blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2408449

EP2408449 - METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  18.11.2016
Database last updated on 02.11.2024
Most recent event   Tooltip18.11.2016Application deemed to be withdrawnpublished on 21.12.2016  [2016/51]
Applicant(s)For all designated states
The Board Of Trustees Of The University Of the Leland Stanford Junior University
1705 El Camino Real
Palo Alto, CA 94306-1106 / US
For all designated states
Eiger Biopharmaceuticals, Inc.
3350 W. Bayshore Road, Suite 120
Palo Alto, CA 94303 / US
[N/P]
Former [2012/04]For all designated states
The Board Of Trustees Of The University Of the Leland Stanford Junior University
1705 El Camino Real
Palo Alto, CA 94306-1106 / US
For all designated states
Eiger Biopharmaceuticals, Inc.
3350 W. Bayshore Road, Suite 120
Palo Alto, CA 94303 / US
Inventor(s)01 / CHOONG, Ingrid, C.
3350 W. Bayshore Rd.
Suite 120
Palo Alto, CA 94303 / US
02 / CORY, David
1541 Morse Blvd.
San Carlos CA 94070 / US
03 / GLENN, Jeffrey, S.
1130 Welch Rd., 336
Palo Alto CA 94304 / US
04 / YANG, Wenjin
383 Bodega St.
Foster City CA 94404 / US
 [2012/04]
Representative(s)Vidon Brevets & Stratégie
16B, rue de Jouanet
BP 90333
35703 Rennes Cedex 7 / FR
[N/P]
Former [2014/42]Marollé, Patrick Pierre Pascal, et al
Cabinet Vidon
Technopôle Atalante
16B, rue Jouanet
BP 90333
35703 Rennes Cedex 7 / FR
Former [2012/04]Larcher, Dominique
Cabinet Vidon, 16 B, rue Jouanet, BP 90333 Technopole Atalante
35703 Rennes Cedex 7 / FR
Application number, filing date10753954.616.03.2010
WO2010US27400
Priority number, dateUS2009038303018.03.2009         Original published format: US 383030
US2009038307118.03.2009         Original published format: US 383071
US20100299886P29.01.2010         Original published format: US 299886 P
[2012/04]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2010107739
Date:23.09.2010
Language:EN
[2010/38]
Type: A2 Application without search report 
No.:EP2408449
Date:25.01.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 23.09.2010 takes the place of the publication of the European patent application.
[2012/04]
Search report(s)International search report - published on:KR10.03.2011
(Supplementary) European search report - dispatched on:EP10.07.2012
ClassificationIPC:A61K31/4184, A61K31/437, A61K31/4178, A61K31/337, A61K31/4965, A61P31/12
[2012/04]
CPC:
A61K31/4184 (EP,US); A61K31/437 (EP,US); A61K31/4965 (EP,US);
A61K45/06 (EP,US); A61P31/12 (EP); A61P31/14 (EP);
C07D235/06 (EP,US); C07D235/08 (EP,US); C07D235/10 (EP,US);
C07D235/14 (EP,US); C07D235/16 (EP,US); C07D235/28 (EP,US);
C07D401/04 (EP,US); C07D401/06 (EP,US); C07D401/12 (EP,US);
C07D401/14 (EP,US); C07D403/06 (EP,US); C07D403/14 (EP,US);
C07D405/06 (EP,US); C07D409/06 (EP,US); C07D413/06 (EP,US);
C07D417/04 (EP,US); C07D471/08 (EP,US); C07D491/04 (EP,US) (-)
C-Set:
A61K31/4184, A61K2300/00 (EP,US);
A61K31/437, A61K2300/00 (US,EP);
A61K31/4965, A61K2300/00 (US,EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/04]
TitleGerman:VERFAHREN UND ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON FLAVIVIRIDAE-VIRUSINFEKTIONEN[2012/04]
English:METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION[2012/04]
French:MÉTHODES ET COMPOSITIONS POUR TRAITER L'INFECTION PAR UN VIRUS DE LA FAMILLE DES FLAVIVIRIDAE[2012/04]
Entry into regional phase18.10.2011National basic fee paid 
18.10.2011Search fee paid 
18.10.2011Designation fee(s) paid 
18.10.2011Examination fee paid 
Examination procedure18.10.2011Examination requested  [2012/04]
25.01.2013Amendment by applicant (claims and/or description)
19.04.2013Despatch of a communication from the examining division (Time limit: M06)
18.10.2013Reply to a communication from the examining division
16.05.2014Despatch of a communication from the examining division (Time limit: M06)
31.10.2014Reply to a communication from the examining division
05.02.2015Despatch of a communication from the examining division (Time limit: M06)
25.06.2015Reply to a communication from the examining division
25.09.2015Despatch of a communication from the examining division (Time limit: M04)
28.12.2015Reply to a communication from the examining division
07.03.2016Despatch of a communication from the examining division (Time limit: M04)
19.07.2016Application deemed to be withdrawn, date of legal effect  [2016/51]
16.08.2016Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2016/51]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  19.04.2013
Fees paidRenewal fee
30.03.2012Renewal fee patent year 03
27.03.2013Renewal fee patent year 04
25.03.2014Renewal fee patent year 05
23.03.2015Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
31.03.201607   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[YP]US2010028299  (EINAV SHIRIT [US], et al) [YP] 1-3,7-14 * the whole document *;
 [YP]WO2009039248  (UNIV STANFORD [US], et al) [YP] 1-3,7-14 * the whole document *;
 [X]US4011322  (RAHTZ DIETER, et al) [X] 1,2,4,8,10 * abstract *;
 [X]WO03060475  (NEUROGEN CORP [US], et al) [X] 1 * page 39; compound 15 *;
 [X]WO2006010446  (7TM PHARMA AS [DK], et al) [X] 1 * page 48; example 23 *;
 [X]WO2007115077  (ASTRAZENECA AB [SE], et al) [X] 1 * page 84; example 26.3 *;
 [XYI]  - EINAV SHIRIT ET AL, "Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 26, no. 9, doi:10.1038/NBT.1490, ISSN 1087-0156, (20080901), pages 1019 - 1027, (20080831), XP002597121 [X] 4 * page 1022 - page 1024 * [Y] 1-3,7-14 [I] 1-3,7-14

DOI:   http://dx.doi.org/10.1038/NBT.1490
 [X]  - CAROTI P ET AL, "Synthesis, antilipidemic and platelet antiaggregatory activity of 2-aminobenzimidazole amide derivatives", IL FARMACO, ELSEVIER FRANCE * EDITIONS SCIENTIFIQUES ET MEDICALES, IT, (19890101), vol. 44, no. 3, ISSN 0014-827X, pages 227 - 255, XP008128293 [X] 1 * compound X (Scheme 1) *
 [A]  - TUNCBILEK M ET AL, "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW ANILINO BENZIMIDAZOLES", ARCHIV DER PHARMAZIE, WILEY - VCH VERLAG GMBH & CO. KGAA, DE, (19971201), vol. 330, no. 12, doi:10.1002/ARDP.19973301203, ISSN 0365-6233, pages 372 - 376, XP001064267 [A] 1 * compounds 13,5 *

DOI:   http://dx.doi.org/10.1002/ardp.19973301203
International search[Y]US4011322  (RAHTZ DIETER, et al);
 [A]WO2005012288  (GENELABS TECH INC [US], et al);
 [A]US6211177  (SPERL GERHARD [US], et al);
 [A]KR950031074  (ELI LILLY AND COMPANY);
 [A]US5552426  (LUNN WILLIAM H W [US], et al);
 [XP]WO2009039248  (UNIV STANFORD [US], et al)
 [Y]  - BEAULIEU,C. ET AL., "Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (2004), vol. 14, pages 3195 - 3199, XP004841373

DOI:   http://dx.doi.org/10.1016/j.bmcl.2004.04.005
 [Y]  - EINAV,S. ET AL., "Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis", NATURE BIOTECHNOLOGY, (200809), vol. 26, no. 9, pages 1019 - 1027, XP002597121

DOI:   http://dx.doi.org/10.1038/NBT.1490
by applicantUS3470194
 US4692147
 US4360019
 US4487603
 US4725852
 US5820589
 US5643207
 US6198966
 WO9727840
 US5985305
 US5728396
 US3760984
 US3845770
 US3916899
 US3923426
 US3987790
 US3995631
 US4016880
 US4036228
 US4111202
 US4111203
 US4203440
 US4203442
 US4210139
 US4327725
 US4627850
 US4865845
 US5057318
 US5059423
 US5112614
 US5137727
 US5234692
 US5234693
 US4350155
 US5443450
 US5814019
 US5976109
 US6017328
 US6171276
 US6241704
 US6464687
 US6475180
 US6512954
 WO02089731
 WO2005032329
 WO2009148541
 WO2006133326
 WO2008021928
 WO2007018692
 US2006199174
 US2008118511
 US2007065427
 US2007122378
 US5503973
 US5876920
 US6159939
 US6627610
 US7342016
 US5874442
 US7101897
 US6232338
 US4211771
 US6277830
 US5559101
 US6423695
 US2002058635
 WO0190121
 WO02069903
 WO02057287
 WO02057425
 US6642204
 US6534523
 US6420380
 US6410531
 US6329417
 US6329379
 US6323180
 US6143715
 US6608027
 US6617309
 US6608067
 US6265380
 US6624290
 US5990276
 WO9907733
 WO9907734
 WO0009558
 WO0009543
 WO0059929
 WO02060926
 US2003019067
 US2003187018
 US2003186895
 US6479508
 US6440985
 WO0147883
 WO02100846
 WO02100851
 WO0185172
 WO02098424
 WO0006529
 WO0206246
 WO03000254
 EP1256628
 US4695623
 US4897471
 US5382657
 US5981709
 US5951974
 US2010028299
    - ANNALS INTERNAL MED, (2000), vol. 132, pages 296 - 305
    - CURR TOP MICROBIOL IMMUNOL, (2000), vol. 242, pages 55 - 84
    - J VIROL, (2002), vol. 76, pages 5974 - 5984
    - J VIROL, (2004), vol. 78, pages 11393 - 11400
    - "Drug Latentiation", HARPER, N.J., Progress in Drug Research, (1962), vol. 4, pages 221 - 294
    - WANG ET AL., "Prodrug approaches to the improved delivery of peptide drug", CURR. PHARM. DESIGN, (1999), vol. 5, no. 4, pages 265 - 287
    - PAULETTI ET AL., "Improvement in peptide bioavailability: Peptidomimetics and Prodrug Strategies", ADV. DRUG. DELIVERY REV., (1997), vol. 27, pages 235 - 256
    - MIZEN ET AL., "The Use of Esters as Prodrugs for Oral Delivery of P-Lactam antibiotics", PHARM. BIOTECH, (1998), vol. 11, pages 345 - 365
    - GAIGNAULT ET AL., "Designing Prodrugs and Bioprecursors I. Carrier Prodrugs", PRACT. MED. CHEM, (1996), pages 671 - 696
    - M. ASGHARNEJAD, "Improving Oral Drug Transport Via Prodrugs", TRANSPORT PROCESSES IN PHARMACEUTICAL SYSTEMS, (2000), pages 185 - 218
    - BALANT ET AL., "Prodrugs for the improvement of drug absorption via different routes of administration", EUR. J. DRUG METAB. PHARMACOKINET, (1990), vol. 15, no. 2, pages 143 - 53
    - BALIMANE; SINKO, "Involvement of multiple transporters in the oral absorption of nucleoside analogues", ADV. DRUG DELIVERY REV., (1999), vol. 39, no. 1-3, pages 183 - 209
    - BROWNE, "Fosphenytoin (Cerebyx", CLIN. NEUROPHARMACOL, (1997), vol. 20, no. 1, pages 1 - 12
    - BUNDGAARD, "Bioreversible derivatization of drugs--principle and applicability to improve the therapeutic effects of drugs", ARCH. PHARM. CHEMI, (1979), vol. 86, no. 1, pages 1 - 39
    - FLEISHER ET AL., "Improved oral drug delivery: solubility limitations overcome by the use of prodrugs", ADV. DRUG DELIVERY REV, (1996), vol. 19, no. 2, pages 115 - 130
    - FLEISHER ET AL., "Design of prodrugs for improved gastrointestinal absorption by intestinal enzyme targeting", METHODS ENZYMOL., (1985), vol. 112, pages 360 - 81
    - FARQUHAR D ET AL., "Biologically Reversible Phosphate-Protective Groups", J. PHARM. SCI., (1983), vol. 72, no. 3, pages 324 - 325
    - HAN, H.K ET AL., "Targeted prodrug design to optimize drug delivery", AAPS PHARMSCI., (2000), vol. 2, no. 1, page E6
    - SADZUKA Y, "Effective prodrug liposome and conversion to active metabolite", CURR. DRUG METAB, (2000), vol. 1, no. 1, pages 31 - 48
    - D.M. LAMBERT, "Rationale and applications of lipids as prodrug carriers", EUR. J. PHARM. SCI., (2000), vol. 11, no. 2, pages 15 - 27
    - WANG, W ET AL., "Prodrug approaches to the improved delivery of peptide drugs", CURR. PHARM. DES., (1999), vol. 5, no. 4, pages 265 - 87
    - CURRENT OPINION IN INVESTIGATIONAL DRUGS, (2006), vol. 7, no. 2, pages 109 - 117
    - J. MED. CHEM., (2008), vol. 51, pages 2328 - 2345
    - NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACIDS, (2005), vol. 24, no. 5 - 7, pages 375 - 381
    - GRETCH ET AL., ANN. INTERN. MED., (1995), vol. 123, pages 321 - 329
    - VARGO ET AL., TRANSFUSION, (2002), vol. 42, pages 876 - 885
    - PEARLSTEIN ET AL., J. MED. CHEM., (2003), vol. 46, no. 11, pages 2017 - 2022
    - FERMINI ET AL., ANNUAL REPORTS IN MEDICINAL CHEMISTRY, (2004), vol. 39, page 323
    - ., Synthetic Organic Chemistry, JOHN WILEY & SONS, INC.
    - LAROCK, R. C., Comprehensive Organic Transformations: A Guide to Functional Group Preparations 2nd Edition, WILEY-VCH, (1999), ISBN 0-471-19031-4
    - MARCH, J., Advanced Organic Chemistry: Reactions, Mechanisms, and Structure 4th Edition, JOHN WILEY & SONS, (1992), ISBN 0-471-60180-2
    - OTERA, J., Modem Carbonyl Chemistry, WILEY-VCH, (2000), ISBN 3-527-29871-1
    - PATAI, S., Patai's 1992 Guide to the Chemistry of Functional Groups, (1992), ISBN 0-471-93022-9
    - SOLOMONS, T. W. G, Organic Chemistry 7th Edition, JOHN WILEY & SONS, (2000), ISBN 0-471-19095-0
    - STOWELL, J.C., Intermediate Organic Chemistry 2nd Edition, WILEY, (1993), ISBN 0-471-57456-2
    - Industrial Organic Chemicals: Starting Materials and Intermediates: An Ullmann's Encyclopedia, JOHN WILEY & SONS, (1999), ISBN 3-527-29645-X
    - ., Chemistry of Functional Groups, JOHN WILEY & SONS
    - ROTH, T. ET, J. MED CHEM., (1997), vol. 40, no. 26, page 4199
    - ZHANG, P. ET AL., TET. LETT., (2007), vol. 48, page 8659
    - SEFTON, CRC CRIT. REF. BIOMED. ENG, (1987), vol. 14, page 201
    - BUCHWALD ET AL., SURGERY, (1980), vol. 88, page 507
    - SAUDEK ET AL., N. ENGL. J. MED., (1989), vol. 321, page 574
    - LANGER, SCIENCE, (1990), vol. 249, pages 1527 - 1533
    - BRUNT, HEPATOL., (2000), vol. 31, pages 241 - 246
    - METAVIR, HEPATOLOGY, (1994), vol. 20, pages 15 - 20
    - KNODELL, HEPATOL, (1981), vol. 1, page 431
    - SCHEUER, J. HEPATOL., (1991), vol. 13, page 372
    - ISHAK, J. HEPATOL., (1995), vol. 22, pages 696 - 699
    - PAUSE ET AL., J. BIOL. CHEM., (2003), vol. 278, pages 20374 - 20380
    - LAMARRE ET AL., HEPATOLOGY, (2002), vol. 36, page 301A
    - ZHONG ET AL., ANTIMICROB. AGENTS CHEMOTHER., (2003), vol. 47, pages 2674 - 2681
    - DHANAK ET AL., J. BIOL CHEM., (2002), vol. 277, no. 41, pages 38322 - 7
    - OSBORN ET AL., J. PHARMACOL. EXP. THERAP., (2002), vol. 303, pages 540 - 548
    - MASCI ET AL., CURR. ONCOL. REP., (2003), vol. 5, pages 108 - 113
    - NATURE BIOTECHNOLOGY, (2008), vol. 26, pages 1019 - 1027
    - BLIGHT ET AL., J. VIROL., (2002), vol. 76, page 13001
    - ZHANG ET AL., J. VIROL., (2004), vol. 78, page 1448
    - ELAZAR ET AL., J. VIROL., (2003), vol. 77, no. 10, pages 6055 - 61
 US20070844993
 US20080057188
 WO2002CA01127
 WO2002CA01128
 WO2002CA01129
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.