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Extract from the Register of European Patents

EP About this file: EP2363479

EP2363479 - Oligoribonucucleotide for inhibiting the expression of a predefined gene [Right-click to bookmark this link]
StatusOpposition rejected
Status updated on  12.10.2018
Database last updated on 09.09.2024
FormerThe patent has been granted
Status updated on  24.06.2018
Most recent event   Tooltip12.10.2018Opposition rejectedpublished on 14.11.2018  [2018/46]
Applicant(s)For all designated states
Alnylam Europe AG
Fritz-Hornschuch-Strasse 9
95326 Kulmbach / DE
[2011/36]
Inventor(s)01 / Kreutzer, Roland
c/o Alnylam Pharmaceutical, Inc.
300 Third Street
Cambridge, Massachusetts 02142 / US
02 / Limmer, Stephan
c/o Alnylam Pharmaceutical, Inc.
300 Third Street
Cambridge, Massachusetts 02142 / US
 [2011/36]
Representative(s)Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
[2016/28]
Former [2011/36]Vossius & Partner
Siebertstrasse 4
81675 München / DE
Application number, filing date10011217.629.01.2000
[2011/36]
Priority number, dateDE1999100371330.01.1999         Original published format: DE 19903713
DE1999105656824.11.1999         Original published format: DE 19956568
[2011/36]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report 
No.:EP2363479
Date:07.09.2011
Language:DE
[2011/36]
Type: B1 Patent specification 
No.:EP2363479
Date:13.07.2016
Language:DE
[2016/28]
Search report(s)(Supplementary) European search report - dispatched on:EP08.08.2011
ClassificationIPC:C12N15/11, A61K31/713, A61K9/127
[2011/36]
CPC:
A61K31/713 (EP,US); C12N15/113 (US); A61P25/28 (EP);
A61P31/00 (EP); A61P31/04 (EP); A61P31/10 (EP);
A61P31/12 (EP); A61P31/20 (EP); A61P35/00 (EP);
A61P43/00 (EP); C12N15/111 (EP,US); A61K38/00 (EP,US);
C12N2310/111 (EP,US); C12N2310/14 (EP,US); C12N2310/53 (EP,US);
C12N2330/30 (EP,US); Y02A50/30 (EP,US) (-)
Designated contracting statesAT,   BE,   CH,   CY,   DE,   DK,   ES,   FI,   FR,   GB,   GR,   IE,   IT,   LI,   LU,   MC,   NL,   PT,   SE [2011/36]
TitleGerman:Oligoribonukleotid zur Hemmung der Expression eines vorgegebenen Gens[2011/36]
English:Oligoribonucucleotide for inhibiting the expression of a predefined gene[2011/36]
French:Oligoribonucléotide destiné à inhiber l'expression d'un gène donné[2011/36]
Examination procedure27.10.2010Examination requested  [2011/36]
09.10.2013Despatch of a communication from the examining division (Time limit: M04)
19.02.2014Reply to a communication from the examining division
02.09.2015Despatch of a communication from the examining division (Time limit: M04)
05.11.2015Reply to a communication from the examining division
18.01.2016Communication of intention to grant the patent
25.05.2016Fee for grant paid
25.05.2016Fee for publishing/printing paid
25.05.2016Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP00910510.7  / EP1144623
EP02003683.6  / EP1214945
EP05002454.6  / EP1550719
EP06025389.5  / EP1798285
Divisional application(s)EP15194718.1  / EP3018207
Opposition(s)Opponent(s)01  13.04.2017    ADMISSIBLE
Silence Therapeutics GmbH
Robert-Rössle-Strasse 10
13125 Berlin / DE
Opponent's representative
Stephen, Robert John
CMS Cameron McKenna Nabarro
Olswang LLP
Cannon Place
78 Cannon Street
London EC4N 6AF / GB
 [N/P]
Former [2017/20]
Opponent(s)01  13.04.2017    ADMISSIBLE
Silence Therapeutics GmbH
Robert-Rössle-Strasse 10
13125 Berlin / DE
Opponent's representative
Stephen, Robert John
Olswang LLP 90 High Holborn
London WC1V 6XX / GB
18.05.2017Invitation to proprietor to file observations on the notice of opposition
26.09.2017Reply of patent proprietor to notice(s) of opposition
18.06.2018Cancellation of oral proceeding that was planned for 02.07.2018
25.06.2018Date of despatch of rejection of opposition
02.07.2018Date of oral proceedings
05.07.2018Legal effect of rejection of opposition [2018/46]
Fees paidRenewal fee
13.01.2011Renewal fee patent year 03
13.01.2011Renewal fee patent year 04
13.01.2011Renewal fee patent year 05
13.01.2011Renewal fee patent year 06
13.01.2011Renewal fee patent year 07
13.01.2011Renewal fee patent year 08
13.01.2011Renewal fee patent year 09
13.01.2011Renewal fee patent year 10
13.01.2011Renewal fee patent year 11
25.01.2011Renewal fee patent year 12
25.01.2012Renewal fee patent year 13
25.01.2013Renewal fee patent year 14
27.01.2014Renewal fee patent year 15
27.01.2015Renewal fee patent year 16
27.01.2016Renewal fee patent year 17
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Documents cited:Search[XY]WO9219732  (GENSET SA [FR]) [X] 1-4,6-11 * Zusammenfassung, Seite 11 Z.18-28, Seiten 12-13, Seite 15 Z.22 bis Seite 20 Z.1, Seiten 33 und 46, Abbildungen 1-6 * [Y] 5,12-15;
 [Y]WO9705266  (INTROGENE BV [NL], et al) [Y] 13,14 * the whole document *;
 [Y]WO9805770  (DEUTCHES KREBSFORSCHUNGSZENTRU [DE], et al) [Y] 1-15 * Zusammenfassung, Seiten 2-3 *;
 [AP]WO9953050  (COMMW SCIENT IND RES ORG [AU], et al) [AP] 1-32* the whole document *;
 [E]WO0063364  (AMERICAN HOME PROD [US], et al) [E] 1-15 * page 3, lines 11-16 * * page 8, lines 6-8 * * page 9, lines 5-7,16,17 * * page 17, lines 16,17 * * page 18, lines 17-19 * * page 19, lines 4-6 * * page 20, lines 8-12, 17-22 * * page 23, lines 8-14 * * page 27, lines 1-10 * * page 29, lines 4-6,18-20 * * page 28, lines 25,26 * * page 30, lines 17-20 *;
 [Y]  - UHLMANN E ET AL, "ANTISENSE OLIGONUCLEOTIDES: A NEW THERAPEUTIC PRINCIPLE", CHEMICAL REVIEWS,US,AMERICAN CHEMICAL SOCIETY. EASTON, (19900601), vol. 90, no. 4, ISSN 0009-2665, pages 543 - 584, XP000141412 [Y] 1-15 * Seiten 558,565-566,574-575 *

DOI:   http://dx.doi.org/10.1021/cr00102a001
 [Y]  - GRYAZNOV S M ET AL, "Template controlled coupling and recombination of oligonucleotide blocks containing thiophosphoryl groups.", NUCLEIC ACIDS RESEARCH. 25 MAR 1993, (19930325), vol. 21, no. 6, ISSN 0305-1048, pages 1403 - 1408, XP002326215 [Y] 8-11 * the whole document *
 [Y]  - SKRIPKIN E ET AL, "Psoralen crosslinking between human immunodeficiency virus type 1 RNA and primer tRNA3(Lys).", NUCLEIC ACIDS RESEARCH. 1 FEB 1996, (19960201), vol. 24, no. 3, ISSN 0305-1048, pages 509 - 514, XP002326216 [Y] 8-11 * the whole document *

DOI:   http://dx.doi.org/10.1093/nar/24.3.509
 [A]  - MONTGOMERY M K ET AL, "DOUBLE-STRANDED RNA AS A MEDIATOR IN SEQUENCE-SPECIFIC GENETIC SILENCING AND CO-SUPPRESSION", TRENDS IN GENETICS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, (199807), vol. 14, no. 7, ISSN 0168-9525, pages 255 - 258, XP002939521 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0168-9525(98)01510-8
 [A]  - FIRE ANDREW ET AL, "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, (19980219), vol. 391, no. 6669, ISSN 0028-0836, pages 806 - 811, XP002199982 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1038/35888
ExaminationWO0136646
OppositionWO9932619
 WO0044914
 WO2004015107
    - WU et al., "Identification and partial purification of human double strand RNase activity. A novel terminating mechanism for oligoribonucleotide antisense drugs", J. Biol. Chem., (19980000), vol. 273, no. 5, pages 2532 - 2542, XP002234692

DOI:   http://dx.doi.org/10.1074/jbc.273.5.2532
    - ELBASHIR SM et al., "Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate", The EMBO Journal, (20010000), vol. 20, no. 23, pages 6877 - 6888, XP002225998

DOI:   http://dx.doi.org/10.1093/emboj/20.23.6877
    - CZAUDEMA F et al., "Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells", Nucleic Acids Research, (20030000), vol. 31, no. 11, pages 1 - 12, XP002270732

DOI:   http://dx.doi.org/10.1093/nar/gkg393
    - SCHWARZ DS et al., "Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways", Molecular Cell, (20020900), vol. 10, pages 537 - 548, XP002257820

DOI:   http://dx.doi.org/10.1016/S1097-2765(02)00651-2
    - DOENCH JG et al., "siRNAs can function as miRNAs", Genes & Dev, (20030215), vol. 17, no. 4, pages 438 - 442, XP002982608

DOI:   http://dx.doi.org/10.1101/gad.1064703
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    - ZHENG X. et al., "Activation of the protein kinase PKR by short double-stranded RNAs with single-stranded tails", RNA, (20041200), vol. 10, pages 1934 - 1945, XP055377706

DOI:   http://dx.doi.org/10.1261/rna.7150804
    - MONTGOMERY et al., "DOUBLE-STRANDED RNA AS A MEDIATOR IN SEQUENCE-SPECIFIC GENETIC SILENCING AND CO-SUPPRESSION", TRENDS IN GENETICS, (19980700), vol. 14, no. 7, pages 255 - 258, XP002939521

DOI:   http://dx.doi.org/10.1016/S0168-9525(98)01510-8
    - HOMUNG et al., "Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7", Nature Medicine, (20050300), vol. 11, no. 3, pages 263 - 270, XP002371477

DOI:   http://dx.doi.org/10.1038/nm1191
    - JUDGE et al., "Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA", Nature Biotechnology, (20050400), vol. 23, no. 4, pages 457 - 462, XP002371480

DOI:   http://dx.doi.org/10.1038/nbt1081
    - SLEDZ, C.A. et al., "ACTIVATION OF THE INTERFERON SYSTEM BY SHORT-INTERFERING RNAS", Nature Cell Biology, (20030900), vol. 5, no. 9, pages 834 - 839, XP009043516

DOI:   http://dx.doi.org/10.1038/ncb1038
    - Beigelman et al., "CHEMICAL MODIFICATION OF HAMMERHEAD RIBOZYMES. ÖCATALYTIC ACTIVITY AND NUCLEASE RESISTANCE", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (19951027), vol. 270, no. 43, pages 25702 - 25708, XP000601905

DOI:   http://dx.doi.org/10.1074/jbc.270.43.25702
    - FIRE et al., "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans", Nature, (19980219), vol. 39, pages 806 - 811, XP002095876

DOI:   http://dx.doi.org/10.1038/35888
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