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EP2287306
European procedure
Extract from the Register of European Patents
EP About this file: EP2287306
| EP2287306 - RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) [Right-click to bookmark this link] | Status | Patent maintained as amended Status updated on 09.09.2016 Database last updated on 31.08.2024 | Most recent event Tooltip | 09.09.2016 | Patent maintained (B2 publication) | published on 12.10.2016 [2016/41] | Applicant(s) | For all designated states Sirna Therapeutics, Inc. 300 Third Street Cambridge MA 02142 / US | [2014/17] |
| Former [2011/08] | For all designated states Sirna Therapeutics, Inc. 2950 Wilderness Place Boulder, CO 80301 / US | Inventor(s) | 01 /
Mcswiggen, James 4866 Franklin Drive Boulder, CO 80301 / US | 02 /
Beigelman, Leonid 5530 Colt Drive Longmont, CO 80503 / US | 03 /
Chowrira, Bharat 576 Manorwood Lane Louisville, CO 80027 / US | 04 /
Pavco, Pamela 705 Barberry Circle Lafayette, CO 80026 / US | 05 /
Fosnaugh, Kathy 1030 Edinboro Drive Boulder, CO 80305 / US | 06 /
Jamison, Sharon 4985 Twin Lakes Rd 89 Boulder, CO 80301 / US | 07 /
Usman, Nassim 2129 Night Sky Lane Lafayette, CO 80026 / US | 08 /
Thompson, James 705 Barberry Circle Lafayette, CO 80026 / US | [2011/08] | Representative(s) | Potter Clarkson Chapel Quarter Mount Street Nottingham NG1 6HQ / GB | [N/P] |
| Former [2016/41] | Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham NG1 5GG / GB | ||
| Former [2014/17] | Potter Clarkson LLP The Belgrave Centre Talbot Street Nottingham, NG1 5GG / GB | ||
| Former [2011/08] | Hussain, Deeba, et al Merck Sharp & Dohme Limited Hertford Road Hoddesdon Hertfordshire EN11 9BU / GB | Application number, filing date | 10008930.9 | 20.02.2003 | [2011/08] | Priority number, date | US20020358580P | 20.02.2002 Original published format: US 358580 P | US20020363124P | 11.03.2002 Original published format: US 363124 P | US20020386782P | 06.06.2002 Original published format: US 386782 P | US20020406784P | 29.08.2002 Original published format: US 406784 P | US20020408378P | 05.09.2002 Original published format: US 408378 P | US20020409293P | 09.09.2002 Original published format: US 409293 P | US20030440129P | 15.01.2003 Original published format: US 440129 P | [2011/08] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP2287306 | Date: | 23.02.2011 | Language: | EN | [2011/08] | Type: | B1 Patent specification | No.: | EP2287306 | Date: | 22.08.2012 | Language: | EN | [2012/34] | Type: | B2 New European patent specification | No.: | EP2287306 | Date: | 12.10.2016 | Language: | EN | [2016/41] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 03.01.2011 | Classification | IPC: | C12N15/113, A61K31/713 | [2011/08] | CPC: |
C12N15/8218 (EP,US);
A61K47/54 (EP,US);
A61P1/00 (EP);
A61P1/04 (EP);
A61P1/16 (EP);
A61P11/00 (EP);
A61P11/06 (EP);
A61P13/08 (EP);
A61P13/10 (EP);
A61P13/12 (EP);
A61P15/00 (EP);
A61P17/00 (EP);
A61P17/02 (EP);
A61P19/00 (EP);
A61P19/02 (EP);
A61P21/00 (EP);
A61P25/00 (EP);
A61P25/02 (EP);
A61P25/08 (EP);
A61P25/14 (EP);
A61P25/16 (EP);
A61P25/28 (EP);
A61P27/02 (EP);
A61P27/16 (EP);
A61P29/00 (EP);
A61P3/00 (EP);
A61P3/10 (EP);
A61P31/00 (EP);
A61P31/04 (EP);
A61P31/10 (EP);
A61P31/12 (EP);
A61P31/14 (EP);
A61P31/16 (EP);
A61P31/18 (EP);
A61P31/20 (EP);
A61P31/22 (EP);
A61P35/00 (EP);
A61P35/02 (EP);
A61P37/00 (EP);
A61P37/04 (EP);
A61P37/06 (EP);
A61P37/08 (EP);
A61P41/00 (EP);
A61P43/00 (EP);
A61P5/00 (EP);
A61P9/00 (EP);
A61P9/10 (EP);
C07H21/02 (EP,US);
C12N15/111 (EP,US);
C12N15/1131 (EP,US);
C12N15/1138 (EP,US);
A61K38/00 (EP,US);
C12N2310/111 (EP,US);
C12N2310/14 (EP,US);
C12N2310/315 (EP,US);
C12N2310/317 (EP,US);
C12N2310/318 (EP,US);
C12N2310/321 (EP,US);
C12N2310/322 (EP,US);
C12N2310/332 (EP,US);
C12N2310/344 (EP,US);
C12N2310/346 (EP,US);
C12N2310/53 (EP,US);
| C-Set: |
C12N2310/321, C12N2310/3521 (EP,US)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PT, SE, SI, SK, TR [2016/41] |
| Former [2011/08] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PT, SE, SI, SK, TR | Title | German: | RNA-Interferenz-vermittelte Inhibition von Genexpression unter Verwendung kurzer interferierender Nukleinsäure (siNA) | [2011/08] | English: | RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA) | [2011/08] | French: | Inhibition au moyen d'interférence ARN d'une expression de gène utilisant un acide nucléique à petit interférent (siNA) | [2011/08] | Examination procedure | 23.08.2011 | Examination requested [2011/40] | 05.10.2011 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time | 13.12.2011 | Amendment by applicant (claims and/or description) | 17.02.2012 | Communication of intention to grant the patent | 20.06.2012 | Fee for grant paid | 20.06.2012 | Fee for publishing/printing paid | Parent application(s) Tooltip | EP03743684.7 / EP1423406 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20030743684) is 25.07.2005 | Opposition(s) | Opponent(s) | 01
22.05.2013
05.06.2013
ADMISSIBLE Quark Pharmaceuticals, Inc. 6501 Dumbarton Circle Fremont, California 94555 / US Opponent's representative Almond-Martin, Carol, et al, et al Ernest Gutmann - Yves Plasseraud S.A.S. 88, Boulevard des Belges 69452 Lyon Cedex 06 / FR | 02
21.05.2013
10.03.2014
WITHDRAWN Alnylam Pharmaceuticals Inc. 300 Third street, Third Floor Cambridge MA 02142 / US Opponent's representative Müller-Boré & Partner Patentanwälte PartG mbB Friedenheimer Brücke 21 80639 München / DE | [N/P] |
| Former [2014/16] | |||
| Opponent(s) | 01
22.05.2013
05.06.2013
ADMISSIBLE Quark Pharmaceuticals, Inc. 6501 Dumbarton Circle Fremont, California 94555 / US Opponent's representative Almond-Martin, Carol, et al, et al Ernest Gutmann - Yves Plasseraud S.A.S. 88, Boulevard des Belges 69452 Lyon Cedex 06 / FR | ||
| 02
21.05.2013
10.03.2014
WITHDRAWN Alnylam Pharmaceuticals Inc. 300 Third street, Third Floor Cambridge MA 02142 / US Opponent's representative Müller-Boré & Partner Patentanwälte PartG mbB Friedenheimer Brücke 21 80639 München / DE | |||
| Former [2014/13] | |||
| Opponent(s) | 01
22.05.2013
05.06.2013
ADMISSIBLE Quark Pharmaceuticals, Inc. 6501 Dumbarton Circle Fremont, California 94555 / US Opponent's representative Almond-Martin, Carol, et al, et al Ernest Gutmann - Yves Plasseraud S.A.S. 88, Boulevard des Belges 69452 Lyon Cedex 06 / FR | ||
| 02
21.05.2013
28.05.2013
ADMISSIBLE Alnylam Pharmaceuticals Inc. 300 Third street, Third Floor Cambridge MA 02142 / US Opponent's representative Müller-Boré & Partner Patentanwälte PartG mbB Friedenheimer Brücke 21 80639 München / DE | |||
| Former [2014/12] | |||
| Opponent(s) | 01
22.05.2013
05.06.2013
ADMISSIBLE Quark Pharmaceuticals, Inc. 6501 Dumbarton Circle Fremont, California 94555 / US Opponent's representative Sellin, Carole, et al, et al Ernest Gutmann - Yves Plasseraud S.A.S 88, Boulevard des Belges 69452 Lyon Cedex 06 / FR | ||
| 02
21.05.2013
28.05.2013
ADMISSIBLE Alnylam Pharmaceuticals Inc. 300 Third street, Third Floor Cambridge MA 02142 / US Opponent's representative Müller-Boré & Partner Patentanwälte PartG mbB Grafinger Straße 2 81671 München / DE | |||
| Former [2013/26] | |||
| Opponent(s) | 01
22.05.2013
Quark Pharmaceuticals, Inc. 6501 Dumbarton Circle Fremont, California 94555 / US Opponent's representative Sellin, Carole, et al, et al Ernest Gutmann - Yves Plasseraud S.A.S 88, Boulevard des Belges 69452 Lyon Cedex 06 / FR | ||
| 02
21.05.2013
Alnylam Pharmaceuticals Inc. 300 Third street, Third Floor Cambridge MA 02142 / US Opponent's representative Lenhard, Konstanze Müller-Boré & Partner Grafinger Straße 2 81671 München / DE | 17.06.2013 | Invitation to proprietor to file observations on the notice of opposition | 24.12.2013 | Reply of patent proprietor to notice(s) of opposition | 25.11.2015 | Legal effect of interlocutory decision in opposition | 25.11.2015 | Date of oral proceedings | 28.01.2016 | Despatch of minutes of oral proceedings | 17.02.2016 | Despatch of interlocutory decision in opposition | 02.06.2016 | Despatch of communication that the patent will be maintained as amended | 01.09.2016 | Fee for printing new specification paid | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report | 13.12.2011 | Request for further processing filed | 13.12.2011 | Full payment received (date of receipt of payment) Request granted | 23.12.2011 | Decision despatched | Fees paid | Renewal fee | 27.12.2010 | Renewal fee patent year 03 | 27.12.2010 | Renewal fee patent year 04 | 27.12.2010 | Renewal fee patent year 05 | 27.12.2010 | Renewal fee patent year 06 | 27.12.2010 | Renewal fee patent year 07 | 27.12.2010 | Renewal fee patent year 08 | 08.02.2011 | Renewal fee patent year 09 | 07.02.2012 | Renewal fee patent year 10 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 20.02.2003 | CY | 22.08.2012 | CZ | 22.08.2012 | EE | 22.08.2012 | SI | 22.08.2012 | SK | 22.08.2012 | TR | 22.08.2012 | BG | 22.11.2012 | GR | 23.11.2012 | PT | 24.12.2012 | LU | 20.02.2013 | MC | 28.02.2013 | AT | 20.02.2014 | FI | 20.02.2014 | IE | 20.02.2014 | IT | 20.02.2014 | ES | 21.02.2014 | SE | 21.02.2014 | BE | 28.02.2014 | DK | 28.02.2014 | [2016/33] |
| Former [2016/29] | HU | 20.02.2003 | |
| CY | 22.08.2012 | ||
| CZ | 22.08.2012 | ||
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| TR | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| LU | 20.02.2013 | ||
| MC | 28.02.2013 | ||
| AT | 20.02.2014 | ||
| FI | 20.02.2014 | ||
| IE | 20.02.2014 | ||
| IT | 20.02.2014 | ||
| SE | 21.02.2014 | ||
| BE | 28.02.2014 | ||
| DK | 28.02.2014 | ||
| Former [2015/34] | HU | 20.02.2003 | |
| CY | 22.08.2012 | ||
| CZ | 22.08.2012 | ||
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| TR | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| LU | 20.02.2013 | ||
| MC | 28.02.2013 | ||
| AT | 20.02.2014 | ||
| FI | 20.02.2014 | ||
| IE | 20.02.2014 | ||
| SE | 21.02.2014 | ||
| BE | 28.02.2014 | ||
| DK | 28.02.2014 | ||
| Former [2015/32] | CY | 22.08.2012 | |
| CZ | 22.08.2012 | ||
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| TR | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| MC | 28.02.2013 | ||
| AT | 20.02.2014 | ||
| FI | 20.02.2014 | ||
| IE | 20.02.2014 | ||
| SE | 21.02.2014 | ||
| BE | 28.02.2014 | ||
| DK | 28.02.2014 | ||
| Former [2015/08] | CY | 22.08.2012 | |
| CZ | 22.08.2012 | ||
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| MC | 28.02.2013 | ||
| AT | 20.02.2014 | ||
| FI | 20.02.2014 | ||
| IE | 20.02.2014 | ||
| SE | 21.02.2014 | ||
| BE | 28.02.2014 | ||
| DK | 28.02.2014 | ||
| Former [2015/07] | CY | 22.08.2012 | |
| CZ | 22.08.2012 | ||
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| MC | 28.02.2013 | ||
| AT | 20.02.2014 | ||
| FI | 20.02.2014 | ||
| IE | 20.02.2014 | ||
| SE | 21.02.2014 | ||
| Former [2014/51] | CY | 22.08.2012 | |
| CZ | 22.08.2012 | ||
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| MC | 28.02.2013 | ||
| AT | 20.02.2014 | ||
| FI | 20.02.2014 | ||
| SE | 21.02.2014 | ||
| Former [2014/50] | CY | 22.08.2012 | |
| CZ | 22.08.2012 | ||
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| MC | 28.02.2013 | ||
| FI | 20.02.2014 | ||
| SE | 21.02.2014 | ||
| Former [2014/49] | CY | 22.08.2012 | |
| CZ | 22.08.2012 | ||
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| MC | 28.02.2013 | ||
| FI | 20.02.2014 | ||
| Former [2013/52] | CY | 22.08.2012 | |
| CZ | 22.08.2012 | ||
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| MC | 28.02.2013 | ||
| Former [2013/42] | CZ | 22.08.2012 | |
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| MC | 28.02.2013 | ||
| Former [2013/34] | CZ | 22.08.2012 | |
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| BG | 22.11.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| Former [2013/23] | CZ | 22.08.2012 | |
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| SK | 22.08.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| Former [2013/22] | CZ | 22.08.2012 | |
| EE | 22.08.2012 | ||
| SI | 22.08.2012 | ||
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| Former [2013/13] | SI | 22.08.2012 | |
| GR | 23.11.2012 | ||
| PT | 24.12.2012 | ||
| Former [2013/11] | SI | 22.08.2012 | |
| GR | 23.11.2012 | Documents cited: | Search | [A]WO0136646 (CANCER RES CAMPAIGN TECH [GB], et al) [A] 1-27* page 6, line 29 - page 7, line 8 *; | [A] - ELBASHIR S M ET AL, Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate, EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, PAGE(S) 6877 - 6888, (20011203), ISSN 0261-4189, XP002225998 [A] 1-27 * page 6881, column r, paragraph 2 - page 6882, column l, paragraph 1 * * figure 4 * DOI: http://dx.doi.org/10.1093/emboj/20.23.6877 | [A] - PARRISH S ET AL, Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference, MOLECULAR CELL, CELL PRESS, CAMBRIDGE, MA, US, PAGE(S) 1077 - 1087, (20001101), ISSN 1097-2765, XP002226298 [A] 1-27 * page 1081, column l, paragraph 1 - column r, paragraph 4 * * figure 5 * DOI: http://dx.doi.org/10.1016/S1097-2765(00)00106-4 | [A] - BASS B L, RNA interference: the short answer, NATURE, NATURE PUBLISHING GROUP, LONDON, GB, PAGE(S) 428 - 429, (20010524), ISSN 0028-0836, XP002239989 [A] 1-27 * page 428, column r, paragraph 3 - page 429, column l, paragraph 1 * DOI: http://dx.doi.org/10.1038/35078175 | by applicant | WO8902439 | WO9103162 | WO9207065 | WO9315187 | WO9323569 | WO9402595 | US5334711 | WO9506731 | WO9511910 | WO9610391 | WO9610390 | WO9610392 | WO9618736 | US5624803 | US5627053 | US5631360 | WO9726270 | US5672695 | US5716824 | WO9813526 | US5804683 | US5831071 | US5854038 | WO9905094 | WO9904819 | WO9907409 | WO9914226 | US5889136 | US5902880 | WO9931262 | WO9932619 | WO9949029 | WO9953050 | WO9954459 | US5998203 | US6001311 | US6008400 | WO0001846 | US6054576 | WO0044914 | CA2359180 | WO0044895 | US6111086 | US6117657 | WO0053722 | WO0063364 | WO0066604 | US6146886 | US6162909 | WO0104313 | WO0129058 | WO0136646 | WO0138551 | WO0142443 | US6248878 | WO0149844 | WO0153475 | WO0168836 | WO0170944 | WO0170949 | AU4037501 | WO0172774 | US6300074 | WO0175164 | US6303773 | WO0192513 | US6353098 | US6362323 | WO0238805 | US6395713 | WO0244321 | WO02055692 | WO02055693 | US6437117 | EP1144623 | US6469158 | US6506559 | - FIRE ET AL., NATURE, (1998), vol. 391, page 806 | - FIRE ET AL., TRENDS GENET., (1999), vol. 15, page 358 | - BERSTEIN ET AL., NATURE, (2001), vol. 409, page 363 | - ELBASHIR ET AL., GENES DEV., (2001), vol. 15, page 188 | - HUTVAGNER ET AL., SCIENCE, (2001), vol. 293, page 834 | - WIANNY; GOETZ, NATURE CELL BIOL., (1999), vol. 2, page 70 | - HAMMOND ET AL., NATURE, (2000), vol. 404, page 293 | - ELBASHIR ET AL., NATURE, (2001), vol. 411, page 494 | - ELBASHIR ET AL., EMBO J., (2001), vol. 20, page 6877 | - NYKANEN ET AL., CELL, (2001), vol. 107, page 309 | - PARRISH ET AL., MOLECULAR CELL, (2000), vol. 6, pages 1977 - 1087 | - TUSCHL, CHEM. 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