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Extract from the Register of European Patents

EP About this file: EP2272566

EP2272566 - Humanisation of antibodies [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  17.06.2016
Database last updated on 24.08.2024
Most recent event   Tooltip17.06.2016Application deemed to be withdrawnpublished on 20.07.2016  [2016/29]
Applicant(s)For all designated states
MedImmune, LLC
One MedImmune Way
Gaithersburg, MD 20878 / US
[2011/02]
Inventor(s)01 / Dall-Acqua, William
564 Chestertown Street
Gaithersburg, MD 20878 / US
02 / Damschroder, Melissa
43 Steeple Court
Germantown, MD 20874 / US
03 / Wu, Herren
14405 Harvest Moon Road
Boyds, MD 20841 / US
 [2011/02]
Representative(s)Gibbs, Richard
Marks & Clerk LLP The Beacon
176 St Vincent Street
Glasgow G2 5SG / GB
[N/P]
Former [2013/27]Gibbs, Richard
Marks & Clerk LLP Aurora 120 Bothwell Street
Glasgow G2 7JS / GB
Former [2011/02]Bates, Rosica Florence
Medlmmune Ltd. Milstein Building Granta Park
Cambridge CB21 6GH / GB
Application number, filing date10185161.618.08.2004
[2011/02]
Priority number, dateUS20030496367P18.08.2003         Original published format: US 496367 P
[2011/02]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2272566
Date:12.01.2011
Language:EN
[2011/02]
Type: A3 Search report 
No.:EP2272566
Date:02.01.2013
Language:EN
[2013/01]
Search report(s)(Supplementary) European search report - dispatched on:EP03.12.2012
ClassificationIPC:C07K16/00, C40B40/10, C12N15/10
[2014/43]
CPC:
C07K16/005 (EP,US); A61P35/00 (EP); A61P43/00 (EP);
C07H21/04 (EP,US); C07K16/40 (EP,US); C12N15/1037 (EP,US)
C-Set:
C12N15/1037, C12Q2563/131 (EP,US)
Former IPC [2011/02]A61P35/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IT,   LI,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/02]
TitleGerman:Humanisierung von antikörpern[2015/40]
English:Humanisation of antibodies[2011/02]
French:Humanisation d'anticorps[2011/02]
Former [2011/02]Humanisierung von antikörpern
Examination procedure27.06.2013Amendment by applicant (claims and/or description)
27.06.2013Examination requested  [2013/32]
03.09.2013Despatch of a communication from the examining division (Time limit: M06)
13.03.2014Reply to a communication from the examining division
01.04.2014Despatch of a communication from the examining division (Time limit: M04)
11.08.2014Reply to a communication from the examining division
02.10.2014Communication of intention to grant the patent
12.02.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
12.03.2015Communication of intention to grant the patent
22.07.2015Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
14.09.2015Communication of intention to grant the patent
25.01.2016Application deemed to be withdrawn, date of legal effect  [2016/29]
01.03.2016Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2016/29]
Parent application(s)   TooltipEP04816814.0  / EP1660186
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20040816814) is  08.06.2007
Fees paidRenewal fee
01.10.2010Renewal fee patent year 03
01.10.2010Renewal fee patent year 04
01.10.2010Renewal fee patent year 05
01.10.2010Renewal fee patent year 06
01.10.2010Renewal fee patent year 07
25.08.2011Renewal fee patent year 08
27.08.2012Renewal fee patent year 09
27.08.2013Renewal fee patent year 10
27.08.2014Renewal fee patent year 11
27.08.2015Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
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Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[A]WO03002607  (LEUNG SHAWN SHUI-ON [US]) [A] 1-14;
 [A]  - SODERLIND E ET AL, "RECOMBINING GERMLINE-DERIVED CDR SEQUENCES FOR CREATING DIVERSE SINGLE-FRAMEWORK ANTIBODY LIBRARIES", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20000801), vol. 18, no. 8, doi:10.1038/78458, ISSN 1087-0156, pages 852 - 856, XP009010618 [A] 1-14

DOI:   http://dx.doi.org/10.1038/78458
 [T]  - DALL'ACQUA W F ET AL, "Antibody humanization by framework shuffling", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, (200505), vol. 36, no. 1, ISSN 1046-2023, pages 43 - 60, XP004852552

DOI:   http://dx.doi.org/10.1016/j.ymeth.2005.01.005
Examination   - TANG Y ET AL, "Use of a peptide mimotope to guide the humanization of MRK-16, an anti-P-glycoprotein monoclonal antibody.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (19990924), vol. 274, no. 39, ISSN 0021-9258, pages 27371 - 27378
by applicantUS4176174
 US4526938
 WO8605807
 US4618486
 US4623627
 US4624846
 US4676980
 EP0239400
 US4724213
 US4724212
 US4742000
 WO8901036
 EP0307434
 US4816402
 US4880078
 US4910133
 WO9002809
 EP0367166
 US4946778
 US4980286
 WO9105548
 WO9106570
 WO9110737
 EP0439095
 US5057313
 US5080883
 WO9201047
 WO9206180
 US5112946
 US5122464
 US5122447
 US5128326
 WO9218619
 WO9219244
 WO9220316
 WO9222324
 WO9222635
 US5182107
 WO9311236
 US5223409
 WO9314188
 WO9320221
 WO9321232
 US5258498
 US5273743
 US5290540
 WO9408598
 US5318892
 WO9412649
 US5336603
 US5346687
 US5349053
 US5359046
 US5403484
 WO9515982
 US5427908
 US5436146
 WO9520401
 US5447851
 US5474981
 US5484704
 WO9604388
 US5516637
 US5521153
 US5521169
 US5530101
 WO9620698
 US5571698
 US5580717
 US5587459
 US5604126
 US5605793
 US5618709
 US5622929
 US5648239
 US5652114
 US5658727
 WO9732572
 WO9733899
 WO9734911
 US5679377
 WO9744013
 US5698426
 US5728868
 US5733743
 US5734033
 US5750753
 US5780225
 WO9831346
 WO9837186
 US5811238
 US5811310
 US5821047
 US5830721
 US5834252
 US5833988
 US5837458
 US5840745
 US5855913
 US5863904
 US5872223
 US5874064
 US5883120
 US5885834
 WO9915154
 WO9920253
 WO9923105
 US5911995
 US5912015
 US5916597
 US5922844
 US5925376
 US5929212
 US5934272
 US5958769
 US5969108
 US5985877
 US5985320
 US5985309
 US5989463
 US5998596
 WO9966903
 US6015555
 US6019968
 US6034053
 US6040305
 US6048528
 US6051582
 US6051574
 US6054297
 US6054466
 US6057300
 US6063930
 US6066738
 US6071935
 US6077853
 US6080870
 US6090948
 US6093737
 US6103723
 US6124465
 US6124295
 US6127366
 US6133303
 US6136526
 US6143766
 US6156498
 US6159984
 US6169096
 US6187786
 US6211193
 US6218410
 US6218372
 US6218406
 US6225322
 US6228865
 US6228856
 US6232338
 US6239140
 US6242196
 US6245759
 US6248756
 US6265422
 US6268363
 US6271242
 US6277832
 US6281344
 US6300501
 US6335156
 US6342765
 US6342487
 US6362188
 US6369034
 US6372747
 US6383790
 US6387905
 US6392020
 US6399633
 US6399615
 US6403581
 US6410541
 US6410539
 US6414145
 US6420387
 US6432959
 US6436960
 US6440974
 US6451812
 US6458935
 US2003040606
    - H CHAIN. ALBERTS ET AL., Molecular Biology of the Cell, GARLAND PUBLISHING, INC., (1989), page 1019
    - ALBERTS ET AL., Molecular Biology of the Cell, GARLAND PUBLISHING, INC., (1989), pages 1019 - 1020
    - RIECHMANN ET AL., NATURE, (1988), vol. 3, no. 32, pages 323 - 327
    - CHOTHIA; LESK, J. MOL. BIOL., (1987), vol. 196, pages 901 - 917
    - CHOTHIA ET AL., NATURE, (1989), vol. 342, pages 877 - 883
    - PADLAN, FASEB J., (1995), vol. 9, pages 133 - 139
    - MACCALLUM, J MOL BIOL, (1996), vol. 262, no. 5, pages 732 - 45
    - SHAPIRO ET AL., CRIT. REV. IMMUNOL., (2002), vol. 22, no. 3, pages 183 - 200
    - MARCHALONIS ET AL., ADV EXP MED BIOL., (2001), vol. 484, pages 13 - 30
    - KAWASAKI ET AL., EUR. J. IMMUNOL., (2001), vol. 31, pages 1017 - 1028
    - SCHABLE; ZACHAU, BIOL. CHEM. HOPPE SEYLER, (1993), vol. 374, pages 1001 - 1022
    - BRENSING-KUPPERS ET AL., GENE, (1997), vol. 191, pages 173 - 181
    - HIETER ET AL., J. BIOL. CHEM., (1982), vol. 257, pages 1516 - 1522
    - MATSUDA ET AL., J. EXP. MED., (1998), vol. 188, pages 1973 - 1975
    - KANG ET AL., PROC. NATL. ACAD. SCI., USA, (1991), vol. 88, pages 4363 - 4366
    - BARBAS ET AL., PROC. NATL. ACAD. SCI., USA, (1991), vol. 88, pages 7978 - 7982
    - ZEBEDEE ET AL., PROC. NATL. ACAD. SCI., USA, (1992), vol. 89, pages 3175 - 3179
    - KANG ET AL., PROC. NATL. ACAD. SCI., USA, (1991), vol. 88, pages 11120 - 11123
    - BARBAS ET AL., PROC. NATL. ACAD. SCI., USA, (1992), vol. 89, pages 4457 - 4461
    - GRAM ET AL., PROC. NATL. ACAD. SCI., USA, (1992), vol. 89, pages 3576 - 3580
    - BRINKMAN ET AL., J. HNMUNOL. METHODS, (1995), vol. 182, pages 41 - 50
    - AMES ET AL., J. HNMUNOL. METHODS, (1995), vol. 184, pages 177 - 186
    - KETTLEBOROUGH ET AL., EUR. J. IMMUNOL., (1994), vol. 24, pages 952 - 958
    - PERSIC ET AL., GENE, (1997), vol. 187, pages 9 - 18
    - BURTON ET AL., ADVANCES IN IMMUNOLOGY, (1994), vol. 57, pages 191 - 280
    - OHKAWA ET AL., J. BIOL. CHEM., (1981), vol. 256, pages 9951 - 9958
    - RACHED ET AL., MICROBIOL. REV., (1986), vol. 50, pages 401 - 427
    - MODEL ET AL., The Bacteriophages, PLENUM PUBLISHING CO., (1988), vol. 2, pages 375 - 456
    - BETTER ET AL., SCIENCE, (1988), vol. 240, pages 1041 - 1043
    - SASTRY, PROC. NATL. ACAD. SCI., USA, (1989), vol. 86, pages 5728 - 5732
    - MULLINAX ET AL., PROC. NATL. ACAD. SCI., USA, (1990), vol. 87, pages 8095 - 8099
    - LEI ET AL., NATURE, (1988), vol. 331, pages 543 - 546
    - OLIVER, Escherichia coli and Salmonella Typhimurium, AMERICAN SOCIETY FOR MICROBIOLOGY, (1987), vol. 1, pages 56 - 69
    - RASCHED ET AL., MICROBIOL. REV., (1986), vol. 50, pages 401 - 427
    - HORIUCHI, J. MOL. BIOL., (1986), vol. 188, pages 215 - 223
    - SHORT ET AL., NUCL. ACIDS RES., (1988), vol. 16, pages 7583 - 7600
    - MULLINAX ET AL., BIOTECHNIQUES, (1992), vol. 12, no. 6, pages 864 - 869
    - SAWAI ET AL., AJRI, (1995), vol. 34, pages 26 - 34
    - HUSTON ET AL., METHODS IN ENZYMOLOGY, (1991), vol. 203, pages 46 - 88
    - SHU ET AL., PNAS, (1993), vol. 90, pages 7995 - 7999
    - SKERRA ET AL., SCIENCE, (1988), vol. 240, pages 1038 - 1040
    - WU; AN, METHODS MOL. BIOL., (2003), vol. 207, pages 213 - 233
    - WU, METHODS MOL. BIOL., (2003), vol. 207, pages 197 - 212
    - KUNKEL ET AL., METHODS ENZYMOL., (1987), vol. 154, pages 367 - 382
    - VERMA ET AL., J IMMUNOL METHODS, (1998), vol. 216, no. 1-2, pages 165 - 81
    - KOLLER; SMITHIES, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 8932 - 8935
    - ZIJLSTRA ET AL., NATURE, (1989), vol. 342, pages 435 - 438
    - GHERARDI, E ET AL., J. IMMUNOL. METH., (1990), vol. 126, pages 61 - 68
    - WATKINS ET AL., ANAL. BIOCHEM., (1997), vol. 253, pages 37 - 45
    - GRADDIS ET AL., CURR PHARM BIOTECLMOL., (2002), vol. 3, no. 4, pages 285 - 97
    - HANES; PLUCTHAU, PNAS USA, (1997), vol. 94, pages 4937 - 4942
    - HE, J. IMMUNOL. METHODS, (1999), vol. 231, page 105
    - JERMUTUS ET AL., CURRENT OPINION IN BIOTECHNOLOGY, (1998), vol. 9, pages 534 - 548
    - Current Protocols in Molecular Biology, JOHN WILEY & SONS, INC., (1994), vol. I, page 11.2.1
    - WU ET AL., J. MOL. BIOL., (1999), vol. 294, pages 151 - 162
    - Current Protocols in Molecular Biology, JOHN WILEY & SONS, INC., (1994), vol. 1
    - GinTent Protocols in Molecular Biology, JOHN WILEY & SONS, INC., (1994), vol. 1
    - R. E. HAWKINS; S. J. RUSSELL; G. WINTER, J. MOL. BIOL., (1992), vol. 226, pages 889 - 896
    - J. K. SCOTT; G. P. SMITH, SCIENCE, (1990), vol. 249, pages 386 - 390
    - FOECKING ET AL., GENE, (1986), vol. 45, page 101
    - COCKETT ET AL., BIO/TECHNOLOGY, (1990), vol. 8, page 2
    - RUTHER ET AL., EMBO, (1983), vol. 12, page 1791
    - INOUYE; INOUYE, NUCLEIC ACIDS RES., (1985), vol. 13, pages 3101 - 3109
    - VAN HEEKE; SCHUSTER, J. BIOL. CHEM., (1989), vol. 24, pages 5503 - 5509
    - LOGAN; SHENK, PROC. NATL. ACAD. SCI. USA, (1984), vol. 8, no. 1, pages 355 - 359
    - BITTNER ET AL., METHODS IN ENZYMOL., (1987), vol. 153, pages 516 - 544
    - WIGLER ET AL., CELL, (1977), vol. 11, page 223
    - SZYBALSKA; SZYBALSKI, PROC. NATL. ACAD. SCI. USA, (1992), vol. 48, page 202
    - LOWY ET AL., CELL, (1980), vol. 22, pages 8 - 17
    - WIGLER ET AL., NATL. ACAD. SCI. USA, (1980), vol. 77, page 357
    - O'HARE ET AL., PROC. NATL. ACAD. SCI. USA, (1981), vol. 78, page 1527
    - MULLIGAN; BERG, PROC. NATL. ACAD. SCI. USA, (1981), vol. 78, page 2072
    - WU; WU, BIOTHERAPY, (1991), vol. 3, pages 87 - 95
    - TOLSTOSHEV, ANN. REV. PHARMACOL. TOXICOL., (1993), vol. 32, pages 573 - 596
    - MULLIGAN, SCIENCE, (1993), vol. 260, pages 926 - 932
    - MORGAN; ANDERSON, ANN. REV. BIOCHEM., (1993), vol. 62, pages 191 - 217
    - TIB TECH, (199305), vol. 11, no. 5, pages 155 - 2 15
    - SANTERRE ET AL., GENE, (1984), vol. 30, page 147
    - COLBERRE-GARAPIN ET AL., J. MOL. BIOL., (1981), vol. 150, page 1
    - DNA cloning, ACADEMIC PRESS, (1987), vol. 3
    - CROUSE ET AL., MOL. CELL. BIOL., (1983), vol. 3, page 257
    - PROUDFOOT, NATURE, (1986), vol. 322, page 52
    - KOHLER, PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, page 2 197
    - BRUGGEMANN, ARCH. IMMUNOL. THER. EXP. (WARSZ), (2001), vol. 49, no. 3, pages 203 - 8
    - BRUGGEMANN; NEUBERGER, IMMUNOL. TODAY, (1996), vol. 8, pages 391 - 7
    - NARAMURA ET AL., IMMUNOL. LETT., (1994), vol. 39, pages 91 - 99
    - GILLIES, PNAS, (1992), vol. 89, pages 1428 - 1432
    - FELL, J. IMMUNOL., (1991), vol. 146, pages 2446 - 2452
    - ASHKENAZI ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 10535 - 10539
    - ZHENG, J. IMMUNOL., (1995), vol. 154, pages 5590 - 5600
    - VIL ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 11337 - 11341
    - PATTEN ET AL., CURR. OPINION BIOTECHNOL., (1997), vol. 8, pages 724 - 33
    - HARAYAMA, TRENDS BIOTECHNOL., (1998), vol. 16, no. 2, pages 76 - 82
    - HANSSON ET AL., J. MOL. BIOL., (1999), vol. 287, pages 265 - 76
    - LORENZO; BLASCO, BIOTECHNIQUES, (1998), vol. 24, no. 2, pages 308 - 313
    - GENTZ, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 821 - 824
    - WILSON, CELL, (1984), vol. 37, page 767
    - WOYKE, ANTIMICROB. AGENTS CHEMOTHER, (2002), vol. 46, pages 3802 - 8
    - WOYKE ET AL., ANTIMICROB. AGENTS CHEMOTHER, (2001), vol. 45, pages 3580 - 4
    - MOHAMMAD ET AL., ANTICANCER DRUGS, (2001), vol. 12, pages 735 - 40
    - WALL, BIOCHEM. BIOPHYS. RES. COMMUN., (1999), vol. 266, pages 76 - 80
    - MOHAMMAD, INT. J. ONCOL., (1999), vol. 15, pages 367 - 72
    - KANTARJIAN ET AL., CLIN CANCER RES., (2002), vol. 8, no. 7, pages 2167 - 76
    - ROTHENBERG, M.L., ANNALS OF ONCOLOGY, (1997), vol. 8, pages 837 - 855
    - MOREAU, P. ET AL., J. MED. CHEM., (1998), vol. 41, pages 1631 - 1640
    - TAKAHASHI ET AL., J. IMMUNOL., (1994), vol. 6, pages 1567 - 1574
    - DENARDO ET AL., CLIN CANCER RES., (1998), vol. 4, no. 10, pages 2483 - 90
    - PETERSON ET AL., BIOCONJUG. CHEM., (1999), vol. 10, no. 4, pages 553 - 7
    - ZIMMERMAN ET AL., NUCL. MED. BIOL., (1999), vol. 26, no. 8, pages 943 - 50
    - "Monoclonal Antibodies For Immunotargeting Of Drugs In Cancer Therapy", ARNON ET AL., Monoclonal Antibodies And Cancer Therapy, ALAN R. LISS, INC., (1985), pages 243 - 56
    - "Antibodies For Drug Delivery", HELLSTROM ET AL., Controlled Drug Delivery, MARCEL DEKKER, INC., (1987), pages 623 - 53
    - "Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review", THORPE ET AL., Monoclonal Antibodies 84: Biological And Clinical Applications, (1985), pages 475 - 506
    - "Analysis, Results, And Future Prospective Of The Therapeutic Use Of Radiolabeled Antibody In Cancer Therapy", Monoclonal Antibodies For Cancer Detection And Therapy, ACADEMIC PRESS, (1985), pages 303 - 16
    - THORPE ET AL., IMMUNOL. REV., (1982), vol. 62, pages 119 - 58
    - UANANUE; BENACERRAF, Textbook of Immunology, WILLIAMS & WILKINS, (1984), page 218
    - WU; WU, J. BIOL. CHEM., (1987), vol. 262, pages 4429 - 4432
    - SEFTON, CRC CRIT. REF. BIOMED. ENG., (1987), vol. 14, page 20
    - BUCHWALD ET AL., SURGERY, (1980), vol. 88, page 507
    - SAUDEK ET AL., N. ENGL. J. MED., (1989), vol. 321, page 574
    - RANGER; PEPPAS, J., MACROMOL. SCI. REV. MACROMOL. CHEM., (1983), vol. 23, page 61
    - LEVY ET AL., SCIENCE, (1985), vol. 228, page 190
    - DURING ET AL., ANN. NEUROL., (1989), vol. 25, page 351
    - HOWARD ET AL., J. NEUROSURG., (1989), vol. 7 1, page 105
    - GOODSON, MEDICAL APPLICATIONS OF CONTROLLED RELEASE, (1984), vol. 2, pages 115 - 138
    - LANGER, SCIENCE, (1990), vol. 249, pages 1527 - 1533
    - NING ET AL., "Intratumoral Radioimmunotheraphy of a Human Colon Cancer Xenograft Using a Sustained-Release Gel", RADIOTHERAPY & ONCOLOGY, (1996), vol. 39, pages 179 - 189
    - SONG ET AL., "Antibody Mediated Lung Targeting of Long-Circulating Emulsions", PDA JOURNAL OF PHARMACEUTICAL SCIENCE & TECHNOLOGY, (1995), vol. 50, pages 372 - 397
    - CLEEK ET AL., "Biodegradable Polymeric Carriers for a bFGF Antibody for Cardiovascular Application", PRO. MFL. SYMP. CONTROL. REL. BIOACT. MATER., (1997), vol. 24, pages 853 - 854
    - LAM ET AL., "Microencapsulation of Recombinant Humanized Monoclonal Antibody for Local Delivery", PROC. INT'L. SYMP. CONTROL REL. BIOACT. MATER., (1997), vol. 24, pages 759 - 760
    - JOLIOT ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 1864 - 1868
    - GOLDSPIEL ET AL., CLINICAL PHARMACY, (1993), vol. 12, pages 488 - 505
    - TIBTECH, (199305), vol. 11, no. 5, pages 155 - 215
    - ZIJLSTRA, NATURE, (1989), vol. 342, pages 435 - 438
    - MILLER, METH. ENZYMOL., (1993), vol. 217, pages 581 - 599
    - BOESEN ET AL., BIOTHERAPY, (1994), vol. 6, pages 291 - 302
    - CLOWES ET AL., J. CLIN. INVEST., (1994), vol. 93, pages 644 - 651
    - KLEIN ET AL., BLOOD, (1994), vol. 83, pages 1467 - 1473
    - SALMONS; GUNZBERG, HUMAN GENE THERAPY, (1993), vol. 4, pages 129 - 141
    - GROSSMAN; WILSON, CURR. OPIN. IN GENETICS AND DEVEL., (1993), vol. 3, pages 110 - 114
    - KOZARSKY; WILSON, CURRENT OPINION IN GENETICS AND DEVELOPMENT, (1993), vol. 3, pages 499 - 503
    - BOUT ET AL., HUMAN GENE THERAPY, (1994), vol. 5, pages 3 - 10
    - ROSENFELD ET AL., SCIENCE, (1991), vol. 252, pages 431 - 434
    - ROSENFELD ET AL., CELL, (1992), vol. 68, pages 143 - 155
    - MASTRANGELI ET AL., J. CLIN. INVEST., (1993), vol. 91, pages 225 - 234
    - WANG ET AL., GENE THERAPY, (1995), vol. 2, pages 775 - 783
    - WALSH ET AL., PROC. SOC. EXP. BIOL. MED., (1993), vol. 204, pages 289 - 300
    - LOEFFLER; BEHR, METH. ENZYMOL., (1993), vol. 217, pages 599 - 618
    - COHEN ET AL., METH. ENZYMOL., (1993), vol. 217, pages 618 - 644
    - CLIN. PHARMA. THER., (1985), vol. 29, pages 69 - 92
    - STEMPLE; ANDERSON, CELL, (1992), vol. 7, no. 1, pages 973 - 985
    - RHEINWALD, METH. CELL BIO., (1980), vol. 21A, page 229
    - PITTELKOW; SCOTT, MAYO CLINIC PROC., (1986), vol. 61, page 771
    - HOUGHTEN, BIO/TECHNIQUES, (1992), vol. 13, pages 412 - 421
    - LAM, NATURE, (1991), vol. 354, pages 82 - 84
    - FODOR, NATURE, (1993), vol. 364, pages 555 - 556
    - CULL ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 1865 - 1869
    - SCOTT; SMITH, SCIENCE, (1990), vol. 249, pages 386 - 390
    - CWIRLA ET AL., PROC. NATL. ACAD. SCI. USA, (1990), vol. 87, pages 6378 - 6382
    - FELICI, J. MOL. BIOL., (1991), vol. 222, pages 301 - 310
    - JOHNSON ET AL., JOURNAL OF INFECTIOUS DISEASES, (1997), vol. 176, pages 1215 - 1224
    - GALES ET AL., DIAG. NICROBIOL. INFECT. DIS., (2002), vol. 44, no. 3, pages 301 - 311
    - HICKS ET AL., CLIN. MICROBIOL. INFECT., (2002), vol. 8, no. 11, pages 753 - 757
    - NICHOLSON ET AL., DIAGN. MICROBIOL. INFECT. DIS., (2002), vol. 44, no. 1, pages 101 - 107
    - PFALLER ET AL., INFECTIOUS DIS. CLIN. N. AM., (1993), vol. 7, pages 435 - 444
    - CLANCY ET AL., JOURNAL OF CLINICAL MICROBIOLOGY, (1997), vol. 35, no. 11, pages 2878 - 82
    - RYDER ET AL., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1998), vol. 42, no. 5, pages 1057 - 61
    - PFALLER ET AL., JOURNAL OF CLINICAL MICROBIOLOGY, (1994), vol. 32, no. 8, pages 1993 - 6
    - TIBALLI ET AL., JOURNAL OF CLINICAL MICROBIOLOGY, (1995), vol. 33, no. 4, pages 915 - 7
    - JAHN ET AL., JOURNAL OF CLINICAL MICROBIOLOGY, (1995), vol. 33, no. 3, pages 661 - 667
    - CARLES-KINCH ET AL., CANCER RES., (2002), vol. 62, pages 2840 - 2847
    - KINCH ET AL., CLIN. EXP. METASTASIS, (2003), vol. 20, pages 59 - 68
    - SANGER ET AL., PROC. NATL. ACAD. SCI. USA., (1977), vol. 74, pages 5463 - 5467
    - K.F. SCHABLE ET AL., BIOL. CHEM. HOPPE SEYLER, (1993), vol. 374, pages 1001 - 1022
    - J. BRENSING-KUPPERS ET AL., GENE, (1997), vol. 191, pages 173 - 181
    - P.A. HIETER ET AL., J. BIOL. CHEM., (1982), vol. 257, pages 1516 - 1522
    - F. MATSUDA ET AL., J. EXP. MED., (1998), vol. 188, pages 1973 - 1975
    - J.V. RAVETCH ET AL., CELL, (1981), vol. 27, no. 3 PT 2, pages 583 - 591
    - HO ET AL., GENE, (1989), vol. 77, pages 51 - 59
    - H. WU ET AL., METHODS MOL. BIOL., (2003), vol. 207, pages 213 - 233
    - WU ET AL., METHODS MOL. BIOL., (2003), vol. 207, pages 213 - 233
    - H. WU, METHODS MOL. BIOL., (2003), vol. 207, pages 197 - 212
    - WU, METHODS MOL. BIOL., (2003), vol. 207, pages 213 - 233
    - S. JOHNSON ET AL., J. INFECT. DIS., (1997), vol. 176, pages 1215 - 1224
    - M. BOSHART ET AL., CELL, (1985), vol. 41, pages 521 - 530
    - S. JOHNSON ET AL., INFECT. DIS., (1997), vol. 176, pages 1215 - 1224
    - B. JOHNSSON ET AL., ANAL. BIOCHEM., (1991), vol. 198, pages 268 - 277
    - D.M. CROTHERS ET AL., IMMUNOCHEMISTRY, (1972), vol. 9, pages 341 - 357
    - K.M. MULLER ET AL., ANAL. BIOCHEM., (1998), vol. 261, pages 49 - 158
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