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EP2270006
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EP About this file: EP2270006
| EP2270006 - Pyridazine derivatives useful as vanilloid receptor ligands [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 20.01.2012 Database last updated on 03.09.2024 | Most recent event Tooltip | 20.01.2012 | Application deemed to be withdrawn | published on 22.02.2012 [2012/08] | Applicant(s) | For all designated states Amgen, Inc One Amgen Center Drive Thousand Oaks, CA 91320-1799 / US | [2011/01] | Inventor(s) | 01 /
Chakrabarti, Partha P. 4/25 Usha bhavan Maruti Nagar Near Duttawadi Nagpur MH 440023 / IN | 02 /
Chen, Ning 2342 Gillingham Circle Thousand Oaks, CA 91362 / US | 03 /
Doherty, Elizabeth M. 1542 Campbell Avenue Thousand Oaks, CA 91360 / US | 04 /
Dominguez, Celia 8606 Allenwood Road Los Angeles, CA 90046 / US | 05 /
Falsey, James Richard 4943 Hollyglen Court Moorpark, CA 93021 / US | 06 /
Fotsh, Christopher H. 533 Timberwood Avenue Thousand Oaks, CA 91360 / US | 07 /
Hulme, Christopher 9560 Copley Drive Indianapolis, IN 46260 / US | 08 /
Katon, Jodie 6330 Randi Avenue Apt. E115 Woodland Hills, CA 91367 / US | 09 /
Nixey, Thomas 4554 Via Laguna Newbury Park, CA 91320 / US | 10 /
Norman, Mark H. 130 Venus Street Thousand Oaks, CA 91360 / US | 11 /
Ognyanov, Vassil I. 902 West Marcello Avenue Thousand Oaks, CA 91320 / US | 12 /
Pettus, Liping H. 3309 Big Cloud Circle Thousand Oaks, CA 91360 / US | 13 /
Rzasa, Robert Michael 160 Kennedy Avenue Ventura, CA 93003 / US | 14 /
Stec, Markian 11210 Shadyridge Drive Moorpark, CA 93021 / US | 15 /
Wang, Hui-Ling 822 Lynnmere Drive Thousand Oaks, CA 91360 / US | 16 /
Zhu, Jiawang 529 Pomelo Avenue., E. Monterey Park CA 91755 / US | [2011/12] |
| Former [2011/01] | 01 /
Chakrabarti, Partha P. 4/25 Usha bhavan Maruti Nagar Near Duttawadi Nagpur MH 440023 / IN | ||
| 02 /
Chen, Ning 2342 Gillingham Circle Thousand Oaks, CA 91362 / US | |||
| 03 /
Doherty, Elizabeth M. 1542 Campbell Avenue Thousand Oaks, CA 91360 / US | |||
| 04 /
Dominguez, Celia 8606 Allenwood Road Los Angeles, CA 90046 / US | |||
| 05 /
Falsey, James Richard 4943 Hollyglen Court Moorpark, CA 93021 / US | |||
| 06 /
Fotsh, Christopher H. 533 Timberwood Avenue Thousand Oaks, CA 91360 / US | |||
| 07 /
Hulme, Christopher 9560 Copley Drive Indianapolis, IN 46260 / US | |||
| 08 /
Katon, Jodie 6330 Randi Avenue Apt. E115 Woodland Hills, CA 91367 / US | |||
| 09 /
Nixey, Thomas 4554 Via Laguna Newbury Park, CA 91320 / US | |||
| 10 /
Norman, Mark H. 130 Venus Street Thousand Oaks, CA 91360 / US | |||
| 11 /
Ognyanov, Vassil I. 902 West Marcello Avenue Thousand Oaks, CA 91320 / US | |||
| 12 /
Pettus, Liping H. 3309 Big Cloud Circle Thousand Oaks, CA 91360 / US | |||
| 13 /
Rzasa, Robert Michael 160 Kennedy Avenue Ventura, CA 93003 / US | |||
| 14 /
Stec, Markian 11210 Shadyridge Drive Moorpark, CA 93021 / US | |||
| 15 /
Wang, Hui-Ling 822 Lynnmere Drive Thousand Oaks, CA 91360 / US | |||
| 16 /
Zhu, Jiawang 5000 Via Mesita Thousand Oaks, CA 91320 / US | Representative(s) | Grünecker Patent- und Rechtsanwälte PartG mbB Leopoldstraße 4 80802 München / DE | [N/P] |
| Former [2011/01] | Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät Leopoldstrasse 4 80802 München / DE | Application number, filing date | 10008426.8 | 08.08.2003 | [2011/01] | Priority number, date | US20020402422P | 08.08.2002 Original published format: US 402422 P | [2011/01] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP2270006 | Date: | 05.01.2011 | Language: | EN | [2011/01] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 03.11.2010 | Classification | IPC: | C07D417/12, C07D401/12, A61K31/501, A61P29/00 | [2011/01] | CPC: |
C07D231/40 (EP,KR,US);
C07D239/34 (KR);
A61P1/02 (EP);
A61P1/04 (EP);
A61P1/12 (EP);
A61P11/02 (EP);
A61P11/06 (EP);
A61P13/10 (EP);
A61P15/00 (EP);
A61P17/02 (EP);
A61P17/04 (EP);
A61P17/06 (EP);
A61P17/14 (EP);
A61P19/02 (EP);
A61P25/04 (EP);
A61P25/06 (EP);
A61P27/02 (EP);
A61P29/00 (EP);
A61P3/10 (EP);
A61P35/00 (EP);
A61P37/08 (EP);
C07D209/08 (EP,US);
C07D209/12 (EP,US);
C07D209/42 (EP,US);
C07D209/48 (EP,US);
C07D213/26 (EP,KR,US);
C07D213/643 (EP,KR,US);
C07D213/74 (EP,KR,US);
C07D213/75 (EP,KR,US);
C07D215/227 (EP,KR,US);
C07D215/38 (EP,KR,US);
C07D217/04 (EP,KR,US);
C07D231/56 (EP,US);
C07D233/38 (EP,US);
C07D239/42 (EP,KR,US);
C07D239/90 (EP,KR,US);
C07D241/42 (EP,US);
C07D263/56 (EP,US);
C07D265/36 (EP,US);
C07D277/62 (EP,US);
C07D277/82 (EP,US);
C07D307/79 (EP,US);
C07D319/20 (EP,US);
C07D401/12 (EP,US);
C07D403/12 (EP,US);
C07D405/12 (EP,US);
C07D407/12 (EP,US);
C07D409/14 (EP,US);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PT, RO, SE, SI, SK, TR [2011/01] | Extension states | AL | 12.08.2010 | LT | 12.08.2010 | LV | 12.08.2010 | MK | 12.08.2010 | Title | German: | Pyridazin-Derivate zur Verwendung als Vanilloidrezeptorliganden | [2011/01] | English: | Pyridazine derivatives useful as vanilloid receptor ligands | [2011/01] | French: | Dérivés de pyridazine en tant que ligands de récepteur vanilloïde | [2011/01] | Examination procedure | 06.07.2011 | Application deemed to be withdrawn, date of legal effect [2012/08] | 13.09.2011 | Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time [2012/08] | Parent application(s) Tooltip | EP03785220.9 / EP1546116 | EP06008555.2 / EP1717220 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20030785220) is 28.10.2005 | Fees paid | Renewal fee | 12.08.2010 | Renewal fee patent year 03 | 12.08.2010 | Renewal fee patent year 04 | 12.08.2010 | Renewal fee patent year 05 | 12.08.2010 | Renewal fee patent year 06 | 12.08.2010 | Renewal fee patent year 07 | 12.08.2010 | Renewal fee patent year 08 | Penalty fee | Additional fee for renewal fee | 31.08.2011 | 09 M06 Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [X]WO0142241 (MERCK & CO INC [US], et al) [X] 1,3-6* example 7; claims 1,8 *; | [X]WO0204427 (KOWA CO [JP]) [X] 1,3-6; | [XPI]EP1300399 (KOWA CO [JP]) [XP] 1,3-6 * paragraph [0034]; examples 2-21,23,25-27,29,30,32-34,36,37,39; claims 1,8 * [I] 2,7; | [X] - MATSUDA T ET AL, "Synthesis and Bioactivities of Novel Pyridazine Derivatives: Inhibitors of Interleukin-1 Beta Production", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB LNKD- DOI:10.1016/S0960-894X(01)00432-2, (20010903), vol. 11, no. 17, ISSN 0960-894X, pages 2369 - 2372, XP002263195 [X] 1,3-6 * Scheme 5;;; table 2 * DOI: http://dx.doi.org/10.1016/S0960-894X(01)00432-2 | by applicant | EP0039051 | WO0121606 | US6239267 | WO0168653 | US6335180 | US6406908 | WO03049702 | - BIRDER-LA.; KANAI-AJ.; DE-GROAT-WC.; KISS-S.; NEALEN-ML.; BURKE-NE.; DINELEY-KE; WATKINS-S; REYNOLDS-IJ.; CATERINA-MJ., "Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells", PNAS 98, (2001), vol. 23, pages 13396 - 13401 | - CATERINA, M.J; SCHUMACHER, M.A; TOMINAGA, M.; ROSEN, T.A.; LEVINE, J.D.; JULIUS, D, "The capsaicin receptor: a heat-activated ion channel in the pain pathway", NATURE, (1997), vol. 389, pages 816 - 824 | - CATERINA-MJ.; LEFFIER-A.; MALMBERG-AB.; MARTIN-WJ.; TRAFTON-J.; PETERSEN-ZEITZ KR; KOLTZENBURG-M.; BASBAUM-AI.; JULIUS-D, "Impaired nociception and pain sensation in mice lacking the capsaicin receptor", SCIENCE-(WASH-DC), (2000), vol. 288, no. 5464, pages 306 - 313 | - WHITE-G, "The tissue distribution and functional characterization of human VR1", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (2001), vol. 281, no. 5, pages 1183 - 1189 | - DRAY, A., "Therapeutic potential of capsaicin-like molecules", LIFE SCIENCES, (1992), vol. 51, pages 1759 - 1765 | - GAULDIE-SD.; MCQUEEN-DS.; PERTWEE-R.; CHESSELL-IP.; HELLIWELL-RJA; MCLATCHIE-LM.; CLARKE-M.; WINTER-J.; BEVAN-S, "Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints", BRITISH JOURNAL OF PHARMACOLOGY, (2001), vol. 132, no. 3, pages 617 - 621 | - MCINTYRE-P, "Capsaicin sensitivity is associated with expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia", NEUROSCIENCE LETT., (1998), vol. 250, no. 3, pages 177 - 180 | - HOLZER, P., "Capsaicin: Cellular targets, Mechanisms of Action and selectivity for thin sensory neurons", PHARMACOLOGICAL REVIEWS, (1991), vol. 43, no. 2, pages 143 - 201 | - HWANG-SW.; CHO-H.; KWAK-J.; LEE-SY.; KANG-CJ.; JUNG-J.; CHO-S.; MIN-KH.; SUH-YG.; KIM-D., "Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances", PNAS, (2000), vol. 97, no. 11, pages 6155 - 6160 | - MEZEY-E.; TOTH-ZE.; CORTRIGHT-DN.; ARZUBI-MK.; KRAUSE-JE.; ELDE-R.; GUO-A.; BLUMBERG-PM.; SZALLASI-A, "Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human.", PNAS, (2000), vol. 97, no. 7, pages 3655 - 3660 | - NOZAWA-Y.; NISHIHARA-K.; YAMAMOTO-A.; NAKANO-M.; AJIOKA-H.; MATSUURA-N., "Distribution and characterization of vanilloid receptors in the rat stomach", NEUROSCIENCE LETTERS, (2001), vol. 309, no. 1, pages 33 - 36 | - OLAH-Z.; KARAI-L.; IADAROLA-MJ., "Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1", JOURNAL OF BIOLOGICAL CHEMISTRY, (2001), vol. 276, no. 33, pages 31163 - 31170 | - KOHAMA-K., "Tissue distribution of capsaicin receptor in the various organs of rats.", PROC. JPN. ACAD. SER. B, PHYS.-BIOL. SCI., (2000), vol. 76, no. 5, pages 68 - 72 | - PREMKUMAR-LS.; AHERN-GP., "Induction of vanilloid receptor channel activity by protein kinase C", NATURE, (2000), vol. 408, no. 6815, pages 985 - 990 | - SINGH-LK.; PANG-X.; ALEXACOS-N.; LETOURNEAU-R.; THEOHARIDES-TC., "Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin, and substance P: A link to neurogenic skin disorders", BRAIN BEHAV. IMMUN., (1999), vol. 13, no. 3, pages 225 - 239 | - SZALLASI, A.; BLUMBERG-PM, "Vanilloid receptors: New insights enhance potential as a therapeutic target", PAIN, (1996), vol. 68, pages 195 - 208 | - SZALLASI-A.; BLUMBERG-PM., "Vanilloid (capsaicin) receptors and mechanisms", PHARMACOL. REV., (1999), vol. 51, no. 2, pages 159 - 211 | - SZABO-T.; WANG-J.; GONZALEZ-A.; KEDEI-N.; LILE-J.; TREANOR-J.; BLUMBERG-PM., "Pharmacological characterization of the human vanilloid receptor type-(hVRI)", SOCIETY FOR NEUROSCIENCE ABSTRACTS., (2000), vol. 26, no. 1-2, page 634.18 | - TOMINAGA, M.; CATERINA, M.J.; MALMBERG, A.B.; ROSEN, T.A.; GILBERT, H.; SKINNER, K.; RAUMANN, B.E.; BASBAUM, A.I.; JULIUS, D., "The cloned capsaicin receptor integrates multiple pain-producing stimuli", NEURON, (1998), vol. 21, pages 531 - 543 | - YIANGOU-Y.; FACER-P.; DYER-NHC.; CHAN-CLH.; KNOWLES-C.; WILLIAMS-NS.; ANAND-P., "Vanilloid receptor 1 immunoreactivity in inflamed human bowel.", LANCET, (2001), vol. 357, no. 9265, pages 1338 - 1339 | - YIANGOU-Y.; FACER-P.; FORD-A.; BRADY-C.; WISEMAN-O.; FOWLER-CJ.; ANAND-P., "Capsaicin receptor VRl and ATP-gated ion channel P2X3 in human urinary bladder", BJU INTERNATIONAL, (2001), vol. 87, no. 9, pages 774 - 779 | - WANG-H.; BIAN-D.; ZHU-D.; ZAJIC-G.; LOELOFF-R.; LILE-J.; WILD-K.; TREANOR-J.; CURRAN-E., "Inflammation-induced upregulation of VR1 in rat spinal cord and DRG correlates with enhanced nociceptive processing", SOCIETY FOR NEUROSCIENCE ABSTRACTS, (2000), vol. 26, no. 1-2, page 632.15 | - SVENSSON; TUNEK, DRUG METABOLISM REVIEWS, (1988), vol. 165 | - BUNGAARD, J. MED. CHEM., (1989), page 2503 | - ATAEV, A ET AL., TEORETICHESKAYA I EKSPERIMENTAL'NAYA KHIMYA, (1980), vol. 16, no. 2, pages 243 - 249 | - J. MED CHEM., (1988), vol. 41, pages 4062 - 4079 | - J. CHEM. SOC. PERKIN. TRANS., (1999), vol. 1, page 1789 | - DAN, W.D.; BLUM, D.M., J. ORG. CHEM., (1993), vol. 58, pages 7916 - 7917 | - DAN, W.D.; BLUM, D.M., 1. ORG. CHEM., (1993), vol. 58, pages 7916 - 7917 | - AUGUSTIN, M.; REINEMANN, P., Z. CHEM., (1973), vol. 13, pages 12 - 13 | - AUGUSTIN, M.; REINEMANN, P., Z CHEM., (1973), vol. 13, pages 12 - 13 | - J. SCI. INDRESEARCH, (1956), vol. 15C, page 1 | - J. MED CHEM., (1994), vol. 37, page 2106 | - ERICKSON, E. H. ET AL., J. MED CHEM., (1979), vol. 22, no. 7, pages 816 - 823 | - ERICKSON, E. ET AL., J. MED CHEM., (1979), vol. 22, no. 7, pages 816 - 823 | - BLACK, T. H., ALD ACTA, (1983), vol. 16, no. 1, pages 3 - 10 | - BESSON, T. ET AL., TETRAHEDRON, (1995), vol. 55, pages 3197 - 3204 | - BOISNARD, S.; CARBONNELLE, A. C.; ZHU, J., ORG. LET., (2001), vol. 3, pages 2061 - 2064 | - HEWAWASAM, P.; MEANWELL, N. A., TETRAHEDRON LETT., (1994), vol. 35, page 7303 | - WHITE, E. H.; WORTER, H., J. ORG. CHEM., (1966), vol. 31, pages 1484 - 1488 | - TETRAHEDRON LETT., (2000), vol. 41, pages 3705 - 3708 |