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Extract from the Register of European Patents

EP About this file: EP2332534

EP2332534 - Phenol and benzoquinone derivatives for use in the treatment of mitochondrial diseases and modulation of energy biomarkers [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  20.09.2019
Database last updated on 19.07.2024
FormerThe patent has been granted
Status updated on  12.10.2018
FormerGrant of patent is intended
Status updated on  07.06.2018
FormerExamination is in progress
Status updated on  06.10.2017
Most recent event   Tooltip16.07.2021Lapse of the patent in a contracting state
New state(s): HU		published on 18.08.2021  [2021/33]
Applicant(s)For all designated states
BIOELECTRON TECHNOLOGY CORPORATION
350 North Bernardo Avenue
Mountain View, CA 94043 / US
[2017/27]
Former [2011/24]For all designated states
Edison Pharmaceuticals, Inc.
350 North Bernardo Avenue
Mountain View, CA 94043 / US
Inventor(s)01 / Miller, Guy, M.
350 North Bernardo Avenue
Mountain View, CA 94043 / US
02 / Hecht, Sidney, M.
Department of Chemistry
University of Virginia
McCormick Road
P.O.Box 400319
Charlottesville, VA 22904-4319 / US
03 / Jankowski, Orion, D.
350 North Bernardo Avenue
Mountain View, CA 94043 / US
04 / Wesson, Kieron, E.
350 North Bernardo Avenue
Mountain View, CA 94043 / US
05 / Mollard, Paul
350 North Bernardo Avenue
Mountain View, CA 94043 / US
 [2018/46]
Former [2011/24]01 / Miller, Guy, M.
350 North Bernardo Avenue
Mountain View, CA 94043 / US
02 / Hecht, Sidney, M.
Department of Chemistry University of Virginia Maccormick Road P.O.Box 400319
Charlottesville, VA 22904-4319 / US
03 / Jankowski, Orion, D.
350 North Bernardo Avenue
Mountain View, CA 94043 / US
04 / Wesson, Kieron, E.
350 North Bernardo Avenue
Mountain View, CA 94043 / US
05 / Mollard, Paul
350 North Bernardo Avenue
Mountain View, CA 94043 / US
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2018/46]J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2011/24]Sexton, Jane Helen
J.A. Kemp & Co. 14 South Square Gray's Inn
London WC1R 5JJ / GB
Application number, filing date10015055.622.02.2007
[2011/24]
Priority number, dateUS20060776028P22.02.2006         Original published format: US 776028 P
US20060873395P06.12.2006         Original published format: US 873395 P
[2011/24]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2332534
Date:15.06.2011
Language:EN
[2011/24]
Type: B1 Patent specification 
No.:EP2332534
Date:14.11.2018
Language:EN
[2018/46]
Search report(s)(Supplementary) European search report - dispatched on:EP14.04.2011
ClassificationIPC:A61K31/355, A61P3/00, A61P25/28, A61K31/05
[2011/24]
CPC:
A61K31/05 (EP); A61K31/355 (EP); A61P25/28 (EP);
A61P3/00 (EP); C07C215/56 (EP); C07C39/08 (EP);
C07C39/11 (EP); C07C39/19 (EP); C07C39/245 (EP);
C07C403/04 (EP); C07C403/08 (EP); C07C403/18 (EP);
C07C50/02 (EP); C07C50/06 (EP); C07C50/24 (EP);
C07C50/28 (EP); C07C2601/16 (EP) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/46]
Former [2011/24]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  NL,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Phenol- und Benzoquinonederivate zur Verwendung in der Behandlung von Mitochondriopathien und zur Modulation von Energie-Biomarkern[2011/24]
English:Phenol and benzoquinone derivatives for use in the treatment of mitochondrial diseases and modulation of energy biomarkers[2011/24]
French:Dérivés du phénol et de la benzoquinone pour leur utilisation dans le traitement des maladies mitochondriales et dans la modulation de biomarqueurs énergétiques[2018/22]
Former [2011/24]Dérivés du phénol et de la benzoquinone pour leur utilisation dans le traitement de maladies mitochondriales et dans la modulation de biomarqueurs énergétiques
Examination procedure14.12.2011Examination requested  [2012/04]
23.04.2012Amendment by applicant (claims and/or description)
02.07.2012Despatch of a communication from the examining division (Time limit: M08)
22.04.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
02.07.2013Reply to a communication from the examining division
10.07.2014Despatch of a communication from the examining division (Time limit: M06)
20.01.2015Reply to a communication from the examining division
05.02.2016Despatch of a communication from the examining division (Time limit: M04)
15.06.2016Reply to a communication from the examining division
27.09.2017Despatch of a communication from the examining division (Time limit: M06)
03.04.2018Reply to a communication from the examining division
08.06.2018Communication of intention to grant the patent
03.10.2018Fee for grant paid
03.10.2018Fee for publishing/printing paid
03.10.2018Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP07751472.7  / EP1986636
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20070751472) is  01.12.2008
Opposition(s)15.08.2019No opposition filed within time limit [2019/43]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
02.07.2013Request for further processing filed
02.07.2013Full payment received (date of receipt of payment)
Request granted
15.07.2013Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
23.04.2012Request for further processing filed
23.04.2012Full payment received (date of receipt of payment)
Request granted
07.05.2012Decision despatched
Fees paidRenewal fee
24.02.2011Renewal fee patent year 03
24.02.2011Renewal fee patent year 04
15.02.2011Renewal fee patent year 05
15.02.2012Renewal fee patent year 06
12.02.2013Renewal fee patent year 07
12.02.2014Renewal fee patent year 08
11.02.2015Renewal fee patent year 09
10.02.2016Renewal fee patent year 10
10.02.2017Renewal fee patent year 11
14.02.2018Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.02.2007
AT14.11.2018
CY14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
MC14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
SI14.11.2018
SK14.11.2018
TR14.11.2018
BG14.02.2019
GR15.02.2019
IE22.02.2019
LU22.02.2019
BE28.02.2019
IS14.03.2019
PT14.03.2019
[2021/33]
Former [2021/26]AT14.11.2018
CY14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
MC14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
SI14.11.2018
SK14.11.2018
TR14.11.2018
BG14.02.2019
GR15.02.2019
IE22.02.2019
LU22.02.2019
BE28.02.2019
IS14.03.2019
PT14.03.2019
Former [2020/17]AT14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
MC14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
SI14.11.2018
SK14.11.2018
TR14.11.2018
BG14.02.2019
GR15.02.2019
IE22.02.2019
LU22.02.2019
BE28.02.2019
IS14.03.2019
PT14.03.2019
Former [2020/12]AT14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
MC14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
SI14.11.2018
SK14.11.2018
BG14.02.2019
GR15.02.2019
IE22.02.2019
LU22.02.2019
BE28.02.2019
IS14.03.2019
PT14.03.2019
Former [2020/09]AT14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
MC14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
SI14.11.2018
SK14.11.2018
BG14.02.2019
GR15.02.2019
IE22.02.2019
LU22.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/50]AT14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
MC14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
SI14.11.2018
SK14.11.2018
BG14.02.2019
GR15.02.2019
LU22.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/47]AT14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
MC14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
SK14.11.2018
BG14.02.2019
GR15.02.2019
LU22.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/45]AT14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
MC14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
SK14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/40]AT14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
SK14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/37]AT14.11.2018
CZ14.11.2018
DK14.11.2018
EE14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
NL14.11.2018
PL14.11.2018
RO14.11.2018
SE14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/35]AT14.11.2018
CZ14.11.2018
DK14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
NL14.11.2018
PL14.11.2018
SE14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/34]AT14.11.2018
DK14.11.2018
ES14.11.2018
FI14.11.2018
IT14.11.2018
LT14.11.2018
LV14.11.2018
NL14.11.2018
SE14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/26]AT14.11.2018
ES14.11.2018
FI14.11.2018
LT14.11.2018
LV14.11.2018
NL14.11.2018
SE14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/24]AT14.11.2018
ES14.11.2018
FI14.11.2018
LT14.11.2018
LV14.11.2018
NL14.11.2018
SE14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
Former [2019/23]AT14.11.2018
ES14.11.2018
FI14.11.2018
LT14.11.2018
LV14.11.2018
NL14.11.2018
BG14.02.2019
IS14.03.2019
Former [2019/22]FI14.11.2018
LT14.11.2018
BG14.02.2019
IS14.03.2019
Former [2019/21]FI14.11.2018
LT14.11.2018
IS14.03.2019
Former [2019/20]LT14.11.2018
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 [I]  - JAUSLIN MATTHIAS L ET AL, "Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants.", THE FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY. OCT 2003, (200310), vol. 17, no. 13, ISSN 1530-6860, pages 1972 - 1974, XP002409006 [I] 1-15 * abstract * * figures 1-2 *
 [I]  - WALTER L ET AL, "Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US, (20000922), vol. 275, no. 38, doi:10.1074/JBC.M004128200, ISSN 0021-9258, pages 29521 - 29527, XP002474841 [I] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1074/jbc.M004128200
 [I]  - GILLE L ET AL, "Effects of tocopheryl quinone on the heart: Model experiments with xanthine oxidase, heart mitochondria, and isolated perfused rat hearts", FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE, US, (20010415), vol. 30, no. 8, doi:10.1016/S0891-5849(01)00475-0, ISSN 0891-5849, pages 865 - 876, XP002474923 [I] 1-15 * page 868; compound TQ * * abstract *

DOI:   http://dx.doi.org/10.1016/S0891-5849(01)00475-0
 [A]  - LIPSHUTZ B H ET AL, "An Expeditious Route to CoQn, Vitamins K1 and K2, and Related Allylated para-Quinones Utilizing Ni(0) Catalysis", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (19980212), vol. 54, no. 7, doi:10.1016/S0040-4020(97)10222-8, ISSN 0040-4020, pages 1241 - 1253, XP004107470 [A] 1-15 * table 1 *

DOI:   http://dx.doi.org/10.1016/S0040-4020(97)10222-8
by applicantWO2004003565
 US2005043553
 US2005065099
 US2005067303
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.