blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2341135

EP2341135 - Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  07.09.2012
Database last updated on 13.07.2024
Most recent event   Tooltip07.09.2012Application deemed to be withdrawnpublished on 10.10.2012  [2012/41]
Applicant(s)For all designated states
Precision Biosciences
104 T.W. Anderson Drive, Bldg. 7 P.O. Box 12292, Research Triangle Park
Durham, NC 27709 / US
[2011/27]
Inventor(s)01 / Hellinga, Homme, W.
5212 Pine Cone Lane
Durham, NC 27705 / US
02 / Smith, James, Jefferson
1808 Carnation Drive
Durham, NC 27703 / US
03 / Jantz, Derek
914 Ninth Street
Durham, NC 27705 / US
 [2011/27]
Representative(s)Grund, Martin
Grund Intellectual Property Group
Patentanwälte und Solicitor PartG mbB
Steinsdorfstraße 2
80538 München / DE
[N/P]
Former [2011/27]Grund, Martin
GRUND Intellectual Property Group Postfach 44 05 16
80754 München / DE
Application number, filing date10191915.718.10.2006
[2011/27]
Priority number, dateUS20050727512P18.10.2005         Original published format: US 727512 P
[2011/27]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2341135
Date:06.07.2011
Language:EN
[2011/27]
Type: A3 Search report 
No.:EP2341135
Date:12.10.2011
Language:EN
[2011/41]
Search report(s)(Supplementary) European search report - dispatched on:EP13.09.2011
ClassificationIPC:C12N9/22, C12N15/90
[2011/27]
CPC:
C12N9/22 (EP,US); A61K38/465 (EP,US); A61P3/00 (EP);
A61P31/00 (EP); A61P31/12 (EP); A61P43/00 (EP);
C12N15/8213 (US); C12N15/902 (US); C12N15/905 (US);
C12N15/907 (US); A61K48/00 (US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/27]
TitleGerman:Rational konstruierte Meganukleasen mit veränderter Sequenzspezifität und DNA-Bindungsaffinität[2011/27]
English:Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity[2011/27]
French:Méganucléases conçues rationnellement possédant une spécificité de séquence modifiée et une affinité de liaison modifiée pour L'ADN[2011/27]
Examination procedure13.04.2012Application deemed to be withdrawn, date of legal effect  [2012/41]
22.05.2012Despatch of communication that the application is deemed to be withdrawn, reason: examination fee not paid in time  [2012/41]
Parent application(s)   TooltipEP06826293.0  / EP1945762
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20060826293) is  20.11.2008
Fees paidRenewal fee
17.03.2011Renewal fee patent year 03
17.03.2011Renewal fee patent year 04
17.03.2011Renewal fee patent year 05
Penalty fee
Additional fee for renewal fee
31.10.201106   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[A]WO2004067753  (CELLECTIS [FR], et al) [A] 1-13 * abstract * * page 6, line 24 - line 27 * * page 8, line 1 - line 28 * * page 12, line 1 - line 12 * * page 16, line 30 - page 17, line 5 * * page 17, line 30 - page 18, line 29 *;
 [AP]  - DOYON J B ET AL, "Directed evolution and substrate specificity profile of homing endonuclease I-Scel", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC; US, vol. 128, no. 7, doi:10.1021/JA0575191, ISSN 0002-7863, (20060222), pages 2477 - 2484, (20060131), XP002611223 [AP] 1-13 * abstract * * tables 1-3 * * Evolution of I-SceI Variants with Altered DNA Cleavage Specificities; page 2479 - page 2480 *

DOI:   http://dx.doi.org/10.1021/JA0575191
 [A]  - MOURE C M ET AL, "The Crystal Structure of the Gene Targeting Homing Endonuclease I-SceI Reveals the Origins of its Target Site Specificity", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, (20031205), vol. 334, no. 4, doi:10.1016/J.JMB.2003.09.068, ISSN 0022-2836, pages 685 - 695, XP004473365 [A] 1-13 * abstract * * figure 4 * * page 693, column l, line 6 - line 11 *

DOI:   http://dx.doi.org/10.1016/j.jmb.2003.09.068
by applicantEP0264166
 US4873316
 US5384253
 US6316024
 US6379699
 US6387397
 US6511676
 US6593308
 US6988041
 US2006078552
 US7037492
 US7041814
    - PORTEUS ET AL., NAT. BIOTECHNOL., (2005), vol. 23, pages 967 - 73
    - TZFIRA ET AL., TRENDS BIOTECHNOL., (2005), vol. 23, pages 567 - 9
    - MCDANIEL ET AL., CURR. OPIN. BIOTECHNOL., (2005), vol. 16, pages 476 - 83
    - PORTEUS, MOL 77TER, (2006), vol. 13, pages 438 - 46
    - WRIGHT ET AL., PLANT J., (2005), vol. 44, pages 693 - 705
    - URNOV ET AL., NATURE, (2005), vol. 435, pages 646 - 51
    - SMITH ET AL., NUCLEIC ACIDS RES., (2000), vol. 28, pages 3361 - 9
    - STODDARD, Q. REV. BIOPHYS., (2006), vol. 38, pages 49 - 95
    - CHEVALIER ET AL., NUCLEIC ACIDS RES., (2001), vol. 29, no. 18, pages 3757 - 3774
    - VAN ROEY ET AL., NATURE STRUCT. BIOL., (2002), vol. 9, pages 806 - 811
    - MONNAT ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (1999), vol. 255, pages 88 - 93
    - ROUET ET AL., MOL. CELL. BIOL., (1994), vol. 14, pages 8096 - 106
    - CHILTON ET AL., PLANT PHYSIOL., (2003), vol. 133, pages 956 - 65
    - PUCHTA ET AL., PROC. NATL. ACAD. SCI. USA, (1996), vol. 93, pages 5055 - 60
    - RONG E, GENES DEV., (2002), vol. 16, pages 1568 - 81
    - GOUBLE ET AL., J. GENE MED., (2006), vol. 8, no. 5, pages 616 - 622
    - SUSSMAN ET AL., J. MOL. BIOL, (2004), vol. 342, pages 31 - 41
    - EPINAT ET AL., NUCLEIC ACIDS RES., (2003), vol. 31, pages 2952 - 62
    - SUSSMAN, J. MOL. BIOL., (2004), vol. 342, pages 31 - 41
    - CHAMES ET AL., NUCLEIC ACIDS RES., (2005), vol. 33, page E178
    - SELIGMAN ET AL., NUCLEIC ACIDS RES., (2002), vol. 30, pages 3870 - 9
    - ARNOULD ET AL., J. MOL. BIOL., (2006), vol. 355, pages 443 - 58
    - CAHILL ET AL., FRONT. BIOSCI., (2006), vol. 11, pages 1958 - 1976
    - SALOMON ET AL., EMBO, (1998), vol. 1, no. 17, pages 6086 - 6095
    - ALTSCHUL ET AL., J. MOL. BIOL., (1990), vol. 215, pages 403 - 410
    - GISH; STATES, NATURE GENET., (1993), vol. 3, pages 266 - 272
    - MADDEN ET AL., METH, ENZYMOL., (1996), vol. 266, pages 131 - 141
    - ALTSCHUL ET AL., NUCLEIC ACIDS RES., (1997), vol. 25, pages 33 89 - 3402
    - ZHANG ET AL., J. COMPUT. BIOL., (2000), vol. 7, no. 1-2, pages 203 - 14
    - TZAKOS ET AL., ANNU. REV. BIOPHYS. BIOMOL. STRUCT., (2006), vol. 35, pages 19 - 42
    - ADAMS ET AL., ACTA CRYSTALLOGR. D. BIOL. CRYSTALLOGR., (1999), vol. 55, pages 181 - 90
    - JONES, ACTA CRYSTALLOGRAPHY, (1991), vol. A47, page 110
    - NICHOLLS ET AL., PROTEINS, STRUCTURE, FUNCTION AND GENETICS, (1991), vol. 11, no. 4, page 281FF
    - BRUNGER, METH. ENZYM., (1997), vol. 276, pages 558 - 580
    - NAVAZA; SALUDJIAN, METH. ENZYM., (1997), vol. 276, pages 581 - 594
    - TONG; ROSSMANN, METH. ENZYM., (1997), vol. 276, pages 594 - 611
    - BENTLEY, METH. ENZYM., (1997), vol. 276, pages 611 - 619
    - NAVAZA, ACTA CRYST. A50, (1994), pages 157 - 163
    - ACTA CRYST., vol. D50, pages 760 - 763
    - WANG ET AL., NUCLEIC ACIDS RES., (2006), vol. 34, no. 2, pages 517 - 527
    - WANG ET AL., NUCLEIC ACID RES., (1997), vol. 25, pages 3767 - 3776
    - RUDIN ET AL., GENETICS, (1989), vol. 122, pages 519 - 534
    - FISHMAN-LOBELL ET AL., SCIENCE, (1992), vol. 258, pages 480 - 4
    - CHEVALIER ET AL., NUCLEIC ACID RES., (2001), vol. 29, no. 18, pages 3757 - 3774
    - SPIEGEL ET AL., STRUCTURE, (2006), vol. 14, pages 869 - 80
    - AMOULD ET AL., J. MOL. BIOL., (2006), vol. 355, pages 443 - 58
    - SUSSMAN ET AL., J. MOL. BIOL., (2004), vol. 342, pages 31 - 41
    - ASHWORTH ET AL., NATURE, (2006), vol. 441, no. 7093, pages 656 - 659
    - HUDECZ ET AL., MED. RES, REV., (2005), vol. 25, pages 679 - 736
    - LASIC ET AL., SCIENCE, (1995), vol. 267, pages 1275 - 76
    - RUI ET AL., LIFE SCI., (2002), vol. 71, no. 15, pages 1771 - 8
    - GRAHAM ET AL., VIROLOGY, (1973), vol. 54, no. 2, pages 536 - 539
    - ZATLOUKAL ET AL., ANN. N.Y. ACAD. SCI., (1992), vol. 660, pages 136 - 153
    - CAPECCHI, CELL, (1980), vol. 22, no. 2, pages 479 - 488
    - WONG ET AL., BIOCHIM. BIOPHYS. RES. COMMUN., (1982), vol. 107, no. 2, pages 584 - 587
    - FROMM ET AL., PROC. NAT'L ACAD. SCI. USA, (1985), vol. 82, no. 17, pages 5824 - 5828
    - JOHNSTON ET AL., METHODS CELL. BIOL., (1994), vol. 43, no. A, pages 353 - 365
    - FYNAN ET AL., PROC. NAT'L ACAD. SCI. USA, (1993), vol. 90, no. 24, pages 11478 - 11482
    - CLAPP, CLIN. PERINATOL., (1993), vol. 20, no. 1, pages 155 - 168
    - LU ET AL., J. EXP. MED., (1993), vol. 178, no. 6, pages 2089 - 2096
    - EGLITIS ET AL., AVD. EXP. MED. BIOL., (1988), vol. 241, pages 19 - 27
    - EGLITIS ET AL., BIOTECHNIQUES, (1988), vol. 6, no. 7, pages 608 - 614
    - CURIEL ET AL., PROC. NAT'L ACAD. SCI. USA, (1991), vol. 88, no. 19, pages 8850 - 8854
    - CURIEL ET AL., HUM. GEN. THER., (1992), vol. 3, no. 2, pages 147 - 154
    - WAGNER ET AL., PROC. NAT'L A CAD. SCI. USA, (1992), vol. 89, no. 13, pages 6099 - 6103
    - GREMILLON ET AL., PLANT J., (2004), vol. 37, pages 218 - 228
    - SINGH ET AL., FEBS LETT., (2003), vol. 542, pages 47 - 52
    - OMIRULLEH ET AL., PLANT MOLECULAR BIOLOGY, (1993), vol. 21, pages 415 - 428
    - GOSSLER ET AL., PROC. NATL. ACAD. SCI. USA, (1986), vol. 83, pages 9065 - 9069
    - PINKERT ET AL., GENES DEV., (1987), vol. 1, pages 268 - 277
    - CALAME; EATON, ADV. IMMUNOL., (1988), vol. 43, pages 235 - 275
    - WINOTO; BALTIMORE, EMBO J., (1989), vol. 8, pages 729 - 733
    - BANERJI ET AL., CELL, (1983), vol. 33, pages 729 - 740
    - QUEEN; BALTIMORE, CELL, (1983), vol. 33, pages 741 - 748
    - BYRNE; RUDDLE, PROC. NATL. ACAD. SCI. USA, (1989), vol. 86, pages 5473 - 5477
    - EDLUND ET AL., SCIENCE, (1985), vol. 230, pages 912 - 916
    - KESSEL; GRUSS, SCIENCE, (1990), vol. 249, pages 374 - 379
    - CAMPES; TILGHMAN, GENES DEV., (1989), vol. 3, pages 537 - 546
    - KORMAN ET AL., PROC. NAT'L ACAD. SCI., (1987), vol. 84, pages 2150 - 2154
    - YOUNG ET AL., J. CALIF DENT. ASSOC., (2005), vol. 33, no. 12, pages 967 - 71
    - PFEIFFER ET AL., J. VASC. SURG., (2006), vol. 43, no. 5, pages 1021 - 7
    - VAN DER GIESSEN ET AL., MICROBIOLOGY, (1994), vol. 140, pages 1103 - 1108
    - CHEVALIER ET AL., BIOCHEMISTRY, (2001), vol. 43, pages 14015 - 14026
    - PAPWORTH ET AL., GENE, (2006), vol. 366, pages 27 - 38
    - SANGER ET AL., PROC. NATL. ACAD. SCI. USA., (1977), vol. 74, no. 12, pages 5463 - 7
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.