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Extract from the Register of European Patents

EP About this file: EP2446059

EP2446059 - POLYNUCLEOTIDES FOR DIAGNOSTIC AND PROGNOSTIC OF A CARDIAC DISEASE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.11.2015
Database last updated on 03.01.2025
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
Max-Delbrück-Centrum für Molekulare Medizin Berlin-Buch
Robert-Rössle-Str. 10
13092 Berlin / DE
[2012/18]
Inventor(s)01 / GOTTHARDT, Michael
Wichertstr 39
10439 Berlin / DE
02 / GREASER, Marion Lewis
2374 Branch Street
Middleton, Wl 53562 / US
03 / GUO, Wei
6133 Jeffers Drive
Madison, Wl 53719 / US
04 / HÜBNER, Norbert
Hermann-Günther-Str. 28
13158 Berlin / DE
 [2012/39]
Former [2012/24]01 / GOTTHARDT, Michael
Wichertstr 39
10439 Berlin / DE
02 / GREASER, Lewis
2374 Branch Street
Middleton, Wl 53562 / US
03 / GUO, Wei
6133 Jeffers Drive
Madison, Wl 53719 / US
Former [2012/18]01 / GOTTHARDT, Michael
Wichertstr 39
10439 Berlin / DE
02 / GREASER, Lewis
2374 Branch Street
Middleton, Wl 53562 / US
03 / GUO, Wei
943 Eagle Heights B
Madison, Wl 53705 / US
Representative(s)Hoppe, Georg Johannes
Darani Anwaltskanzlei
Hohenzollerndamm 117
14199 Berlin / DE
[N/P]
Former [2015/02]Hoppe, Georg Johannes
Darani Anwaltskanzlei
Beuckestrasse 20
14163 Berlin / DE
Former [2012/18]Hoppe, Georg Johannes
darani Anwaltskanzlei Beuckestrasse 20
14163 Berlin / DE
Application number, filing date10736605.622.06.2010
WO2010EP03743
Priority number, dateUS20090219125P22.06.2009         Original published format: US 219125 P
[2012/18]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2010149332
Date:29.12.2010
Language:EN
[2010/52]
Type: A2 Application without search report 
No.:EP2446059
Date:02.05.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 29.12.2010 takes the place of the publication of the European patent application.
[2012/18]
Type: B1 Patent specification 
No.:EP2446059
Date:07.01.2015
Language:EN
[2015/02]
Search report(s)International search report - published on:EP05.05.2011
ClassificationIPC:C12Q1/68
[2012/18]
CPC:
C12Q1/6853 (EP,US); A61P9/00 (EP); C12Q1/6883 (EP,US);
C12Q2535/125 (US); C12Q2535/131 (US)
C-Set:
C12Q1/6853, C12Q2535/125 (US,EP);
C12Q1/6853, C12Q2535/131 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/18]
Extension statesBANot yet paid
MENot yet paid
RSNot yet paid
TitleGerman:POLYNUKLEOTIDE ZUR DIAGNOSTIK UND PROGNOSTIK EINER KARDIALEN ERKRANKUNG[2014/33]
English:POLYNUCLEOTIDES FOR DIAGNOSTIC AND PROGNOSTIC OF A CARDIAC DISEASE[2012/18]
French:POLYNUCLÉOTIDES POUR LE DIAGNOSTIC ET PROGNOSTIC D'UNE MALADIE CARDIAQUE[2014/33]
Former [2012/18]POLYNUKLEOTIDE ZUR DIAGNOSE UND PROGNOSE VON HERZLEIDEN
Former [2012/18]POLYNUCLÉOTIDES POUR LA DIAGNOSTIQUE ET PROGNOSTIQUE D'UNE MALADIE CARDIALE
Entry into regional phase12.01.2012National basic fee paid 
12.01.2012Designation fee(s) paid 
12.01.2012Examination fee paid 
Examination procedure12.01.2012Examination requested  [2012/18]
02.07.2012Amendment by applicant (claims and/or description)
30.09.2013Despatch of a communication from the examining division (Time limit: M06)
14.03.2014Reply to a communication from the examining division
30.07.2014Communication of intention to grant the patent
26.11.2014Fee for grant paid
26.11.2014Fee for publishing/printing paid
26.11.2014Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  30.09.2013
Opposition(s)08.10.2015No opposition filed within time limit [2015/51]
Fees paidRenewal fee
27.06.2012Renewal fee patent year 03
17.06.2013Renewal fee patent year 04
16.05.2014Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.06.2010
AL07.01.2015
AT07.01.2015
BE07.01.2015
CY07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
MC07.01.2015
MK07.01.2015
MT07.01.2015
NL07.01.2015
PL07.01.2015
PT07.01.2015
RO07.01.2015
SE07.01.2015
SI07.01.2015
SK07.01.2015
SM07.01.2015
TR07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
IE22.06.2015
LU22.06.2015
[2018/46]
Former [2018/34]HU22.06.2010
AT07.01.2015
BE07.01.2015
CY07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
MC07.01.2015
MK07.01.2015
MT07.01.2015
NL07.01.2015
PL07.01.2015
PT07.01.2015
RO07.01.2015
SE07.01.2015
SI07.01.2015
SK07.01.2015
SM07.01.2015
TR07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
IE22.06.2015
LU22.06.2015
Former [2018/30]HU22.06.2010
AT07.01.2015
BE07.01.2015
CY07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
MC07.01.2015
MK07.01.2015
MT07.01.2015
NL07.01.2015
PL07.01.2015
RO07.01.2015
SE07.01.2015
SI07.01.2015
SK07.01.2015
SM07.01.2015
TR07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
IE22.06.2015
LU22.06.2015
Former [2017/38]HU22.06.2010
AT07.01.2015
BE07.01.2015
CY07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
MC07.01.2015
MT07.01.2015
NL07.01.2015
PL07.01.2015
RO07.01.2015
SE07.01.2015
SI07.01.2015
SK07.01.2015
SM07.01.2015
TR07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
IE22.06.2015
LU22.06.2015
Former [2017/03]AT07.01.2015
BE07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
MC07.01.2015
MT07.01.2015
NL07.01.2015
PL07.01.2015
RO07.01.2015
SE07.01.2015
SI07.01.2015
SK07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
IE22.06.2015
LU22.06.2015
Former [2016/24]AT07.01.2015
BE07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
MC07.01.2015
NL07.01.2015
PL07.01.2015
RO07.01.2015
SE07.01.2015
SI07.01.2015
SK07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
IE22.06.2015
LU22.06.2015
Former [2016/20]AT07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
MC07.01.2015
NL07.01.2015
PL07.01.2015
RO07.01.2015
SE07.01.2015
SI07.01.2015
SK07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
IE22.06.2015
LU22.06.2015
Former [2016/11]AT07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
MC07.01.2015
NL07.01.2015
PL07.01.2015
RO07.01.2015
SE07.01.2015
SI07.01.2015
SK07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
LU22.06.2015
Former [2016/09]AT07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
MC07.01.2015
NL07.01.2015
PL07.01.2015
RO07.01.2015
SE07.01.2015
SK07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
Former [2016/03]AT07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
IT07.01.2015
LT07.01.2015
LV07.01.2015
NL07.01.2015
PL07.01.2015
RO07.01.2015
SE07.01.2015
SK07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
Former [2015/49]AT07.01.2015
CZ07.01.2015
DK07.01.2015
EE07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
LT07.01.2015
LV07.01.2015
NL07.01.2015
PL07.01.2015
RO07.01.2015
SE07.01.2015
SK07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
Former [2015/39]AT07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
LT07.01.2015
LV07.01.2015
NL07.01.2015
PL07.01.2015
SE07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
Former [2015/38]AT07.01.2015
ES07.01.2015
FI07.01.2015
HR07.01.2015
LT07.01.2015
PL07.01.2015
SE07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
IS07.05.2015
Former [2015/37]ES07.01.2015
FI07.01.2015
HR07.01.2015
LT07.01.2015
PL07.01.2015
SE07.01.2015
BG07.04.2015
NO07.04.2015
GR08.04.2015
Former [2015/36]ES07.01.2015
FI07.01.2015
HR07.01.2015
LT07.01.2015
SE07.01.2015
BG07.04.2015
NO07.04.2015
Former [2015/35]ES07.01.2015
LT07.01.2015
NO07.04.2015
Former [2015/33]ES07.01.2015
Cited inInternational search[AD]  - ELLINOR P T ET AL, "A Novel Locus for Dilated Cardiomyopathy, Diffuse Myocardial Fibrosis, and Sudden Death on Chromosome 10q25-26", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 48, no. 1, doi:DOI:10.1016/J.JACC.2006.01.079, ISSN 0735-1097, (20060704), pages 106 - 111, (20060704), XP025147262 [AD] 4-6 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.jacc.2006.01.079
 [XP]  - BRAUCH K M ET AL., "Mutations in ribonucleic acid vinding protein gene cause familial dilated cardiomyopathy", JOURNAL OF THE AMEICAN COLLEGE OF CARDIOLOGY, (200909), vol. 54, no. 10, pages 930 - 941, XP002625765 [XP] 1-8 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.jacc.2009.05.038
 [IP]  - LI D ET AL., "Identification of novel mutations in RBM20 in patients with dilated cardiomyopathy", CLINICAL AND TRANSLATIONAL SCIENCE, (201006), vol. 3, pages 90 - 97, XP002625766 [IP] 1-8 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1752-8062.2010.00198.x
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    - GREASER, M. L. ET AL., "Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension", J MOL CELL CARDIOL, (2008), vol. 44, doi:doi:10.1016/j.yjmcc.2008.02.272, pages 983 - 991, XP022717423

DOI:   http://dx.doi.org/10.1016/j.yjmcc.2008.02.272
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    - ELLINOR, P. T. ET AL., "A novel locus for dilated cardiomyopathy, diffuse myocardial fibrosis, and sudden death on chromosome 10q25-26", JAM COLL CARDIOL, (2006), vol. 48, doi:doi:10.1016/j.jacc.2006.01.079, pages 106 - 111, XP028006632

DOI:   http://dx.doi.org/10.1016/j.jacc.2006.01.079
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DOI:   http://dx.doi.org/10.1038/338342a0
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    - MURRAY, A. ET AL., "Splicing mutations in KCNQ 1: a mutation hot spot at codon 344 that produces in frame transcripts", CIRCULATION, (1999), vol. 100, pages 1077 - 1084
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    - BERS, D. M., "Cardiac excitation-contraction coupling", NATURE, (2002), vol. 415, pages 198 - 205
    - ROGER, V. L. ET AL., "Trends in heart failure incidence and survival in a community-based population", JAMA, (2004), vol. 292, pages 344 - 350
    - MAHON, N. G. ET AL., "Echocardiographic evaluation in asymptomatic relatives of patients with dilated cardiomyopathy reveals preclinical disease", ANN. INTERN. MED., (2005), vol. 143, pages 108 - 115
    - LIEW, C. C.; DZAU, V. J., "Molecular genetics and genomics of heart failure", NAT REV GENET, (2004), vol. 5, pages 811 - 825
    - WANG, G. S.; COOPER, T. A., "Splicing in disease: disruption of the splicing code and the decoding machinery", NAT REV GENET, (2007), vol. 8, pages 749 - 761
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DOI:   http://dx.doi.org/10.1007/s10974-005-9039-0
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DOI:   http://dx.doi.org/10.1038/nbt821
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    - GOTTHARDT,M. ET AL., "Conditional Expression of Mutant M-line Titins Results in Cardiomyopathy with Altered Sarcomere Structure", JBIOL CHEM, (2003), vol. 278, doi:doi:10.1074/jbc.M211723200, pages 6059 - 6065, XP002249070

DOI:   http://dx.doi.org/10.1074/jbc.M211723200
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    - SAAR,K. ET AL., "SNP and haplotype mapping for genetic analysis in the rat", NAT GENET, (2008), vol. 40, pages 560 - 566
    - BENJAMINI,Y.; HOCHBERG,Y., "Controlling the false discovery rate: a practical and powerful approach to multiple testing", J ROY STATIST SOC SER, (1995), vol. B 57, pages 289 - 300
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    - ELLINOR,P.T. ET AL., "A novel locus for dilated cardiomyopathy, diffuse myocardial fibrosis, and sudden death on chromosome 1Oq25-26", JAM COLL CARDIOL, (2006), vol. 48, doi:doi:10.1016/j.jacc.2006.01.079, pages 106 - 111, XP028006632

DOI:   http://dx.doi.org/10.1016/j.jacc.2006.01.079
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