Extract from the Register of European Patents

EP About this file: EP2338995

EP2338995 - Interfering RNA duplex having blunt-ends and 3'-modifications [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  14.12.2012
Database last updated on 11.04.2026
Most recent event   Tooltip14.12.2012Application deemed to be withdrawnpublished on 16.01.2013  [2013/03]
Applicant(s)For:BE  BG  CH  CY  CZ  DE  DK  EE  ES  FI  FR  GB  GR  HU  IE  IT  LI  LU  MC  NL  PL  PT  RO  SE  SI  SK  TR 
Novartis AG
Lichtstrasse 35
4056 Basel / CH
For:AT 
Novartis Pharma GmbH
Brunner Strasse 59
1230 Wien / AT
[2011/26]
Inventor(s)01 / Weiler, Jan
Kandelstrasse 4
79541, Lörrach-Haagen / DE
02 / Hall, Jonathan
Ramstelweg 19
4143, Dornach / CH
03 / Bologna, Jean-Charles
10, rue du Grand-Pont
1950, Sion / CH
04 / Natt, François Jean-Charles
Traugott Meyer-Strasse 5
4147, Aesch / CH
05 / Häner, Robert
Scheuermattweg 23
3043, Uettligen / CH
 [2011/26]
Representative(s)Kassow, Anders
Novartis Pharma AG
Patent Department
4002 Basel / CH
[N/P]
Former [2011/26]Kassow, Anders
Novartis Pharma AG Patent Department
4002 Basel / CH
Application number, filing date10184568.327.08.2004
[2011/26]
Priority number, dateUS20030498514P28.08.2003         Original published format: US 498514 P
[2011/26]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2338995
Date:29.06.2011
Language:EN
[2011/26]
Type: A3 Search report 
No.:EP2338995
Date:11.01.2012
Language:EN
[2012/02]
Search report(s)(Supplementary) European search report - dispatched on:EP08.12.2011
ClassificationIPC:C12N15/11, A61K48/00
[2011/26]
CPC:
C12N15/111 (EP,US); C12N15/11 (KR); A61K48/00 (KR);
A61P31/00 (EP); A61P31/04 (EP); A61P31/12 (EP);
A61P35/00 (EP); A61P43/00 (EP); C12N2310/14 (EP,US);
C12N2310/311 (EP,US); C12N2310/315 (EP,US); C12N2310/321 (EP,US);
C12N2310/322 (EP,US); C12N2310/332 (EP,US); C12N2320/51 (EP,US);
C12N2330/30 (EP,US) (-)
C-Set:
C12N2310/321, C12N2310/3525 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/26]
Extension statesHR11.07.2012
LT11.07.2012
LV11.07.2012
TitleGerman:Interfering RNA Duplex umfassend glatte Ende und 3'-Modifizierungen[2011/26]
English:Interfering RNA duplex having blunt-ends and 3'-modifications[2011/26]
French:Double hélice d'ARN d'interférence possédant des extrémités franches et des modifications en 3'[2011/26]
Examination procedure11.07.2012Examination requested  [2012/34]
12.07.2012Application deemed to be withdrawn, date of legal effect  [2013/03]
21.08.2012Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time  [2013/03]
Parent application(s)   TooltipEP04764573.4  / EP1660657
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20040764573) is  19.01.2010
Fees paidRenewal fee
31.01.2011Renewal fee patent year 03
31.01.2011Renewal fee patent year 04
31.01.2011Renewal fee patent year 05
31.01.2011Renewal fee patent year 06
31.01.2011Renewal fee patent year 07
11.08.2011Renewal fee patent year 08
10.08.2012Renewal fee patent year 09
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Documents cited:Search[Y] WO02096927  (RIBOZYME PHARM INC et al.)
 [AP] EP1389637  (ATUGEN AG et al.)
 [AP] WO2004015107  (ATUGEN AG et al.)
 [AP] WO03070918  (RIBOZYME PHARM INC et al.)
 [Y] WO2004092383  (SIRNA THERAPEUTICS INC et al.)
 [A] WO2004090105  (DHARMACON INC et al.)
 [Y]   CZAUDERNA F ET AL: "Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells", NUCLEIC ACIDS RESEARCH, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 31, no. 11, 1 June 2003 (2003-06-01), pages 2705 - 2716, XP002270732, ISSN: 0305-1048

DOI:   http://dx.doi.org/10.1093/nar/gkg393
 [A]   HAMADA M ET AL: "EFFECTS OF RNA INTERFERENCE IN GENE EXPRESSION (RNAI) IN CULTURED MAMMALAIN CELLS OF MISMATCHES AND THE INTRODUCTION OF CHEMICAL MODIFICATIONS AT THE 3'-ENDS OF SIRNAS", ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, MARY ANN LIEBERT, INC., NEW YORK, US, vol. 12, no. 5, October 2002 (2002-10-01), pages 301 - 309, XP009006637, ISSN: 1087-2906

DOI:   http://dx.doi.org/10.1089/108729002761381285
 [Y]   SCHWARZ D S ET AL: "EVIDENCE THAT SIRNAS FUNCTION AS GUIDES, NOT PRIMERS, IN THE DROSOPHILA AND HUMAN RNAI PATHWAYS", MOLECULAR CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 10, no. 3, 1 September 2002 (2002-09-01), pages 537 - 548, XP009019083, ISSN: 1097-2765, DOI: 10.1016/S1097-2765(02)00651-2

DOI:   http://dx.doi.org/10.1016/S1097-2765(02)00651-2
by applicant  ELBASHIR ET AL., METHODS, vol. 26, 2002, pages 199 - 213
   GRIBSKOV; DEVEREUX: "Sequence Analysis Primer", 1991, STOCKTON PRESS
   ELBASHIR S.M. ET AL., EMBO J., vol. 20, 2001, pages 6877 - 6888
   MARTIN ET AL., HELV. CHIM. ACTA, vol. 78, 1995, pages 486 - 504
   HEMMINGS ET AL., NAR, vol. 31, 2003, pages 2117 - 2126
   DORN ET AL., ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, vol. 11, 2001, pages 165 - 174
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