blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2457585

EP2457585 - Methods for treating conditions associated with MASP-2 dependent complement activation [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  29.05.2015
Database last updated on 15.07.2024
Most recent event   Tooltip29.05.2015Withdrawal of applicationpublished on 01.07.2015  [2015/27]
Applicant(s)For all designated states
Omeros Corporation
201 Elliott Avenue West
Seattle, WA 98119 / US
For all designated states
UNIVERSITY OF LEICESTER
University Road Leicester
Leicestershire LE1 7RH / GB
[2013/04]
Former [2012/22]For all designated states
Omeros Corporation
1420 Fifth Avenue Suite 2600
Seattle, WA 98101 / US
For all designated states
UNIVERSITY OF LEICESTER
University Road Leicester
Leicestershire LE1 7RH / GB
Inventor(s)01 / Schwaeble, Hans-Wilhelm
36 The Green
Mountsorrel, Leicestershire LE12 7AF / GB
02 / Stover, Cordula M.
5 Yarwell Drive
Wigston Meadows, LE18 3QF / GB
03 / Tedford, Clark E.
4058 NE Lookout Lane
Poulsbo, WA 98370 / US
04 / Parent, James B.
PO Box 10278
Bainbridge Island, WA 98110 / US
05 / Fujita, Teizo
2F-2-10-7 Horai
Fukushima 960-8157 / JP
 [2012/22]
Representative(s)Cole, William Gwyn
Avidity IP
Broers Building
Hauser Forum
21 J J Thomson Avenue
Cambridge CB3 0FA / GB
[N/P]
Former [2012/22]Cole, William Gwyn
avidity IP
Merlin House
Falconry Court
Baker's Lane
Epping, Essex CM16 5DQ / GB
Application number, filing date10184696.209.06.2005
[2012/22]
Priority number, dateUS20040578847P10.06.2004         Original published format: US 578847 P
[2012/22]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2457585
Date:30.05.2012
Language:EN
[2012/22]
Search report(s)(Supplementary) European search report - dispatched on:EP26.04.2012
ClassificationIPC:A61K39/395, A61P17/00, A61K31/00, A61K38/02, // C07K16/40
[2012/22]
CPC:
A01K67/0276 (EP,US); A61P9/00 (EP,US); C07K16/40 (EP,US);
C12N9/6424 (EP,US); A01K2217/075 (EP,US); A01K2227/105 (EP,US);
A01K2267/03 (EP,US); A61K2039/505 (EP,US); C07K2317/24 (EP,US);
C07K2317/55 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2012/22]
TitleGerman:Verfahren zur Behandlung von Leiden in Zusammenhang mit MASP-2-abhängiger Komplementaktivierung[2012/22]
English:Methods for treating conditions associated with MASP-2 dependent complement activation[2012/22]
French:Procédés pour le traitement d'états pathologiques liés à l'activation du complément MASP-2 dépendant[2012/22]
Examination procedure28.11.2012Examination requested  [2013/02]
29.11.2012Amendment by applicant (claims and/or description)
25.02.2013Despatch of a communication from the examining division (Time limit: M06)
08.10.2013Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
16.12.2013Reply to a communication from the examining division
21.05.2015Application withdrawn by applicant  [2015/27]
22.05.2015Cancellation of oral proceeding that was planned for 18.06.2015
18.06.2015Date of oral proceedings (cancelled)
Parent application(s)   TooltipEP05765604.3  / EP1753456
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20050765604) is  22.05.2007
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
16.12.2013Request for further processing filed
16.12.2013Full payment received (date of receipt of payment)
Request granted
15.01.2014Decision despatched
Fees paidRenewal fee
13.01.2011Renewal fee patent year 03
13.01.2011Renewal fee patent year 04
13.01.2011Renewal fee patent year 05
13.01.2011Renewal fee patent year 06
13.06.2011Renewal fee patent year 07
28.05.2012Renewal fee patent year 08
21.05.2013Renewal fee patent year 09
03.06.2014Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[AP]WO2004075837  (TANOX INC [US], et al) [AP] 1-15 * page 6, paragraphs 37,38 * * claims 1,4,8, 29-32 *;
 [AP]WO2004106384  (NATIMMUNE AS [DK], et al) [AP] 1-15 * page 3, line 15 - line 27; example 1 * * pages 9-10 * * page 15, lines 23-25,27-28 *;
 [AP]  - STOVER C ET AL, "Functional MASP2 single nucleotide polymorphism plays no role in psoriasis", BRITISH JOURNAL OF DERMATOLOGY, OXFORD : WILEY-BLACKWELL, UK, (20050601), vol. 152, no. 6, doi:10.1111/J.1365-2133.2005.06547.X, ISSN 0007-0963, pages 1313 - 1315, XP002357886 [AP] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1365-2133.2005.06547.x
 [T]  - MOLLER-KRISTENSEN METTE ET AL, "Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice", JOURNAL OF INVESTIGATIVE DERMATOLOGY, (200706), vol. 127, no. 6, ISSN 0022-202X, pages 1524 - 1531, XP002671565 [T] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1038/SJ.JID.5700748
 [T]  - MILLER CHRISTOPHER ET AL, "Molecular defects in the mannose binding lectin pathway in dermatological disease: Case report and literature review.", CLINICAL AND MOLECULAR ALLERGY, (2010), vol. 8, no. 6, ISSN 1476-7961, pages 1 - 9, XP002671566 [T] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1186/1476-7961-8-6
 [A]  - VORUP-JENSEN T ET AL, "DISTINCT PATHWAYS OF MANNAN-BINDING LECTIN (MBL)- AND C1-COMPLEX AUTOACTIVATION REVEALED BY RECONSTITUION OF MBL WITH RECOMBINANT MBL-ASSOCIATED SERINE PROTEASE-2", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, (20000815), vol. 165, no. 4, ISSN 0022-1767, pages 2093 - 2100, XP001183499 [A] 1-15 * the whole document *
 [A]  - COLLARD CHARLES D ET AL, "Endothelial oxidative stress activates the lectin complement pathway: Role of cytokeratin 1", AMERICAN JOURNAL OF PATHOLOGY, (200109), vol. 159, no. 3, ISSN 0002-9440, pages 1045 - 1054, XP002378477 [A] 1-15 * the whole document *
Examination   - RADKE A ET AL, "C1 inhibitor prevents capillary leakage after thermal trauma.", CRITICAL CARE MEDICINE SEP 2000, (200009), vol. 28, no. 9, ISSN 0090-3493, pages 3224 - 3232
    - KIRSCHFINK M ET AL, "C1-inhibitor: an anti-inflammatory reagent with therapeutic potential.", EXPERT OPINION ON PHARMACOTHERAPY JUL 2001, (200107), vol. 2, no. 7, ISSN 1465-6566, pages 1073 - 1083
by applicantUS4331647
 US4394370
 US4526909
 US4563489
 WO8804300
 US4816567
 US4946778
 US4975527
 WO9111465
 US5211657
 US5223409
 US5403484
 WO9523161
 US5552157
 US5565213
 US5567434
 US5571698
 US5610288
 US5693762
 US5718709
 US5739119
 US5738868
 US5741516
 US5759829
 US5789573
 US5795587
 US5801154
 WO0107067
 US2002019369
 US6420432
 US6492332
 WO03063799
 US6645168
 US6649592
 WO2004009664
 US2004072809
    - KALLI, K.R. ET AL., SPRINGER SEMIN. IMMUNOPATHOL., (1994), vol. 15, pages 417 - 431
    - MORGAN, B.P., EUR. J. CLINICAL INVESTIG., (1994), vol. 24, pages 219 - 228
    - LU, J. ET AL., BIOCHIM. BIOPHYS. ACTA, (2002), vol. 1572, pages 387 - 400
    - HOLMSKOV ET AL., ANNU. REV. IMMUNOL., (2003), vol. 21, pages 547 - 578
    - TEH ET AL., IMMUNOLOGY, (2000), vol. 101, pages 225 - 232
    - DCEDA, K. ET AL., J. BIOL. CHEM., (1987), vol. 262, pages 7451 - 7454
    - WEIS, W.I. ET AL., NATURE, (1992), vol. 360, pages 127 - 134
    - LEE, R.T. ET AL., ARCHIV. BIOCHEM. BIOPHYS., (1992), vol. 299, pages 129 - 136
    - MAYNARD, Y. ET AL., I BIOL. CHEM., (1982), vol. 257, pages 3788 - 3794
    - LYNCH, N.J. ET AL., J. IMMUNOL., (2004), vol. 172, pages 1198 - 1202
    - KUHLMAN, M. ET AL., J. EXP. MED., (1989), vol. 169, page 1733
    - MATSUSHITA, M. ET AL., J. BIOL. CHEM., (1996), vol. 271, pages 2448 - 54
    - JI, Y.H. ET AL., J. IMMUNOL., (1993), vol. 150, pages 571 - 578
    - THIEL, S. ET AL., NATURE, (1997), vol. 386, pages 506 - 510
    - VORUP-JENSEN, T. ET AL., J. IMMUNOL., (2000), vol. 165, pages 2093 - 2100
    - AMBRUS, G. ET AL., J. IMMUNOL., (2003), vol. 170, pages 1374 - 1382
    - DAHL, M.R. ET AL., IMMUNITY, (2001), vol. 15, pages 127 - 35
    - SIM, R.B. ET AL., BIOCHEM. SOC. TRANS., (2000), vol. 28, page 545
    - STENGAARD-PEDERSEN, K. ET AL., NEW ENG. J. MED., (2003), vol. 349, pages 554 - 560
    - STOVER, C.M., I IMMUNOL., (1999), vol. 162, pages 3481 - 90
    - TAKAHASHI, M. ET AL., INT. IMMUNOL., (1999), vol. 11, pages 859 - 863
    - SCHWAEBLE, W. ET AL., IMMUNOBIOLOGY, (2002), vol. 205, pages 455 - 466
    - THIEL, S. ET AL., J. IMMUNOL., (2000), vol. 165, pages 878 - 887
    - MATSUSHITA, M. ET AL., J. IMMUNOL., (2002), vol. 168, pages 3502 - 3506
    - KILPATRICK, D.C., BIOCHIM. BIOPHYS. ACTA, (2002), vol. 1572, pages 401 - 413
    - COLLARD, C.D. ET AL., AM. J. PATHAL., (2000), vol. 156, pages 1549 - 1556
    - JORDAN, J.E. ET AL., CIRCULATION, (2001), vol. 104, pages 1413 - 1418
    - COLLARD, C.D. ET AL., AM. J. PATHOL., (2001), vol. 159, pages 1045 - 1054
    - RIEDERMANN, N.C. ET AL., AM. J. PATHOL., (2003), vol. 162, pages 363 - 367
    - LACLUNANN, P.J. ET AL., SPRINGER SEMIN. IMMURAOPATHOL., (1984), vol. 7, pages 143 - 162
    - PANGBURN, M.K. ET AL., J. EXP. MED, (1981), vol. 154, pages 856 - 867
    - PILLEMER, L. ET AL., J. EXP. MED., (1956), vol. 103, pages 1 - 13
    - LEPOW, I.H., J. IMMUNOL., (1980), vol. 125, pages 471 - 478
    - LACHMANN, P.J. ET AL., SPRINGER SEMIN. IMMUNOPATHOL., (1984), vol. 7, pages 143 - 162
    - VAN DIJK, H. ET AL., J. IMMUNOL. METHODS, (1985), vol. 85, pages 233 - 243
    - PANGBURN, M.K., METHODS IN ENZYMOL., (1988), vol. 162, pages 639 - 653
    - SCHWEINIE, J.E. ET AL., J. CLIN. INVEST., (1989), vol. 84, pages 1821 - 1829
    - MOLLER-KRISTENSEN, M. ET AL., J. IMMUNOL METHODS, (2003), vol. 282, pages 159 - 167
    - HILL, J.H. ET AL., J. EXP. MED., (1971), vol. 133, pages 885 - 900
    - MAROKO, P.R. ET AL., J CLIN INVEST., (1978), vol. 61, pages 661 - 670
    - STEIN, S.H. ET AL., MINER ELECTROLYTE METAB., (1985), vol. 11, pages 256 - 61
    - WEISMAN, H.F. ET AL., SCIENCE, (1990), vol. 249, pages 146 - 51
    - BUERKE, M. ET AL., CIRCULATION, (1995), vol. 91, pages 393 - 402
    - WEISER, M.R. ET AL., J. EXP. MED., (1996), vol. 183, pages 2343 - 48
    - AUSTEN, W.G. JR. ET AL., SURGERY, (1999), vol. 126, pages 343 - 48
    - REHRIG, S. ET AL., J. IMMUNOL., (2001), vol. 167, pages 5921 - 27
    - KYRIAKIDES, C. ET AL., AM. J. PHYSIOL. CELL PHYSIOL., (2001), vol. 281, pages C244 - 30
    - AMSTERDAM, E.A. ET AL., AM. J. PHYSIOL. HEART CIRC. PHYSIOL., (1995), vol. 268, pages H448 - 57
    - VAKEVA, A. ET AL., CIRCULATION, (1998), vol. 97, pages 2259 - 67
    - ZHOU, W. ET AL., J. CLIN. INVEST., (2000), vol. 105, pages 1363 - 71
    - STAHL, G. ET AL., AM. J. PATHOL., (2003), vol. 162, pages 449 - 55
    - WILLIAMS, J.P. ET AL., J. APPL. PHYSIOL., (1999), vol. 86, pages 938 - 42
    - JORDAN, J.E. ET AL., CIRCULATION, (2001), vol. 104, pages 1413 - 18
    - COLLARD, C.D. ET AL., AM. J. PATHOL., (2000), vol. 156, pages 1549 - 56
    - FLEMING, S.D. ET AL., J. IMMUNOL., (2002), vol. 169, pages 2126 - 33
    - REID, R.R. ET AL., J. IMMUNOL., (2002), vol. 169, pages 5433 - 40
    - MAHAFFEY, K.W. ET AL., CIRCULATION, (2003), vol. 108, pages 1176 - 83
    - NICULESCU, F. ET AL., MOL. IMMUNOL., (1999), vol. 36, pages 949 - 55
    - RUS, H.G. ET AL., IMMUNO'..LET!., (1989), vol. 20, pages 305 - 310
    - TORZEWSKI, M. ET AL., ARTERIASCLER. THROMB. VASC. BIOL., (1998), vol. 18, pages 369 - 378
    - HANSSON, G.K. ET AL., ACTA PATHOL. MICROBIOL. IMMUNOL. SCAND. (A), (1984), vol. 92, pages 429 - 35
    - VLAICU, R. ET AL., ATHEROSCLEROSIS, (1985), vol. 57, pages 163 - 77
    - TASKINEN S. ET AL., BIOCHEM. J., (2002), vol. 367, pages 403 - 12
    - SEIFER, P.S. ET AL., LAB INVEST., (1989), vol. 60, pages 747 - 54
    - BHAKDI, S. ET AL., ARTERIOSCLER. THROMB. VASC. BIOL., (1999), vol. 19, pages 2348 - 54
    - TORZEWSKI, J. ET AL., ARTERIOSCLER. THROMB. VASE. BIOL., (1998), vol. 18, pages 1386 - 92
    - WITZTUM, J.L., LANCET, (1994), vol. 344, pages 793 - 95
    - SEIFERT P.S. ET AL., J. EXP. MED., (1990), vol. 172, pages 547 - 57
    - CAMPBELL L.A. ET AL., J. INFECT. DIS., (1995), vol. 172, pages 585 - 8
    - SEIFERT, P.S. ET AL., MOL. IMMUNOL., (1987), vol. 24, pages 1303 - 08
    - TORZEWSKI J. ET AL., ARTERIOSCLER. THROMB. VASC. BIOL., (1996), vol. 18, pages 673 - 77
    - YASOJIMA, K. ET AL., ARTERIOSCLER. THROMB. VASC. BIOL., (2001), vol. 21, pages 1214 - 19
    - GEERTINGER P. ET AL., ACTA. PATHOL. MICROBIOL. SCAND. (A), (1970), vol. 78, pages 284 - 88
    - GEERTINGER, P. ET AL., ARTERY, (1977), vol. 1, pages 177 - 84
    - SCHMIEDT, W. ET AL., ARTERIOSCL. THROMB. VASC. BIOL., (1998), vol. 18, pages 1790 - 1795
    - SAITO, E. ET AL., J. DRUG DEV., (1990), vol. 3, pages 147 - 54
    - PATEL, S. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (2001), vol. 286, pages 164 - 70
    - BUONO, C. ET AL., CIRCULATION, (2002), vol. 105, pages 3025 - 31
    - SEIFERT, P.S. ET AL., ATHEROSCLEROSIS, (1988), vol. 73, pages 91 - 104
    - WEISMAN, H.F., SCIENCE, (1990), vol. 249, pages 146 - 51
    - TADA, T. ET AL., VIRCHOWS ARCH, (1997), vol. 430, pages 327 - 332
    - KAWANA, S. ET AL., ARCH. DERMATOL. RES., (1990), vol. 282, pages 183 - 7
    - ENDO, M. ET AL., AM J. KIDNEY DIS., (2000), vol. 35, pages 401 - 7
    - CINES, D.B. ET AL., J. CLIN. INVEST., (1984), vol. 73, pages 611 - 25
    - TOMOOKA, K., FUKUOKA IGAKU ZASSHI, (1989), vol. 80, pages 456 - 66
    - TRIPATHY, N.K. ET AL., J. RHEUMATOL., (2001), vol. 28, pages 805 - 8
    - ZWAKA, T.P. ET AL., ARN. J. PATHOL., (2002), vol. 161, no. 2, pages 449 - 57
    - KOLIOS, G. ET AL., GASTROENTEROLOGY, (1998), vol. 45, pages 1601 - 9
    - ELMGREEN, J., DAN. MED. BULL., (1986), vol. 33, page 222
    - HALSTENSEN, T.S. ET AL., IMMUNOL. RES., (1991), vol. 10, pages 485 - 92
    - HALSTENSEN, T.S. ET AL., GASTROENTEROLOGY, (1990), vol. 98, page 1264
    - KOHL, J., MOL. IMMUNOL., (2001), vol. 38, page 175
    - KITANO, A. ET AL., DIS. COLON RECTUM, (1992), vol. 35, page 560
    - KITANO, A. ET AL., CLIN. EXP. IMMUNOL., (1993), vol. 94, pages 348 - 53
    - WOODRUFF, T.M. ET AL., J. IMMUNOL., (2003), vol. 171, pages 5514 - 20
    - LIN, F. ET AL., J. IMMUNOL., (2004), vol. 172, pages 3836 - 41
    - WARE, I. ET AL., N. ENGL. J. MED., (2000), vol. 342, pages 1334 - 49
    - SEEGER, W. ET AL., BLOOD, (1990), vol. 76, pages 1438 - 44
    - XIAO, F. ET AL., J. APPL. PHYSIOL., (1997), vol. 82, pages 1459 - 65
    - KRUG, N. ET AL., AM. J. RESPIR. CRIT. CARE MED., (2001), vol. 164, pages 1841 - 43
    - KALLURI, R. ET AL., J. AM. SOC. NEPHROL., (1997), vol. 8, pages 1795 - 800
    - KONDO, C. ET AL., CLIN. EXP. IMMUNOL., (2001), vol. 124, pages 323 - 9
    - STANLEY, T.P., EMERGING THERAPEUTIC TARGETS, (1998), vol. 2, pages 1 - 16
    - HAMMERSCHMIDT, D.F. ET AL., LANCET, (1980), vol. 1, pages 947 - 49
    - SOLOMKIN, J.S. ET AL., J. SURGERY, (1985), vol. 97, pages 668 - 78
    - TILL, G.O. ET AL., AM. J. PATHOL., (1987), vol. 129, pages 44 - 53
    - WARD, P.A., AM. J. PATHOL., (1996), vol. 149, pages 1081 - 86
    - MULLIGAN, M.S. ET AL., J. CLIN. INVEST., (1996), vol. 98, pages 503 - 512
    - MULLIGAN, M.S., YEH ET AL., J. IMMUNOL., (1992), vol. 148, pages 1479 - 85
    - HETLAND, G. ET AL., SCAND J. IMMUNOL., (1986), vol. 24, pages 603 - 8
    - ROTHMAN, B.I. ET AL., J. IMMUNOL., (1990), vol. 145, pages 592 - 98
    - HUMBLES, A.A. ET AL., NATURE, (2002), vol. 406, pages 998 - 01
    - VAN DE GRAF, E.A. ET AL., J. IMMUNOL. METHODS, (1992), vol. 147, pages 241 - 50
    - KARP, C.L. ET AL., NAT. IMMUNOL., (2000), vol. 1, pages 221 - 26
    - BAUTSCH, W. ET AL., J. IMMUNOL., (2000), vol. 165, pages 5401 - 5
    - DROUIN, S.M. ET AL., J. IMMUNOL., (2002), vol. 169, pages 5926 - 33
    - WALTERS, D.M. ET AL., AM. J. RESPIR. CELL MOL. BIOL., (2002), vol. 27, pages 413 - 18
    - HOGABOAM, C.M. ET AL., J. LEUKOC. BIOL., (2004), vol. 75, pages 805 - 14
    - CRADDOCK, P.R. ET AL., N. ENGL. J. MED., (1977), vol. 296, pages 769 - 74
    - CHENOWETH, D.E., ANN. N.Y. ACAD. SCI., (1987), vol. 516, pages 306 - 313
    - HUGLI, TE, COMPLEMENT, (1986), vol. 3, pages 111 - 127
    - CHEUNG, A.K., J. AM. SOC. NEPHROL., (1990), vol. 1, pages 150 - 161
    - JOHNSON, R.J., NEPHROL. DIAL. TRANSPLANT, (1994), vol. 9, pages 36 - 45
    - HAKIM, R.M., KIDNEY INT., (1993), vol. 44, pages 484 - 4946
    - KIRKLIN, J.K. ET AL., J. THORAC. CARDIOVASC. SURG., (1983), vol. 86, pages 845 - 57
    - VALLHONRAT, H. ET AL., ASAIO J., (1999), vol. 45, pages 113 - 4
    - WACHTFOGEL, Y.T. ET AL., BLOOD, (1989), vol. 73, pages 468 - 471
    - BUTLER, J. ET AL., ANN. THORAC. SURG., (1993), vol. 55, pages 552 - 9
    - EDMUNDS, L.H., ANN. THORAC. SURG., (1998), vol. 66, pages 12 - 6
    - ASIMAKOPOULOS, G., PERFUSION, (1999), vol. 14, pages 269 - 77
    - FITCH, J. ET AL., CIRCULATION, (1999), vol. 100, no. 25, pages 2499 - 2506
    - WAN, S. ET AL., CHEST, (1997), vol. 112, pages 676 - 692
    - CHENOWETH, K. ET AL., N. ENGL. J. MED., (1981), vol. 304, pages 497 - 503
    - P. HASLAM ET AL., ANAESTHESIA, (1980), vol. 25, pages 22 - 26
    - J.K. KIRKLIN ET AL., J. THORAC. CARDIOVASC. SURG., (1983), vol. 86, pages 845 - 857
    - MOORE, F.D. ET AL., ANN. SURG, (1988), vol. 208, pages 95 - 103
    - J. STEINBERG ET AL., J. THORAC. CARDIOVASC. SURG, (1993), vol. 106, pages 1901 - 1918
    - KIRKLIN, J.K. ET AL., ANN. THORAC. SURG., (1986), vol. 41, pages 193 - 199
    - VALLHONRAT H. ET AL., ASAIO J., (1999), vol. 45, pages 113 - 4
    - HAEFFNER-CAVAILLON, N. ET AL., J. IMMUNOL., (1987), vol. 139, pages 794 - 9
    - FLETCHER, M.P. ET AL., AM. J. PHYSFOL., (1993), vol. 265, pages H1750 - 61
    - RINDER, C.S. ET AL., J. CLIN. INVEST., (1995), vol. 96, pages 1564 - 72
    - RINDER, C.S. ET AL., CIRCULATION, (1999), vol. 100, pages 553 - 8
    - SCHINDLER, R. ET AL., BLOOD, (1990), vol. 76, pages 1631 - 8
    - CRUICKSHANK, A.M. ET AL., CLIN SCI. (LOND), (1990), vol. 79, pages 161 - 5
    - KAWAMURA, T. ET AL., CAN. J. ANAESTH., (1993), vol. 40, pages 1016 - 21
    - STEINBERG, J.B. ET AL., J. THORAC. CARDIOVASC. SURG., (1993), vol. 106, pages 1008 - 1
    - FINN, A. ET AL., J. THORAC. CARDIOVASC. SURG., (1993), vol. 105, pages 234 - 41
    - ASHRAF, S.S. ET AL., J. CARDIOTHORAC. VASC. ANESTH., (1997), vol. 11, pages 718 - 22
    - RINDER, C. ET AL., CARDIOVASC PHARMACOL., (1996), vol. 27, no. 1, pages 6 - 12
    - EVANGELISTA, V. ET AL., BLOOD, (1999), vol. 93, pages 876 - 85
    - KINKADE, J.M., JR. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (1983), vol. 114, pages 296 - 303
    - LAMB, N.J. ET AL., CRIT. CARE MED., (1999), vol. 27, pages 1738 - 44
    - FUJIE, K. ET AL., EUR. J. PHARMACOL., (1999), vol. 374, pages 117 - 25
    - RINDER, C.S. ET AL., J. THORAC. CARDIOVASC. SURG., (1999), vol. 118, pages 460 - 6
    - FOREMAN, K.E. ET AL., J. CLIN. INVEST., (1994), vol. 94, pages 1147 - 55
    - LENTSCH, A.B. ET AL., J. PATHOL., (2000), vol. 190, pages 343 - 8
    - CHAI, P.J. ET AL., CIRCULATION, (2000), vol. 101, pages 541 - 6
    - FITCH, J.C.K. ET AL., CIRCULATION, (1999), vol. 100, pages 3499 - 506
    - NILSSON, B. ET AL., BLOOD, (1998), vol. 92, pages 1661 - 7
    - FUNG, M. ET AL., J. THORACIC CARDIOVASC. SURG., (2001), vol. 122, pages 113 - 22
    - VERRIER, E.D. ET AL., JAAL4, (2004), vol. 291, pages 2319 - 27
    - LINTON, S.M. ET AL., MOLEC. IMMUNOL., (1999), vol. 36, pages 905 - 14
    - MOLLNES, T.E. ET AL., ARTHRITIS RHEUM., (1986), vol. 29, pages 1359 - 64
    - KEMP, P.A. ET AL., J. CLIN. LAB. IMMUNOL., (1992), vol. 37, pages 147 - 62
    - MOLINA, H., CURRENT OPINION IN RHEUMATOL., (2002), vol. 14, pages 492 - 497
    - RUMFELD, W.R. ET AL., BR. J. RHEUMATOL., (1986), vol. 25, pages 266 - 70
    - SANDERS, M.E. ET AL., J. IMMUNOL., (1987), vol. 138, pages 2095 - 9
    - MORGAN, B.P. ET AL., CLIN. EXP. IMMUNOL, (1988), vol. 73, pages 473 - 478
    - AUDA, G. ET AL., RHEUMATOL. INT., (1990), vol. 10, pages 185 - 189
    - RUMFELD, W.R. ET AL., BR. J. RHEUMATOL., (1986), vol. 25, pages 266 - 270
    - MALDNDE, V.A. ET AL., ANN. RHEUM. DIS., (1989), vol. 48, pages 302 - 306
    - BRODEUR, J.P ET AL., ARTHRITIS RHEUMATISM, (1991), vol. 34, pages 1531 - 1537
    - EL-GHOBAREY, A.F. ET AL., J. RHEUMATOLOGY, (1980), vol. 7, pages 453 - 460
    - AGARWAL, A. ET AL., RHEUMATOLOGY, (2000), vol. 39, pages 189 - 192
    - MORGAN, K. ET AL., ARTHRITIS RHEUMAT., (1981), vol. 24, pages 1356 - 1362
    - VAN LENT, P.L. ET AL., AM. J. PATHOL., (1992), vol. 140, pages 1451 - 1461
    - GOODFELLOW, R.M. ET AL., CLIN. EXP. IMMUNOL., (1997), vol. 110, pages 45 - 52
    - GOODFELLOW, R.M. ET AL., CLIN EXP. IMMUNOL., (2000), vol. 119, pages 210 - 216
    - COURTENAY, J.S. ET AL., NATURE, (1980), vol. 283, pages 666 - 68
    - BANDA ETAI., J. OF IMMUNOL., (2003), vol. 171, pages 2109 - 2115
    - MYERS, L.K. ET AL., LIFE SCIENCES, (1997), vol. 61, pages 1861 - 78
    - CINADER, B. ET AL., J. EXP. MED., (1964), vol. 120, pages 897 - 902
    - WANG, Y. ET AL., J. IMMUNOL., (2000), vol. 164, pages 4340 - 4347
    - WANG, Y. ET AL., PROC. NATL. ACAD. SCI. USA, (1995), vol. 92, pages 8955 - 59
    - KORGANOW, A.S. ET AL., IMMUNITY, (1999), vol. 10, pages 451 - 461
    - JI, H. ET AL., IMMUNITY, (2002), vol. 16, pages 157 - 68
    - GRANT, E.P. ET AL., J. EXP. MED., (2002), vol. 196, pages 1461 - 1471
    - ABRAMSON, S.B. ET AL., HOSPITAL PRACTICE, (1998), vol. 33, pages 107 - 122
    - MANZI, S. ET AL., ARTHRIT. RHEUMAT., (1996), vol. 39, pages 1178 - 1188
    - BUYON, J.P. ET AL., ARTHRITIS RHEUM., (1992), vol. 35, pages 55 - 61
    - SEELEN, M.A. ET AL., CLIN EXP. IMMUNOL., (2003), vol. 134, pages 335 - 343
    - PICKERING, M.C. ET AL., ADV. IMMUNOL., (2000), vol. 76, pages 227 - 324
    - KOHLER, P.F. ET AL., AM. J. MED., (1974), vol. 56, pages 406 - 11
    - MEVORARCH, D. ET AL., J. EXP. MED., (1998), vol. 188, pages 2313 - 2320
    - BOTTO, M. ET AL., NAT. GENET., (1998), vol. 19, pages 56 - 59
    - BOTTO, M., ARTHRITIS RES., (2001), vol. 3, pages 201 - 10
    - WANG Y. ET AL., PROC. NATL. ACAD. SCI. USA, (1996), vol. 93, pages 8563 - 8
    - RAVIRAJAN, C.T. ET AL., RHEUMATOLOGY, (2004), vol. 43, pages 442 - 7
    - WATANABE, H. ET AL., J. IMMUNOL., (2000), vol. 164, pages 786 - 794
    - STRAND, V., LUPUS, (2001), vol. 10, pages 216 - 221
    - ENDO, M. ET AL., CLIN. NEPHROLOGY, (2001), vol. 55, pages 185 - 191
    - KERJASHKZ, D., ARCH B CELL PATHOL., (1990), vol. 58, pages 253 - 71
    - BRENCHLEY, P.E. ET AL., KIDNEY INT., (1992), vol. 41, pages 933 - 7
    - SALANT, D.J. ET AL., KIDNEY INT., (1989), vol. 35, pages 976 - 84
    - BARTLOW, B.G. ET AL., KIDNEY INT., (1979), vol. 15, pages 294 - 300
    - MERI, S. ET AL., J. EXP. MED., (1992), vol. 175, pages 939 - 50
    - OHSAWA, I. ET AL., CLIN LMMUNOL., (2001), vol. 101, pages 59 - 66
    - GATENBY, P.A., AUTOIMMUNITY, (1991), vol. 11, pages 61 - 6
    - ENDO, M. ET AL., AM. J. KIDNEY DIS., (2000), vol. 35, pages 401 - 407
    - KAHN, T.N. ET AL., HISTOPATH., (1995), vol. 26, pages 351 - 6
    - ALEXOPOULOS, A. ET AL., NEPHROL. DIAL. TRANSPLANT, (1995), vol. 10, pages 1166 - 1172
    - KON, S.P. ET AL., KIDNEY INT., (1995), vol. 48, pages 1953 - 58
    - LEHTO, T. ET AL., KIDNEY INT., (1995), vol. 47, pages 1403 - 11
    - BRANDT, J. ET AL., KIDNEY INT., (1996), vol. 49, pages 335 - 343
    - SCANDRETT, A.L. ET AL., AM. J. PHYSIOL., (1995), vol. 268, pages F256 - F265
    - COUSER, W.G. ET AL., J. AM. SOC. NEPHROL., (1995), vol. 5, pages 1888 - 94
    - AULT, B.H., NEPHROL., (2000), vol. 14, pages 1045 - 1053
    - LEVY, M. ET AL., KIDNEY INT., (1986), vol. 30, pages 949 - 56
    - PICKERING, M.C. ET AL., NAT. GENET., (2002), vol. 31, pages 424 - 8
    - JANSEN, J.H. ET AL., KIDNEY INT., (1998), vol. 53, pages 331 - 49
    - WALPORT, M.J., DAVIES ET AL., ANN. N.Y. ACAD. SCI., (1997), vol. 815, pages 267 - 81
    - TROUW, L.A. ET AL., MOL. IMMUNOL., (2001), vol. 38, pages 199 - 206
    - SPITZER, R.E. ET AL., CLIN. IMMUNOL. IMMUNOPATHOL., (1992), vol. 64, pages 177 - 83
    - DAHA, MR. ET AL., J. IMMUNOL., (1976), vol. 116, pages 1 - 7
    - DAHA, M.R. ET AL., J. IMMUNOL., (1980), vol. 125, pages 2051 - 2054
    - HALBWACHS, L. ET AL., J. CLIN. INVEST., (1980), vol. 65, pages 1249 - 56
    - HOVATH, L. ET AL., CLIN. EXP. RHEUMATOL., (2001), vol. 19, pages 667 - 72
    - SIEGERT, C. ET AL., J. RHEUMATOL., (1991), vol. 18, pages 230 - 34
    - SIEGERT, C. ET AL., CLIN. EXP. RHEUMATOL., (1992), vol. 10, pages 19 - 23
    - COREMANS, I.E. ET AL., AM. J. KIDNEY DIS., (1995), vol. 26, pages 595 - 601
    - MANNICK, M. ET AL., ARTHRITIS RHEUMATOL., (1997), vol. 40, pages 1504 - 11
    - SIEGERT, C.E. ET AL., CLIN. IMMUNOL. IMMUNOPATHOL., (1993), vol. 67, pages 204 - 9
    - OHSAWA, I. ET AL., CLIN. IMMUNOL., (2001), vol. 101, pages 59 - 66
    - TERUI, T., TAHOKU J. EXP. MED., (2000), vol. 190, pages 239 - 248
    - TERUI, T., EXP. DERMATOL., (2000), vol. 9, pages 1 - 10
    - TAKEMATSU, H. ET AL., DERMATOLOGICA, (1990), vol. 181, pages 289 - 292
    - OHKONOHCHI, K. ET AL., DERRNATOLOGICA, (1989), vol. 179, pages 30 - 34
    - BALDWIN, W.M. ET AL., SPRINGER SEMINOL IMMUNOPATHOL., (2003), vol. 25, pages 181 - 197
    - NICKELEIT, V., J. AM. SOC. NEPHROL., (2002), vol. 13, pages 242 - 251
    - NICKELEIT, V. ET AL., NEPHROL. DIAL. TRANSPLANT, (2003), vol. 18, pages 2232 - 2239
    - SALERNO, C.T. ET AL., XENOTRANSPLANTATION, (2002), vol. 9, pages 125 - 134
    - WANG, H. ET AL., TRANSPLANTATION, (1999), vol. 68, pages 1643 - 1651
    - MORGAN, B.P. ET AL., IMMUNOLOGY TODAY, (1996), vol. 17, no. 10, pages 461 - 466
    - BARUM, S.R., IMMUNOLOGIC RESEARCH, (2002), vol. 26, pages 7 - 13
    - KACZOROWSKI ET AL., J. CEREB. BLOOD FLOW METAB., (1995), vol. 15, pages 860 - 864
    - GRONBLAD, M. ET AL., SPINE, (2003), vol. 28, no. 2, pages 114 - 118
    - PRINEAS, J.W. ET AL., LAB INVEST., (1978), vol. 38, pages 409 - 421
    - RYBERG, B., J. NEUROL. SCI., (1982), vol. 54, pages 239 - 261
    - GASQUE, P. ET AL., IMMUNOPHARMACOLOGY, (2000), vol. 49, pages L71 - 186
    - Inflammatory events in neurodegeneration, PROMINENT PRESS, (2001), pages 139 - 156
    - BARNUM, IMMUNOLOGIC RESEARCH, (2002), vol. 26, pages 7 - 13
    - NATAF ET AL., J. IMMUNOLOGY, (2000), vol. 165, pages 5867 - 5873
    - MCGEER ET AL., RES. IMMUNOL., (1992), vol. 143, pages 621 - 630
    - ROGERS ET AL., RES. IMMUNOL., (1992), vol. 143, pages 624 - 630
    - SHEN, Y. ET AL., BRAIN RESEARCH, (1997), vol. 769, pages 391 - 395
    - SHEN, Y. ET AL., NEUROSCI. LETTERS, (2001), vol. 305, no. 3, pages 165 - 168
    - SHEN, Y. ET AL., PROGRESS IN NEUROBIOLOGY, (2003), vol. 70, pages 463 - 472
    - CZLONKOWSKA, A. ET AL., MED. SCI. MONIT., (2002), vol. 8, pages 165 - 177
    - BONE, R.C., ANNALS. INTERNAL. MED., (1991), vol. 115, pages 457 - 469
    - BONE, R.C. ET AL., CRIT. CARE MED., (1992), vol. 20, pages 724 - 726
    - HAENEY, M.R. ET AL., ANTIMICROBIAL CHEMOTHERAPY, (1998), vol. 41, no. A, pages 41 - 6
    - MARTIN, G.S. ET AL., N. ENG. J. MED., (2003), vol. 348, pages 1546 - 54
    - FEARON, D.T. ET AL., N. ENGL. J. MED., (1975), vol. 292, pages 937 - 400
    - JOINER, K.A. ET AL., ANN. REV. IMMUNOL., (1984), vol. 2, pages 461 - 2
    - SCHUMACHER, W.A. ET AL., AGENTS ACTIONS, (1991), vol. 34, pages 345 - 349
    - SHIN, H.S. ET AL., SCIENCE, (1968), vol. 162, pages 361 - 363
    - VOGT, W., COMPLEMENT, (1986), vol. 3, pages 177 - 86
    - HAMMERSCHMIDT, D.E. ET AL., LANCET, (1980), vol. 1, pages 947 - 949
    - SLOTMAN, G.T. ET AL., SURGERY, (1986), vol. 99, pages 744 - 50
    - HACK, C.E. ET AL., AM. J. MED., (1989), vol. 86, pages 20 - 26
    - HSEUH, W. ET AL., IMMUNOL., (1990), vol. 70, pages 309 - 14
    - CZERMAK, B.J. ET AL., NAT. MED., (1999), vol. 5, pages 788 - 792
    - HUBER-LANG, M.S. ET AL., FASEB J., (2002), vol. 16, pages 1567 - 74
    - RIEDEMANN, N.C. ET AL., J. CLIN. INVEST., (2002), vol. 110, pages 101 - 8
    - HANGEN, D.H. ET AL., J. SURG. RES., (1989), vol. 46, pages 195 - 9
    - STEVENS, J.H. ET AL., J. CLIN. INVEST., (1986), vol. 77, pages 1812 - 16
    - NAKAE, H. ET AL., RES. COMMUN. CHEM. PATHOL. PHARMACAL., (1994), vol. 84, pages 189 - 95
    - NAKAE ET AL., SURG. TODAY, (1996), vol. 26, pages 225 - 29
    - BENGTSON, A. ET AL., ARCH. SURG., (1988), vol. 123, pages 645 - 649
    - HUBER-LANG, M.S. ET AL., J. IMMUNAL., (2002), vol. 169, pages 3223 - 31
    - RIEDEMANN, N.C. ET AL., IMMUNITY, (2003), vol. 19, pages 193 - 202
    - LAUDES, I.J. ET AL., AM. J. PATHOL., (2002), vol. 160, pages 1867 - 75
    - DICKNEITE, G., BEHRING INS. MITT., (1993), vol. 93, pages 299 - 305
    - NETH, O. ET AL., INFECT. IMMUN., (2000), vol. 68, page 688
    - MORATH, S. ET AL., J. EXP. MED, (2002), vol. 195, page 1635
    - MORATH, S. ET AL., INFECT. IMMUN., (2002), vol. 70, page 938
    - LYNCH, N.J. ET AL., J. IMMUNOL., (2004), vol. 172, pages 1198 - 02
    - POLOTSKY, V.Y. ET AL., INFECT. IMMUN., (1996), vol. 64, page 380
    - HOLM-BENTZEN, M. ET AL., J. UROL., (1987), vol. 138, pages 503 - 507
    - CRUZ ET AL., BIOL. REPROD., (1996), vol. 54, pages 1217 - 1228
    - XU, C. ET AL., SCIENCE, (2000), vol. 287, pages 498 - 507
    - HAEGER, M., INT. J. GYNECOL. OBSTET., (1993), vol. 43, pages 113 - 127
    - MATTILA, J. ET AL., EUR. UROL., (1983), vol. 9, pages 350 - 352
    - HELIN, H. ET AL., CLIN. IMMUNOL. IMMUNOPATHOL., (1987), vol. 43, pages 88 - 96
    - HAEGER ET AL., OBSTET. GYNECOL., (1991), vol. 78, page 46
    - HAEGER ET AL., OBSTET. GYNECOL., (1989), vol. 73, page 551
    - D'CRUZ, O.J. ET AL., J. IMMUNOL., (1990), vol. 144, pages 3841 - 3848
    - D'CRUZ, O.J. ET AL., J. IMMUNOL., (1991), vol. 146, pages 611 - 620
    - ALEXANDER, N.J., FERTIL. STERIL., (1984), vol. 41, pages 433 - 439
    - D'CRUZ, O.J. ET AL., BIOL. REPROD., (1996), vol. 54, pages 1217 - 1228
    - ZHANG ET AL., DIABETES, (2002), vol. 51, pages 3499 - 3504
    - GERL ET AL., INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE, (2000), vol. 43, pages 1104 - 08
    - NICOLOFF ET AL., CLIN. DEV. IMMUNOL., (2004), vol. 11, pages 61 - 66
    - KOTNIK ET AL., CROAT. MED. J., (2003), vol. 44, pages 707 - 11
    - CARAHER ET AL., J. ENDOCRINOL., (1999), vol. 162, pages 143 - 53
    - NICULESCU, F. ET AL., AM. J. PATHOL., (1992), vol. 140, pages 1039 - 1043
    - CECIC, I. ET AL., CANCER LETT., (2002), vol. 183, pages 43 - 51
    - VAN DER KOLK, L.E. ET AL., BR. J. HAEMATOL., (2001), vol. 115, pages 807 - 811
    - BLANCHIN, S. ET AL., EXP. EYE RES., (2001), vol. 73, no. 6, pages 887 - 96
    - FRANCIS, K. ET AL., FASEB J., (2003), vol. 17, pages 2266 - 2268
    - HANSEN, T.K., ENDOCRINOLOGY, (2003), vol. 144, no. 12, pages 5422 - 9
    - HAGEMAN, G.S. ET AL., PROG. RETIN. EYE RES., (2001), vol. 20, pages 705 - 732
    - KLEIN, R.J. ET AL., SCIENCE, (2005), vol. 308, pages 362 - 364
    - HAINES ET AL., SCIENCE, (2005), vol. 308, pages 362 - 364
    - EDWARDS ET AL., SCIENCE, (2005), vol. 308, pages 263 - 264
    - D.W. SCHULTZ ET AL., HUM. MOL. GENET., (2003), vol. 12, page 3315
    - JOHNSON, L.V. ET AL., EXP. EYE RES., (2001), vol. 73, pages 887 - 896
    - IKEDA, K. ET AL., J. BIOL. CHEM., (1987), vol. 262, pages 7451 - 7454
    - MATSUSHITA, M. ET AL., J. EXP. MED., (2000), vol. 176, pages 1497 - 2284
    - THIELENS, N.M. ET AL., J. IMMUNOL., (2001), vol. 166, page 5068
    - WALLIS, R. ET AL., J. BIOL. CHEM., (2000), vol. 275, pages 30962 - 30969
    - DUNCAN, A.R. ET AL., NATURE, (1988), vol. 332, pages 738 - 740
    - JOLLIFFE ET AL., INT'L REV. IMMUNOL., vol. 10, pages 241 - 250
    - RODRIGUES ET AL., J IMMUNOL., (1998), vol. 151, pages 6954 - 6961
    - RAVETCH, J.V. ET AL., ANNU. REV. IMMUNOL., (1991), vol. 9, pages 457 - 492
    - ISAACS, J.D., J. IMMUNOL., (1992), vol. 148, pages 3062 - 3071
    - VAN DE WINKEL, J.G. ET AL., IMMUNOL. TODAY, (1993), vol. 14, pages 215 - 221
    - VAUGHAN, T.J. ET AL., NATURE BIOTECHNICAL, (1998), vol. 16, pages 535 - 539
    - "Production of Polyclonal Antisera", GREEN ET AL., Immunochemical Protocols, page 105
    - LOSMAN, M.J. ET AL., INT. J. CANCER, (1990), vol. 46, page 310
    - KOHLER, G. ET AL., NATURE, (1975), vol. 256, page 495
    - CLACKSON, T. ET AL., NATURE, (1991), vol. 352, pages 624 - 628
    - MARKS, J.D. ET AL., J. MOL. BIOL., (1991), vol. 222, pages 581 - 597
    - Current Protocols in Immunology, JOHN WILEY & SONS, (1991), vol. 1, pages 2.5.1 - 2.6.7
    - GREEN, L.L. ET AL., NATURE GENET., (1994), vol. 7, page 13
    - LONBERG, N. ET AL., NATURE, (1994), vol. 368, page 856
    - TAYLOR, L.D. ET AL., INT. IMMUN., (1994), vol. 6, page 579
    - "Purification of Immunoglobulin G (IgG)", BAINES ET AL., Methods in Molecular Biology, THE HUMANA PRESS, INC., (1992), vol. 10, pages 79 - 104
    - SCATCHARD, A., NY ACAD. SCI., (1949), vol. 51, pages 660 - 672
    - MORRISON, S.L. ET AL., PROC. NAT'L ACAD. SCI. USA, (1984), vol. 81, pages 6851 - 6855
    - JONES, P.T. ET AL., NATURE, (1986), vol. 321, pages 522 - 525
    - REICHMANN, L. ET AL., NATURE, (1988), vol. 332, pages 323 - 329
    - PRESTA, CURR. OP. STRUCT. BIOL., (1992), vol. 2, pages 593 - 596
    - JONES, P.T. ET AL., NATURE, (1986), vol. 321, page 522
    - CARTER, P. ET AL., PROC. NAT'L. ACAD. SCI. USA, (1992), vol. 89, page 4285
    - SANDHU, J.S., CRIT. REV. BIOTECH., (1992), vol. 12, page 437
    - SINGER, 11. ET AL., J. 1MMUN., (1993), vol. 150, page 2844
    - "Engineering Therapeutic Antibodies", KELLEY ET AL., Protein Engineering: Principles and Practice, JOHN WILEY & SONS, INC., (1996), pages 399 - 434
    - GREENSPAN, N.S. ET AL., FASEB J., (1993), vol. 7, page 437
    - NISONOFF, A. ET AL., ARCH. BIOCHEM. BIOPHYS., (1960), vol. 89, page 230
    - PORTER, R.R., BIOCHEM. J., (1959), vol. 73, page 119
    - EDELMAN ET AL., Methods in Enzymology, ACADEMIC PRESS, (1967), vol. 1, page 422
    - MARIANI, M. ET AL., MOL. IMMUNOL., (1991), vol. 28, pages 69 - 71
    - WHITLOW ET AL., METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, (1991), vol. 2, page 97
    - BIRD ET AL., SCIENCE, (1988), vol. 242, page 423
    - LADNER; PACK, P. ET AL., BIO/TECHNOLOGY, (1993), vol. 11, page 1271
    - LARRICK ET AL., METHODS: A COMPANION TO METHODS IN ENZYMOLOGY, (1991), vol. 2, page 106
    - "Genetic Manipulation of Monoclonal Antibodies", COURTENAY-LUCK ET AL., Monoclonal Antibodies: Production, Engineering and Clinical Application, CAMBRIDGE UNIVERSITY PRESS, (1995), page 166
    - "Genetic Manipulation and Expression of Antibodies", WARD ET AL., Monoclonal Antibodies: Principles and Applications, WILEY-LISS, INC., (1995), page 137
    - OHMAN, E.M. ET AL., EUROPEAN HEART J., (1995), vol. 16, pages 50 - 55
    - MURAYAMA, O. ET AL., J. BIOCHEM., (1996), vol. 120, pages 445 - 51
    - ZHANG, L., J. BIOL. CHEM., (1996), vol. 271, no. 47, pages 29953 - 57
    - JACKSON, D.Y. ET AL., J. MED. CHEM., (1997), vol. 40, pages 3359 - 68
    - STENGAARD-PEDERSEN, K. ET AL., NEW ENGLAND J. MED., (2003), vol. 349, pages 554 - 560
    - MATSUSHITA, M. ET AL., J. IMMUNOL., (2000), vol. 164, page 2281
    - WALLIS, R. ET AL., J. BIOL. CHEM., (2004), vol. 279, page 14065
    - GLOVER, G.I. ET AL., MOL. IMMUNOL., (1988), vol. 25, page 1261
    - SHEA, K.J., "Molecular Imprinting of Synthetic Network Polymers: The De Novo synthesis of Macromolecular Binding and Catalytic Sties", TRIP, (1994), vol. 2, no. 5
    - MERRIFIELD, J. AMER. CHEM. SOC., (1963), vol. 85, pages 2149 - 2154
    - ITAKURA, K. ET AL., ANNU. REV. BIOCHEM, (1984), vol. 53, page 323
    - CLIMIE, S. ET AL., PROC. NAT'L ACAD. SCI. USA, (1990), vol. 8 7, page 633
    - KUNTZ I.D. ET AL., SCIENCE, (1992), vol. 257, page 1078
    - FEINBERG, H. ET AL., EMBOJ., (2003), vol. 22, pages 2348 - 2359
    - KUNTZ, I.D. ET AL., J MOL. BIOL., (1982), vol. 161, pages 269 - 288
    - DESJARLAIS, R.L. ET AL., PNAS, (1990), vol. 87, pages 6644 - 6648
    - SCHERR, M. ET AL., NUCLEIC ACIDS RES., (1998), vol. 26, pages 5079 - 5085
    - LLOYD ET AL., NUCLEIC ACIDS RES., (2001), vol. 29, pages 3665 - 3673
    - ALTSCHUL, S.F. ET AL., NUCL. ACIDS RES., (1997), vol. 25, pages 3389 - 3402
    - JENSEN, J. ET AL., NAT. GENET., (1999), vol. 21, page 209M12
    - HASELOFF, J. ET AL., NATURE, (1988), vol. 334, pages 585 - 591
    - FEDOR, M.J. ET AL., PROC. NATL. ACAD. SCI. USA, (1990), vol. 87, pages 1668 - 1672
    - CECH, T.R. ET AL., ANN. REV. BIOCHEM, (1986), vol. 55, pages 599 - 629
    - MOLLER-KRISTENSEN M. ET AL., J. OF IMMUNOL. METHODS, (2003), vol. 282, pages 159 - 167
    - ASGHAR, S.S., PHARMACOL. REV., (1984), vol. 36, pages 223 - 44
    - MIYAGAWA, S. ET AL., TRANSPLANT PROC., (1992), vol. 24, pages 483 - 484
    - EDENS, R.E. ET AL., COMPLEMENT TODAY, (1993), pages 96 - 120
    - PLATT J.L. ET AL., IMMUNOL. TODAY, (1990), vol. 11, pages 450 - 6
    - MARINO I.R. ET AL., TRANSPLANT PROC., (1990), pages 1071 - 6
    - JOHNSTONE, P.S. ET AL., TRANSPLANTATION, (1992), vol. 54, pages 573 - 6
    - LEVENTHAL, J.R. ET AL., TRANSPLANTATION, (1993), vol. 55, pages 857 - 66
    - PRUITT, S.K. ET AL., TRANSPLANTATION, (1994), vol. 57, pages 363 - 70
    - IDSON, Pharmaceutical Dosage Forms, MARCEK DEKKER, INC., (1988), vol. 1
    - ROSOFF, PHARMACEUTICAL DOSAGE FORMS, vol. 1
    - LEE, V.H.L., CRIT. REV. THER. DRUG CARRIER SYS., (1988), vol. 5, page 69
    - LEE, V.H.L., J. CONTROLLED RELEASE, (1990), vol. 13, page 213
    - DEBOER, A.G. ET AL., J. CONTROLLED RELEASE, (1990), vol. 13, page 241
    - LEE, W.A., BIOPHARM., (199011), vol. 22
    - FUERTGES, F. ET AL., J. CONTROLLED RELEASE, (1990), vol. 11, page 139
    - BAE, Y.H. ET AL., J. CONTROLLED RELEASE, (1989), vol. 9, page 271
    - HORI, R. ET AL., PHARM RES., (1989), vol. 6, page 813
    - YAMAKAWA, I. ET AL., J. PHARM. SCI., (1990), vol. 79, page 505
    - YOSHIHIRO, I. ET AL., J. CONTROLLED RELEASE, (1989), vol. 10, page 195
    - ASANO, M. ET AL., J. CONTROLLED RELEASE, (1989), vol. 9, page 111
    - ROSENBLATT, J. ET AL., J. CONTROLLED RELEASE, (1989), vol. 9, page 195
    - MAKINO, K., J. CONTROLLED RELEASE, (1990), vol. 12, page 235
    - TAKAKURA, Y. ET AL., J. PHARM. SCI., (1989), vol. 78, page 117
    - TAKAKURA, Y. ET AL., J. PHARM. SCI., (1989), vol. 78, page 219
    - FLUGELMAN, M.Y. ET AL., CIRCULATION, (1992), vol. 85, pages 1110 - 1117
    - D.B. SMITH; K.S. JOHNSON, GENE, (1988), vol. 67, page 31
    - E. HOCHULI ET AL., J. CHROMATOG., (1987), vol. 411, page 77
    - PETERSEN ET AL., J. IMMUNOL. METHODS, (2001), vol. 257, page 107
    - MATSUSHITA ET AL., J. IMMUNOL., (2000), vol. 165, pages 2637 - 2642
    - KAUFINAN R.J. ET AL., NUCLEIC ACIDS RESEARCH, (1991), vol. 19, pages 4485 - 90
    - KAUFMAN, METHODS IN ENZYMOLOGY, (1991), vol. 185, pages 537 - 66
    - CHEN ET AL., J. BIOL. CHEM., (2001), vol. 276, no. 28, pages 25894 - 25902
    - THIEL ET AL., NATURE, (1997), vol. 386, page 506
    - THIELENS, N.M. ET AL., J. IMMUNOL., (2001), vol. 166, pages 5068 - 5077
    - KING; POSSEE, The Baculovirus Expression System: A Laboratory Guide, CHAPMAN AND HALL LTD., (1992), pages 111 - 114
    - SMALL, J.A. ET AL., MOL. CELL BIOL., (1985), vol. 5, pages 642 - 48
    - THOMSON, A.D., NATURE, (1994), vol. 148, pages 1547 - 1553
    - SLOANE, B.F., NATURE BIOTECHNOLOGY, (1996), vol. 14, page 826
    - CHEN, P.F., SCAND. J. IMMUNOL., (1992), vol. 35, pages 539 - 549
    - PETERSEN, S.V. ET AL., I IMMUNOL. METHODS, (2001), vol. 257, page 107
    - DODDS, A.W., METHODS ENZYMOL., (1993), vol. 223, page 46
    - KOUSKOFF, V. ET AL., CELL, (1996), vol. 87, pages 811 - 822
    - MATSUMOTO, I. ET AL., SCIENCE, (1999), vol. 286, pages 1732 - 1735
    - MACCIONI M. ET AL., J. EXP. MED., (2002), vol. 195, no. 8, pages 1071 - 1077
    - JI, H. ET AL., IMMUNITY, (2002), vol. 16, pages 157 - 168
    - JOHNSTON, P.S. ET AL., TRANSPLANT PROC., (1991), vol. 23, pages 877 - 879
    - GRALINSKI, M.R. ET AL., IMMUNOPHARMACOLOGY, (1996), vol. 34, pages 79 - 88
    - GUPTA-BANSAL, R. ET AL., MOLECULAR IMMUNOL., (2000), vol. 37, pages 191 - 201
    - VAKEVA ET AL., CIRCULATION, (1998), vol. 97, pages 2259 - 2267
    - JORDAN ET AL., CIRCULATION, (2001), vol. 104, no. 12, pages 1413 - 1418
    - WEISMAN ET AL., SCIENCE, (1990), vol. 249, pages 146 - 151
    - MULLIGAN ET AL., J. IMMUNOL., (1992), vol. 148, pages 1479 - 1486
    - PRATT ET AL., AM. J. PATH., (2003), vol. 163, no. 4, pages 1457 - 1465
    - PRATT ET AL., AM. J. PATH., vol. 163, no. 4, pages 1457 - 1465
    - COURTNEY ET AL., NATURE, (1980), vol. 283, page 666
    - TRENTHAN ET AL., J. EXP. MED., (1977), vol. 146, page 857
    - WANG ET AL., J. IMMUNOL., (2000), vol. 164, pages 4340 - 4347
    - WANG ET AL., PROC. NATL. ACAD. SCI., (1996), vol. 93, pages 8563 - 8568
    - ASIMAKOPOULOS, G., PEIFUSION, (1999), vol. 14, pages 269 - 77
    - GONG ET AL., I CLINICAL IMMUNOL., (1996), vol. 16, no. 4, pages 222 - 229
    - GUPTA-BANSAL ET AL., MOLECULAR IMMUNOL., (2000), vol. 37, pages 191 - 201
    - WARD, P., NATURE REVIEW IMMUNOLOGY, (2004), vol. 4, pages 133 - 142
    - HUBER-LANG ET AL., J. OF IMMUNOL., (2002), vol. 169, pages 3223 - 3231
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.