EP2272566 - Humanisation of antibodies [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 17.06.2016 Database last updated on 24.08.2024 | Most recent event Tooltip | 17.06.2016 | Application deemed to be withdrawn | published on 20.07.2016 [2016/29] | Applicant(s) | For all designated states MedImmune, LLC One MedImmune Way Gaithersburg, MD 20878 / US | [2011/02] | Inventor(s) | 01 /
Dall-Acqua, William 564 Chestertown Street Gaithersburg, MD 20878 / US | 02 /
Damschroder, Melissa 43 Steeple Court Germantown, MD 20874 / US | 03 /
Wu, Herren 14405 Harvest Moon Road Boyds, MD 20841 / US | [2011/02] | Representative(s) | Gibbs, Richard Marks & Clerk LLP The Beacon 176 St Vincent Street Glasgow G2 5SG / GB | [N/P] |
Former [2013/27] | Gibbs, Richard Marks & Clerk LLP Aurora 120 Bothwell Street Glasgow G2 7JS / GB | ||
Former [2011/02] | Bates, Rosica Florence Medlmmune Ltd. Milstein Building Granta Park Cambridge CB21 6GH / GB | Application number, filing date | 10185161.6 | 18.08.2004 | [2011/02] | Priority number, date | US20030496367P | 18.08.2003 Original published format: US 496367 P | [2011/02] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP2272566 | Date: | 12.01.2011 | Language: | EN | [2011/02] | Type: | A3 Search report | No.: | EP2272566 | Date: | 02.01.2013 | Language: | EN | [2013/01] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 03.12.2012 | Classification | IPC: | C07K16/00, C40B40/10, C12N15/10 | [2014/43] | CPC: |
C07K16/005 (EP,US);
A61P35/00 (EP);
A61P43/00 (EP);
C07H21/04 (EP,US);
C07K16/40 (EP,US);
C12N15/1037 (EP,US)
| C-Set: |
C12N15/1037, C12Q2563/131 (EP,US)
|
Former IPC [2011/02] | A61P35/00 | Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LI, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR [2011/02] | Title | German: | Humanisierung von antikörpern | [2015/40] | English: | Humanisation of antibodies | [2011/02] | French: | Humanisation d'anticorps | [2011/02] |
Former [2011/02] | Humanisierung von antikörpern | Examination procedure | 27.06.2013 | Amendment by applicant (claims and/or description) | 27.06.2013 | Examination requested [2013/32] | 03.09.2013 | Despatch of a communication from the examining division (Time limit: M06) | 13.03.2014 | Reply to a communication from the examining division | 01.04.2014 | Despatch of a communication from the examining division (Time limit: M04) | 11.08.2014 | Reply to a communication from the examining division | 02.10.2014 | Communication of intention to grant the patent | 12.02.2015 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 12.03.2015 | Communication of intention to grant the patent | 22.07.2015 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 14.09.2015 | Communication of intention to grant the patent | 25.01.2016 | Application deemed to be withdrawn, date of legal effect [2016/29] | 01.03.2016 | Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time [2016/29] | Parent application(s) Tooltip | EP04816814.0 / EP1660186 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20040816814) is 08.06.2007 | Fees paid | Renewal fee | 01.10.2010 | Renewal fee patent year 03 | 01.10.2010 | Renewal fee patent year 04 | 01.10.2010 | Renewal fee patent year 05 | 01.10.2010 | Renewal fee patent year 06 | 01.10.2010 | Renewal fee patent year 07 | 25.08.2011 | Renewal fee patent year 08 | 27.08.2012 | Renewal fee patent year 09 | 27.08.2013 | Renewal fee patent year 10 | 27.08.2014 | Renewal fee patent year 11 | 27.08.2015 | Renewal fee patent year 12 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [A]WO03002607 (LEUNG SHAWN SHUI-ON [US]) [A] 1-14; | [A] - SODERLIND E ET AL, "RECOMBINING GERMLINE-DERIVED CDR SEQUENCES FOR CREATING DIVERSE SINGLE-FRAMEWORK ANTIBODY LIBRARIES", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, (20000801), vol. 18, no. 8, doi:10.1038/78458, ISSN 1087-0156, pages 852 - 856, XP009010618 [A] 1-14 DOI: http://dx.doi.org/10.1038/78458 | [T] - DALL'ACQUA W F ET AL, "Antibody humanization by framework shuffling", METHODS : A COMPANION TO METHODS IN ENZYMOLOGY, ACADEMIC PRESS INC., NEW YORK, NY, US, (200505), vol. 36, no. 1, ISSN 1046-2023, pages 43 - 60, XP004852552 DOI: http://dx.doi.org/10.1016/j.ymeth.2005.01.005 | Examination | - TANG Y ET AL, "Use of a peptide mimotope to guide the humanization of MRK-16, an anti-P-glycoprotein monoclonal antibody.", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (19990924), vol. 274, no. 39, ISSN 0021-9258, pages 27371 - 27378 | by applicant | US4176174 | US4526938 | WO8605807 | US4618486 | US4623627 | US4624846 | US4676980 | EP0239400 | US4724213 | US4724212 | US4742000 | WO8901036 | EP0307434 | US4816402 | US4880078 | US4910133 | WO9002809 | EP0367166 | US4946778 | US4980286 | WO9105548 | WO9106570 | WO9110737 | EP0439095 | US5057313 | US5080883 | WO9201047 | WO9206180 | US5112946 | US5122464 | US5122447 | US5128326 | WO9218619 | WO9219244 | WO9220316 | WO9222324 | WO9222635 | US5182107 | WO9311236 | US5223409 | WO9314188 | WO9320221 | WO9321232 | US5258498 | US5273743 | US5290540 | WO9408598 | US5318892 | WO9412649 | US5336603 | US5346687 | US5349053 | US5359046 | US5403484 | WO9515982 | US5427908 | US5436146 | WO9520401 | US5447851 | US5474981 | US5484704 | WO9604388 | US5516637 | US5521153 | US5521169 | US5530101 | WO9620698 | US5571698 | US5580717 | US5587459 | US5604126 | US5605793 | US5618709 | US5622929 | US5648239 | US5652114 | US5658727 | WO9732572 | WO9733899 | WO9734911 | US5679377 | WO9744013 | US5698426 | US5728868 | US5733743 | US5734033 | US5750753 | US5780225 | WO9831346 | WO9837186 | US5811238 | US5811310 | US5821047 | US5830721 | US5834252 | US5833988 | US5837458 | US5840745 | US5855913 | US5863904 | US5872223 | US5874064 | US5883120 | US5885834 | WO9915154 | WO9920253 | WO9923105 | US5911995 | US5912015 | US5916597 | US5922844 | US5925376 | US5929212 | US5934272 | US5958769 | US5969108 | US5985877 | US5985320 | US5985309 | US5989463 | US5998596 | WO9966903 | US6015555 | US6019968 | US6034053 | US6040305 | US6048528 | US6051582 | US6051574 | US6054297 | US6054466 | US6057300 | US6063930 | US6066738 | US6071935 | US6077853 | US6080870 | US6090948 | US6093737 | US6103723 | US6124465 | US6124295 | US6127366 | US6133303 | US6136526 | US6143766 | US6156498 | US6159984 | US6169096 | US6187786 | US6211193 | US6218410 | US6218372 | US6218406 | US6225322 | US6228865 | US6228856 | US6232338 | US6239140 | US6242196 | US6245759 | US6248756 | US6265422 | US6268363 | US6271242 | US6277832 | US6281344 | US6300501 | US6335156 | US6342765 | US6342487 | US6362188 | US6369034 | US6372747 | US6383790 | US6387905 | US6392020 | US6399633 | US6399615 | US6403581 | US6410541 | US6410539 | US6414145 | US6420387 | US6432959 | US6436960 | US6440974 | US6451812 | US6458935 | US2003040606 | - H CHAIN. ALBERTS ET AL., Molecular Biology of the Cell, GARLAND PUBLISHING, INC., (1989), page 1019 | - ALBERTS ET AL., Molecular Biology of the Cell, GARLAND PUBLISHING, INC., (1989), pages 1019 - 1020 | - RIECHMANN ET AL., NATURE, (1988), vol. 3, no. 32, pages 323 - 327 | - CHOTHIA; LESK, J. MOL. BIOL., (1987), vol. 196, pages 901 - 917 | - CHOTHIA ET AL., NATURE, (1989), vol. 342, pages 877 - 883 | - PADLAN, FASEB J., (1995), vol. 9, pages 133 - 139 | - MACCALLUM, J MOL BIOL, (1996), vol. 262, no. 5, pages 732 - 45 | - SHAPIRO ET AL., CRIT. REV. IMMUNOL., (2002), vol. 22, no. 3, pages 183 - 200 | - MARCHALONIS ET AL., ADV EXP MED BIOL., (2001), vol. 484, pages 13 - 30 | - KAWASAKI ET AL., EUR. J. IMMUNOL., (2001), vol. 31, pages 1017 - 1028 | - SCHABLE; ZACHAU, BIOL. CHEM. HOPPE SEYLER, (1993), vol. 374, pages 1001 - 1022 | - BRENSING-KUPPERS ET AL., GENE, (1997), vol. 191, pages 173 - 181 | - HIETER ET AL., J. BIOL. CHEM., (1982), vol. 257, pages 1516 - 1522 | - MATSUDA ET AL., J. EXP. MED., (1998), vol. 188, pages 1973 - 1975 | - KANG ET AL., PROC. NATL. ACAD. SCI., USA, (1991), vol. 88, pages 4363 - 4366 | - BARBAS ET AL., PROC. NATL. ACAD. SCI., USA, (1991), vol. 88, pages 7978 - 7982 | - ZEBEDEE ET AL., PROC. NATL. ACAD. SCI., USA, (1992), vol. 89, pages 3175 - 3179 | - KANG ET AL., PROC. NATL. ACAD. SCI., USA, (1991), vol. 88, pages 11120 - 11123 | - BARBAS ET AL., PROC. NATL. ACAD. SCI., USA, (1992), vol. 89, pages 4457 - 4461 | - GRAM ET AL., PROC. NATL. ACAD. SCI., USA, (1992), vol. 89, pages 3576 - 3580 | - BRINKMAN ET AL., J. HNMUNOL. METHODS, (1995), vol. 182, pages 41 - 50 | - AMES ET AL., J. HNMUNOL. METHODS, (1995), vol. 184, pages 177 - 186 | - KETTLEBOROUGH ET AL., EUR. J. IMMUNOL., (1994), vol. 24, pages 952 - 958 | - PERSIC ET AL., GENE, (1997), vol. 187, pages 9 - 18 | - BURTON ET AL., ADVANCES IN IMMUNOLOGY, (1994), vol. 57, pages 191 - 280 | - OHKAWA ET AL., J. BIOL. CHEM., (1981), vol. 256, pages 9951 - 9958 | - RACHED ET AL., MICROBIOL. REV., (1986), vol. 50, pages 401 - 427 | - MODEL ET AL., The Bacteriophages, PLENUM PUBLISHING CO., (1988), vol. 2, pages 375 - 456 | - BETTER ET AL., SCIENCE, (1988), vol. 240, pages 1041 - 1043 | - SASTRY, PROC. NATL. ACAD. SCI., USA, (1989), vol. 86, pages 5728 - 5732 | - MULLINAX ET AL., PROC. NATL. ACAD. SCI., USA, (1990), vol. 87, pages 8095 - 8099 | - LEI ET AL., NATURE, (1988), vol. 331, pages 543 - 546 | - OLIVER, Escherichia coli and Salmonella Typhimurium, AMERICAN SOCIETY FOR MICROBIOLOGY, (1987), vol. 1, pages 56 - 69 | - RASCHED ET AL., MICROBIOL. REV., (1986), vol. 50, pages 401 - 427 | - HORIUCHI, J. MOL. BIOL., (1986), vol. 188, pages 215 - 223 | - SHORT ET AL., NUCL. ACIDS RES., (1988), vol. 16, pages 7583 - 7600 | - MULLINAX ET AL., BIOTECHNIQUES, (1992), vol. 12, no. 6, pages 864 - 869 | - SAWAI ET AL., AJRI, (1995), vol. 34, pages 26 - 34 | - HUSTON ET AL., METHODS IN ENZYMOLOGY, (1991), vol. 203, pages 46 - 88 | - SHU ET AL., PNAS, (1993), vol. 90, pages 7995 - 7999 | - SKERRA ET AL., SCIENCE, (1988), vol. 240, pages 1038 - 1040 | - WU; AN, METHODS MOL. BIOL., (2003), vol. 207, pages 213 - 233 | - WU, METHODS MOL. BIOL., (2003), vol. 207, pages 197 - 212 | - KUNKEL ET AL., METHODS ENZYMOL., (1987), vol. 154, pages 367 - 382 | - VERMA ET AL., J IMMUNOL METHODS, (1998), vol. 216, no. 1-2, pages 165 - 81 | - KOLLER; SMITHIES, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 8932 - 8935 | - ZIJLSTRA ET AL., NATURE, (1989), vol. 342, pages 435 - 438 | - GHERARDI, E ET AL., J. IMMUNOL. METH., (1990), vol. 126, pages 61 - 68 | - WATKINS ET AL., ANAL. BIOCHEM., (1997), vol. 253, pages 37 - 45 | - GRADDIS ET AL., CURR PHARM BIOTECLMOL., (2002), vol. 3, no. 4, pages 285 - 97 | - HANES; PLUCTHAU, PNAS USA, (1997), vol. 94, pages 4937 - 4942 | - HE, J. IMMUNOL. METHODS, (1999), vol. 231, page 105 | - JERMUTUS ET AL., CURRENT OPINION IN BIOTECHNOLOGY, (1998), vol. 9, pages 534 - 548 | - Current Protocols in Molecular Biology, JOHN WILEY & SONS, INC., (1994), vol. I, page 11.2.1 | - WU ET AL., J. MOL. BIOL., (1999), vol. 294, pages 151 - 162 | - Current Protocols in Molecular Biology, JOHN WILEY & SONS, INC., (1994), vol. 1 | - GinTent Protocols in Molecular Biology, JOHN WILEY & SONS, INC., (1994), vol. 1 | - R. E. HAWKINS; S. J. RUSSELL; G. WINTER, J. MOL. BIOL., (1992), vol. 226, pages 889 - 896 | - J. K. SCOTT; G. P. SMITH, SCIENCE, (1990), vol. 249, pages 386 - 390 | - FOECKING ET AL., GENE, (1986), vol. 45, page 101 | - COCKETT ET AL., BIO/TECHNOLOGY, (1990), vol. 8, page 2 | - RUTHER ET AL., EMBO, (1983), vol. 12, page 1791 | - INOUYE; INOUYE, NUCLEIC ACIDS RES., (1985), vol. 13, pages 3101 - 3109 | - VAN HEEKE; SCHUSTER, J. BIOL. CHEM., (1989), vol. 24, pages 5503 - 5509 | - LOGAN; SHENK, PROC. NATL. ACAD. SCI. USA, (1984), vol. 8, no. 1, pages 355 - 359 | - BITTNER ET AL., METHODS IN ENZYMOL., (1987), vol. 153, pages 516 - 544 | - WIGLER ET AL., CELL, (1977), vol. 11, page 223 | - SZYBALSKA; SZYBALSKI, PROC. NATL. ACAD. SCI. USA, (1992), vol. 48, page 202 | - LOWY ET AL., CELL, (1980), vol. 22, pages 8 - 17 | - WIGLER ET AL., NATL. ACAD. SCI. USA, (1980), vol. 77, page 357 | - O'HARE ET AL., PROC. NATL. ACAD. SCI. USA, (1981), vol. 78, page 1527 | - MULLIGAN; BERG, PROC. NATL. ACAD. SCI. USA, (1981), vol. 78, page 2072 | - WU; WU, BIOTHERAPY, (1991), vol. 3, pages 87 - 95 | - TOLSTOSHEV, ANN. REV. PHARMACOL. TOXICOL., (1993), vol. 32, pages 573 - 596 | - MULLIGAN, SCIENCE, (1993), vol. 260, pages 926 - 932 | - MORGAN; ANDERSON, ANN. REV. BIOCHEM., (1993), vol. 62, pages 191 - 217 | - TIB TECH, (199305), vol. 11, no. 5, pages 155 - 2 15 | - SANTERRE ET AL., GENE, (1984), vol. 30, page 147 | - COLBERRE-GARAPIN ET AL., J. MOL. BIOL., (1981), vol. 150, page 1 | - DNA cloning, ACADEMIC PRESS, (1987), vol. 3 | - CROUSE ET AL., MOL. CELL. BIOL., (1983), vol. 3, page 257 | - PROUDFOOT, NATURE, (1986), vol. 322, page 52 | - KOHLER, PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, page 2 197 | - BRUGGEMANN, ARCH. IMMUNOL. THER. EXP. (WARSZ), (2001), vol. 49, no. 3, pages 203 - 8 | - BRUGGEMANN; NEUBERGER, IMMUNOL. TODAY, (1996), vol. 8, pages 391 - 7 | - NARAMURA ET AL., IMMUNOL. LETT., (1994), vol. 39, pages 91 - 99 | - GILLIES, PNAS, (1992), vol. 89, pages 1428 - 1432 | - FELL, J. IMMUNOL., (1991), vol. 146, pages 2446 - 2452 | - ASHKENAZI ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 10535 - 10539 | - ZHENG, J. IMMUNOL., (1995), vol. 154, pages 5590 - 5600 | - VIL ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 11337 - 11341 | - PATTEN ET AL., CURR. OPINION BIOTECHNOL., (1997), vol. 8, pages 724 - 33 | - HARAYAMA, TRENDS BIOTECHNOL., (1998), vol. 16, no. 2, pages 76 - 82 | - HANSSON ET AL., J. MOL. BIOL., (1999), vol. 287, pages 265 - 76 | - LORENZO; BLASCO, BIOTECHNIQUES, (1998), vol. 24, no. 2, pages 308 - 313 | - GENTZ, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 821 - 824 | - WILSON, CELL, (1984), vol. 37, page 767 | - WOYKE, ANTIMICROB. AGENTS CHEMOTHER, (2002), vol. 46, pages 3802 - 8 | - WOYKE ET AL., ANTIMICROB. AGENTS CHEMOTHER, (2001), vol. 45, pages 3580 - 4 | - MOHAMMAD ET AL., ANTICANCER DRUGS, (2001), vol. 12, pages 735 - 40 | - WALL, BIOCHEM. BIOPHYS. RES. COMMUN., (1999), vol. 266, pages 76 - 80 | - MOHAMMAD, INT. J. ONCOL., (1999), vol. 15, pages 367 - 72 | - KANTARJIAN ET AL., CLIN CANCER RES., (2002), vol. 8, no. 7, pages 2167 - 76 | - ROTHENBERG, M.L., ANNALS OF ONCOLOGY, (1997), vol. 8, pages 837 - 855 | - MOREAU, P. ET AL., J. MED. CHEM., (1998), vol. 41, pages 1631 - 1640 | - TAKAHASHI ET AL., J. IMMUNOL., (1994), vol. 6, pages 1567 - 1574 | - DENARDO ET AL., CLIN CANCER RES., (1998), vol. 4, no. 10, pages 2483 - 90 | - PETERSON ET AL., BIOCONJUG. CHEM., (1999), vol. 10, no. 4, pages 553 - 7 | - ZIMMERMAN ET AL., NUCL. MED. BIOL., (1999), vol. 26, no. 8, pages 943 - 50 | - "Monoclonal Antibodies For Immunotargeting Of Drugs In Cancer Therapy", ARNON ET AL., Monoclonal Antibodies And Cancer Therapy, ALAN R. LISS, INC., (1985), pages 243 - 56 | - "Antibodies For Drug Delivery", HELLSTROM ET AL., Controlled Drug Delivery, MARCEL DEKKER, INC., (1987), pages 623 - 53 | - "Antibody Carriers Of Cytotoxic Agents In Cancer Therapy: A Review", THORPE ET AL., Monoclonal Antibodies 84: Biological And Clinical Applications, (1985), pages 475 - 506 | - "Analysis, Results, And Future Prospective Of The Therapeutic Use Of Radiolabeled Antibody In Cancer Therapy", Monoclonal Antibodies For Cancer Detection And Therapy, ACADEMIC PRESS, (1985), pages 303 - 16 | - THORPE ET AL., IMMUNOL. REV., (1982), vol. 62, pages 119 - 58 | - UANANUE; BENACERRAF, Textbook of Immunology, WILLIAMS & WILKINS, (1984), page 218 | - WU; WU, J. BIOL. CHEM., (1987), vol. 262, pages 4429 - 4432 | - SEFTON, CRC CRIT. REF. BIOMED. ENG., (1987), vol. 14, page 20 | - BUCHWALD ET AL., SURGERY, (1980), vol. 88, page 507 | - SAUDEK ET AL., N. ENGL. J. MED., (1989), vol. 321, page 574 | - RANGER; PEPPAS, J., MACROMOL. SCI. REV. MACROMOL. CHEM., (1983), vol. 23, page 61 | - LEVY ET AL., SCIENCE, (1985), vol. 228, page 190 | - DURING ET AL., ANN. NEUROL., (1989), vol. 25, page 351 | - HOWARD ET AL., J. NEUROSURG., (1989), vol. 7 1, page 105 | - GOODSON, MEDICAL APPLICATIONS OF CONTROLLED RELEASE, (1984), vol. 2, pages 115 - 138 | - LANGER, SCIENCE, (1990), vol. 249, pages 1527 - 1533 | - NING ET AL., "Intratumoral Radioimmunotheraphy of a Human Colon Cancer Xenograft Using a Sustained-Release Gel", RADIOTHERAPY & ONCOLOGY, (1996), vol. 39, pages 179 - 189 | - SONG ET AL., "Antibody Mediated Lung Targeting of Long-Circulating Emulsions", PDA JOURNAL OF PHARMACEUTICAL SCIENCE & TECHNOLOGY, (1995), vol. 50, pages 372 - 397 | - CLEEK ET AL., "Biodegradable Polymeric Carriers for a bFGF Antibody for Cardiovascular Application", PRO. MFL. SYMP. CONTROL. REL. BIOACT. MATER., (1997), vol. 24, pages 853 - 854 | - LAM ET AL., "Microencapsulation of Recombinant Humanized Monoclonal Antibody for Local Delivery", PROC. INT'L. SYMP. CONTROL REL. BIOACT. MATER., (1997), vol. 24, pages 759 - 760 | - JOLIOT ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 1864 - 1868 | - GOLDSPIEL ET AL., CLINICAL PHARMACY, (1993), vol. 12, pages 488 - 505 | - TIBTECH, (199305), vol. 11, no. 5, pages 155 - 215 | - ZIJLSTRA, NATURE, (1989), vol. 342, pages 435 - 438 | - MILLER, METH. ENZYMOL., (1993), vol. 217, pages 581 - 599 | - BOESEN ET AL., BIOTHERAPY, (1994), vol. 6, pages 291 - 302 | - CLOWES ET AL., J. CLIN. INVEST., (1994), vol. 93, pages 644 - 651 | - KLEIN ET AL., BLOOD, (1994), vol. 83, pages 1467 - 1473 | - SALMONS; GUNZBERG, HUMAN GENE THERAPY, (1993), vol. 4, pages 129 - 141 | - GROSSMAN; WILSON, CURR. OPIN. IN GENETICS AND DEVEL., (1993), vol. 3, pages 110 - 114 | - KOZARSKY; WILSON, CURRENT OPINION IN GENETICS AND DEVELOPMENT, (1993), vol. 3, pages 499 - 503 | - BOUT ET AL., HUMAN GENE THERAPY, (1994), vol. 5, pages 3 - 10 | - ROSENFELD ET AL., SCIENCE, (1991), vol. 252, pages 431 - 434 | - ROSENFELD ET AL., CELL, (1992), vol. 68, pages 143 - 155 | - MASTRANGELI ET AL., J. CLIN. INVEST., (1993), vol. 91, pages 225 - 234 | - WANG ET AL., GENE THERAPY, (1995), vol. 2, pages 775 - 783 | - WALSH ET AL., PROC. SOC. EXP. BIOL. MED., (1993), vol. 204, pages 289 - 300 | - LOEFFLER; BEHR, METH. ENZYMOL., (1993), vol. 217, pages 599 - 618 | - COHEN ET AL., METH. ENZYMOL., (1993), vol. 217, pages 618 - 644 | - CLIN. PHARMA. THER., (1985), vol. 29, pages 69 - 92 | - STEMPLE; ANDERSON, CELL, (1992), vol. 7, no. 1, pages 973 - 985 | - RHEINWALD, METH. CELL BIO., (1980), vol. 21A, page 229 | - PITTELKOW; SCOTT, MAYO CLINIC PROC., (1986), vol. 61, page 771 | - HOUGHTEN, BIO/TECHNIQUES, (1992), vol. 13, pages 412 - 421 | - LAM, NATURE, (1991), vol. 354, pages 82 - 84 | - FODOR, NATURE, (1993), vol. 364, pages 555 - 556 | - CULL ET AL., PROC. NATL. ACAD. SCI. USA, (1992), vol. 89, pages 1865 - 1869 | - SCOTT; SMITH, SCIENCE, (1990), vol. 249, pages 386 - 390 | - CWIRLA ET AL., PROC. NATL. ACAD. SCI. USA, (1990), vol. 87, pages 6378 - 6382 | - FELICI, J. MOL. BIOL., (1991), vol. 222, pages 301 - 310 | - JOHNSON ET AL., JOURNAL OF INFECTIOUS DISEASES, (1997), vol. 176, pages 1215 - 1224 | - GALES ET AL., DIAG. NICROBIOL. INFECT. DIS., (2002), vol. 44, no. 3, pages 301 - 311 | - HICKS ET AL., CLIN. MICROBIOL. INFECT., (2002), vol. 8, no. 11, pages 753 - 757 | - NICHOLSON ET AL., DIAGN. MICROBIOL. INFECT. DIS., (2002), vol. 44, no. 1, pages 101 - 107 | - PFALLER ET AL., INFECTIOUS DIS. CLIN. N. AM., (1993), vol. 7, pages 435 - 444 | - CLANCY ET AL., JOURNAL OF CLINICAL MICROBIOLOGY, (1997), vol. 35, no. 11, pages 2878 - 82 | - RYDER ET AL., ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (1998), vol. 42, no. 5, pages 1057 - 61 | - PFALLER ET AL., JOURNAL OF CLINICAL MICROBIOLOGY, (1994), vol. 32, no. 8, pages 1993 - 6 | - TIBALLI ET AL., JOURNAL OF CLINICAL MICROBIOLOGY, (1995), vol. 33, no. 4, pages 915 - 7 | - JAHN ET AL., JOURNAL OF CLINICAL MICROBIOLOGY, (1995), vol. 33, no. 3, pages 661 - 667 | - CARLES-KINCH ET AL., CANCER RES., (2002), vol. 62, pages 2840 - 2847 | - KINCH ET AL., CLIN. EXP. METASTASIS, (2003), vol. 20, pages 59 - 68 | - SANGER ET AL., PROC. NATL. ACAD. SCI. USA., (1977), vol. 74, pages 5463 - 5467 | - K.F. SCHABLE ET AL., BIOL. CHEM. HOPPE SEYLER, (1993), vol. 374, pages 1001 - 1022 | - J. BRENSING-KUPPERS ET AL., GENE, (1997), vol. 191, pages 173 - 181 | - P.A. HIETER ET AL., J. BIOL. CHEM., (1982), vol. 257, pages 1516 - 1522 | - F. MATSUDA ET AL., J. EXP. MED., (1998), vol. 188, pages 1973 - 1975 | - J.V. RAVETCH ET AL., CELL, (1981), vol. 27, no. 3 PT 2, pages 583 - 591 | - HO ET AL., GENE, (1989), vol. 77, pages 51 - 59 | - H. WU ET AL., METHODS MOL. BIOL., (2003), vol. 207, pages 213 - 233 | - WU ET AL., METHODS MOL. BIOL., (2003), vol. 207, pages 213 - 233 | - H. WU, METHODS MOL. BIOL., (2003), vol. 207, pages 197 - 212 | - WU, METHODS MOL. BIOL., (2003), vol. 207, pages 213 - 233 | - S. JOHNSON ET AL., J. INFECT. DIS., (1997), vol. 176, pages 1215 - 1224 | - M. BOSHART ET AL., CELL, (1985), vol. 41, pages 521 - 530 | - S. JOHNSON ET AL., INFECT. DIS., (1997), vol. 176, pages 1215 - 1224 | - B. JOHNSSON ET AL., ANAL. BIOCHEM., (1991), vol. 198, pages 268 - 277 | - D.M. CROTHERS ET AL., IMMUNOCHEMISTRY, (1972), vol. 9, pages 341 - 357 | - K.M. MULLER ET AL., ANAL. BIOCHEM., (1998), vol. 261, pages 49 - 158 | WO1991GB01134 | US20030496367 |