osteolysis model with continuous infusion of polyethylene particles", J ORTHOP RES, (2002), vol. 20, pages 499 - 505 | - TANAHASHI M, FUNABA Y, TATEISHI A, KAWABE N, NAKADATE-MATSUSHIMA T, "MPMBP inhibits accumulation of superoxide anions derived from human polymorphonuclear leukocytes and bone resorption induced by activated osteoclasts", PHARMACOLOGY, (1998), vol. 56, pages 125 - 130 | - SIKDER MN, ITOH M, IWATSUKI N, SHINODA H, "Inhibitory effect of a novel bisphosphonate, MPMBP, on dental calculus formation in rats", J PERIODONTOL, (2004), vol. 75, pages 537 - 45 | - SHINODA H, TAKEYAMA S, SUZUKI K, MURAKAMI S, YAMADA S, "A novel bisphosphonate for the treatment of periodontitis", J PHARMACOL SCI, (2008), vol. 106, pages 555 - 558 | - FLEISCH H, "Experimental basis for the use of bisphosphonates in Paget's disease of bone", CLIN ORTHOP RELAT RES, (1987), vol. 217, pages 72 - 78 | - LOWRY ET AL., J BIOCHEM, (1954), vol. 207, pages 19 - 37 | - FELIX, FLEISCH, BIOCHEM J, (1979), vol. 183, pages 73 - 81 | - IGARASHI ET AL., PROSTAGLANDINS, LEUKOTRIENS, AND ESSENTIAL FATTY ACIDS, (1997), vol. 56, pages 12 - 125 | - STEM, KRIEGER, CALCIF TISSUE INT, (1983), vol. 35, pages 172 - 17 | - SUZUKI, TAKEYAMA ET AL., J HISTOCHEM CYTOCHEM, (2005), vol. 53, pages 1525 - 1537 | - TSUCHIMOTO, AZUMA ET AL., JPN J PHARMACOL, (1994), vol. 66, pages 25 - 33 | - DUQUE, RIVAS, J BONE MINER RES, (2007), vol. 22, pages 1603 - 1611 |