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Extract from the Register of European Patents

EP About this file: EP2408758

EP2408758 - CRYSTALLINE TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  28.08.2015
Database last updated on 31.08.2024
Most recent event   Tooltip28.08.2015No opposition filed within time limitpublished on 30.09.2015  [2015/40]
Applicant(s)For all designated states
Onyx Therapeutics, Inc.
249 E. Grand Avenue
South San Francisco, CA 94080 / US
[2014/43]
Former [2012/04]For all designated states
Onyx Therapeutics, Inc.
249 E. Grand Avenue
South San Francisco, CA 94080 / US
Inventor(s)01 / PHIASIVONGSA, Pasit
2712 Saint Regis Avenue
Brentwood CA 94513 / US
02 / SEHL, Louis, C.
403 Alameda de la Pulgas
Redwood City CA 94062 / US
 [2012/04]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[N/P]
Former [2014/02]HOFFMANN EITLE
Patent- und Rechtsanwälte
Arabellastrasse 4
81925 München / DE
Former [2012/04]Coehn, Markus
Fish & Richardson P.C. Mies-van-der-Rohe-Strasse 8
80807 München / DE
Application number, filing date10754225.022.03.2010
WO2010US28126
Priority number, dateUS20090180561P22.05.2009         Original published format: US 180561 P
US20090162196P20.03.2009         Original published format: US 162196 P
[2012/04]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2010108172
Date:23.09.2010
Language:EN
[2010/38]
Type: A1 Application with search report 
No.:EP2408758
Date:25.01.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 23.09.2010 takes the place of the publication of the European patent application.
[2012/04]
Type: B1 Patent specification 
No.:EP2408758
Date:22.10.2014
Language:EN
[2014/43]
Search report(s)International search report - published on:AU23.09.2010
(Supplementary) European search report - dispatched on:EP03.08.2012
ClassificationIPC:A61K38/55, C07K5/08, C07D417/12
[2012/36]
CPC:
A61K31/427 (EP,US); C07D417/12 (EP,KR,US); C07K5/0802 (US);
A61P19/08 (EP); A61P19/10 (EP); A61P25/28 (EP);
A61P29/00 (EP); A61P31/00 (EP); A61P31/04 (EP);
A61P31/12 (EP); A61P33/00 (EP); A61P35/00 (EP);
A61P35/02 (EP); A61P37/00 (EP); A61P37/02 (EP);
A61P37/06 (EP); A61P37/08 (EP); A61P43/00 (EP);
A61P7/00 (EP); A61P9/10 (EP); C07D277/56 (KR);
C07K1/026 (KR,US); C07K5/0804 (KR); C07K5/0821 (KR,US);
Y02A50/30 (EP,US) (-)
Former IPC [2012/04]C07D277/56, A61K38/55, C07K5/08
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/04]
Extension statesAL18.10.2011
BA18.10.2011
RS18.10.2011
TitleGerman:KRISTALLINE TRIPEPTID-EPOXIDKETON-PROTEASEHEMMER[2012/04]
English:CRYSTALLINE TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS[2012/04]
French:INHIBITEURS DE TRIPEPTIDE ÉPOXY CÉTONE PROTÉASES CRISTALLINES[2012/04]
Entry into regional phase18.10.2011National basic fee paid 
18.10.2011Search fee paid 
18.10.2011Designation fee(s) paid 
18.10.2011Examination fee paid 
Examination procedure18.10.2011Examination requested  [2012/04]
27.02.2013Amendment by applicant (claims and/or description)
26.06.2013Despatch of a communication from the examining division (Time limit: M04)
16.10.2013Reply to a communication from the examining division
21.05.2014Communication of intention to grant the patent
03.09.2014Fee for grant paid
03.09.2014Fee for publishing/printing paid
03.09.2014Receipt of the translation of the claim(s)
Divisional application(s)EP14178725.9  / EP2813241
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  26.06.2013
Opposition(s)23.07.2015No opposition filed within time limit [2015/40]
Fees paidRenewal fee
26.03.2012Renewal fee patent year 03
27.03.2013Renewal fee patent year 04
27.03.2014Renewal fee patent year 05
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Documents cited:Search   [ ] - No further relevant documents disclosed
International search[X]WO2008140782  (PROTEOLIX INC [US], et al);
 [XP]WO2009045497  (PROTEOLIX INC [US], et al);
 [A]  - GROLL M ET AL., "Crystal Structure of Epoxomicin:20S Proteasome Reveals a Molecular Basis for Selectivity of alpha', beta'-Epoxyketone Proteasome Inhibitors", J. AM. CHEM. SOC., (2000), vol. 122, pages 1237 - 1238, XP008128036

DOI:   http://dx.doi.org/10.1021/ja993588m
 [XP]  - ZHOU HJ ET AL., "Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)", J. MED. CHEM., (2009), vol. 52, pages 3028 - 3038, XP055086446

DOI:   http://dx.doi.org/10.1021/jm801329v
 [A]  - "2.20 Recrystallisation Techniques", VOGEL'S TEXTBOOK OF PRACTICAL ORGANIC CHEMISTRY, vol. 5TH, pages 135 1 - 153, XP008166193
 [A]  - CAIRA, "Crystalline Polymorphism of Organic Compounds", TOPICS IN CURRENT CHEMISTRY, (1998), vol. 198, pages 163 - 208, XP008166276

DOI:   http://dx.doi.org/10.1007/3-540-69178-2_5
by applicant   - CAIRA ET AL., TOPICS IN CURRENT CHEMISTRY, (1998), vol. 198, pages 163 - 208
    - Vogel's Textbook of Practical Organic Chemistry, vol. 5, page 135,141
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.