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Extract from the Register of European Patents

EP About this file: EP2419741

EP2419741 - RISK ASSESSMENT FOR ANTIBIOTICS TREATMENT IN PATIENTS SUFFERING FROM PRIMARY NON-INFECTIOUS DISEASE BY DETERMINING THE LEVEL OF PROCALCITONIN [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  24.04.2025
Database last updated on 28.03.2026
FormerThe patent has been granted
Status updated on  28.06.2019
FormerGrant of patent is intended
Status updated on  10.02.2019
FormerExamination is in progress
Status updated on  30.11.2016
Most recent event   Tooltip13.03.2026Lapse of the patent in a contracting state
New state(s): GR		published on 15.04.2026 [2026/16]
Applicant(s)For all designated states
B.R.A.H.M.S GmbH
Neuendorfstrasse 25
16761 Hennigsdorf / DE
[2019/31]
Former [2012/08]For all designated states
B.R.A.H.M.S GmbH
Neuendorfstrasse 25
16761 Hennigsdorf / DE
Inventor(s)01 / BERGMANN, Andreas
Baumläuferweg 47
12351 Berlin / DE
02 / STRUCK, Joachim
Zerndorfer Weg 52 a
13465 Berlin / DE
 [2012/08]
Representative(s)Hertin und Partner Rechts- und Patentanwälte PartG mbB
Kurfürstendamm 63
10707 Berlin / DE
[N/P]
Former [2019/31]Simandi, Claus
Badehausallee 55
27476 Cuxhaven / DE
Former [2012/08]Kilger, Ute, et al
Forrester & Boehmert Pettenkoferstrasse 20-22
80336 München / DE
Application number, filing date10717531.714.04.2010
[2019/31]
WO2010EP02279
Priority number, dateEP2009015788614.04.2009         Original published format: EP 09157886
[2012/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010118855
Date:21.10.2010
Language:EN
[2010/42]
Type: A1 Application with search report 
No.:EP2419741
Date:22.02.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 21.10.2010 takes the place of the publication of the European patent application.
[2012/08]
Type: B1 Patent specification 
No.:EP2419741
Date:31.07.2019
Language:EN
[2019/31]
Search report(s)International search report - published on:EP21.10.2010
ClassificationIPC:G01N33/74
[2012/08]
CPC:
G01N33/74 (EP,CN,US); G01N2333/585 (EP,CN,US); G01N2800/32 (EP,CN,US);
G01N2800/325 (US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/08]
Extension statesALNot yet paid
BANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:RISIKOBEURTEILUNG FÜR ANTIBIOTIKABEHANDLUNG MITTELS BESTIMMUNG DES PROCALCITONINNIVEAUS BEI PATIENTEN MIT EINER PRIMÄR NICHTINFEKTIÖSEN KRANKHEIT[2019/04]
English:RISK ASSESSMENT FOR ANTIBIOTICS TREATMENT IN PATIENTS SUFFERING FROM PRIMARY NON-INFECTIOUS DISEASE BY DETERMINING THE LEVEL OF PROCALCITONIN[2012/08]
French:ÉVALUATION DE RISQUE DE TRAITEMENT PAR DES ANTIBIOTIQUES DE PATIENTS ATTEINT D'UNE MALADIE PRIMAIRE NON INFECTIEUSE PAR DÉTERMINATION DU NIVEAU DE PROCALCITONINE[2019/04]
Former [2012/08]RISIKOBEWERTUNG FÜR EINE ANTIBIOTIKABEHANDLUNG BEI PATIENTEN MIT PRIMÄRER NICHT-INFEKTIÖSER ERKRANKUNG MITTELS BESTIMMUNG DER PROCALCITONIN-KONZENTRATION
Former [2012/08]ÉVALUATION DES RISQUES LIÉS À UN TRAITEMENT ANTIBIOTIQUE CHEZ DES PATIENTS SOUFFRANT D'UNE MALADIE NON INFECTIEUSE PRIMAIRE PAR LA DÉTERMINATION DU TAUX DE PROCALCITONINE
Entry into regional phase19.09.2011National basic fee paid 
19.09.2011Designation fee(s) paid 
19.09.2011Examination fee paid 
Examination procedure19.09.2011Examination requested  [2012/08]
06.01.2012Amendment by applicant (claims and/or description)
24.11.2014Despatch of a communication from the examining division (Time limit: M06)
13.05.2015Reply to a communication from the examining division
01.08.2016Despatch of a communication from the examining division (Time limit: M06)
08.03.2017Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
17.05.2017Reply to a communication from the examining division
27.02.2018Despatch of a communication from the examining division (Time limit: M06)
29.08.2018Reply to a communication from the examining division
11.02.2019Communication of intention to grant the patent
14.06.2019Receipt of the translation of the claim(s)
21.06.2019Fee for grant paid
21.06.2019Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.11.2014
Opposition(s)Opponent(s)01  30.04.2020  04.05.2020  ADMISSIBLE
Radiometer Medical ApS
Akandevej 21
2700 Bronshoj / DK
Opponent's representative
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
 [N/P]
Former [2021/20]
Opponent(s)01  30.04.2020  04.05.2020  ADMISSIBLE
Radiometer Medical ApS
Akandevej 21
2700 Bronshoj / DK
Opponent's representative
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2020/24]
Opponent(s)01  30.04.2020  04.05.2020  ADMISSIBLE
Radiometer Medical ApS
Akandevej 21
2700 Bronshoj / DK
Opponent's representative
Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
16.06.2020Invitation to proprietor to file observations on the notice of opposition
16.10.2020Reply of patent proprietor to notice(s) of opposition
11.11.2021Date of oral proceedings
21.12.2021Despatch of interlocutory decision in opposition
21.12.2021Despatch of minutes of oral proceedings
25.02.2025Legal effect of revocation of patent [2025/22]
23.04.2025Despatch of communication that the patent will be revoked
Appeal following opposition28.02.2022Appeal received No.  T0589/22
28.02.2022Payment of appeal fee
02.05.2022Statement of grounds filed
25.02.2025Result of appeal procedure: revocation of the patent
23.04.2025Despatch of the decision of the Board of Appeal
25.02.2025Date of oral proceedings
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
17.05.2017Request for further processing filed
17.05.2017Full payment received (date of receipt of payment)
Request granted
20.07.2017Decision despatched
Fees paidRenewal fee
28.03.2012Renewal fee patent year 03
22.04.2013Renewal fee patent year 04
25.03.2014Renewal fee patent year 05
10.04.2015Renewal fee patent year 06
11.04.2016Renewal fee patent year 07
10.04.2017Renewal fee patent year 08
11.04.2018Renewal fee patent year 09
15.04.2019Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipSM31.07.2019
GR30.04.2024
[2026/16]
Former [2020/28]SM31.07.2019
Cited inInternational search[X] DE102006046996  (BRAHMS AG et al.)
 [X] WO2009019230  (BRAHMS AG et al.)
 [X] WO2006071583  (BIOSITE INC et al.) [X] 1-11 * abstract * * paragraphs [0010] , [0011] , [0013] , [0015] , [0016] , [0021] , [0031] , [0032] , [0034] , [0035] * * claims 1,3,16,17,21 *
 [X]   CHRIST-CRAIN M. ET AL.: "Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial", THE LANCET, vol. 363, no. 9409, 21 February 2004 (2004-02-21), pages 600 - 607, XP004747009

DOI:   http://dx.doi.org/10.1016/S0140-6736(04)15591-8
 [X]   SANDEK A. ET AL.: "Procalcitonin-guided antibiotic treatment in heart failure", THE LANCET, vol. 363, no. 9420, 8 May 2004 (2004-05-08), pages 1555, XP004769809

DOI:   http://dx.doi.org/10.1016/S0140-6736(04)16165-5
by applicant  HULTSCHIG C ET AL., CURR OPIN CHEM BIOL., vol. 10, no. L, February 2006 (2006-02-01), pages 4 - 1 0
   LEROY ET AL., INTENSIVE CARE MED, vol. 21, 1995, pages 24 - 31
   FINE ET AL., AM J MED, vol. 89, 1990, pages 713 - 721
   MORGENTHALER ET AL., CLIN CHEM, vol. 48, 2002, pages 788 - 790
OppositionWO2008040328
   MAISEL ET AL.: "Use of procalcitonin for the diagnosis of pneumonia in patients presenting with a chief complaint of dyspnoea: results from the BACH (Biomarkers in Acute Heart Failure) trial", EUROPEAN JOURNAL OF HEART FAILURE, vol. 14, 2012, pages 278 - 286, XP055739315

DOI:   http://dx.doi.org/10.1093/eurjhf/hfr177
   CHRIST-CRAIN ET AL.: "Procalcitonin Guidance of Antibiotic Therapy in Community-acquired Pneumonia", AM J RESPIR CRIT CARE MED, vol. 174, 2006, pages 84 - 93, XP055021728, DOI: 10.1164/rccm.200512-1922OC

DOI:   http://dx.doi.org/10.1164/rccm.200512-1922OC
   CHRIST-CRAIN ET AL.: "Procalcitonin in bacterial infections - hype, hope, more or less?", SWISS MED WKLY, vol. 135, 2005, pages 451 - 460, XP055739488
   CHRIST-CRAIN ET AL.: "Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial", THE LANCET, vol. 363, 21 February 2004 (2004-02-21), pages 600 - 607, XP004747009, DOI: 10.1016/S0140-6736(04)15591-8

DOI:   http://dx.doi.org/10.1016/S0140-6736(04)15591-8
   ZELTSER ET AL.: "Torsade de Pointes Due to Noncardiac Drugs", MEDICINE, vol. 82, no. 4, July 2003 (2003-07-01), pages 282 - 290, XP055739493

DOI:   http://dx.doi.org/10.1097/01.md.0000085057.63483.9b
   PSATY: "Clinical Trial Design and Selected Drug Safety Issues for Antibiotics Used to treat Community-Acquired Pneumonia", CID, vol. 47, no. 3, 2008, pages 176 - 179, XP055739494
   FAULKNER ET AL.: "Unique Aspects of Antimicrobial Use in Older Adults", AGING AND INFECTIOUS DISEASES, vol. 40, 1 April 2005 (2005-04-01), pages 997 - 1004, XP055739496

DOI:   http://dx.doi.org/10.1086/428125
   CUBEDDU: "latrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance", CURR. CARDIOL. REV., vol. 5, no. 3, August 2009 (2009-08-01), pages 166 - 176, XP055739499
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.