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Extract from the Register of European Patents

EP About this file: EP2308964

EP2308964 - Culturing method of mesenchymal stem cell [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.09.2014
Database last updated on 31.08.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
GC Corporation
76-1, Hasunuma-cho, Itabashi-ku Tokyo
174-8585 / JP
For all designated states
Two Cells Co., Ltd
4-5-17-501, Danbara Minami-ku
Hiroshima-shi, Hiroshima 732-0811 / JP
[2011/15]
Inventor(s)01 / Sakai, Yuhiro
c/o GC Corporation
76-1, Hasunuma-cho
Itabashi-ku
Tokyo 174-8585 / JP
02 / Yamanaka, Katsuyuki
c/o GC Corporation
76-1, Hasunuma-cho
Itabashi-ku
Tokyo 174-8585 / JP
03 / Takeda, Mika
c/o Two Cells Co., Ltd
4-5-17-501, Danbara
Minami-ku
Hiroshima-shi, Hiroshima / JP
04 / Okura, Tomohisa
c/o Two Cells Co., Ltd
4-5-17-501, Danbara
Minami-ku
Hiroshima-shi, Hiroshima / JP
05 / Tsuji, Koichiro
c/o Two Cells Co., Ltd
4-5-17-501, Danbara
Minami-ku
Hiroshima-shi, Hiroshima / JP
 [2013/47]
Former [2011/15]01 / Sakai, Yuhiro
c/o GC Corporation 76-1, Hasunuma-cho, Itabashi-ku
Tokyo 174-8585 / JP
02 / Yamanaka, Katsuyuki
c/o GC Corporation 76-1, Hasunuma-cho, Itabashi-ku
Tokyo 174-8585 / JP
03 / Takeda, Mika
c/o Two Cells Co., Ltd 4-5-17-501, Danbara Minami-ku
Hiroshima-shi, Hiroshima / JP
04 / Okura, Tomohisa
c/o Two Cells Co., Ltd 4-5-17-501, Danbara Minami-ku
Hiroshima-shi, Hiroshima / JP
05 / Tsuji, Koichiro
c/o Two Cells Co., Ltd 4-5-17-501, Danbara Minami-ku
Hiroshima-shi, Hiroshima / JP
Representative(s)Müller-Boré & Partner Patentanwälte PartG mbB
Friedenheimer Brücke 21
80639 München / DE
[N/P]
Former [2013/47]Müller-Boré & Partner Patentanwälte
Grafinger Straße 2
81671 München / DE
Former [2011/15]Müller-Boré & Partner Patentanwälte
Grafinger Straße 2
81671 München / DE
Application number, filing date10010934.727.09.2010
[2011/15]
Priority number, dateJP2009022298128.09.2009         Original published format: JP 2009222981
[2011/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2308964
Date:13.04.2011
Language:EN
[2011/15]
Type: B1 Patent specification 
No.:EP2308964
Date:20.11.2013
Language:EN
[2013/47]
Search report(s)(Supplementary) European search report - dispatched on:EP13.12.2010
ClassificationIPC:C12N5/0775
[2013/30]
CPC:
C12N5/0663 (EP,US); C12N2500/50 (EP,US)
Former IPC [2011/15]C12N5/077
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2011/15]
TitleGerman:Kultivierungsverfahren für mesenchymale Stammzellen[2011/15]
English:Culturing method of mesenchymal stem cell[2011/15]
French:Procédé de culture de cellule souche mésenchymateuse[2011/15]
Examination procedure30.05.2011Amendment by applicant (claims and/or description)
01.06.2011Examination requested  [2011/28]
05.07.2013Communication of intention to grant the patent
02.10.2013Fee for grant paid
02.10.2013Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  05.07.2013
Opposition(s)21.08.2014No opposition filed within time limit [2014/44]
Fees paidRenewal fee
27.09.2012Renewal fee patent year 03
30.09.2013Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU27.09.2010
AL20.11.2013
AT20.11.2013
BG20.11.2013
CY20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
MC20.11.2013
MK20.11.2013
MT20.11.2013
PL20.11.2013
RO20.11.2013
SI20.11.2013
SK20.11.2013
SM20.11.2013
TR20.11.2013
NO20.02.2014
GR21.02.2014
IS20.03.2014
PT20.03.2014
[2018/46]
Former [2018/30]HU27.09.2010
AT20.11.2013
BG20.11.2013
CY20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
MC20.11.2013
MK20.11.2013
MT20.11.2013
PL20.11.2013
RO20.11.2013
SI20.11.2013
SK20.11.2013
SM20.11.2013
TR20.11.2013
NO20.02.2014
GR21.02.2014
IS20.03.2014
PT20.03.2014
Former [2016/33]HU27.09.2010
AT20.11.2013
BG20.11.2013
CY20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
MC20.11.2013
MT20.11.2013
PL20.11.2013
RO20.11.2013
SI20.11.2013
SK20.11.2013
SM20.11.2013
TR20.11.2013
NO20.02.2014
GR21.02.2014
IS20.03.2014
PT20.03.2014
Former [2016/32]HU27.09.2010
AT20.11.2013
BG20.11.2013
CY20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
MC20.11.2013
MT20.11.2013
PL20.11.2013
RO20.11.2013
SI20.11.2013
SK20.11.2013
SM20.11.2013
NO20.02.2014
GR21.02.2014
IS20.03.2014
PT20.03.2014
Former [2016/31]AT20.11.2013
BG20.11.2013
CY20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
MC20.11.2013
MT20.11.2013
PL20.11.2013
RO20.11.2013
SI20.11.2013
SK20.11.2013
SM20.11.2013
NO20.02.2014
GR21.02.2014
IS20.03.2014
PT20.03.2014
Former [2016/28]AT20.11.2013
BG20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
MC20.11.2013
MT20.11.2013
PL20.11.2013
RO20.11.2013
SI20.11.2013
SK20.11.2013
SM20.11.2013
NO20.02.2014
GR21.02.2014
IS20.03.2014
PT20.03.2014
Former [2016/22]AT20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
MC20.11.2013
PL20.11.2013
RO20.11.2013
SI20.11.2013
SK20.11.2013
SM20.11.2013
NO20.02.2014
IS20.03.2014
PT20.03.2014
Former [2015/20]AT20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
MC20.11.2013
PL20.11.2013
RO20.11.2013
SI20.11.2013
SK20.11.2013
NO20.02.2014
IS20.03.2014
PT20.03.2014
Former [2015/14]AT20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
PL20.11.2013
RO20.11.2013
SI20.11.2013
SK20.11.2013
NO20.02.2014
IS20.03.2014
PT20.03.2014
Former [2014/41]AT20.11.2013
CZ20.11.2013
DK20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
PL20.11.2013
RO20.11.2013
SK20.11.2013
NO20.02.2014
IS20.03.2014
PT20.03.2014
Former [2014/37]AT20.11.2013
CZ20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
PL20.11.2013
RO20.11.2013
SK20.11.2013
NO20.02.2014
IS20.03.2014
PT20.03.2014
Former [2014/36]AT20.11.2013
EE20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
NO20.02.2014
IS20.03.2014
PT20.03.2014
Former [2014/28]AT20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
NO20.02.2014
IS20.03.2014
PT20.03.2014
Former [2014/25]AT20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
LV20.11.2013
NO20.02.2014
IS20.03.2014
Former [2014/24]AT20.11.2013
ES20.11.2013
FI20.11.2013
HR20.11.2013
LT20.11.2013
NO20.02.2014
IS20.03.2014
Former [2014/23]FI20.11.2013
HR20.11.2013
LT20.11.2013
NO20.02.2014
IS20.03.2014
Former [2014/22]FI20.11.2013
LT20.11.2013
NO20.02.2014
Former [2014/20]LT20.11.2013
NO20.02.2014
Documents cited:Search[A]US2002045260  (HUNG SHIH-CHIEH [TW], et al) [A] 1,2 * paragraph [0034] - paragraph [0035]; examples 1-2 *;
 [A]  - WAGNER ET AL, "Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood", EXPERIMENTAL HEMATOLOGY, ELSEVIER INC, US, (20051101), vol. 33, no. 11, doi:10.1016/J.EXPHEM.2005.07.003, ISSN 0301-472X, pages 1402 - 1416, XP005136979 [A] 1,2 * page 1402 - page 1404 *

DOI:   http://dx.doi.org/10.1016/j.exphem.2005.07.003
 [A]  - ZVAIFLER NATHAN J ET AL, "Mesenchymal precursor cells in the blood of normal individuals", ARTHRITIS RESEARCH, CURRENT SCIENCE, LONDON, GB, (20000831), vol. 2, no. 6, doi:10.1186/AR130, ISSN 1465-9905, pages 477 - 488, XP021026898 [A] 1,2 * page 477 - page 478 * * page 485 *

DOI:   http://dx.doi.org/10.1186/ar130
 [A]  - KASTEN P ET AL, "INSTANT STEM CELL THERAPY: CHARACTERIZATION AND CONCENTRATION OF HUMAN MESENCHYMAL STEM CELLS IN VITRO", EUROPEAN CELLS AND MATERIALS, SWISS SOCIETY FOR BIOMATERIALS, CH, (20080701), vol. 16, ISSN 1473-2262, pages 47 - 55, XP009141726 [A] 1,2 * the whole document *
 [A]  - CATERSON EDWARD J ET AL, "Human marrow-derived mesenchymal progenitor cells: Isolation, culture expansion, and analysis of differentiation", MOLECULAR BIOTECHNOLOGY, HUMANA PRESS, INC, US, (20020301), vol. 20, no. 3, ISSN 1073-6085, pages 245 - 256, XP009141649 [A] 1,2 * page 246 * * page 252 - page 253 *
 [A]  - BARI DE C ET AL, "Multipotent mesenchymal stem cells from adult human synovial membrane", ARTHRITIS & RHEUMATISM, JOHN WILEY & SONS, INC, US, (20010801), vol. 44, no. 8, doi:10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P, ISSN 0004-3591, pages 1928 - 1942, XP002266867 [A] 1,2 * page 1929, column l, paragraph l - column r, paragraph 2 *

DOI:   http://dx.doi.org/10.1002/1529-0131(200108)44:8<1928::AID-ART331>3.0.CO;2-P
 [A]  - ZHAO P ET AL, "Human amniotic mesenchymal cells have some characteristics of cardiomyocytes", TRANSPLANTATION, WILLIAMS AND WILKINS, BALTIMORE US, (20050315), vol. 79, no. 5, doi:10.1097/01.TP.0000149503.92433.39, ISSN 0041-1337, pages 528 - 535, XP003012076 [A] 1,2 * page 528, column r, paragraph l - page 529, column l, paragraph f *

DOI:   http://dx.doi.org/10.1097/01.TP.0000149503.92433.39
 [A]  - SHIGEMATSU M ET AL, "PROLIFERATION AND DIFFERENTIATION OF UNILOCULAR FAT CELLS IN THE BONE MARROW", CELL STRUCTURE AND FUNCTION, JAPAN SOCIETY FOR CELL BIOLOGY (JSCB), KYOTO, JP, (19990401), vol. 24, no. 2, doi:10.1247/CSF.24.89, ISSN 0386-7196, pages 89 - 100, XP009067456 [A] 1,2 * page 89 - page 91; figure 1 *

DOI:   http://dx.doi.org/10.1247/csf.24.89
 [A]  - KUHLMANN U ET AL, "PRODUCTION OF DOUBLED HAPLOID LINES IN FREQUENCIES SUFFICIENT FOR BARLEY BREEDING PROGRAMS", PLANT CELL REPORTS, SPRINGER VERLAG, DE, (19890101), vol. 8, no. 2, ISSN 0721-7714, pages 78 - 81, XP009141693 [A] 1,2 * the whole document *
 [A]  - GE healthcare, "Instructions Cell preparation media: Ficoll-Plaque", (20081201), URL: http://www.gelifesciences.com/aptrix/upp00919.nsf/Content/B667315FF1FF28F4C1257628001D284E/$file/28403956AC.pdf, (20101124), XP007915955 [A] 1,2 * the whole document *
 [A]  - GE Healthcare, "Instructions Percoll PLUS/Percoll", (20090501), URL: http://www.gelifesciences.com/aptrix/upp00919.nsf/Content/9621EB268A7D5AD1C1257628001D31E9/$file/28903834AB_.pdf, (20101130), XP007916039 [A] 1,2 * the whole document *
by applicantWO0183709
 WO0246501
 JP2004254519
    - TOHOKU, J EXP MED, (2008), vol. 216, no. 2, pages 149 - 56
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.