Deutsch English Français

Contact

EP2292733

European procedure

Quick help

Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...

News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...

Extract from the Register of European Patents

EP About this file: EP2292733

EP2292733 - Production from blood of cells of neural lineage [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 31.07.2020 Database last updated on 19.07.2024
Former	The patent has been granted Status updated on 23.08.2019
Former	Grant of patent is intended Status updated on 02.04.2019
Former	Examination is in progress Status updated on 07.12.2016
Most recent event Tooltip	31.07.2020	No opposition filed within time limit	published on 02.09.2020 [2020/36]
Applicant(s)	For all designated states Kwalata Trading Limited Zinonos Kiteos 8, Kato Lakatamia 2322 Nicosia / CY
	[2019/38]
Former [2011/10]	For all designated states Kwalata Trading Limited PO. Box 22454 1522 Nicosia / CY
Inventor(s)	01 / Fulga, Valentin 475 Glengarry Ave. Toronto, ON M5M 1E9 / CA
	02 / Porat, Yael 47 Herzl Street Hod Hasharon 4528353 / IL
	03 / Porozov, Svetlana Via Varna 4b Gambassi Terme (FI) 50050 / IT
	[2019/38]
Former [2011/30]	01 / Fulga, Valentin 7 Helsinki Street 62996, Tel Aviv / IL
	02 / Porat, Yael 47 Herzl Street 45283, Hod Hasharon / IL
	03 / Porozov, Svetlana Via Varna 4b 50050 Gambassi Terme (FI) / IT
Former [2011/22]	01 / Fulga, Valentin 7 Helsinki Street 62996, Tel Aviv / IL
	02 / Porat, Yael 47 Herzl Street 45283, Hod Hasharon / IL
	03 / Porozov, Svetlana Via Varna 4b 50050 Gambassi Terme (FI) / IT
	04 / Fisher, Yehudit 10/28 Zecharia HaTuka Street Rehovot / IL
Former [2011/10]	01 / Fulga, Valentin 7 Helsinki Street 62996, Tel Aviv / IL
	02 / Porat, Yael 47 Herzl Street 45283, Hod Hasharon / IL
	03 / Porozov, Svetlana 4 Bar-Shaul Street 76251, Rehovot / IL
	04 / Fisher, Yehudit 10/28 Zecharia HaTuka Street Rehovot / IL
Representative(s)	Boult Wade Tennant LLP Salisbury Square House 8 Salisbury Square London EC4Y 8AP / GB
	[N/P]
Former [2019/39]	Boult Wade Tennant LLP 5th Floor, Salisbury Square House 8, Salisbury Square London EC4Y 8AP / GB
Former [2013/51]	Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT / GB
Former [2011/10]	Spencer, Matthew Peter Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT / GB
Application number, filing date	10190450.6	14.12.2005
	[2011/10]
Priority number, date	US20040636391P	14.12.2004 Original published format: US 636391 P
	US20050668739P	05.04.2005 Original published format: US 668739 P
	[2011/10]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP2292733
	Date:	09.03.2011
	Language:	EN
	[2011/10]
	Type:	B1 Patent specification
	No.:	EP2292733
	Date:	25.09.2019
	Language:	EN
	[2019/39]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	28.01.2011
Classification	IPC:	C12N5/00, C12N5/02, C12N5/10, C12N5/16, C12N5/077, C12N5/0786, C12N5/0789	[2011/10]
	CPC:	C12N5/0647 (EP); A61P25/00 (EP); C12N5/0623 (EP); C12N5/0645 (EP); C12N5/0657 (EP); C12N2500/90 (EP); (+) C12N2501/11 (EP); C12N2501/115 (EP); C12N2501/13 (EP); C12N2501/165 (EP); C12N2506/11 (EP); C12N2533/52 (EP) (-)
Designated contracting states	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2019/39]
Former [2011/10]	AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR
Title	German:	Produktion aus dem Blut von Zellen neuronaler Abstammung	[2011/10]
	English:	Production from blood of cells of neural lineage	[2011/10]
	French:	Production à partir du sang de cellules du lignée neurale	[2011/10]
Examination procedure	09.11.2010	Examination requested [2011/10]
	09.09.2011	Amendment by applicant (claims and/or description)
	13.10.2011	Despatch of a communication from the examining division (Time limit: M06)
	11.04.2012	Reply to a communication from the examining division
	26.07.2013	Despatch of a communication from the examining division (Time limit: M04)
	25.11.2013	Reply to a communication from the examining division
	25.11.2015	Despatch of a communication from the examining division (Time limit: M04)
	05.04.2016	Reply to a communication from the examining division
	11.08.2016	Despatch of a communication from the examining division (Time limit: M06)
	21.02.2017	Reply to a communication from the examining division
	27.11.2017	Despatch of a communication from the examining division (Time limit: M04)
	03.04.2018	Reply to a communication from the examining division
	09.08.2018	Despatch of a communication from the examining division (Time limit: M04)
	03.12.2018	Reply to a communication from the examining division
	03.04.2019	Communication of intention to grant the patent
	12.08.2019	Fee for grant paid
	12.08.2019	Fee for publishing/printing paid
	12.08.2019	Receipt of the translation of the claim(s)
Parent application(s) Tooltip	EP05817653.8 / EP1831351
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20050817653) is 03.11.2008
Opposition(s)	26.06.2020	No opposition filed within time limit [2020/36]
Fees paid	Renewal fee
	09.11.2010	Renewal fee patent year 03
	09.11.2010	Renewal fee patent year 04
	09.11.2010	Renewal fee patent year 05
	11.11.2010	Renewal fee patent year 06
	29.12.2011	Renewal fee patent year 07
	19.12.2012	Renewal fee patent year 08
	27.12.2013	Renewal fee patent year 09
	22.12.2014	Renewal fee patent year 10
	22.12.2015	Renewal fee patent year 11
	29.12.2016	Renewal fee patent year 12
	21.12.2017	Renewal fee patent year 13
	19.12.2018	Renewal fee patent year 14
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	deleted
	[2020/12]
Former [2020/10]	SE	25.09.2019
Documents cited:	Search	[XI]WO0130981 (NS GENE AS [DK], et al) [X] 1 * claims 1-2 * [I] 2-15;
		[XI]US2003044977 (SAKURAGAWA NORIO [JP], et al) [X] 1 * claims 1-2 * [I] 2-15;
		[XI]WO03055989 (MOUNT SINAI HOSPITAL CORP [CA], et al) [X] 1 * page 39, line 12 - page 40, line 6 * [I] 2-15;
		[XI]WO03078610 (MILTENYI BIOTEC GMBH [DE], et al) [X] 1 * claims 41-42 * [I] 2-15;
		[XI] - ORTIZ-GONZALEZ XILMA R ET AL, "Neural induction of adult bone marrow and umbilical cord stem cells.", CURRENT NEUROVASCULAR RESEARCH JUL 2004, (200407), vol. 1, no. 3, ISSN 1567-2026, pages 207 - 213, XP001538190 [X] 1 * abstract * [I] 2-15 DOI: http://dx.doi.org/10.2174/1567202043362342
		[A] - SHIM W S N ET AL, "Ex vivo differentiation of human adult bone marrow stem cells into cardiomyocyte-like cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, (20041112), vol. 324, no. 2, ISSN 0006-291X, pages 481 - 488, XP004599632 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1016/j.bbrc.2004.09.087
		[A] - YEH E T H ET AL, "Transdifferentiation of Human Peripheral Blood CD34<+>-Enriched Cell Population Into Cardiomyocytes, Endothelial Cells, and Smooth Muscle Cells In Vivo", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, (20031028), vol. 108, no. 17, ISSN 0009-7322, pages 2070 - 2073, XP002433317 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1161/01.CIR.0000099501.52718.70
		[A] - BADORFF ET AL, "Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, (20030225), vol. 107, ISSN 0009-7322, pages 1024 - 1032, XP002987256 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1161/01.CIR.0000051460.85800.BB
		[A] - WAGERS AMY J ET AL, "Little evidence for developmental plasticity of adult hematopoietic stem cells", SCIENCE (WASHINGTON D C), (20020927), vol. 297, no. 5590, ISSN 0036-8075, pages 2256 - 2259, XP002487073 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1126/science.1074807
		[A] - GAZITT YAIR ET AL, "Expression of adhesion molecules on CD34+ cells in peripheral blood of non-Hodgkin's lymphoma patients mobilized with different growth factors", STEM CELLS (MIAMISBURG), (2001), vol. 19, no. 2, ISSN 1066-5099, pages 134 - 143, XP002487070 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1634/stemcells.19-2-134
		[A] - MURRY C E ET AL, "Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts", NATURE 20040408 GB, (20040408), vol. 428, no. 6983, ISSN 0028-0836, pages 664 - 668, XP002487895 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1038/nature02446
		[A] - NYGREN J M ET AL, "Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation", NATURE MEDICINE 200405 GB, (200405), vol. 10, no. 5, ISSN 1078-8956, pages 494 - 501, XP002487896 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1038/nm1040
		[A] - LIOUTERMAN L ET AL, "TRANSPLANTATION OF HUMAN HEMATOPOIETIC STEM CELLS INTO RAT BRAIN: ANALYSIS OF CELL SURVIVAL AND DIFFERENTIATION", ABSTRACTS OF THE SOCIETY FOR NEUROSCIENCE, SOCIETY FOR NEUROSCIENCE, WASHINGTON, DC, US, (20011110), vol. 27, no. 1, ISSN 0190-5295, page 632, XP001098867 [A] 1-15 * the whole document *
		[A] - FERRERO D ET AL, "MOBILISED PERIPHERAL BLOOD PROGENITOR CELLS GIVE RISE IN VITRO TO CELLS EXPRESSING NEURONAL PHENOTYPE", BLOOD, W.B.SAUNDERS COMPANY, ORLANDO, FL, (20011216), vol. 98, no. 11, PART 02, ISSN 0006-4971, page 1238, XP001062755 [A] 1-15 * the whole document *
		[A] - CASTRO RAYMOND F ET AL, "Failure of bone marrow cells to transdifferentiate into neural cells in vivo", SCIENCE (WASHINGTON D C), (20020823), vol. 297, no. 5585, ISSN 0036-8075, page 1299, XP002487072 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1126/science.297.5585.1299
		[A] - CAO T M ET AL, "Rapid engraftment after allogeneic transplantation of density-enriched peripheral blood CD34+ cells in patients with advanced hematologic malignancies", CANCER 20010615 US, (20010615), vol. 91, no. 12, ISSN 0008-543X, pages 2205 - 2213, XP002487071 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1002/1097-0142(20010615)91:12<2205::AID-CNCR1250>3.0.CO;2-Q
		[A] - GOOLSBY J ET AL, "Hematopoietic progenitors express neural genes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, (20031209), vol. 100, no. 25, ISSN 0027-8424, pages 14926 - 14931, XP002339337 [A] 1-15 * abstract * DOI: http://dx.doi.org/10.1073/pnas.2434383100
	by applicant	- LEBLOND C.P., "Classification of cell populations on the basis of their proliferative behaviour", NATL. CANCER INST. MONOGR., (1964), vol. 14, pages 119 - 150
		- EVANS M.J.; KAUFMAN M.H., "Establishment in culture of pluripotential cells from mouse embryos", NATURE, (1981), vol. 292, pages 154 - 156
		- DONOVAN P.J.; GEARHART J., "The end of the beginning for pluripotent stem cells", NATURE, (2001), vol. 414, pages 92 - 97
		- SPRADLING A. ET AL., "Stem cells find their niche", NATURE, (2001), vol. 414, pages 98 - 104
		- WEISSMAN I.L. ET AL., "Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations", ANNU. REV. CELL. DEV. BIOL., (2001), vol. 17, pages 387 - 403
		- WEISSMAN I.L., "Stem cells: units of development, units of regeneration, and units in evolution", CELL, (2000), vol. 100, pages 157 - 68
		- CHENG A; WANG S; CAI J; RAO MS; MATTSON MP, "Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain", DEV BIOL., (2003), vol. 258, no. 2, pages 319 - 33
		- COUSIN B; ANDRE M; ARNAUD E; PENICAUD L; CASTEILLA L, "Reconstitution of lethally irradiated mice by cells isolated from adipose tissue", BIOCHEM BIOPHYS RES COMMUN., (2003), vol. 301, no. 4, pages 1016 - 22
		- ANDERSON D.J.; GAGE, F.H.; WEISSMAN, I.L., "Can stem cells cross lineage boundaries?", NAT. MED., (2001), vol. 7, pages 393 - 395
		- ROBEY P.G., "Stem cells near the century mark", J. CLIN. INVEST., (2000), vol. 105, pages 1489 - 1491
		- EISENBERG LM; BURNS L; EISENBERG CA, "Hematopoietic cells from bone marrow have the potential to differentiate into cardiomyocytes in vitro", ANAT REC., (2003), vol. 274, no. L, pages 870 - 82
		- BRAZELTON TR; ROSSI FM; KESHET GI; BLAU HM, "From marrow to brain: expression of neuronal phenotypes in adult mice", SCIENCE, (2000), vol. 290, no. 5497, pages 1775 - 9
		- SLACK, J.M., "Stem cells in epithelial tissues", SCIENCE, (2000), vol. 287, pages 1431 - 1433
		- JACKSON KA; MI T; GOODELL MA, "Hematopoietic potential of stem cells isolated from murine skeletal muscle", PROC NATL ACAD SCI U S A, (1999), vol. 96, no. 25, pages 14482 - 6
		- FERRARI G.; CUSELLA-DE ANGELIS G.; COLETTA M.; PAOLUCCI E.; STORNAIUOLO A.; COSSU G.; MAVILIO F., "Muscle regeneration by bone marrow-derived myogenic progenitors", SCIENCE, (1998), vol. 279, pages 528 - 30
		- LAGASSE E; CONNORS H; AL-DHALIMY M; REITSMA M; DOHSE M; OSBORNE L; WANG X; FINEGOLD M; WEISSMAN IL; GROMPE M, "Purified hematopoietic stem cells can differentiate into hepatocytes in vivo", NAT MED., (2000), vol. 6, pages 1229 - 34
		- HIRSCHI, K. K.; GOODELL, M. A., "Hematopoietic, vascular and cardiac fates of bone marrow-derived stem cells", GENE THER., (2002), vol. 9, pages 648 - 652
		- THEISE N.D. ET AL., "Liver from bone marrow in humans", HEPATOLOGY, (2000), vol. 32, pages 11 - 16
		- KLEEBERGER W. ET AL., "High frequency of epithelial chimerism in liver transplants demonstrated by microdissection and STR-analysis", HEPATOLOGY, (2002), vol. 35, pages 110 - 116
		- WEIMANN J.M. ET AL., "Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains", PROC. NATL. ACAD. SCI. USA, (2003), vol. 100, pages 2088 - 2093
		- QUAINI F. ET AL., "Chimerism of the transplanted heart", N. ENGL. MED, (2002), vol. 346, pages 5 - 15
		- BLAU H.M. ET AL., "The evolving concept of a stem cell: entity or function?", CELL, (2001), vol. 105, pages 829 - 841
		- GOODELL M.A. ET AL., "Stem cell plasticity in muscle and bone marrow", ANN. NY ACAD. SCI., (2001), vol. 938, pages 208 - 218
		- KRAUSE D.S., "Plasticity of marrow-derived stem cells", GENE THER., (2002), vol. 9, pages 754 - 758
		- WULF G.G. ET AL., "Somatic stem cell plasticity", EXP HEMATOL., (2001), vol. 29, pages 1361 - 1370
		- PITTENGER M.F. ET AL., "Multilineage potential of adult human mesenchymal stem cells", SCIENCE, (1999), vol. 284, pages 143 - 147
		- LIECHTY K.W., "Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep", NATURE MED., (2000), vol. 6, pages 1282 - 1286
		- JANG YY; COLLECTOR MI; BAYLIN SB; DIEHL AM; SHARKIS SJ, "Hematopoietic stem cells convert into liver cells within days without fusion", NAT CELL BIOL., (2004), vol. 6, no. 6, pages 532 - 9
		- BITTNER R.E.; SCHOFER C.; WEIPOLTSHAMMER K.; IVANOVA S.; STREUBEL B.; HAUSER E.; FREILINGER M.; HOGER H.; ELBE-BURGER A.; WACHTLER, "Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice", ANAT. EMBRYOL., (1999), vol. 199, pages 391 - 396
		- MEZEY E; CHANDROSS KJ; HARTA G; MAKI RA; MCKERCHER SR, "Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow", SCIENCE, (2000), vol. 290, no. 5497, pages 1779 - 82
		- DOUGLAS W.L.; DIMMELER S., "Therapeutic angiogenesis and vasculogenesis for ischemic diseases. Part I: Angiogenic cytokines", CIRCULATION, (2004), vol. 109, pages 2487 - 2491
		- DOUGLAS W.L.; DIMMELER S., "Therapeutic angiogenesis and vasculogenesis for ischemic diseases. Part II: Cell-based therapy", CIRCULATION, (2004), vol. 109, pages 2692 - 2697
		- EGLITIS MA; MEZEY E, "Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice", PROC NATL ACAD SCI U S A, (1997), vol. 94, pages 4080 - 4085
		- BONILLA S; ALARCON P; VILLAVERDE R; APARICIO P; SILVA A; MARTINEZ S, "Haematopoietic progenitor cells from adult bone marrow differentiate into cells that express oligodendroglial antigens in the neonatal mouse brain", EUR J NEUROSCI, (2002), vol. 15, pages 575 - 582
		- CORTI S; LOCATELLI F; STRAZZER S; SALANI S; DEL BO R; SOLIGO D; BOSSOLASCO P; BRESOLIN N; SCARLATO G; COMI GP, "Modulated generation of neuronal cells from bone marrow by expansion and mobilization of circulating stem cells with in vivo cytokine treatment", EXP NEUROL, (2002), vol. 177, pages 443 - 452
		- BRAZELTON TR; ROSSI FM; KESHET GI; BLAU HM, "From marrow to brain: expression of neuronal phenotypes in adult mice", SCIENCE, (2000), vol. 290, pages 1775 - 1779
		- MEZEY E; CHANDROSS KJ; HARTA G; MAKI RA; MCKERCHER SR, "Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow", SCIENCE, (2000), vol. 290, pages 1779 - 1782
		- PRILLER J; PERSONS DA; KLETT FF; KEMPERMANN G; KREUTZBERG GW; DIMAGL U, "Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo", J CELL BIOL, (2001), vol. 155, pages 733 - 738
		- WAGERS AJ; SHERWOOD RI; CHRISTENSEN JL; WEISSMAN IL, "Little evidence for developmental plasticity of adult hematopoietic stem cells", SCIENCE, (2002), vol. 297, pages 2256 - 2259
		- KOLLET 0; SHIVTIEL S; CHEN YQ ET AL., "HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver", J CLIN INVEST., (2003), vol. 112, no. 2, pages 160 - 9
		- EGLITIS MA; DAWSON D; PARK KW; MOURADIAN MM, "Targeting of marrow-derived astrocytes to the ischemic brain", NEUROREPORT, (1999), vol. 10, pages 1289 - 1292
		- PRILLER J; FLOGEL A; WEHNER T; BOENTERT M; HAAS CA; PRINZ M; FEMANDEZ-KLETT F; PRASS K; BECHMANN I; DE BOER BA, "Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment", NAT MED, (2001), vol. 7, pages 1356 - 1361
		- BIANCO, P.; ROBEY P.G., "Stem cells in tissue engineering", NATURE, (2001), vol. 414, pages 118 - 121
		- LAGASSE E. ET AL., "Toward regenerative medicine", IMMUNITY, (2001), vol. 14, pages 425 - 436
		- LI Y; CHOPP M; CHEN J; WANG L; GAUTAM SC; XU YX; ZHANG Z, "Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice", J CEREB BLOOD FLOW METAB, (2000), vol. 20, pages 1311 - 1319
		- LI Y; CHEN J; WANG L; LU M; CHOPP M, "Treatment of stroke in rat with intracarotid administration of marrow stromal cells", NEUROLOGY, (2001), vol. 56, pages 1666 - 1672
		- CHEN J, LI Y; WANG L; ZHANG Z; LU D; LU M; CHOPP M, "Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats", STROKE, (2001), vol. 32, pages 1005 - 1011
		- ZHAO LR; DUAN WM; REYES M; KEENE CD; VERFAILLIE CM; LOW WC, "Human bone marrow stem cells exhibit neural phenotypes and ameliorate neurological deficits after grafting into the ischemic brain of rats", EXP NEUROL, (2002), vol. 174, pages 11 - 20
		- ZHANG ZG; ZHANG L; JIANG Q; CHOPP M, "Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse", CIRC RES, (2002), vol. 90, pages 284 - 288
		- HESS DC; HILL WD; MARTIN-STUDDARD A; CARROLL J; BRAILER J; CAROTHERS J, "Bone marrow as a source of endothelial cells and NeuN-expressing cells after stroke", STROKE, (2002), vol. 33, pages 1362 - 1368
		- LI Y; CHEN J; WANG L; ZHANG L; LU M; CHOPP M, "Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease", NEUROSCI LETT, (2001), vol. 316, pages 67 - 70
		- MAHMOOD A; LU D; WANG L; LI Y; LU M; CHOPP M, "Treatment of traumatic brain injury in female rats with intravenous administration of bone marrow stromal cells", NEUROSURGERY, (2001), vol. 49, pages 1196 - 1203
		- HOFSTETTER CP; SCHWARZ EJ; HESS D; WIDENFALK J; EL MANIRA A; PROCKOP DJ; OLSON L, "Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery", PROC NATL ACAD SCI U S A, (2002), vol. 99, pages 2199 - 2204
		- AKIYAMA Y; RADTKE C; KOCSIS JD, "Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells", J NEUROSCI, (2002), vol. 22, pages 6623 - 6630
		- HERSHFINKEL M; MORAN A; GROSSMAN N ET AL., "A zinc-sensing receptor triggers the release of intracellular Ca2+ and regulates ion transport", PROC NATL ACAD SCI USA, (2001), vol. 98, pages 11749 - 11754
		US20040576266
		US20040588520

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.

Legal notice
Terms of use
24.1.24; 34p