EP2269636 - Chlamydia trachomatis antigens for vaccine and diagnostic use [Right-click to bookmark this link] | Status | The application has been refused Status updated on 15.11.2013 Database last updated on 31.08.2024 | Most recent event Tooltip | 15.11.2013 | Refusal of application | published on 18.12.2013 [2013/51] | Applicant(s) | For all designated states Statens Serum Institut Artillerivej 5 2300 Copenhagen S / DK | [2012/50] |
Former [2011/35] | For all designated states Statens Serum Institut Orestads Boulevard 5 2300 Copenhagen S / DK | ||
Former [2011/01] | For all designated states Statens Serum Institut Artillerivej 5 2300 Copenhagen S / DK | Inventor(s) | 01 /
Theisen, Michael Hegnsvej 155 2850 Naerum / DK | 02 /
Olsen, Anja Jacob Bulls Allé 121 2860 Søborg / DK | 03 /
Leah, Robert Henrik Thomsensvej 26 3460 Birkerød / DK | 04 /
Follmann, Frank Morkhoj Parkalle 8D 2860 Soborg / DK | 05 /
Jensen, Klaus Gyngemose Parkvej 33, 5.th. 2860 Soborg / DK | 06 /
Andersen, Peter Sparreholmvej 47 2700 Brønshøj / DK | [2011/07] |
Former [2011/01] | 01 /
Theisen, Michael N.J. Fjords Allé 20, 4. Th 1957 Frederiksberg C / DK | ||
02 /
Olsen, Anja Jacob Bulls Allé 121 2860 Søborg / DK | |||
03 /
Leah, Robert Henrik Thomsensvej 26 3460 Birkerød / DK | |||
04 /
Follmann, Frank Frejasgade 9, 3.th 2200 Copenhagen N / DK | |||
05 /
Jensen, Klaus Skyttegade 2, 2.tv 2200 Copenhagen N / DK | |||
06 /
Andersen, Peter Sparreholmvej 47 2700 Brønshøj / DK | Representative(s) | Plougmann Vingtoft a/s Strandvejen 70 2900 Hellerup / DK | [N/P] |
Former [2011/01] | Plougmann & Vingtoft A/S Sundkrogsgade 9 P.O. Box 831 2100 Copenhagen Ø / DK | Application number, filing date | 10178623.4 | 11.10.2005 | [2011/01] | Priority number, date | DK20040001633 | 25.10.2004 Original published format: DK 200401633 | DK20050001069 | 19.07.2005 Original published format: DK 200501069 | [2011/01] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP2269636 | Date: | 05.01.2011 | Language: | EN | [2011/01] | Type: | A3 Search report | No.: | EP2269636 | Date: | 06.04.2011 | [2011/14] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 09.03.2011 | Classification | IPC: | A61K39/118, C07K16/12, G01N33/569 | [2011/01] | CPC: |
C07K14/295 (EP,US);
A61K39/118 (EP,US);
A61P31/04 (EP);
A61P37/04 (EP)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2011/01] | Title | German: | Chlamydia trachomatis-Antigene als Impfstoff und zur diagnostischen Verwendung | [2011/01] | English: | Chlamydia trachomatis antigens for vaccine and diagnostic use | [2011/01] | French: | Antigènes de Chlamydia trachomatis pour une utilisation en tant que vaccin et pour le diagnostic | [2011/01] | Examination procedure | 06.10.2011 | Amendment by applicant (claims and/or description) | 06.10.2011 | Examination requested [2011/46] | 01.06.2012 | Despatch of a communication from the examining division (Time limit: M04) | 09.10.2012 | Reply to a communication from the examining division | 05.07.2013 | Application refused, date of legal effect [2013/51] | 05.07.2013 | Date of oral proceedings | 11.07.2013 | Minutes of oral proceedings despatched | 02.08.2013 | Despatch of communication that the application is refused, reason: substantive examination [2013/51] | Parent application(s) Tooltip | EP05790937.6 / EP1812058 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20050790937) is 15.02.2008 | Fees paid | Renewal fee | 23.09.2010 | Renewal fee patent year 03 | 23.09.2010 | Renewal fee patent year 04 | 23.09.2010 | Renewal fee patent year 05 | 23.09.2010 | Renewal fee patent year 06 | 24.10.2011 | Renewal fee patent year 07 | 15.10.2012 | Renewal fee patent year 08 | 15.10.2013 | Renewal fee patent year 09 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [I]WO9928475 (GENSET SA [FR], et al) [I] 1-16 * page 93, line 31 - page 94, line 20 * * page 47, line 8 - line 18 *; | [E]WO2006050571 (UNIV QUEENSLAND [AU], et al) [E] 1-16 * page 3, line 31 - page 8, line 31; compound CT561; sequence 20 * * page 24, line 32 - page 26, line 1 * * page 31, line 25 - page 39, line 13 * * page 56, line 4 - line 7 * | [I] - "Chlamydia trachomatis secreted protein.", Geneseq, (19991007), Database accession no. AAY37652, URL: EBI, XP002624761 [I] 1-16 * the whole document * | [A] - SLEPENKIN ANATOLY ET AL, "Temporal expression of type III secretion genes of Chlamydia pneumoniae.", INFECTION AND IMMUNITY, (200305), vol. 71, no. 5, ISSN 0019-9567, pages 2555 - 2562, XP002624762 [A] 1-16 * the whole document * DOI: http://dx.doi.org/10.1128/IAI.71.5.2555-2562.2003 | [A] - STEPHENS RICHARD S ET AL, "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis", SCIENCE (WASHINGTON D C), (19981023), vol. 282, no. 5389, ISSN 0036-8075, pages 754 - 759, XP002624763 [A] 1-16 * page 757, column r, paragraph 2 * DOI: http://dx.doi.org/10.1126/science.282.5389.754 | [ ] - "SubName: Full=Yop proteins translocation protein L;", UniProt, (19981101), Database accession no. O84565, URL: EBI [ ] * compound . * | by applicant | WO9928475 | WO9927105 | WO9640718 | US4608251 | US4601903 | US4599231 | US4599230 | US4816567 | US6136958 | - ALDERSON, M.R.; BEMENT, T.; DAY, C.H.; ZHU, L.; MOLESH, D.; SLEIKY, Y. A. W.; COLER, R.; LEWINSOHN, D.M.; REED, S.G.; DILLON, D.C., "Wxpression cloning of an immunodominant family of Mycobacterium tuberculosos antigen using human CD4+ T cells", J. EXP. MED., (2000), vol. 191, no. 3, pages 551 - 9 | - ANDERSEN, P.; I. HERON, "Simultaneous electroelution of whole SDS- polyacrylamide gels for the direct cellular analysis of complex protein mixtures", J IMMUNOL METHODS, (1993), vol. 161, no. 1, pages 29 - 39 | - BRANDT, L.; M. ELHAY ET AL., "ESAT-6 subunit vaccination against Mycobacterium tuberculosis", INFECT IMMUN, (2000), vol. 68, no. 2, pages 791 - 5 | - "Human immunity to Chlamydia", BRUNHAM, R. C., Chlamydia Intracellular biology, Pathoqenesis, and Immunity. R. S. Stephens, ASM PRESS, (1999), pages 211 - 238 | - COTE-SIERRA, J.; E. JONGERT ET AL., "A new membrane-bound Oprl lipoprotein expression vector. High production of heterologous fusion proteins in gram (-) bacteria and the implications for oral vaccination", GENE, (1998), vol. 221, no. 1, pages 25 - 34 | - COTTER, T. W.; Q. MENG ET AL., "Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection", INFECT.LMMUN., (1995), vol. 63, no. 12, pages 4704 - 4714 | - FLING, S. P.; R. A. SUTHERLAND ET AL., "CD8+ T cells recognize an inclusion membrane-associated protein from the vacuolar pathogen Chlamydia trachomatis", PROC. NATI.ACAD.SCI. U.S.A, (2001), vol. 98, no. 3, pages 1160 - 1165 | - GOODALL, J. C.; G. YEO ET AL., "Identification of Chlamydia trachomatis antigens recognized by human CD4+ T lymphocytes by screening an expression library", EUR.J.LMMUNOL., (2001), vol. 31, no. 5, pages 1513 - 1522 | - GOSSELIN, E. J.; K. WARDWELL ET AL., "Enhanced antigen presentation using human Fc gamma receptor (monocyte/macrophage)-specific immunogens", J IMMUNOL, (1992), vol. 149, no. 11, pages 3477 - 81 | - GRAYSTON, J. T.; S. P. WANG, "The potential for vaccine against infection of the genital tract with Chlamydia trachomatis", SEX TRANSM.DIS., (1978), vol. 5, pages 73 - 77 | - GU, L.; W. M. WENMAN ET AL., "Chlamydia trachomatis RNA polymerase alpha subunit: sequence and structural analysis", J.BACTERIOL., (1995), vol. 177, no. 9, pages 2594 - 2601 | - HARBOE, M.; T. OETTINGER ET AL., "Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG", INFECT IMMUN, (1996), vol. 64, no. 1, pages 16 - 22 | - HASSELL, A. B.; D. J. REYNOLDS ET AL., "Identification of T-cell stimulatory antigens of Chlamydia trachomatis using synovial fluid-derived T-cell clones", IMMUNOLOGY, (1993), vol. 79, no. 4, pages 513 - 519 | - KATZ, B. P.; B. E. BATTEIGER ET AL., "Effect of prior sexually transmitted disease on the isolation of Chlamydia trachomatis", SEX TRANSM.DIS., (1987), vol. 14, no. 3, pages 160 - 164 | - KILGUS, J.; T. JARDETZKY ET AL., "Analysis of the permissive association of a malaria T cell epitope with DR molecules", J IMMUNOL, (1991), vol. 146, no. 1, pages 307 - 15 | - KUBO, A.; R. S. STEPHENS, "Characterization and functional analysis of PorB, a Chlamydia porin and neutralizing target", MOL.MICROBIOL., (2000), vol. 38, no. 4, pages 772 - 780 | - LAVERDA, D.; L. N. ALBANESE ET AL., "Seroreactivity to Chlamydia trachomatis Hsp10 correlates with severity of human genital tract disease", INFECT.LMMUN., (2000), vol. 68, no. 1, pages 303 - 309 | - MCCAFFERTY, J.; A. D. GRIFFITHS ET AL., "Phage antibodies: filamentous phage displaying antibody variable domains", NATURE, (1990), vol. 348, no. 6301, pages 552 - 4 | - MORRISON, R. P.; H. D. CALDWELL, "Immunity to murine chlamydial genital infection.", INFECT IMMUN, (2002), vol. 70, no. 6, pages 2741 - 51 | - MORRISON, S. G.; H. SU ET AL., "Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4(+) T cells but not CD8(+) T cells", LNFECT. LMMUN., (2000), vol. 68, no. 12, pages 6979 - 6987 | - ORTIZ, L.; K. P. DEMICK ET AL., "Chlamydia trachomatis major outer membrane protein (MOMP) epitopes that activate HLA class II-restricted T cells from infected humans", J IMMUNOL, (1996), vol. 157, no. 10, pages 4554 - 67 | - PAL, S.; K. M. BARNHART ET AL., "Vaccination of mice with DNA plasmids coding for the Chlamydia trachomatis major outer membrane protein elicits an immune response but fails to protect against a genital challenge", VACCINE, (1999), vol. 17, no. 5, pages 459 - 465 | - PAL, S.; I. THEODOR ET AL., "Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein can elicit a protective immune response against a genital challenge", INFECT.LMMUN., (2001), vol. 69, no. 10, pages 6240 - 6247 | - PEARSON, W. R.; D. J. LIPMAN, "Improved tools for biological sequence comparison", PROC NATL ACAD SCI U S A, (1988), vol. 85, no. 8, pages 2444 - 8 | - RAVN, P.; A. DEMISSIE ET AL., "Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis", J INFECT DIS, (1999), vol. 179, no. 3, pages 637 - 45 | - ROLPH, M. S.; I. A. RAMSHAW, "Recombinant viruses as vaccines and immunological tools", CURR OPIN IMMUNOL, (1997), vol. 9, no. 4, pages 517 - 24 | - ROSENKRANDS, I.; E. M. AGGER ET AL., "Cationic liposomes containing mycobacterial lipids: a new powerful Th1 adjuvant system", INFECT IMMUN, (2005), vol. 73, no. 9, pages 5817 - 26 | - SCHACHTER, J.; J. MONCADA ET AL., "Nonculture methods for diagnosing chlamydial infection in patients with trachoma: a clue to the pathogenesis of the disease?", J.LNFECT.DIS., (1988), vol. 158, no. 6, pages 1347 - 1352 | - SHAW, J.; V. GRUND ET AL., "Dendritic cells pulsed with a recombinant chlamydial major outer membrane protein antigen elicit a CD4(+) type 2 rather than type 1 immune response that is not protective", INFECT.LMMUN., (2002), vol. 70, no. 3, pages 1097 - 1105 | - SINIGAGLIA, F.; M. GUTTINGER ET AL., "A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules", NATURE, (1988), vol. 336, no. 6201, pages 778 - 80 | - STARNBACH, M. N.; W. P. LOOMIS ET AL., "An inclusion membrane protein from Chlamydia trachomatis enters the MHC class I pathway and stimulates a CD8+ T cell response", J IMMUNOL, (2003), vol. 171, no. 9, pages 4742 - 9 | - STEPHENS, R. S.; S. KALMAN ET AL., "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis", SCIENCE, (1998), vol. 282, no. 5389, pages 754 - 759 | - STEPHENS, R. S.; E. A. WAGAR ET AL., "High-resolution mapping of serovar-specific and common antigenic determinants of the major outer membrane protein of Chlamydia trachomatis", J.EXP.MED., (1988), vol. 167, no. 3, pages 817 - 831 | - STRYHN, A.; L. O. PEDERSEN ET AL., "Peptide binding specificity of major histocompatibility complex class I resolved into an array of apparently independent subspecificities: quantitation by peptide libraries and improved prediction of binding", EUR J IMMUNOL, (1996), vol. 26, no. 8, pages 1911 - 8 | - SU, H.; H. D. CALDWELL, "CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract", INFECT.LMMUN., (1995), vol. 63, no. 9, pages 3302 - 3308 | - SU, H.; M. PARNELL ET AL., "Protective efficacy of a parenterally administered MOMP-derived synthetic oligopeptide vaccine in a murine model of Chlamydia trachomatis genital tract infection: serum neutralizing IgG antibodies do not protect against chlamydial genital tract infection", VACCINE, (1995), vol. 13, no. 11, pages 1023 - 1032 | - THEISEN, M.; S. SOE ET AL., "A Plasmodium falciparum GLURP-MSP3 chimeric protein; expression in Lactococcus lactis, immunogenicity and induction of biologically active antibodies", VACCINE, (2004), vol. 22, no. 9-10, pages 1188 - 98 | - TIPPLES, G.; G. MCCLARTY, "Cloning and expression of the Chlamydia trachomatis gene for CTP synthetase", J.BIOI.CHEM., (1995), vol. 270, no. 14, pages 7908 - 7914 | - ULMER, J. B.; J. J. DONNELLY ET AL., "Heterologous protection against influenza by injection of DNA encoding a viral protein", SCIENCE, (1993), vol. 259, no. 5102, pages 1745 - 9 | - WANG, S. P.; J. T. GRAYSTON ET AL., "Trachoma vaccine studies in monkeys", AM.J.OPHTHALMOL., (1967), vol. 63, no. 5, page 30 | - ZHANG, D. J.; X. YANG ET AL., "Characterization of immune responses following intramuscular DNA immunization with the MOMP gene of Chlamydia trachomatis mouse pneumonitis strain", IMMUNOLOGY, (1999), vol. 96, no. 2, pages 314 - 321 | - ZHANG, Y.; J. TAO ET AL., "Elongation factor Ts of Chlamydia trachomatis: structure of the gene and properties of the protein", ARCH.BIOCHEM.BIOPHYS., (1997), vol. 344, no. 1, pages 43 - 52 |